Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis by Min-Young Noh, Seong-il Oh, Young-Eun Kim, Sun Joo Cha, Wonjae Sung, Ki-Wook Oh, Yurim Park, Ji Young Mun, Chang-Seok Ki, Minyeop Nahm, Seung Hyun Kim

“…All three NEK1 variants exhibited abnormal primary ciliary structure, impaired sonic hedgehog signaling, and altered cell-cycle progression. …”
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Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model. by Emily A Kendall, Sourya Shrestha, Ted Cohen, Eric Nuermberger, Kelly E Dooley, Lice Gonzalez-Angulo, Gavin J Churchyard, Payam Nahid, Michael L Rich, Cathy Bansbach, Thomas Forissier, Christian Lienhardt, David W Dowdy

“…Limitations include sparse data on key model parameters and necessary simplifications to model structure and outcomes.…”
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Left bundle branch block in coronary artery disease: toward novel electrocardiographic markers by Yuri N. Fedulaev, Irina V. Makarova, Alisa V. Grigorieva, Dzhamilya R. Kapitonova, Gulfiya A. Khairetdinova

“…There were no significant differences in the mortality structure between groups. CONCLUSION: The presence of fragmented QRS complexes on electrocardiogram in patients with complete left bundle branch block is associated with further QRS widening and QTc prolongation, a trend toward reduced left ventricular ejection fraction, increased frequency of cardiovascular-related hospitalizations, and progression of heart failure severity. …”
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Environmental Impact of Physical Visits and Telemedicine in Nursing Care at Home: Comparative Life Cycle Assessment by Egid M van Bree, Lynn E Snijder, Hans C Ossebaard, Evelyn A Brakema

“…Telemedicine visits were elementary in nature, such as supporting patients in taking their medication or structuring their daily agenda. We quantified average environmental impacts from cradle to grave, using the Environmental Footprint method, and verified the robustness of the comparison via uncertainty analysis. …”
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The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies by Bowen Wang, Desheng Xie, Jianming Huang, Zheyuan Huang, Weizong Weng, Danlei Huang, Ying Zhang, Xiaolin Chen

“…Conclusions: Exosome-loaded hydrogels show potential for improving the structure and function of intervertebral discs in IDD treatment, potentially slowing degeneration by inhibiting matrix degradation and cellular aging. …”
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Technical advances and research directions of borehole geophysical prospecting for coal mines by Jianyuan CHENG, Yu YAN, Yuteng LI, Pan WANG, Rui ZHAO, Bici JIANG

“…ProgressFor intra-borehole geophysical technology, high-frequency (HF) reflection radar within a near-horizontal borehole in coal mines allows for the coal-rock interface exploration and geological structure identification within a radial distance range of 0 to 10 m. …”
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In Vitro Effects of Vanadate Erbium/Silver Oxide (ErVO4/AgO) and Vanadate Iron/Silver Oxide (FeVO4/AgO) Nanoparticles on the Adult of Fasciola hepatica by Arbabi Mohsen, Esmaili Monireh, Hooshyar Hossein, Delavari Mahdi, Sobhani Nasab Ali, Nejati Majid

“…To ensure the reliability of the data, the tests on the sample were performed twice. …”
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Multi-branch horizontal well hole docking pressure control extraction technology for close distance coal seam group by Liang CHEN, Zhiheng CHENG, Xin LUO, Hongyang YU, Zherui ZHANG, Peng WANG, Xiangdong WANG

“…Taking Shaqu well field in Lyuliang city, Shanxi province as an example, through theoretical analysis and data statistics, the geological structure of coalbed methane accumulation in the well field, the influence of hydrodynamic conditions, coalbed methane reservoir characteristics and gas-bearing distribution are obtained. …”
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Influence of pyridyl nitrogen’s position and hydrogen bonding interactions on antibacterial activities investigated by in vitro and in silico by Suma Ramachandra Gopady, Thripthi Nagesh Shenoy, Abdul Ajees Abdul Salam, Srikrishna Herga Damodar Kedlaya, Shashanka Puranika Kota, Anusha Prabhu, Yegneswaran Prakash Peralam, Srinivasulu Maddasani

“…A Schiff base with a pyridine moiety in its molecular structure is anticipated with potential biological activity. …”
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Analytic Model for U-Nb Liquidus and U-6Nb Melting Curve by Leonid Burakovsky, Dean L. Preston, Andrew A. Green

“…The key factor determining the performance and safety of a metallic fuel such as U-Nb is its operational limits in the application environment, which are closely related to material’s structure and thermodynamic stability. They are in turn closely related to the ambient (zero-pressure) melting point <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>(</mo><msub><mi>T</mi><mi>m</mi></msub><mo>)</mo><mo>;</mo></mrow></semantics></math></inline-formula> thus, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>T</mi><mi>m</mi></msub></semantics></math></inline-formula> is an important engineering parameter. …”
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Identification of Factors Affecting Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…In addition, it should be noted that the structure used to finance the project in one country may not be effective due to the differences in its laws and conditions, while it is used effectively in another country. according to the conditions of each project and the host country of the project.   …”
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Defining Nocturnal Polyuria in Adolescents by Tasmia Promi, Anthony Brooks, Gulzhan Tologonova, Marie-Claire Roberts, Sarita Dhuper, Meseret Tena, Oluwatoyin Bamgbola, Monique Hanono, Jeffrey P. Weiss, Karel Everaert, Tine DeBacker, Thomas F. Monaghan, Louis Salciccioli, Stephen Wadowski, Elka Jacobson-Dickman, Jason M. Lazar

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Evaluation of drug release from topical dosage forms and permeability prediction through the skin barrier (review) by N. B. Melnikova, I. A. Sheferov, A. A. Emasheva, A. A. Sheferova, D. A. Panteleev, A. I. Slivkin

“…An example of relationship of "structure-permeability" correlation are the equations relating the permeability constant and lipophilicity to the molecular weight of the drug. …”
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Immunological cluster complexes in kidney transplantation by S. V. Zybleva, S. L. Zyblev

“…The composition of the central point of clustering of the hyperergic immunological complex is represented by the cooperation of CD3+CD8+CD69+ and CD3+CD4+CD8+ cells. The structure of the tolerogenic immune response in patients after kidney transplantation is based on intercellular interactions, which has a hierarchical system, the basis of which is represented by the cooperation of regulatory cells CD3+CD4+CD25+highCD127+low, CD3+CD4-CD8-, CD3+CD4+CD69+, CD3+CD16+CD56+, CD19+CD5+, LIN-HLA-DR+CD11c-CD123+. …”
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Volumetric 3D Reconstruction of Large Osteochondral Lesions of the Talus Being Reconstructed with Viable Osteochondral Allograft Combined with Autograft by Nathaniel Zona BA, Daniel Moon MD, MS, MBA

“…A stable bony base and viable cartilage rim was established, removing all damaged cartilage and nonstructural bone debris from the OLT. Talar body structure and morphology was restored using autograft iliac crest or tibial placed into the bony defect. …”
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Association between short-term exposure to meteorological factors on hospital admissions for hemorrhagic stroke: an individual-level, case-crossover study in Ganzhou, China by Kailun Pan, Fen Lin, Kai Huang, Songbing Zeng, Mingwei Guo, Jie Cao, Haifa Dong, Jianing Wei, Qiujiang Xi

“…Within the cumulative lag day structure of the subcomponent layer, both extremely low and extremely high temperature had a more pronounced effect on females and aged ≥65 years. …”
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Automatic MRI Lymph Node Annotation From CT Labels by Souraja Kundu, Yuji Iwahori, M. K. Bhuyan, Manish Bhatt, Boonserm Kijsirikul, Aili Wang, Akira Ouchi, Yasuhiro Shimizu

“…After annotating a medical imaging modality that is relatively straightforward to label, doctors often expect automatic annotations for images from other modalities of the same region, even though these modalities differ in contrast and structure. This study focuses on creating automatic lymph node annotation in MRI images using available CT annotations via deep-learning models. …”
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One step reconstruction of carbon/P zeolite from coal gasification slag and its adsorption mechanism for crystal violet by Yuhua WU, Caizhu LIU, Yulong MA, Yonggang SUN, Wenxin JI, Li ZHU, Hongcun BAI

“…The composite material has a flower shaped multi-level pore structure with a specific surface area of 107 m2/g, mainly composed of mesopores. …”
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Multi-Omics and Sensory Analysis of <i>Coffea canephora</i>: Assessing the Impact of Roasting Speed on Safety and Energy Efficiency by Sara Triachini, Pier Paolo Becchi, Terenzio Bertuzzi, Ettore Capri, Mario Gabrielli, Luigi Lucini, Fosca Vezzulli

“…Notably, their interaction was identified as a statistically significant discriminant factor (Residual Structure Ratio <i>p</i>-value = 0.01), with the highest contribution to the model (Relative Sum of Squares = 32.6%). …”
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Synthesis and physical-chemical properties of 6-(5-(1Н-tetrazole-1-ylmethyl)-4-R-1,2,4-triazole-3-ylthio)pyridin-3-amines and 6-((5-(1Н-tetrazole-1-yl)methil-4-R-1,2,4-triazole-3-y... by Yu. S. Hulina, A. G. Kaplaushenko

“…The computer prediction was performed using PASS online service, it was found that the synthesized 6-(5-(1Н-tetrazole-1-ylmethyl)-4-R-1,2,4-triazole-3-ylthio)pyridin-3-amines and 6-((5-(1Н-tetrazole-1-yl)methil-4-R-1,2,4-triazole-3-ylthio)pyridin-3-yl)-(alk,ar,heter)ylmethanimines are low-toxic compounds and exhibit a wide range of biological actions, which corresponds to literature data. Conclusions. The results of our work have confirmed the structure of the synthesized compounds, which indicates the possibility of their further use in biological studies.…”
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