Bis-Iridoid Glycosides and Triterpenoids from <i>Kolkwitzia amabilis</i> and Their Potential as Inhibitors of ACC1 and ACL by Jiang Wan, Ze-Yu Zhao, Can Wang, Chun-Xiao Jiang, Ying-Peng Tong, Yi Zang, Yeun-Mun Choo, Jia Li, Jin-Feng Hu

“…Amabiliacids A (<b>5</b>) and B (<b>6</b>) are 24-nor-ursane-type triterpenoids characterized by an uncommon ∆^11,13(18) transannular double bond. Their chemical structures and absolute configurations were elucidated through spectroscopic data and electronic circular dichroism analyses. …”
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Analyzing Macro-Regulation Strategies of the Digital Economy in Selected Countries and Providing Macro Components of Regulation for Iran by Fatemeh Kasaei Najafi, Afsaneh Vahedian, Hassan Yeganeh

“…In general, most countries have developed structured, integrated, and measurable strategies to achieve a secure and sustainable digital economy and promote its development across all sectors. …”
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Impact of mealtime social experiences on student consumption of meals at school: a qualitative analysis of caregiver perspectives by Leah Elizabeth Chapman, Wendi Gosliner, Deborah A Olarte, Monica Daniela Zuercher, Lorrene D Ritchie, Dania Orta-Aleman, Marlene B Schwartz, Michele Polacsek, Christina E Hecht, Kenneth Hecht, Anisha I Patel, Punam Ohri-Vachaspati, Margaret Read, Juliana FW Cohen

“…Setting: Semi-structured interviews were conducted with United States (U.S.) caregivers over ZoomTM in English and Spanish during the 2021–2022 school year. …”
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Interpersonal and systemic factors in initiating, developing and maintaining collaborations between European neurosurgical departments and institutions in low-resources settings: A... by Nicolò Marchesini, Vicki M. Butenschoen, Andreas K. Demetriades, Said Idrissa Ahmada, Fazlul Hoque, Thomas Kapapa, Patrick D. Kamalo, Pablo González-López, Rupavathana Mahesperan, Ondra Petr, Wilco Peul, Nicephorus Boniface Rutabasibwa, Ellianne J. dos Santos Rubio, Abenezer Tirsit Aklilu, Jake Timothy, Enoch O. Uche, Magnus Tisell

“…Material and methods: We conducted a prospective qualitative study using semi-structured interviews with fourteen matched neurosurgeons—seven from European centers and seven from LMIC institutions—engaged in such collaborations. …”
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Bi‐allelic mutation in SEC16B alters collagen trafficking and increases ER stress by Ahmed El‐Gazzar, Barbara Voraberger, Frank Rauch, Mario Mairhofer, Katy Schmidt, Brecht Guillemyn, Goran Mitulović, Veronika Reiterer, Margot Haun, Michaela M Mayr, Johannes A Mayr, Susanne Kimeswenger, Oliver Drews, Vrinda Saraff, Nick Shaw, Nadja Fratzl‐Zelman, Sofie Symoens, Hesso Farhan, Wolfgang Högler

“…Abstract Osteogenesis imperfecta (OI) is a genetically and clinically heterogeneous disorder characterized by bone fragility and reduced bone mass generally caused by defects in type I collagen structure or defects in proteins interacting with collagen processing. …”
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Two-dimensional transition metal dichalcogenides for post-silicon electronics by Zhang Xiankun, Zhao Hang, Wei Xiaofu, Zhang Yanzhe, Zhang Zheng, Zhang Yue

“…Rapid advancements in information technology push the explosive growth in data volume, requiring greater computing-capability logic circuits. …”
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A Systematic Review of the Microfinance Literature: An ADO-TCM Framework Approach by Bahman Khodapanah, Mohammad Bashokouh Ajirlou, Fariba Mesri

“…This framework provides an in-depth analysis of the structure of relevant studies, encompassing predecessors, research decisions, research outcomes (ADO), utilized theories, study contexts, and research methods (TCM). …”
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A novel mechanism of sperm midpiece epididymal maturation and the role of CCDC112 in sperm midpiece formation and establishing an optimal flagella waveform by Maddison L. Graffeo, Joseph Nguyen, Farin Yazdan Parast, Jessica E. M. Dunleavy, Denis Korneev, Hongyi Yang, Hidenobu Okuda, Anne E. O’Connor, Donald F. Conrad, Reza Nosrati, Brendan J. Houston, Moira K. O’Bryan

“…Abstract Background The mitochondrial sheath is a defining feature of mammalian sperm with proposed functions in structural support and energy production for flagella movement. …”
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Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis by Xize Wu, Yuxi Huang, Jiaqi Ren, Xue Pan, Qiuying Wu, Qicheng Cai, Ruiying Wang, Teng Feng, Shan Gao, Bo Wang, Meijia Cheng, Meijia Cheng, Yue Li, Lihong Gong

“…Experimental validation was performed by ox-LDL-induced HUVECs and RAW 264.7 cells. Single-cell data analyzes the gene structure and gene expression status of individual cells.ResultsSix ASLMRFeGs (CTSB, CYBB, DPP4, HILPDA, HMOX1, IL1B) alter the immune microenvironment in AS. …”
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Usefulness of differential somatic cell count for udder health monitoring: Association of differential somatic cell count and somatic cell score with quarter-level milk yield and m... by Mariana Fonseca, Daryna Kurban, Jean-Philippe Roy, Débora E. Santschi, Elouise Molgat, Simon Dufour

“…Determination of SCC and DSCC was also performed by Lactanet using a CombiFoss 7 DC instrument. Milk yield data were retrieved from the AMS. Given the hierarchical structure of the data, a linear mixed model was built with either milk yield or milk components as the outcomes. …”
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The effect of radiation dose to the brain on early self-reported cognitive function in brain and head-and-neck cancer patients by Femke Vaassen, David Hofstede, Catharina M.L. Zegers, Jeanette B. Dijkstra, Ann Hoeben, Monique H.M.E. Anten, Ruud M.A. Houben, Frank Hoebers, Inge Compter, Wouter van Elmpt, Daniëlle B.P. Eekers

“…Purpose: Assess cognitive changes after radiotherapy (RT) in brain and head-and-neck (HN) cancer patients using patient-reported outcome measures (PROMs) and evaluate a dose–effect relationship for brain structures. Materials and methods: Primary brain and HN cancer patients treated with RT between 2012–2021 were included. …”
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Papain-like cysteine proteases in Nicotiana benthamiana: gene family members and their potential implications in recombinant protein expression by Yalun Yang, Yalun Yang, Yalun Yang, Zhichao Deng, Zhichao Deng, Zhongqi Zhang, Yong Yang, Xiaolu Pan, Xiaolu Pan, Rongrong Wu, Rongrong Wu, Tao Liu, Tao Liu, Xiaoming Gao, Xiaoming Gao, Lingyan Li, Yongfeng Guo, Yongfeng Guo

“…This study aims to identify NbPLCP genes in N. benthamiana and elucidate their roles in facilitating heterologous protein expression.MethodsA comprehensive bioinformatics approach was employed to identify NbPLCP genes using N. benthamiana genomic data and homology with Arabidopsis thaliana. The analysis included examination of physicochemical properties, phylogenetic relationships, gene structures, conserved motifs, expression profiles, gene duplication events, and chromosomal distribution. …”
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Monoterpene Hydroxy Lactones Isolated from <i>Thalassiosira</i> sp. Microalga and Their Antibacterial and Antioxidant Activities by Alcina M. M. B. Morais, Decha Kumla, Valter F. R. Martins, Ana Alves, Luis Gales, Artur M. S. Silva, Paulo M. Costa, Sharad Mistry, Anake Kijjoa, Rui M. S. C. Morais

“…Two monoterpenoid lactones, loliolide (<b>1</b>) and <i>epi</i>-loliolide (<b>2</b>), were isolated from the crude dichloromethane extract of a microalga, <i>Thalassiosira</i> sp.). The structures of loliolide (<b>1</b>) and <i>epi</i>-loliolide (<b>2</b>) were elucidated by 1D and 2D NMR analysis, as well as a comparison of their ¹H or/and ¹³C NMR data with those reported in the literature. …”
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Instance-based generalization for human judgments about uncertainty. by Philipp Schustek, Rubén Moreno-Bote

“…As probability distributions are high dimensional objects, only constrained families of distributions with a low number of parameters can be specified from finite data. However, it is unknown what the structural assumptions are that the brain uses to estimate them. …”
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Sociodemographic factors associated with trajectories of depression among urban refugee youth in Kampala, Uganda: A longitudinal cohort study by Zerihun Admassu, Sikky Shiqi Chen, Carmen H. Logie, Moses Okumu, Frannie MacKenzie, Robert Hakiza, Daniel Kibuuka Musoke, Brenda Katisi, Aidah Nakitende, Peter Kyambadde, Lawrence Mbuagbaw

“…Sociodemographic (older age, gender [cisgender women vs. cisgender men], longer time in Uganda), and socioecological (structural: unemployment, food insecurity; interpersonal: parenthood, recent intimate partner violence) factors were significantly associated with the sustained high trajectory of depression. …”
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Uncovering the breeding contribution of transposable elements from landraces to improved varieties through pan-genome-wide analysis in rice by Xiaoxia Li, Xiaoxia Li, Xiaofan Dai, Xiaofan Dai, Huiying He, Wu Chen, Qian Qian, Qian Qian, Lianguang Shang, Lianguang Shang, Longbiao Guo, Wenchuang He

“…Advances in pan-genomes and enhanced capacity for analyzing structural variations have increasingly highlighted their role in rice genetic improvement. …”
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Medium-Chain Acyl-CoA Deficiency: Outlines from Newborn Screening, In Silico Predictions, and Molecular Studies by Serena Catarzi, Anna Caciotti, Janita Thusberg, Rodolfo Tonin, Sabrina Malvagia, Giancarlo la Marca, Elisabetta Pasquini, Catia Cavicchi, Lorenzo Ferri, Maria A. Donati, Federico Baronio, Renzo Guerrini, Sean D. Mooney, Amelia Morrone

“…Bioinformatics predictions based on both phylogenetic conservation and functional/structural software were used to characterize the new identified variants. …”
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Changing of the coordination of socioeconomic development and the environment as sustainable development progresses by Dongliang Dang, Xiaobing Li, Xin Lyu, Shiliang Liu, Huashun Dou, Mengyuan Li, Kai Wang, Wanyu Cao

“…The coupling coordination between the two demonstrates a pattern of initial increasing, then decreasing, and finally increasing again, which may be related to changes in industrial structure. Our study delves deeply into the patterns of evolution in the relationship between socioeconomic and environments, exploring the challenges and opportunities faced by regions at different stages of sustainable development. …”
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Pheochromocytoma metastasis to the central nervous system: a case report and systematic review by Justyna Małgorzata Fercho, Justyna Małgorzata Fercho, Justyna Małgorzata Fercho, Justyna Małgorzata Fercho, Oskar G. Chasles, Jakub Chamier-Gliszczyński, Dominik Ryszard Płaza, Bogdan Jabłoński, Klaudia Kokot, Maciej Mielczarek, Małgorzata Małłek-Grabowska, Małgorzata Małłek-Grabowska, Jacek Szypenbejl, Jacek Szypenbejl, Adrian Szkudlarek, Tomasz Szmuda, Tomasz Szmuda, Mariusz Siemiński, Mariusz Siemiński, Jacek Furtak, Jacek Furtak

“…MRI and PET improved the diagnostic accuracy over historical non-contrast CT use (41.7% spinal cases).InterpretationCNS mPCC metastases are exceedingly rare with distinct neurological (cranial) and structural (spinal) presentations. Advanced imaging, particularly magnetic resonance imaging (MRI) and positron emission tomography (PET), is critical for accurate diagnosis and surgical planning. …”
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Mental health of general practitioners and family medicine specialists 2 years into the COVID-19 pandemic by Marija Zafirovska, Marija Zafirovska, Jelena Danilenko, Jelena Danilenko, Aleksandar Zafirovski, Aleksandar Zafirovski, Aleksandar Zafirovski, Kristien Coteur, Heidrun Lingner, Cristián Andrés Frigolett, Milena Cojić, Mustafa Kürşat Şahin, Carmen Iliana Busneag, Carmen Iliana Busneag, Carmen Iliana Busneag, Nicola Buono, Aleksander Stepanović, Aleksander Stepanović, Christine Brütting, Lyubomir Kirilov Kirov, Lyubomir Kirilov Kirov, Lyubomir Kirilov Kirov, Zaim Jatić, Zaim Jatić, Liljana Ramasaco, Monika Brovč, Vanja Lazić, Vanja Lazić, Vanja Lazić, Erjona Abazaj, Ljubin Šukriev

“…IntroductionThe COVID-19 pandemic has significantly impacted general medical practice by altering work structures and increasing teamwork while also adversely affecting the mental health of general practitioners and family medicine specialists. …”
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