Development and Evaluation of Hydrogel-Based Sulfasalazine-Loaded Nanosponges for Enhanced Topical Psoriasis Therapy by Sunil Kumar, Anroop B. Nair, Varsha Kadian, Pooja Dalal, Babu Lal Jangir, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Nouf Alwadei, Rekha Rao

“…The selected nanosponges (SLZ-NS4) were transformed to hydrogel and further evaluated for rheology, texture, safety, skin permeability, and in vivo for anti-psoriatic effect in mouse tail and imiquimod-induced psoriasis-like inflammation models in mice. <b>Results:</b> Physiochemical data confirms nanoscale architecture, drug inclusion in nanosponges, crystalline structure, and formulation stability. …”
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Stem Cells Within Three-Dimensional-Printed Scaffolds Facilitate Airway Mucosa and Bone Regeneration and Reconstruction of Maxillary Defects in Rabbits by Mi Hyun Lim, Jung Ho Jeon, Sun Hwa Park, Byeong Gon Yun, Seok-Won Kim, Dong-Woo Cho, Jeong Hak Lee, Do Hyun Kim, Sung Won Kim

“…The craniofacial region includes many areas where the mucosa, exposed to air, is closely adjacent to bone, with the maxilla being a prominent example of this structure. Therefore, this study explored whether human neural-crest-derived stem cells (hNTSCs) aid bone and airway mucosal regeneration during craniofacial reconstruction using a rabbit model. …”
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RNA-seq analysis of shrimp tropomyosin-induced allergic reactions through PI3K/Akt pathway by Yanchu Li, Yanchu Li, Yuying Yang, Junyao Li, Rui Guo, Zhiqiang Niu, Weicheng Hu, Shucheng Liu, Shucheng Liu, Shuai Wei, Shuai Wei

“…In vitro experiments were conducted to construct TM sensitized Caco-2 and RBL-2H3 cell models at a dose of 100 mg/mL. The results indicated that TM upregulated the expression of phosphorylated PI3K/ Akt and NFκB pathways in Caco-2 cells, further damaged the TJ structure of intestinal epithelial cells and promoted the release of inflammatory factors. …”
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Triclosan exposure induces liver fibrosis in mice: The heterogeneous nuclear ribonucleoprotein A1/pyruvate kinase M2 axis drives hepatic stellate cell activation by Xiao Ni, Ziyun Wei, Yuxuan Peng, Linlin Zheng, Jianing Shang, Fu Liu, Yunwei Li, Jieyu Liu

“…TCS possesses a stable structure, can easily accumulate in the environment, and may have numerous negative impacts on human health. …”
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Synergistic potential of bone marrow mesenchymal stem cells and miR181-a combinational therapy against multiple sclerosis by Xin Xiu, Sijia Chen, Yumei Liu, Bo Sun, Hulun Li, Sifan Zhang, Xixi Yang, Yu Wei, Xichen Peng, Yan Wang, Yanping Wang, Junfeng Wu, Yao Zhang, Lili Mu, Qingfei Kong, Xijun Liu

“…MiR181-a, a positive regulator of immune balance, which has a preference for T cells and B cells differentiation, but degrade rapidly upon entering systemic circulation due to their unstable molecular structure. Methods We propose a synergistic therapy approach that combines the penetrative targeting capability of BMSCs with the immuno-modulatory effects of miR181-a by overexpressing miR181-a to BMSCs through lentivirus packaging system. …”
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Does fiscal decentralization foster renewable electricity generation? A panel data study of OECD countries by Serhiy Lyeonov, Oksana Okhrimenko, Artem Artyukhov, Mariia Saiensus, Iuliia Myroshnychenko, Yuliia Yehorova, Oleksii Havrylenko

“…Additionally, country-level fixed effects demonstrate substantial heterogeneity, with nations like Iceland, Norway, and Canada showing systematically higher renewable electricity shares, regardless of fiscal structure. These results underscore the importance of complementary institutional frameworks and national coordination mechanisms to ensure that decentralization effectively supports climate policy goals. …”
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Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage by Ji Eon Kim, Hyun Su Kim, Wonsik Kim, Eun Hae Lee, Soyeon Kim, Taewoo Kim, Eun-Ae Shin, Kyung-hee Pyo, Haesong Lee, Seo Hee Jin, Jae-Ho Lee, Soo-Min Byeon, Dong Joo Kim, Jinwook Jeong, Jeongwon Lee, Minjae Ohn, Hyojung Lee, Su Jong Yu, Dongyun Shin, Semi Kim, Jun Yeob Yoo, Seung-Chul Lee, Young-Ger Suh, Jung Weon Lee

“…We used comprehensive structure activity relationship analysis to identify TM4SF5-specific isoxazole (TSI)-based small molecules that inhibit TM4SF5-mediated effects. …”
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Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling by Jialu Shi, Wenjun Mao, Yuqing Song, Yuxin Wang, Lili Zhang, Yan Xu, Huiwen Gu, Siyu Yao, Yuanhang Yao, Zhifeng Liu, Vijaya Raghavan, Jin Wang

“…However, butyrate counteracted this loop by restoring microbiota structure and suppressing reactive oxygen species (ROS)/Notch cascades. …”
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Long-term exposure to PM2.5 and cardiorespiratory mortality: an ecological small-area study in five cities in Colombia by Diana Marín, Víctor Herrera, Juan Gabriel Piñeros-Jiménez, Oscar Alberto Rojas-Sánchez, Sonia C. Mangones, Yurley Rojas, Jhon Cáceres, Dayana M. Agudelo-Castañeda, Néstor Y. Rojas, Luis Carlos Belalcazar-Ceron, Jonathan Ochoa-Villegas, María Leonor Montes-Mejía, Veronica Maria Lopera-Velasquez, Sanit María Castillo-Navarro, Alexander Torres-Prieto, Jill Baumgartner, Laura A. Rodríguez-Villamizar

“…We estimated incidence rate ratios (IRR; per 5µg/m3) by fitting negative binomial regressions to smoothed Bayesian mortality rates (BMR) on PM2.5 predicted from land use regression (LUR) models, adjusting for CS demographic structure, multidimensional poverty index, and spatial autocorrelation. …”
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Effects of alginate oligosaccharides on depression-like behavior and gut microbiota in zebrafish induced by chronic unpredictable mild stress by LONG Yan, SHI Yanxia, QIU Yue, NONG Huiting, ZHU Wuchang, SU Hongmei, HE Naihuan, QIN Zhuwen, WEI Jinbin

“…Objective To investigate the effects of alginate oligosaccharides (AOS) on depression-like behavior and gut microbiota in zebrafish, a model of chronic unpredictable mild stress (CUMS). …”
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MRI-based deep learning with clinical and imaging features to differentiate medulloblastoma and ependymoma in children by Yasen Yimit, Yasen Yimit, Parhat Yasin, Yue Hao, Abudouresuli Tuersun, Abudouresuli Tuersun, Chencui Huang, Xiaoguang Zou, Xiaoguang Zou, Ya Qiu, Ya Qiu, Yunling Wang, Mayidili Nijiati, Mayidili Nijiati

“…Thus, the structure of the decision tree in the decision tree classifier is expected to greatly assist clinicians in daily practice.…”
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Therapeutic effects and mechanism analysis of Paeonia lactiflora extract (PLE) in menopausal rats with hot flashes by Weilin Cui, Tingting Song, Dongmei Gao, Xiaoyu Wang, Ya Sun, Liyu Fu, Yichao Han, Jieqiong Wang

“…In terms of pathological manifestations, the model rats had significantly thinner endometrial thickness, looser tissues and reduced integrity, while the rats intervened by PLE treatment had significantly thicker endometrium and more regularly arranged tissue structure. …”
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Development and Psychometric Testing of the Nurses’ Professional Dignity Scale by Michela Piredda, Maddalena De Maria, Rosario Caruso, Anna Marchetti, Giorgia Petrucci, Anna Cerra, Joyce J. Fitzpatrick, Alessandro Stievano

“…It captures both status-dignity and condition-dignity aspects, encompassing respect, professional competence, and societal appreciation, offering a multidimensional structure for assessing individual domains and overall scores. …”
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Planning and construction of Xiong'an New Area (city of over 5 million people): Contributions of China's geologists and urban geology by Bo Han, Zhen Ma, Liang-jun Lin, Hong-wei Liu, Yi-hang Gao, Yu-bo Xia, Hai-tao Li, Xu Guo, Feng Ma, Yu-shan Wang, Ya-long Zhou, Hong-qiang Li

“…The achievements also include a 3D engineering geological structure model for the whole area, along with “one city proper and five clusters”, insights into the ecology and the background endowment of natural resources like land, geothermal resources, groundwater, and wetland of the area before engineering construction, a comprehensive monitoring network of resources and environments in the area, and the “Transparent Xiong'an” geological information platform that is open, shared, dynamically updated, and three-dimensionally visualized. …”
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A web-based artificial intelligence system for label-free virus classification and detection of cytopathic effects by Zeynep Akkutay-Yoldar, Mehmet Türkay Yoldar, Yiğit Burak Akkaş, Sibel Şurak, Furkan Garip, Oğuzcan Turan, Bengisu Ekizoğlu, Osman Can Yüca, Aykut Özkul, Barış Ünver

“…AIRVIC’s hierarchical structure highlights its adaptability to virological diagnostics, providing unbiased infectivity scoring and facilitating viral isolation and antiviral efficacy testing. …”
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Design and assessment of a public health course as a general education elective for non-medical undergraduates by Xinyang Li, Xiaoxi Zheng, Boqiang Wen, Bowei Zhang, Xiaolong Xing, Liye Zhu, Wentao Gu, Shuo Wang

“…Although public health programs among undergraduate students have been increasing and gaining popularity worldwide, few studies have focused on the needs and structure of public health courses for non-medical students. …”
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A wide-spectrum mid-infrared electro-optic intensity modulator employing a two-point coupled lithium niobate racetrack resonator by Hyeon Hwang, Kiyoung Ko, Mohamad Reza Nurrahman, Kiwon Moon, Jung Jin Ju, Sang-Wook Han, Hojoong Jung, Min-Kyo Seo, Hansuek Lee

“…In this study, we introduce an on-chip OIM that operates over a wide wavelength range in the mid-IR, implemented using a racetrack resonator structure in thin film lithium niobate (TFLN). The modulator employs a two-point coupling scheme, allowing active control of the coupling strength to maintain critical coupling and thereby ensuring high modulation extinction across a wide spectral region. …”
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Sociological, Legal, and Psychological Aspects of Social Protection for Individuals Vulnerable to Suicide Due to Psychological Pressure by Fotima U.Imomqulova, Kahramon N. Kayumov, Utkirkhon B. Bakhodirov, Murod Dj. Botayev, Sanjar S. Rustamov, Zafar A. Amirov, Alisher N. Juraev

“…Comparative case studies from Central Asia, North America, and Europe are employed to assess how different countries structure suicide prevention within policy and practice domains. …”
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Flexibly Reconfigurable Kerr Micro-Comb Based on Cascaded Si₃N₄ Micro-Ring Filters by Jieyu Yang, Guang Chen, Lidan Lu, Jianzhen Ou, Chao Mei, Yingjie Xu, Wenbo Bo, Peng Wang, Xinyi Li, Lianqing Zhu

“…In recent years, micro-combs, due to their compact structure and high efficiency, have proven to be a practical solution for optical sources. …”
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Filtering dynamics of an interference comb filter in a ytterbium-doped mode-locked fiber laser by Hailong Xu, Liqiang Zhang, Yicun Yao, Minghong Wang, Yuanzhen Liu, Xiangdong Li, Jiaxin Li, Zhaogang Nie, Xiaohui Li

“…Fiber interference filter has a compact structure and is easy to implement. However, its comb-shaped transmission spectrum introduces sidebands at the edges of the pulse spectrum. …”
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