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Dihydroflavonol 4-reductase genes encode enzymes with contrasting substrate specificity and show divergent gene expression profiles in Fragaria species.
Published 2014-01-01“…One enzyme variant did not accept DHK (with one hydroxyl group present in the B-ring), whereas the other strongly preferred DHK as a substrate. This appears to be an uncharacterized DFR variant with novel substrate specificity. …”
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84
(Quadratically) Refined discrete anomaly cancellation
Published 2025-08-01“…Since the 2-forms in six dimensions are themselves chiral, their formulation needs subtle topological information encoded in a so-called quadratic refinement. A matching between the fermionic anomalies and the defining properties of the quadratic refinement, lead to strong consistency constraints on the charged fermion spectrum. …”
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Induction of gender-like linguistic categories using noun-marking and blocking of learning trials
Published 2024-12-01Get full text
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Rational optimization of glycoprotein E (gE)-encoding mRNA for improved Varicella-zoster virus mRNA vaccine development
Published 2024-12-01“…mRNA platform holds promise for next-generation Varicella-zoster Virus (VZV) vaccine development due to its high potency at inducing strong T-cell response. Built upon the design of our 1st-generation VZV mRNA vaccine that encodes for full-length gE antigen, in this study we reported on a novel combinatorial strategy to further optimize the gE-encoding mRNA sequence through signal peptide replacement, C-terminal modification, and insertion of mRNA-stabilizing motif, which collectively contributed to significantly improved vaccine immunogenicity. …”
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Enhancement of immunogenicity of DNA vaccine against infectious bursal disease virus by co-delivery with oral vaccine encoding chicken interleukin-2
Published 2007-05-01“…These results obviously indicated that chicken IL-2 was a strong adjuvant can be significantly enhance the immunogenicity of IBDV DNA vaccine.…”
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VMDU-net: a dual encoder multi-scale fusion network for polyp segmentation with Vision Mamba and Cross-Shape Transformer integration
Published 2025-06-01“…This architecture employs two parallel encoders: one incorporates Vision Mamba modules, and the other integrates a custom-designed Cross-Shape Transformer. …”
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Lung-Selective Delivery of mRNA-Encoding Anti-MERS-CoV Nanobody Exhibits Neutralizing Activity Both In Vitro and In Vivo
Published 2024-11-01“…<b>Results</b>: The LNP-mRNA-NbMS10 system expressed the nanobody in vitro, showing strong antigen-binding and significant MERS-CoV pseudovirus neutralization. …”
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The medial fronto-parietal network of the macaque: Different specializations for spatial parameters of reaching?
Published 2025-09-01“…Two key nodes in this network are the dorsal premotor area F2 and the medial posterior parietal area V6A, which are strongly reciprocally connected (Gamberini et al., 2021). …”
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A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice.
Published 2024-01-01“…We have designed an adenoviral vector type 35 (Ad35)-based vaccine encoding the HSV-2 major surface antigen gD2 (Ad35.HSV.gD2). …”
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Axiological connotation and the semantic-pragmatic distinction
Published 2023-11-01“…First, I consider the semantic-pragmatic distinction in terms of encoded vs. non encoded meaning: I argue that one should distinguish between linguistically encoded axiological connotation and culturally encoded axiological connotation. …”
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Physiological and biochemical effects of different expression of acyl-CoA: lysophosphatidylethanolamine acyltransferases encoding genes observed in arabidopsis plants cultivated un...
Published 2025-07-01“…In all lpeat mutants, decrease in the amount of all analysed lipid classes per unit of fresh weight was detected, however, it was the most pronounced in the case of phosphatidylglycerol (PG) and monogalactosyldiacylglycerol (MGDG). The strong correlation between different expression levels of genes encoding LPEAT enzymes, in the tested plant lines, and the LPEAT and LPGAT activity (lysophoshatidylethanolamine and lysophoshatidylglycerol serve as fatty acid acceptors, respectively) were noted. …”
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Rational Approach to New Chemical Entities with Antiproliferative Activity on Ab1 Tyrosine Kinase Encoded by the <i>BCR-ABL</i> Gene: An Hierarchical Biochemoinformatics Analysis
Published 2024-11-01“…Our in silico results show that these molecules could be potent protein kinase inhibitors with potential antiproliferative activity on tyrosine kinase encoded by the BCR-ABL gene. <b>Conclusions:</b> In conclusion, the results suggest that these ligands, particularly LMQC04, may bind strongly to the studied target and may have appropriate ADME/Tox properties in experimental studies. …”
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GramSeq-DTA: A Grammar-Based Drug–Target Affinity Prediction Approach Fusing Gene Expression Information
Published 2025-03-01Get full text
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DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in Rhesus macaques.
Published 2006-12-01“…Additionally, there was a strong HIV-1-specific IgG response. The IgG antibody titers increased after each DNA injection, indicating a strong amnestic B-cell response, and were highly elevated in all the macaques after three immunizations. …”
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