Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy by Jorge Barrios, Evan Porter, Dante P. I. Capaldi, Taman Upadhaya, William C. Chen, Julian R. Perks, Aditya Apte, Michalis Aristophanous, Eve LoCastro, Dylan Hsu, Payton H. Stone, Javier E. Villanueva-Meyer, Gilmer Valdes, Fei Jiang, Michael Maddalena, Ase Ballangrud, Kayla Prezelski, Hui Lin, Jinger Y. Sun, Muhtada A. K. Aldin, Oi Wai Chau, Benjamin Ziemer, Maasa Seaberg, Penny K. Sneed, Jean L. Nakamura, Lauren C. Boreta, Shannon E. Fogh, David R. Raleigh, Jessica Chew, Harish Vasudevan, Soonmee Cha, Christopher Hess, Ruben Fragoso, David B. Shultz, Luke Pike, Shawn L. Hervey-Jumper, Derek S. Tsang, Philip Theodosopoulos, Daniel Cooke, Stanley H. Benedict, Ke Sheng, Jan Seuntjens, Catherine Coolens, Joseph O. Deasy, Steve Braunstein, Olivier Morin

“…Additionally, the deep brain structures are relatively spared from metastasis, regardless of primary cancer type. …”
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Quality of Life after Brain Injury in children aged six and seven years (QOLIBRI-KIDDY) – development and scale analysis of the first disease-specific self-report instrument for yo... by Nicole von Steinbuechel, Marina Zeldovich, Fabian Bockhop, Ugne Krenz, Dagmar Timmermann, Anna Buchheim, Inga K. Koerte, Michaela Veronika Bonfert, Steffen Berweck, Matthias Kieslich, Knut Brockmann, Maike Roediger, Sven Greving, Axel Neu, Ulrike Wartemann, Joachim Suss, Christian Auer, Holger Muehlan, Katrin Cunitz

“…After item reduction based on a confirmatory scale analysis considering the six-factor structure of the questionnaire versions for older children, adolescents, and adults (Cognition, Self, Daily Life & Autonomy, Social Relationships, Emotions, Physical Problems), its reliability and validity were investigated. …”
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Urgent natural foci infections transmitted by ticks in Saint-Petersburg by V. V. Nechaev, A. A. Yakovlev, A. N. Uskov, L. E. Boburina, N. V. Lavrova, M. N. Pogromskaya, B. I. Aslanov, A. O. Shapar, S. V. Pavlenko, L. N. Pozhidaeva, A. K. Ivanov, A. I. Kravtsova, S. A. Leppik, E. I. Vitovich, M. I. Fedunyak

“…The clinical forms of both diseases did not differ in their structure from the country data, however after 2012 subclinical forms were more common in women. …”
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Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…In this study, we employed bioinformatics methods to identify eight TaAkPHY genes in the Aikang58 wheat variety. Based on gene structure, conserved domains, and phylogenetic relationships, the TaAkPHY gene family exhibits a high degree of conservation. …”
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New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2 by Miao Yu, Yikang Qiu, Shiji Chen, Jueying Shi, Xiu Gong, Jiayi Feng, Fangru Lin, Weinv Zeng, Wenyuan Kang, Caijuan Zheng, Guolei Huang

“…Three new naphthalene–chroman dimer derivatives, daldinaphchromes A–C (<b>1</b>–<b>3</b>), two new chroman derivatives, daldichromes A (<b>5</b>) and B (<b>6</b>), along with five known compounds (<b>4</b>, <b>7</b>–<b>10</b>) were isolated from the mangrove-derived fungus <i>Daldinia eschscholzii</i> HJX1P2. Their structures and stereochemistries were elucidated through detailed NMR and MS analyses, calculated electronic circular dichroism, and comparison with previously reported data. …”
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The effect of sociodemographic, socioeconomic, and health factors on healthcare utilization in cardiovascular patients in Serbia: a part of National Health Survey by Tamara Lekovic, Tamara Lekovic, Nikoleta Janicijevic, Milos Potezica, Nela Djonovic, Nela Djonovic, Dragan Vasiljevic, Katarina Janicijevic, Melanija Tepavcevic, Snezana Knezevic, Jelena Vuckovic Filipovic, Jelena Vuckovic Filipovic, Amela Rastoder Celebic, Amela Rastoder Celebic, Svetlana Vukosavljevic, Svetlana Vukosavljevic, Maja Mirocevic Rotolo, Maja Mirocevic Rotolo, Dalibor Stajic

“…ObjectivesThis cross-sectional analytical study explores the predictors of the healthcare utilization in the adult population with cardiovascular diseases.MethodologyThe research was carried out as part of the fourth Serbian National Health Survey, in the period from October to December 2019, as a descriptive, cross-sectional analytical study and included the population of cardiovascular patients (N = 4,712) aged over 20 years; Descriptive and inferential statistical methods, including percentage-based structure indicators, Chi-square (χ2) tests for categorical variable differences, and prevalence ratio for examining relationships between dependent and independent variables, were used in the data analysis.ResultsThe analysis identified several significant contributors to cardiovascular healthcare utilization, emphasizing distinct and overlapping factors that impact various types of healthcare use. …”
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Unambiguous identification of fungi: where do we stand and how accurate and precise is fungal DNA barcoding? by Robert Lücking, M. Catherine Aime, Barbara Robbertse, Andrew N. Miller, Hiran A. Ariyawansa, Takayuki Aoki, Gianluigi Cardinali, Pedro W. Crous, Irina S. Druzhinina, David M. Geiser, David L. Hawksworth, Kevin D. Hyde, Laszlo Irinyi, Rajesh Jeewon, Peter R. Johnston, Paul M. Kirk, Elaine Malosso, Tom W. May, Wieland Meyer, Maarja Öpik, Vincent Robert, Marc Stadler, Marco Thines, Duong Vu, Andrey M. Yurkov, Ning Zhang, Conrad L. Schoch

“…Compared to plants and animals, fungi have simple body plans with often morphologically and ecologically obscure structures. This poses challenges for accurate and precise identifications. …”
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“Vaccinating a child is upon the woman”: implications for improving uptake for the recently introduced second dose of measles-containing vaccine based on a rapid community assessme... by Adelline Twimukye, Nessa Ryan, Flavia Vivian Najjuma, Yvette Wibabara, Judith Nanyondo, Shillah Nakato, Maria Sarah Nabaggala, Ciara Sugerman, Daniel Kadobera, Rita Atugonza, John Kamulegeya, Joseph Magoola, Racheal Beyagira, Mohammed Lamorde, Alex Riolexus Ario, Alfred Driwale, Shibani Kulkarni

“…We conducted a rapid analysis based of debriefing notes and in-depth thematic analysis of translated transcripts. Data were analyzed using NVivo version 12, wherein we used the framework analysis approach to define and structure codes deductively and inductively to identify themes. …”
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Precise aftershock activity in the marine source region of the 2024 Noto-Hanto earthquake by rapid response observation using ocean bottom seismometers by Masanao Shinohara, Ryota Hino, Tsutomu Takahashi, Koichiro Obana, Shuichi Kodaira, Ryosuke Azuma, Tomoaki Yamada, Takeshi Akuhara, Yusuke Yamashita, Eiji Kurashimo, Yoshio Murai, Takehi lsse, Kazuo Nakahigashi, Hisatoshi Baba, Yusaku Ohta, Yoshihiro Ito, Hiroshi Yakiwara, Yukihiro Nakatani, Gou Fujie, Toshinori Sato, Hajime Shiobara, Kimihiro Mochizuki, Shin’ichi Sakai, The R/V Hakuho-maru KH-24-JE01 and KH-24-JE02C shipboard science parties

“…A velocity model was derived from the velocity structure by the marine seismic survey. Focal mechanisms were estimated using the grid search method based on the polarities of the first Pwave arrivals. …”
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Examining the evolution and impact of OTC vending machines in Global Healthcare Systems by Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sahab Alkhoujah, Faris El-Dahiyat, Ammar Ali Saleh Jaber, Sa'ed H. Zyoud

“…Conclusions: This study emphasises the practical necessity for enhanced regulatory structures to mitigate risks such as medication abuse, unfavourable drug interactions, and incorrect dispensing practices. …”
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Phytochemical Study and In Vitro Antioxidant Activity of <i>Helianthemum cinereum</i> Along with Antitumor Activity of the Isolated <i>trans</i>-Tiliroside and Luteolin 4′-<i>O</i>... by Anis Bertella, Abla Smadi, Hakim Benhabrou, Diana Salvador, Magdalena Wrona, Helena Oliveira, Abouamama Sidaoui, Georgiana Gavril-Luminita, Diana C. G. A. Pinto, Ewa Olewnik-Kruszkowska, Cristina Nerín, Artur M. S. Silva, Fatma Bitam

“…All compounds were isolated by applying different chromatographic procedures, such as silica gel, RP-18 and Sephadex LH-20 columns. The structures were elucidated by extensive spectroscopic methods, mainly nuclear magnetic resonance NMR 1D and 2D, and mass spectrometry, as well as by comparison with the reported spectroscopic data. …”
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Population-based cross-sectional seroprevalence study of SARS-CoV-2 infection in urban residential areas in Ghana by John H Amuasi, Aurélia Souares, Eva Lorenz, Wibke Loag, Anthony Afum-Adjei Awuah, Sylvester Newton, Christian Obirikorang, Evans Asamoah Adu, Eric Ebenezer Amprofi Boham, Alexander Owusu Boakye, Hakim Alani, Nana Safi Almoustapha, James Deke, Welbeck Odame Dzadey, Louis Adu-Amoah, Sally-Ann Kroduah, Mary Ama Grant, Gracelyn Asare, Amos Amoako-Adusei, Jenny Kettenbeil, Yaw Adu Sarkodie, Ebenezer Oduro, Alfred E Yawson, Stephen Apanga, Rose Odotei Adjei, Austin Gideon Adobasom Anane, Oumou Maiga Ascofare, May Jurgen, Nicole S Struck

“…Bayesian models with poststratification weighting of the demographic structure of the sample population were used for seroprevalence estimates, accounting for the uncertainty of diagnostic assay in a hierarchical model. …”
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Rapid On-Site Histopathological Analysis of Kidney Biopsy With Dynamic Full-Field Optical Coherence Tomography by Léa Zuccarelli, Quentin Bernard, Georges Tarris, Laurent Martin, Mathilde Funes de la Vega, Amélie Jacq, Jean-Michel Rebibou, Claire Tinel, Claude Boccara, Olivier Thouvenin, Jean-Marie Chassot, Marion Rabant, Julien Zuber, Christophe Legendre, Jean-Pierre Quenot, Marie-Noëlle Peraldi, Lucile Amrouche, Anne Scemla, Nathalie Chavarot, Dany Anglicheau, Mathieu Legendre, Thomas Maldiney

“…The clinical and biological data were prospectively collected. Histopathological analysis of kidney biopsies was conducted using both conventional stains and dynamic D-FF-OCT imaging. …”
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Determination of Macro- and Microelements in the Inflorescences of Banana Tree Using ICP OES: Evaluation of the Daily Recommendations of Intake for Humans by Rafaela Henriques Rosa, Melina Ribeiro Fernandes, Elaine Silva de Pádua Melo, Daniela Granja Arakaki, Nayara Vieira de Lima, Luana Carolina Santos Leite, Paulo Renato Espindola, Igor Domingos de Souza, Valdir Aragão do Nascimento, Paula Fabiana Saldanha Tschinkel, Fabiane La Flor Ziegler Sanches, Valter Aragão do Nascimento

“…The inflorescence of Musa paradisiaca, known as “banana heart” is a structure that includes flowers and bracts of banana, commonly used as food source worldwide. …”
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Rainfall as an important process for net N gain during the initial phase of natural recovery in karst desertification by Xia Li, Yu Pang, Hengsheng Lao, Linfang Luo, Tongxin He, Guangting Pei, Shuangshuang Xiao, Baoqing Hu, Jianfei Sun

“…Abstract Nitrogen (N) losses driven by rapid hydrologic processes in karst regions were once considered a potentially key mechanism of N limitation during the initial phase of natural recovery following karst desertification. However, field data are still lacking for studying the hydrologic N budget. …”
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Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary... by Shigeharu Muto, Ayako Furuhama, Mika Yamamoto, Yasuteru Otagiri, Naoki Koyama, Seiji Hitaoka, Yusuke Nagato, Hirofumi Ouchi, Masahiro Ogawa, Kisako Shikano, Katsuya Yamada, Satoshi Ono, Minami Hoki, Fumiya Ishizuka, Soichiro Hagio, Chiaki Takeshita, Hisayoshi Omori, Kiyohiro Hashimoto, Satsuki Chikura, Masamitsu Honma, Kei-ichi Sugiyama, Masayuki Mishima

“…Abstract Background Primary aromatic amines (PAAs) present significant challenges in the prediction of mutagenicity using current standard quantitative structure activity relationship (QSAR) systems, which are knowledge-based and statistics-based, because of their low positive prediction values (PPVs). …”
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Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
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Lessons from the PROTECT-CH COVID-19 platform trial in care homes by Philip M Bath, Jonathan Ball, Matthew Boyd, Heather Gage, Matthew Glover, Maureen Godfrey, Bruce Guthrie, Jonathan Hewitt, Robert Howard, Thomas Jaki, Edmund Juszczak, Daniel Lasserson, Paul Leighton, Val Leyland, Wei Shen Lim, Pip Logan, Garry Meakin, Alan Montgomery, Reuben Ogollah, Peter Passmore, Philip Quinlan, Caroline Rick, Simon Royal, Susan D Shenkin, Clare Upton, Adam L Gordon

“…Generic challenges included working across the four home nations with their different structures and regulations. Limitations The feasibility of contracting between the sponsor and the principal investigators, general practitioners and care homes; screening, consent and treatment of care home residents; data acquisition and the potential benefit of postexposure prophylaxis were never tested. …”
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Genome-Wide Identification and Evolutionary Analysis of <i>Ionotropic Receptors</i> Gene Family: Insights into Olfaction Ability Evolution and Antennal Expression Patterns in <i>Or... by Wen-Qi Yang, Ge Ding, Lin-Lin Wang, Chi-Jie Yin, Hai-Yue Wu, Hua-Bin Zhang, Qiu-Ning Liu, Sen-Hao Jiang, Bo-Ping Tang, Gang Wang, Dai-Zhen Zhang

“…Based on the whole-genome data of <i>O. oratoria</i>, we identified and analyzed 50 members of the <i>IR</i> gene family (<i>OratIRs</i>) through bioinformatics approaches. …”
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3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration by Lincong Luo, Weihan Zheng, Jiaying Li, Tingting Chen, Wanting Xue, Tao Lin, Mingrui Liu, Zi Yan, Jiaxin Yang, Jiamin Li, Jiahao Pu, Yaobin Wu, Konghe Hu, Shiyu Li, Wenhua Huang

“…Abstract Current Ti‐6Al‐4V bone implants lack trabecular structure and pro‑angiogenic cues, both essential for regeneration. …”
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