A Comprehensive Evaluation of a Coumarin Derivative and Its Corresponding Palladium Complex as Potential Therapeutic Agents in the Treatment of Gynecological Cancers: Synthesis, Ch... by Mirela Jevtić, Marijana Stanojević Pirković, Teodora Komazec, Marija Mojić, Sanja Mijatović, Danijela Maksimović-Ivanić, Dušan Dimić, Zoran Marković, Dušica Simijonović, Dejan Milenković, Edina Avdović

“…<b>Results:</b> A low mean absolute error between experimental and theoretical data proved that the optimized structure corresponded to the experimental one. …”
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Annual cycle variations in the gut microbiota of migratory black-necked cranes by Yujia Zhang, Ruifeng Ma, Suolangduoerji, Shujuan Ma, Shujuan Ma, Akebota Nuertai, Ke He, Hongyi Liu, Ying Zhu

“…Despite having greater diversity, the summer gut microbiota had a simpler network structure than the other seasons (fewer edges and nodes). …”
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Integration of ATAC-seq and RNA-seq reveals signal regulation during post-molt and inter-molt stages in muscle of Eriocheir sinensis by Bin Wang, Bin Wang, Jingjing Li, Mingzhi Zhang, Mingzhi Zhang, Anqi Li, Zhentao Song, Zhentao Song, Zhen He, Zhen He, Ruiqi Zhang, Ruiqi Zhang, Tong Hao, Tong Hao, Jinsheng Sun, Jinsheng Sun

“…In all the enriched signaling pathways, GPCR signaling pathway includes the most differentially expressed genes (8 genes), which underlines its importance in the signal transduction from the post-molt stage to the inter-molt stage. Further protein structure analysis and RT-qPCR validation confirmed five GPCR genes related to molting process, in which four genes (GRM7, FMRFaR, mth2, gpr161) are active during the post-molt stage and one gene (moody) functions during the inter-molt stage.DiscussionThese findings highlight the key regulatory proteins and pathways involved in E. sinensis muscle during molting and also offer foundational data for studying the mechanisms of molting and discontinuous growth in crustaceans.…”
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The Chem-Sex Inventory Scale (CSI): A Tool to Assess the Mental Health Risk of Chemsex Behaviors in Men Who Have Sex with Men by Pablo Del Pozo-Herce, Enrique Baca-García, Antonio Martínez-Sabater, Rubén Pérez-Elvira, Vicente Gea-Caballero, Elena Chover-Sierra, Pedro José Satústegui-Dordá, Alberto Tovar-Reinoso, Francisco José Rodríguez-Velasco, Mercedes Sánchez-Barba, Jesús Pérez, Raúl Juárez-Vela

“…The majority of gender identity was cisgender (97.7%). A factor structure was found that can be summarized in four dimensions: emotional instability, risk of psychosis, altered body perception, and risk of suicide. …”
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Enhancing the learning of sports skills through verbal feedback by Tomasz Niźnikowski, Paweł Arnista, Jerzy Sadowski, Andrzej Mastalerz, Oscar Romero-Ramos, Emilio Fernández-Rodríguez, Weronika Łuba-Arnista, Michał Biegajło, Paweł Różański, Ewelina Niźnikowska, Andrzej Karaś, Piotr Kuśmierczyk, Marta Nogal

“…They were randomly assigned to one of two groups: FKE group (n = 8) with feedback on key elements, or FAE group (n = 8) with 100% feedback on all errors made in the phase structure of the task.ResultsBased on research, it was established that key elements could be identified in the preparatory, main and final phases. …”
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Analysis of CYP701A1 genes in gossypium species and functional characterization through gene silencing by Zhao Liang, Di Jiachun, Guo Qi, Xu Zhenzhen, Zhao Jun, Xu Peng, Xu Jianwen, Liu Jianguang, Shen Xinlian, Chen Xusheng

“…Subsequently, 40 CYP701A1 genes were identified from various genomes and conducted a comprehensive analysis of their structure and evolution. Virus-induced gene silencing (VIGS) technology was utilized to knock out the GhCYP701A1 gene in Gossypium hirsutum ac TM-1. …”
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Catalytic gasification of municipal solid waste using eggshell-derived CaO catalyst: An investigation of optimum H2 production, production distribution, and tar compounds by Azhar Ali Laghari, Imtiaz Ali Jamro, Akash Kumar, Guanyi Chen, Shahdev Sajnani, Zhangzhen Guo, Yongheng Shen, Junzhe Zhang, Salim Khoso, Qingxia Guo, Wenchao Ma

“…Scanning electron microscopy, X-ray diffraction, and Brunauer-Emmett-Teller techniques investigated the catalyst's structure hence; presented comparable results. From tar analysis, the aromatics were found as the dominant family followed by polycyclic aromatic, phenyls, aliphatic, aromatic heterocyclic, polycyclic, and aromatic ketones. …”
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Repurposing of compound libraries yields new inhibitors of NDM-1 metallo-β-lactamase with diverse zinc-binding moieties by Vid Kavaš, Philip Hinchliffe, Maša Zorman, Alen Krajnc, Matic Proj, Majda Golob, Martina Hrast Rambaher, James Spencer, Stanislav Gobec

“…This resulted in a compound (14a) with an IC50 of 20 μM, which crystallography shows binds to NDM-1 in two different poses. Using this structure as a starting point for in silico design, we developed a series of larger thiol-based compounds designed to occupy more space in the active site and to utilize other novel zinc-binding groups. …”
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THE NEED FOR JOINT PLANNING OF ORTHOPEDIC DENTAL CARE IN COMPLEX TREATMENT OF PATIENTS WITH DEFECTS OF MAXILLOFACIAL LOCALIZATION by L.I. Voloshyna, M.G. Skikevych, D.S. Avetikov, V.V. Bondarenko, N.A. Sokolova, V.D. Ahmerov

“…Today there are no certain data that allow assessing the level of defects of different genesis. …”
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The Influence Of Work Stress, Work Motivation, Work Environment On The Performance Of Health Workers In 24-Hour Non-Inpatient Community Health Centers In Wonocolo District, Surabay... by Andry Pribadi, Agus Sukoco, Joko Suyono

“…This research adopts a quantitative approach using a survey method with 90 healthcare workers as the sample. Data collection was conducted through questionnaires, and data analysis was carried out using Structural Equation Modeling (SEM). …”
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Assessing the quality of care in primary health care facilities in all municipalities in Kosovo 2016–2023 by Astrid M. Knoblauch, Astrid M. Knoblauch, Sarah Rajkumar, Sarah Rajkumar, Robert Canavan, Robert Canavan, Qamile Ramadani, Ariana Bytyçi Katanolli, Shegë Bahtiri, Debra Stevenson, Debra Stevenson, Debra Stevenson, Merita Stavileci Mustafa, Nicu Fota, Nicu Fota, Nicu Fota, Jana Gerold, Jana Gerold

“…However, substantial challenges remain, particularly among managing non-communicable diseases (NCD) like diabetes and hypertension, due to gaps in structural and procedural aspects. The Accessible Quality Healthcare project (2016–2027) aimed at improving the health of the Kosovar population by strengthening the quality of PHC services with a specific focus on NCDs. …”
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Confirmatory study on the retention rate of ketogenic diet therapy and related factors in children with drug‐resistant epilepsy: A single‐center cohort study by Jie Zhang, Qiang Gu, Yuan Wu, Han Xie, Cuijie Wei, Yao Zhang, Taoyun Ji, Xinhua Bao, Xingzhi Chang, Yuehua Zhang, Yuwu Jiang, Ye Wu

“…Results A total of 337 patients were included. 43.3% (146/337) of the patients had only spasms, 16.9% (57/337) had a genetic etiology, and 14.0% (47/337) had a structural etiology. Overall, 51.9% (175/337) of the patients were classified as having infantile epileptic spasm syndrome. …”
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SMAP Validation Experiment 2019&#x2013;2022 (SMAPVEX19&#x2013;22): Field Campaign to Improve Soil Moisture and Vegetation Optical Depth Retrievals in Temperate Forests by Andreas Colliander, Michael H. Cosh, Laura Bourgeau-Chavez, Victoria R. Kelly, Simon Kraatz, Paul Siqueira, Victoria A. Walker, Xingjian Chen, Alexandre Roy, Tarendra Lakhankar, Kyle C. McDonald, Nicholas Steiner, Mehmet Kurum, Seung-bum Kim, Aaron Berg, Xiaolan Xu, Sidharth Misra, Mehmet Ogut, Cristina Vittucci, John S. Kimball, Dara Entekhabi, Simon H. Yueh

“…Airborne and mobile terrestrial laser scanning measurements captured the three-dimensional forest structure necessary for microwave measurement interpretation. …”
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Identifying Dwarfs of MC Analog GalaxiEs (ID-MAGE): The Search for Satellites around Low-mass Hosts by Laura Congreve Hunter, Burçİn Mutlu-Pakdİl, David J. Sand, Paul Bennet, Donghyeon J. Khim, Denija Crnojević, Amandine Doliva-Dolinsky, Emmanuel Durodola, Catherine Fielder, Rowan Goebel-Bain, Michael G. Jones, Ananthan Karunakaran, Kristine Spekkens, Dennis Zaritsky

“…ID-MAGE nearly triples the number of low-mass galaxies surveyed for satellites with well-characterized completeness limits, providing a unique data set to explore small-scale structure and dwarf galaxy evolution around low-mass hosts in diverse environments.…”
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Urban pertussis epidemiological patterns in a highly vaccinated megacity: Policy impacts and control strategies in Chongqing, China, 2005-2024 by Rui Shen, Jiawei Xu, Yugang Li, Jianxing Yu, Na Sun, Zilu Xu, Xueying Xu, Xiao Liu, Yang Liu, Bosong Li, Li Qi, Luzhao Feng

“…Methods: Using population-based surveillance data (2005-2024) from Chongqing (population 32.1 million; DTP3 coverage >97%), we conducted hierarchical Bayesian spatial modeling and age-structured Susceptible-Infected-Recovered-Vaccinated transmission analysis. …”
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Translating community-wide spectral library into actionable chemical knowledge: a proof of concept with monoterpene indole alkaloids by Sarah Szwarc, Adriano Rutz, Kyungha Lee, Yassine Mejri, Olivier Bonnet, Hazrina Hazni, Adrien Jagora, Rany B. Mbeng Obame, Jin Kyoung Noh, Elvis Otogo N’Nang, Stephenie C. Alaribe, Khalijah Awang, Guillaume Bernadat, Young Hae Choi, Vincent Courdavault, Michel Frederich, Thomas Gaslonde, Florian Huber, Toh-Seok Kam, Yun Yee Low, Erwan Poupon, Justin J. J. van der Hooft, Kyo Bin Kang, Pierre Le Pogam, Mehdi A. Beniddir

“…Additionally, our work enabled the digitization of structural data for diverse MIA skeletons by converting them into machine-readable formats and thereby enhancing their dissemination for the scientific community. …”
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Unraveling the Mysteries of KS 1947+300: Multiwavelength Observations in a Low-eccentricity Be/X-Ray Binary by Wei Liu, Pablo Reig, Jingzhi Yan, Peng Zhang, Xiukun Li, Bo Gao, Guangcheng Xiao, Zhongmu Li, Qingzhong Liu

“…The fact that the amplitude of variability increased with wavelength suggests that the long-term decrease in the optical emission is due to weakening of the circumstellar disk. Structural changes in the disk may also be the origin of the periodic signals with periods ∼200 days detected in the Zwicky Transient Facility (ZTF)- g and ZTF- r band light curves. …”
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The clinical spectrum associated with ERCC5 mutations: Is there a relationship between phenotype and genotype? by Jinpeng Zhang, Jiannan Ma, Yuanyuan Luo, Siqi Hong, Li Jiang, Tianyi Li

“…The gene mutation has not been reported and was predicted to seriously affect the protein structure. According to a review of 59 cases of ERCC5 mutations, cerebrooculofacioskeletal syndrome (COFS) occurred in 16 cases, XP in 19 cases, and XP/CS in 24 cases. …”
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Design of cross-reactive antigens with machine learning and high-throughput experimental evaluation by Chelsy Chesterman, Thomas Desautels, Luz-Jeannette Sierra, Kathryn T. Arrildt, Adam Zemla, Edmond Y. Lau, Shivshankar Sundaram, Jason Laliberte, Lynn Chen, Aaron Ruby, Mark Mednikov, Sylvie Bertholet, Dong Yu, Kate Luisi, Enrico Malito, Corey P. Mallett, Matthew J. Bottomley, Robert A. van den Berg, Daniel Faissol

“…The top mutant identified underwent biophysical and x-ray crystallographic characterization to confirm that the overall structure of fHbp was maintained throughout this epitope engineering experiment. …”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…We also determined the structure of an Mpro-TRMT1 peptide complex that shows how TRMT1 engages the Mpro active site in an uncommon substrate binding conformation. …”
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