The fundamental importance of the ban on turning for the worse for the criminal procedure system by K. D. Vanyan, N. N. Lysov, M. T. Tashilin, A. S. Shuisky, I. R. Gilmanov, V. V. Kosterin

“…The systematic approach allowed to determine not only the mixed nature of the mechanism for changing the prosecution to a more serious one, but the investigative organization of pre-trial proceedings and its place in the structure of criminal proceedings, the separation of the investigative and “accusatory powers” of the prosecutors as well as their balance. …”
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Capsiate attenuates atherosclerosis by activating Nrf2/GPX4 pathway and reshaping the intestinal microbiota in ApoE−/− mice by Yongbin Shen, Chuanqi Zhang, Xue Jiang, Xianwei Li, Bo Chen, Weiliang Jiang

“…However, there has still been no study on the ferroptosis and gut microbiota of capsiate in atherosclerosis (AS) mouse models. Our study is the first to report on the reshaping of the structure of the gut microbiota by capsiate in AS, and to explore the potential mechanism underlying the improvement of AS. …”
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The relationship between work-family conflict, stress and depression among Chinese correctional officers: a mediation and network analysis study by Jingyan Sun, Shurui Chen, Siyuan Wang, Huijuan Guo, Xiaoping Wang

“…Subsequently, correlation and regression analyses were conducted using SPSS 26.0, while mediation analysis was performed using Model 4 in PROCESS. By using the EBICglasso model, network analyses were utilized to estimate the network structure of WFC, stress and depression. …”
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MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism by Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang, Chuan Chen

“…HUVEC activity and mitochondrial structure and function were detected to explore the ability of MT2A to alleviate CPO-induced damage. …”
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Oxoglutarate dehydrogenase-L regulates mitochondrial metabolism reprogramming of renal tubular epithelial cells to alleviate renal fibrosis by YANG Yingxian, HUANG Yinghui, ZHAO Jinghong

“…Immunofluorescence, immunohistochemical and Masson staining showed obvious renal fibrosis after UUO operation. In the mouse model of renal fibrosis, the expression of OGDHL was decreased by 82.9% at mRNA level (P<0.001) and 81.9% at protein level (P<0.001), the production of mitochondrial ATP was reduced by 0.970±0.151 µmol/L (P<0.01), and notable damaged mitochondrial structure was observed, with maximum breathing capacity decreased by 25.260±1.920 pmol/min (P<0.001), expression levels of fatty acid oxidation-related genes were declined by 50.2% (P<0.05), while glycolysis was enhanced, with the genes related to glycolysis increased by 2.5 times when compared with those in the control group (P<0.05). …”
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Research Progress Analysis Regarding Rainfall-Runoff Relationships Based on Bibliometrics and Visual Methods by Yi Qi, Wang Ruifang, Dou Xiaodong, Gao Yuting, Wang Changhao, Yang Lu

“…[Methods] Based on 828 core journal papers regarding rainfall and runoff in China and abroad during the past 50 years, the CiteSpace visualization software was used for sorting and analyzing the knowledge domain map structure of rainfall-runoff research studies. [Results] ① The study of rainfall-runoff relationships has always focused on the relationship between rainfall, infiltration, surface runoff, and erosion, as well as on the simulation of slope runoff. …”
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Role of circCCDC138 in early malignant transformation of human lung epithelial cells induced by carbon black nanoparticles by Runfeng LI, Lichun MA, Shulin QIN, Wen LIU

“…Western blot was used to analyze the expression of p53 protein.ResultsThe CBNPs used in the experiment were spherical particles with a chain-like structure. In the 20 μg·mL−1 CBNPs group, the reduction in the viability of BEAS-2B cells was relatively small (10%). …”
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Spatial yield gains in empty-row optimized rice–crab co-culture are linked to nifH-driven nitrogen compensation in border rows by Tiexin Yang, Dandan Jin, Liqiang Dong, Liang Ma, Zhengyan Pan, Zhiqiang Li, Fuyu Sun, Xiaosen Sun, Lei Yu

“…IntroductionThe rice–crab coculture system is ecologically sustainable with efficient resource utilization, but the soil nitrogen cycling mechanisms underlying yield limitations in different coculture models remain unclear. Here, we aimed to identify yield-limiting factors by comparing rice productivity between the conventional rice–crab coculture model (CK) and an optimized model (12 rows cultivated-1 row empty, ERC-12). …”
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Effect of Xingbi Gel Nasal Drops on Rats with Allergic Rhinitis Based on the Nasal Mucosa-Hippocampus Neuroimmune Mechanism by FAN Xueqi, QIU Caixia, YAN Shuiping, ZHUANG Xiangli, AI Si, GUO Lihua, ZHENG Jian

“…Compared with the model group, IgE and TGF-β1 contents in serum in both the traditional Chinese medicine group and the western medicine group were significantly lower (<italic>P</italic>&lt;0.05). (4) Pathological changes of nasal mucosa and EOS counts: the nasal mucosa in the model group was edematous and the epithelial cells were arranged in disorder; the nasal mucosa edema were alleviated significantly in the traditional Chinese medicine group and the western medicine group after treatment, and the epithelial cell structure was more intact. …”
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Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy by Ming Hao, Xingchen Li, Xinxin Zhang, Boqiang Tao, He Shi, Jianing Wu, Yuyang Li, Xiang Li, Shuangji Li, Han Wu, Jingcheng Xiang, Dongxu Wang, Weiwei Liu, Guoqing Wang

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Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis by Jia Yang, Mingzheng Hu, Mulin Yang, Hua Ni, Jun Zhou, Dengwen Li, Jie Ran, Min Liu

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Targeting APE1/Ref-1 to alleviate formalin-induced pain and spinal neuro-inflammation in rats: a promising therapeutic approach by Eman Elgendy, Amira Zaky, Mayssaa Wahby, Marc Landry, Marc Landry, Ahmad Bassiouny

“…Notably, E3330 treatment maintained normal APE1/Ref-1 levels and promoted a more organized mitochondrial structure. Administration of E3330 correlated with increased dopamine levels, a decrease in the mRNA expression of dopamine receptors DRD1 and DRD5, and a restoration of DRD2 expression in the ipsilateral spinal cords. …”
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Iron-manganese modified corncob biochar for fluoride removal from groundwater: Insights into adsorption mechanisms by Juan-juan Liu, Si-yuan Ma, Xin-wen Yang, Wang-ying Chen, Abdur Rashid

“…Batch experiments for fluoride (F‒) removal were performed by corncob biochar before and after Fe–Mn modified. Their composition, structure, and performance were analyzed by multiple characterization techniques to clarify F‒ removal mechanisms. …”
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Addressing health inequities: validating the Chinese-WSF28 workstyle for work-related musculoskeletal symptoms among cleaners by Kin Cheung, Ka Yan Ma, E.S.P. Cheung, Benjamin Chiu-hang Sin, Kwan Wai Mui, Yuen Kwan Ko, Sin Man Tsoi, Nok Hang Leung, Ka Yee Lui, Winnie Wing Man Ng, Pui Sze Bessie Chan, H.C. Lau, Yu Hin Brian Lee

“…The overall results of the confirmatory factor analysis further support this hypothesized factor structure, supported by the Workstyle Model. Validation against known groups also showed that the Chinese-WSF28 (C-WSF28) can discriminate between cleaners with and without WRMS in various body parts. …”
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3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration by Wenqiang Lou, Xinzhu Qiu, Yiming Qin, Yingnan Lu, Yong Cao, Hongbin Lu

“…Osteochondral defects (OCDs) pose a significant clinical challenge due to their limited self-repair capacity. The complex structure and distinct biological properties of articular cartilage and subchondral bone further complicate regeneration.In this study, we introduce a novel osteochondral regeneration strategy leveraging single-cell RNA sequencing (ScRNA-seq) to identify a unique population of skeletal stem cells (SSCs) derived from the infrapatellar fat pad (IFP). …”
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Investigating the impact of generative AI integration on the sustenance of higher-order thinking skills and understanding of programming logic by Jemimah Nathaniel, Solomon Sunday Oyelere, Jarkko Suhonen, Matti Tedre

“…The intervention followed a one-group pretest-post-test structure over seven weeks with 25 computer science students with no prior C++ experience. …”
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Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma by Ravi Dhital, Yeaseul Kim, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Kevin A. Cassady

“…RUX+oHSV therapy also increased cytokine-expressing CD4(+) populations, predominantly granzyme B(+) cytotoxic-like, interferon (IFN)-γ(+) T helper type 1 (Th1)-like, and interleukin (IL)-21(+) T follicular helper (Tfh)-like phenotypes, within the tumor infiltrates, suggestive of potential tertiary lymphoid structure development in the treated tumors. Here, we illustrate the utility of a high-dimensional spectral flow cytometry panel that permits simultaneous evaluation of intratumoral CD4/CD8 T cell, Treg, γδ-T cell, natural killer T (NKT) cell, B cell, NK cell, monocyte, macrophage, granulocyte, myeloid-derived suppressor cell (MDSC), and dendritic cell functional changes from RUX+oHSV-treated MPNSTs.…”
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Impact of different genomic relationship matrix construction methods on the accuracy of genomic prediction in different species by Shiyi Wang, Yingjia Wei, Dengying Liu, Xiangzhe Zhang, Qishan Wang, Yuchun Pan, Peipei Ma

“…The learning curve for bull data showed the choice of G-matrix had minimal impact on prediction accuracy when the reference population size and genetic marker density reached a certain threshold.DiscussionThe study concluded that the optimal G-matrix construction method varies across species, with population structure being a key factor. These findings highlight the importance of species-specific optimization in genomic prediction and suggest that the influence of G-matrix construction diminishes in large-scale, high-density genomic datasets.…”
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Distribution Characteristics of Nutrients and Eutrophication Assessment in Yueqing Bay by YAO Kaixue, YIN Rui, WANG Yang, CHEN Feng, LI Zhenhua

“…Based on the Marine environment monitoring data of Yueqing Bay in spring, summer, autumn and winter from 2018 to 2019, the spatial and temporal distribution characteristics of nutrient salts (dissolved inorganic nitrogen, DIN) and active phosphate (DIP) in the sea were analyzed, and the pollution degree, eutrophication degree and nutrient structure of the sea area were evaluated by single factor index method, eutrophication index method and potential eutrophication model. …”
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A novel Osteoarthritis scoring system to separate typical OA joint degeneration from non-typical lesions in male Sprague Dawley rats by Nada Abughazaleh, Ruth-Anne Seerattan, David A. Hart, Raylene A. Reimer, Walter Herzog

“…OAHC were divided into 3 categories: (I) Typical OA score evaluating the changes in cartilage structure, cellularity, proteoglycan depletion, and tidemark integrity, (II) A novel Non-typical OA score evaluating cartilage integrity, and the size of local thickening, fragmentation and degeneration along the tidemark and the size and severity of the subchondral bone lesion, and (III) Total OA score comprised of both, the Typical and the Non-typical scores. …”
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