Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer by Parik Kakani, Shruti Ganesh Dhamdhere, Deepak Pant, Rushikesh Joshi, Sachin Mishra, Anchala Pandey, Dimple Notani, Sanjeev Shukla

“…Summary: Hypoxia influences the epithelial-mesenchymal transition (EMT) through the remodeling of the chromatin structure, epigenetics, and alternative splicing. Hypoxia drives CCCTC-binding factor (CTCF) induction through hypoxia-inducible factor 1-alpha (HIF1α), which promotes EMT, although the underlying mechanisms remain unclear. …”
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Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages by Serena Tedesco, Morena Zusso, Laura Facci, Annalisa Trenti, Carlotta Boscaro, Federica Belluti, Gian Paolo Fadini, Stephen D. Skaper, Pietro Giusti, Chiara Bolego, Andrea Cignarella

“…Several studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models. We here investigated the effects of curcumin and the two structurally unrelated analogues GG6 and GG9 in primary human blood-derived macrophages as well as the signalling pathways involved. …”
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Clinical Effectiveness of Anterior Repositioning Splints in Treating Temporomandibular Joint Disc Displacement with Reduction: A Systematic Review and Meta-Analysis by Tayyaba Rafiq, Aqsa Sajji, Iqra Bibi, Mahvish Jabeen, Misbah Noreen, Sajid Ali Majeedano, Ehsan Ul Haq

“… Background: The prevalent condition known as Temporomandibular joint disc displacement with reduction (DDwR) results in pain, together with joint sounds and problems related to the jaw structure. ARS treatment for DDwR was studied in this systematic review and meta-analysis to determine its effect on joint symptoms and pain intensity. …”
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Missing value interpolation algorithm for long-term temperature observation data based on data augmentation multiple interpolation method by Xiaolin Liu, Bo Wang, Shuanglong Jin, Zongpeng Song

“…The noise reduction method based on Graph Attention Network (GAT) is adopted to handle the noise in the data. The graph structure is utilized to represent the time dependence and correlation of temperature data, and the information propagation weight between nodes is dynamically adjusted through the attention mechanism to improve the data quality. …”
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Characteristics and precipitation behavior of (Ti,V)(CxN1-x)-CrC3-MoS2 complex inclusions in GCr15 steel for cylindrical rollers of shield machine main bearings by Jinlong Wang, Wenrui Yang, Xiaohao Mei, Desheng Li, Hao Tian, Aiping Xiao, Zhengliang Xue

“…These inclusions exhibited a cubic structure and appeared dark red under optical microscopy. …”
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The role of genetic testing in accurate diagnosis of X-linked sideroblastic anemia: novel ALAS2 mutations and the impact of X-chromosome inactivation by Daniel Jové-Solavera, Marta Rámila, Xènia Ferrer-Cortés, Mireia Olivella, Veronica Venturi, Marta Morado, Ines Hernández-Rodríguez, Aneal Khan, Santiago Pérez-Montero, Cristian Tornador, Ulrich Germing, Norbert Gattermann, Mayka Sanchez

“…Among these, five represent novel ALAS2 mutations, including the first ever reported stop-loss mutation in ALAS2 associated with XLSA rather than X-linked dominant protoporphyria (XLDPP). Computational modelling of six reported cases revealed that four mutations significantly impact protein structure, conformation and cofactor interaction, consistent with our enzymatic assays demonstrating reduced ALAS2 activity. …”
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Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives by Cristina Martín-Escura, Maria Angeles Bonache, Alicia Medina-Peris, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz

“…Aim: To expand the understanding of the structure-activity relationship within a family of amino acid-derived β-lactam TRPM8 (transient receptor potential melastatin channel, subtype 8) antagonists, this work investigated both the configuration-dependence of potency and selectivity, and explored strategies for increasing total polar surface area (TPSA). …”
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Translation and Cross-Cultural Adaptation of the Individual Work Performance Questionnaire (IWPQ) into Persian and Assessing its Psychometric Properties by Marzieh Izadi Laybidi, Mohammad Asghari-Jafarabadi, Azam Maleki-Ghahfarokhi, Elham Entezarizarch, Mojtaba Khosravi Danesh

“…Exploratory factor analysis confirmed a three-factor structure: task performance, contextual performance, and counterproductive work behavior. …”
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Total Round Cell Concentration in Semen and Its Association With Sperm DNA Fragmentation Index Among Ghanaian Males in Kumasi by Evans Anokye Kumi, Victor Boachie Owusu, Peter Nyarko Coffie, Ebenezer Kojo Addae, Rex Kwadwo Mawuli Djokoto, Kweku Bedu-Addo, John Asiedu Larbi

“…Sperm DNA fragmentation was determined using the Sperm Chromatin Structure Assay, and multivariate logistic regression models were employed to evaluate associations between TRCC and semen quality parameters. …”
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Hybrid Fishnet Metamaterial Based on Liquid Crystal and P-I-N Diodes for Reconfigurable Transmitarrays at <inline-formula><tex-math notation="LaTeX">$10 \,\mathrm{GHz}$</tex-math><... by Adrian Diepolder, Lukas Schmidt, Susanne Brandl, Philipp Hinz, Christian Waldschmidt, Christian Damm

“…This article presents a reconfigurable unit cell for transmitarrays at <inline-formula><tex-math notation="LaTeX">$10 \,\mathrm{GHz}$</tex-math></inline-formula> based on the fishnet metamaterial structure. The proposed design achieves a phase shift of up to <inline-formula><tex-math notation="LaTeX">$180 \mathrm{^{\circ }}$</tex-math></inline-formula> between different states and additional tunability in each phase state by switching the electric response using p-i-n diodes and simultaneously tuning the magnetic response by employing liquid crystal. …”
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Species diversity estimation in a typical tropical forest: which phenological stage and spatial resolution are suitable? by Ping Zhao, Ping Zhao, Ping Zhao, Yuan Zeng, Yuan Zeng, Yuan Zeng, Zhaoju Zheng, Zhaoju Zheng, Cong Xu, Cong Xu, Jinchen Wu, Jinchen Wu, Jinchen Wu, Xuan Mu, Xuan Mu, Xuan Mu, Zhaofu Zhou, Zhaofu Zhou, Zhaofu Zhou, Junhua Chen, Junhua Chen, Junhua Chen, Tao Zhang, Dan Zhao, Dan Zhao, Dan Zhao

“…We constructed stepwise linear regression models for estimating Richness, Simpson, and Shannon-Wiener indices using in-situ species diversity and heterogeneity metrics of spectra and structure. …”
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Design and experimental research on the rocker arm walking mechanism of the wheeled inspection robot for the main transportation roadway of coal mines by YANG Rui, BAO Jiusheng, BAO Zhouyang, YIN Yan, ZHANG Lei, PAN Guoyu, YANG Jiao, GE Shirong

“…A rocker arm walking mechanism for a wheeled inspection robot was designed to complement track-based inspection robots, fulfilling the need for comprehensive inspections. The system structure of the wheeled inspection robot was determined, with a focus on analyzing its walking system. …”
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The Comprehensive Root Metabolite–Rhizomicrobiota Response Patterns of <i>Rhododendron delavayi</i> (<i>R. delavayi</i>) to Waterlogging Stress and Post–Waterlogging Recovery by Jing Tang, Qingqing Huang, Qian Wang, Fei Shan, Shaolong Wu, Ximin Zhang, Ming Tang, Yin Yi

“…A significant correlation between root metabolites and the rhizosphere microbial community structure during waterlogging stress and recovery. …”
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Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity by Thirumurugan Rathinasabapathy, Kimberly Marie Palatini Jackson, Yiwen Thor, Ayuba Sunday Buru, Debora Esposito, Xu Li, Mallikarjuna Rao Pichika, Ahmad Sazali Hamzah, Slavko Komarnytsky

“…Results. Based on the docking model and structure-activity relationships, tetrahydrothiazolopyridine derivatives TR-02 and TR-04 showed the highest potency against 11β-HSD1 by dose-dependently inhibiting conversion of cortisone to cortisol (IC50 values of 1.8 μM and 0.095 μM, resp.). …”
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The effect of age and sex on brain metabolites: from childhood to adulthood by María Ortuño, Adriana Fortea, Isabel Valli, Emma Muñoz-Moreno, Roger Borràs, Irene Martínez-Serrano, Mireia Masias Bruns, Patricia Camprodon-Boadas, Enric Vilajosana, Lydia Fortea, Joaquim Raduà, Elena de la Serna, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes

“…This cross-sectional study set out to examine the relationship between levels of neurometabolites and age and sex —key modulators of brain function and structure—, continuously from childhood to early adulthood, in areas relevant to the study of psychiatric disorders.Magnetic resonance spectroscopy (¹H MRS) data was acquired in the dorsomedial prefrontal region (dmPF) and the medial temporal lobe (mTL) in 128 healthy individuals aged 7 to 34 years, 68.5 % females (ndmPF = 124; nmTL = 75). …”
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An Improved One-Pot Procedure for Preparation Of N,N -Diethyl-m-Toluamide from m-Toluic Acid by Thinh Pham Duc, Thu Nguyen Van, Phuong Bui Thu, Chau Phan Dinh, Duc Viet Le, Duong Vu Binh

“…The analytical data has shown that DEET was collected at a very high yield in the range of 96-98%, purity (HPLC): 95.5-97.6%. The structure of DEET was determined by model spectroscopies MS, and NMR. …”
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Research on the spatial characterization of herder grazing intensity supported by mobile phone signaling data by Zhanming Qiao, Zhanming Qiao, Zhanming Qiao, Min Zheng, Min Zheng, Min Zheng, Zheng Li, Zheng Li, Quanmin Dong, Chunping Zhang, Yang Yu, Quan Cao

“…The equal weight average method was employed to simulate herders’ grazing intensity, with empirical analyses conducted in the Henan Mongolian Autonomous County.ResultsThe findings indicated that: 1) herders’ mobile phone signaling data can quantitatively represent grazing intensity, and when combined with the density and elevation distribution of settlements in Henan County, it reveals that the spatial distribution of grazing intensity aligns with the trajectory of herders’ summer grazing activities. 2) The spatial characteristics of the centrality of the herders’ mobility network exhibited a concentrated point-like ring structure, primarily centered on the townships of Duosong and Youganning, with a decreasing spread outward. 3) The spatial characteristics of the intensity of herders’ mobility ties showed a circular distribution for the overall degree of network ties, which was primarily characterized by low ties. …”
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Precision Adverse Drug Reactions Prediction with Heterogeneous Graph Neural Network by Yang Gao, Xiang Zhang, Zhongquan Sun, Payal Chandak, Jiajun Bu, Haishuai Wang

“…By leveraging edges in the graph, crucial connections are captured such as a patient being affected by diseases, taking specific drugs, and experiencing ADRs. Next, a GNN‐based model is utilized to learn latent representations of the patient nodes and facilitate the propagation of information throughout the graph structure. …”
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Tectono-stratigraphy of the Eocene Zhu-1 Sub-basin in the Pearl River Mouth basin, China: controls on hydrocarbon source rock variability and implications by Pei Liu, Pei Liu, Guangrong Peng, Guangrong Peng, Ming Luo, Ming Luo, Yuchen Wang, Yuchen Wang, Wanlin Xiong, Wanlin Xiong, Penglin Song, Penglin Song, Guanyun Wu, Guanyun Wu

“…The half-graden styles in the different sag change associated with tectonic transitions, and basement uplift and magmatic bottoming reshape the internal stratigraphic structure of the half-graden, leading to the variability of hydrocarbon accumulations. …”
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Variable Polarization of WR 31a: Binary Companion or Corotating Interaction Region? by Christiana Erba, Richard Ignace, Faith Simmons, Ben Davies

“…The linear polarization data of WR 31a trace a “loop” structure in a Stokes Q − U diagram, which is similar in all four passbands. …”
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