The clinical spectrum associated with ERCC5 mutations: Is there a relationship between phenotype and genotype? by Jinpeng Zhang, Jiannan Ma, Yuanyuan Luo, Siqi Hong, Li Jiang, Tianyi Li

“…The gene mutation has not been reported and was predicted to seriously affect the protein structure. According to a review of 59 cases of ERCC5 mutations, cerebrooculofacioskeletal syndrome (COFS) occurred in 16 cases, XP in 19 cases, and XP/CS in 24 cases. …”
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Design of cross-reactive antigens with machine learning and high-throughput experimental evaluation by Chelsy Chesterman, Thomas Desautels, Luz-Jeannette Sierra, Kathryn T. Arrildt, Adam Zemla, Edmond Y. Lau, Shivshankar Sundaram, Jason Laliberte, Lynn Chen, Aaron Ruby, Mark Mednikov, Sylvie Bertholet, Dong Yu, Kate Luisi, Enrico Malito, Corey P. Mallett, Matthew J. Bottomley, Robert A. van den Berg, Daniel Faissol

“…The top mutant identified underwent biophysical and x-ray crystallographic characterization to confirm that the overall structure of fHbp was maintained throughout this epitope engineering experiment. …”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…We also determined the structure of an Mpro-TRMT1 peptide complex that shows how TRMT1 engages the Mpro active site in an uncommon substrate binding conformation. …”
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Study on the incremental carbon sink of tea plantations under spatio-temporal variation characteristics by Yaxiang Pan, Yaxiang Pan, Jingling Bao, Jingling Bao, Yuxuan Ji, Yuxuan Ji, Wen Li, Wen Li, Weiyu Lin, Shuisheng Fan, Shuisheng Fan, Shuisheng Fan, Liyu Mao, Liyu Mao

“…In this study, we selected the data of nine prefecture-level cities in Fujian Province, a major province of tea industry, from 2010 to 2022, and borrowed the standard deviation ellipse and trend surface analysis methods to clarify the spatial and temporal evolution of the carbon sinks in tea plantations, and combined with the geodetic detector model to explore the driving factors of spatial differentiation. …”
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Atmospheric Boundary Layer Stability in Urban Beijing: Insights from Meteorological Tower and Doppler Wind Lidar by Linlin Wang, Bingcheng Wan, Yuanjian Yang, Sihui Fan, Yi Jing, Xueling Cheng, Zhiqiu Gao, Shiguang Miao, Han Zou

“…The limited understanding of the structure of the urban surface atmospheric boundary layer can be attributed to its inherent complexity, as well as a deficiency in comprehensive measurements. …”
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Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension by Patrizia Dardi, Camille Perella Coutinho, Sarah de Oliveira, Simone Aparecida Teixeira, Renaide Rodrigues Ferreira Gacek, Eduardo Purgatto, Marco Aurélio Ramirez Vinolo, Marcelo Nicolás Muscará, Luciana Venturini Rossoni

“…In this sense, the current study explored the influence of normotensive and hypertensive postnatal environments on the intestinal microbiota structure, composition, and functional capacity of SHR and Wistar rats. …”
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Clinical and epidemiological characteristics of imported intestinal infections in children by E. Yu. Pylaeva, N. N. Zverevа, А. А. Erovichenkov, S. K. Pylaeva, E. A. Artamonova, N. Yu. Pshenichnaya, A. M. Demkina, O. N. Solodovnikova, Yu. N. Khlypovka, A. Yu. Dyagileva, A. Kh. Nurpeysova, A. U. Berestovskaia, O. V. Shamsheva, D. N. Protsenko

“…Imported intestinal infections most often occurred with symptoms of gastroenteritis, were assessed by CDS at 5 points, and rotavirus predominated in the etiological structure.…”
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Comparative analysis of mitochondrial genomes in lycoperdaceae fungi reveals intron dynamics and phylogenetic relationships by Xianyi Wang, Guoyu Wang, Jiawei Tao, Zhongyao Guo, Guangyin Xu, Jiayu Li, Jichuan Kang, Qin Zuo, Hongmei Liu, Qirui Li

“…However, mitochondrial genome data for the Lycoperdaceae family is insufficient, and investigating its structure offers valuable insights into the evolutionary relationships between puffball fungi and other Agaricales taxa. …”
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Unveiling host-genetic drivers of caecal microbial communities in chickens through genome-wide association studies by Ankit Hinsu, Xiaoxia Dai, Christos Dadousis, Christos Dadousis, Melanie Hay, Bruno Fosso, Matteo Crotta, Ramesh Pandit, Javier Guitian, Fiona Tomley, Prakash Koringa, Chaitanya Joshi, Chaitanya Joshi, Damer Blake, Androniki Psifidi

“…Whole-genome sequencing data were then used to further investigate candidate regions around significantly associated variants from the high-density DNA array. …”
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A novel gene linked to Imipenem resistance in E. coli isolate lacking known Imipenem-resistance genes by Trang Thu Hoang, Huyen Thanh Thi Le, Sang Ngoc Nguyen, Ung Dinh Nguyen, Tuan Ngoc Tran, Cuong Hung Nguyen, Thang Quang Truong, Nam S. Vo, Duc Quang Le, Son Hoang Nguyen, Minh Duc Cao, Thi Minh Ngoc Dao, Thi Huyen Bui, Thu An Nguyen, Thi Lan Anh Pham, Thi Bich Thao Le, Tho Huu Ho

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Trait-mediated responses and co-occurrence patterns of breeding steppe birds under human footprint in Inner Mongolia by Wenyu Xu, Chunlu Wang, Yanqi Wang, Xi Yang, Lishi Zhang, Piotr Tryjanowski, Frédéric Jiguet, Zheng Han, Haitao Wang

“…This study investigates how human impacts affect the distribution and community structure of breeding steppe birds in Inner Mongolia, a biodiversity hotspot in Asia. …”
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Longitudinal Immunoprofiling of the CD8⁺ T-Cell Response in SARS-CoV-2 mRNA Vaccinees and COVID-19 Patients by Jesús Emanuel Brunetti, Beatriz Escudero-Pérez, Fátima Lasala, Gonzalo Rivas, Mikel Mancheño-Losa, David Rial-Crestelo, Jaime Lora-Tamayo, Dániel Cadar, Miles Carroll, Rafael Delgado, César Muñoz-Fontela, Estefanía Rodríguez

“…Of note, we have observed variations in the memory subset structure at every stage of disease and vaccination. …”
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A systematic review on environmental DNA (eDNA) Science: An eco-friendly survey method for conservation and restoration of fragile ecosystems by Ashish Sahu, Mahender Singh, Adnan Amin, Monisa Mehboob Malik, Shariq Nazir Qadri, Adnan Abubakr, S.Surya Teja, Shabir Ahmad Dar, Ishtiyaq Ahmad

“…The conservation and restoration of fragile ecosystems and their genetic resources depends on precisely assessing species diversity and richness, understanding spatiotemporal dynamics, and stock structure analysis. Traditional monitoring methods like visual surveys, physical captures, individual counting, sibling or cryptic species identification, and immature life stages (juveniles) of animals are often intrusive, time-consuming, and provide rough estimates. …”
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Abundant Molecular Gas in the Central Region of Lenticular Galaxy PGC 39535 by Jiantong Cui, Qiusheng Gu, Shiying Lu, Zhengyi Chen, Can Xu, Zeyu Gao

“…The results of the NOEMA observation suggest that the molecular gas mainly concentrates in the central regions as a gaseous bar and a ring-like structure, and shows similar kinematics as the stellar and ionized gas components. …”
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Diabetes and periodontitis: the role of a high-glucose microenvironment in periodontal tissue cells and corresponding therapeutic strategies by Dan-dan Xiang, Yu-xin Sun, Chen Jiao, Yu-qian Guo, Yu-xiang Fei, Bai-qiang Ren, Xiao-Tao He, Xuan Li

“…Both of these diseases affect many people worldwide. Epidemiological data have revealed a close relationship between periodontitis and diabetes. …”
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Evaluation of the oil and gas preservation conditions, source rocks, and hydrocarbon-generating potential of the Qiangtang Basin: New evidence from the scientific drilling project by Li-jun Shen, Jian-yong Zhang, Shao-yun Xiong, Jian Wang, Xiu-gen Fu, Bo Zheng, Zhong-wei Wang

“…Moreover, the Qiangtang Basin has favorable oil and gas preservation conditions, as verified by the comprehensive study of the sealing capacity of seals, basin structure, tectonic uplift, magmatic activity, and groundwater motion. …”
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Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation by Chiara Sassoli, Federica Pierucci, Alessia Tani, Alessia Frati, Flaminia Chellini, Francesca Matteini, Ambra Vestri, Giulia Anderloni, Daniele Nosi, Sandra Zecchi-Orlandini, Elisabetta Meacci

“…Notably, active S1PR1/MMP-2 signalling is required for F-actin structure assembly (lamellipodia, microspikes, and stress fibers) and, in turn, cell proliferation. …”
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Epidemiological and clinical features of lymphoproliferative diseases in the head and neck region by F. Sh. Kamolova, A. M. Mudunov, P. A. Zeynalova, L. Yu. Grivtsova, G. F. Allakhverdieva, R. I. Azizyan, A. A. Akhundov, I. A. Zaderenko, M. V. Bolotin, D. K. Stelmakh, V. I. Sokorutov, K. D. Il’kaev, V. T. Tsiklauri, I. M. Gelfand, M. B. Pak, O. L. Timofeeva, Yu. E. Ryabukhina, F. M. Abbasbeyli, Ts. Chzhao

“…The high heterogeneity of lymphomas in the head and neck area requires structuring knowledge about their epidemiology and clinical manifestations.Objective: to study the epidemiological and clinical features of the head and neck lymphoproliferative diseases, which will lead to an improvement in diagnostic quality of this nosology’s.Materials and methods. …”
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Presenting the model of social entrepreneurship in the development of rural tourism in the target villages of Gilan province by Fatemeh Doozandeh Ziabari, hamed fallah tafti, Mir Mohammad Asadi, Mahdi Basouli

“…On the other hand, in order for tourism destinations to be able to create a competitive advantage, businesses related to local tourism should follow the model of social businesses that use innovative strategies related to the provision of products and services, organizational structure, operational processes, procurement and marketing.…”
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Development of a zoonotic influenza distribution assessment and ranking system (ZIDAR): Technical application in Nepal to support cross-sectoral risk-based surveillance by Adam Charette-Castonguay, Dipendra Gautam, Binay Shrestha, Hemant Chandra Ojha, Barun Kumar Sharma, Mukul Upadhayaya, Sujan Rana, Roshika Shrestha, Lok Bandu Chaudhary, Bhawana Kandel, Rudra Prasad Marasini, Sharmila Chapagain, Tulsi Ram Gompo, Surendra Karki, Apsara Poudel, Saugat Shrestha, Avinash Sunny Kayastha, Arun Kumar Govindakarnavar, Reuben Samuel, Allison Gocotano, Pushpa Ranjan Wijesinghe, Nilesh Buddha, Edwin Ceniza Salvador, Manish Kakkar, Ricardo J. Soares Magalhães

“…This is then followed by a technical phase involving model building, model structure validation, data gathering and assessment of model performance. …”
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