GABAergic neuron deficit as an idiopathic generalized epilepsy mechanism: the role of BRD2 haploinsufficiency in juvenile myoclonic epilepsy. by Libor Velíšek, Enyuan Shang, Jana Velíšková, Tamar Chachua, Stephania Macchiarulo, Giorgi Maglakelidze, Debra J Wolgemuth, David A Greenberg

“…Idiopathic generalized epilepsy (IGE) syndromes represent about 30% of all epilepsies. They have strong, but elusive, genetic components and sex-specific seizure expression. …”
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Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control by Yuxiang Andy Liu, Yuhan Nong, Jiesi Feng, Guochuan Li, Paul Sajda, Yulong Li, Qi Wang

“…Neuropixels recordings revealed that disrupting LC-BF projections impaired PFC neuronal encoding and altered population firing patterns linked to inhibitory control. …”
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Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus. by Koshiro Inoue, Masahiro Okamoto, Takemune Fukuie, Hideaki Soya, Akihiko Yamaguchi

“…Short-term, hippocampus-dependent memory produced by weak encoding can be transformed into long-term memory through an immediate, strong behavioral event, which causes overlapping activation of the hippocampus. …”
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Exploring the genomic landscape of the GP63 family in Trypanosoma cruzi: Evolutionary dynamics and functional peculiarities. by Luisa Berná, María Laura Chiribao, Sebastián Pita, Fernando Alvarez-Valin, Adriana Parodi-Talice

“…Second, GP63 groups show strong preference for different genomic compartments. …”
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Switched 32-Bit Fixed-Point Format for Laplacian-Distributed Data by Bojan Denić, Zoran Perić, Milan Dinčić, Sofija Perić, Nikola Simić, Marko Anđelković

“…Experimental and simulation results obtained using neural network weights further support the approach. The strong agreement between the experiment, simulation, and theory indicates the efficiency of this proposal in encoding Laplacian data, as well as its potential applicability in neural networks.…”
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TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis. by Christian G Meyer, Norbert Reiling, Christa Ehmen, Gerd Ruge, Ellis Owusu-Dabo, Rolf D Horstmann, Thorsten Thye

“…Association analyses yielded a significant result for the TLR1 variant rs3923647, conferring strong protection against TB (Odds ratio [OR] 0.21, CI confidence interval [CI] 0.05-0.6, Pnominal 1 x 10-3) when applying a recessive model of inheritance. …”
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Preclinical efficacy and safety of adeno-associated virus 5 alpha-galactosidase: A gene therapy for Fabry disease by Jolanda M.P. Liefhebber, Giso Brasser, Elisabeth A. Spronck, Roelof Ottenhoff, Lieke Paerels, Maria J. Ferraz, Lukas K. Schwarz, Nikoleta Efthymiopoulou, Chi-Lin Kuo, Paula S. Montenegro-Miranda, Melvin M. Evers, Johannes M.F.G. Aerts, Ying Poi Liu

“…We developed a novel adeno-associated virus 5 gene therapy (AAV5-GLA) expressing human alpha-galactosidase A (GLA) under the control of a novel, small and strong, liver-restricted promoter. We assessed the preclinical potential of AAV5-GLA for treating Fabry disease, an X-linked hereditary metabolic disorder resulting from mutations in the gene encoding GLA that lead to accumulation of the substrates globotriaosylceramide and globotriaosylsphingosine, causing heart, kidney, and central nervous system dysfunction. …”
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Tomography Method of Cemented Sand Based on Constant Gradient Coded 1D T2 Spectrum by WU Turong, CHEN Jinding, ZHANG Qun, ZHAO Xichun, GUO Minling, CHENG Fanggui

“…The new technology has achieved good results in gas displacement experiments of cemented sandstone, and is expected to play an important role in the analysis of seepage laws of strong heterogeneous rocks.…”
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Predictive modelling of graphene-enhanced greases using classical feedback control and quantum kernel regression by Ethan Stefan-Henningsen, Amirkianoosh Kiani

“…In parallel, a quantum-classical hybrid model employs a fidelity-based quantum kernel with support vector regression. By encoding partial early-cycle temperature measurements (e.g., from 30 to 120s) into a higher-dimensional Hilbert space, the quantum approach captures subtle nonlinearities and yields strong correlations for both final temperature and wear scar area. …”
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Magnetic Electric Detonator Coding Graded Perforation Firing Technology by YANG Bin, LU Caihao, SONG Ning, LIU Bing, ZHAO Li, XIAO Xiangyang

“…The successful application of this technology in multiple wells in China has shown its strong applicability. The technology provides a new detonation technology for pumping graded perforation, and is of great significance in reducing the safety risks of perforation construction.…”
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Diversification, loss, and virulence gains of the major effector AvrStb6 during continental spread of the wheat pathogen Zymoseptoria tritici. by Ana Margarida Sampaio, Sabina Moser Tralamazza, Faharidine Mohamadi, Yannick De Oliveira, Jérôme Enjalbert, Cyrille Saintenac, Daniel Croll

“…We found that AvrStb6 has diversified into 59 protein isoforms with a strong association to the pathogen spreading to new continents. …”
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Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci. by Jacquelyn M Evans, Rooksana E Noorai, Kate L Tsai, Alison N Starr-Moss, Cody M Hill, Kendall J Anderson, Thomas R Famula, Leigh Anne Clark

“…We conducted genome-wide association studies in two modern breeds having common ancestry and detected strong associations with novel loci on canine chromosomes 10 (P-val = 2.3X10-12) and 31 (P-val = 3.95X10-8). …”
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Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. by Chris McDermott-Roe, Marion Leleu, Glenn C Rowe, Oleg Palygin, John D Bukowy, Judy Kuo, Monika Rech, Steffie Hermans-Beijnsberger, Sebastian Schaefer, Eleonora Adami, Esther E Creemers, Matthias Heinig, Blanche Schroen, Zoltan Arany, Enrico Petretto, Aron M Geurts

“…To focus the analysis on a medically-important condition with a strong yet incompletely understood mitochondrial component, candidates were cross-referenced with an MPET-enriched module independently generated via genome-wide co-expression network analysis of a human heart failure gene expression dataset. …”
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Out-of-Distribution in Image Semantic Communication: A Solution With Multimodal Large Language Models by Feifan Zhang, Yuyang Du, Kexin Chen, Yulin Shao, Soung Chang Liew

“…We propose a novel “Plan A - Plan B” framework that leverages the broad knowledge and strong generalization ability of an MLLM to assist a conventional ML model when the latter encounters an OOD input in the semantic encoding process. …”
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Characterization of the VOC Promoter That Is Active Under Low-Salinity Conditions in the Diatom <i>Phaeodactylum tricornutum</i> by Charlotte Toustou, Carole Plasson, Marie-Christine Kiefer-Meyer, Muriel Bardor

“…In this study, we identified thirty-three potential “strong” endogenous promoters based on our previously published transcriptomic data from the <i>P. tricornutum</i> Pt3 strain. …”
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A comparative study of machine learning models for automated detection and classification of retinal diseases in Ghana. by Gifty Duah, Eric Nyarko, Anani Lotsi

“…<h4>Result</h4>All the CNN models evaluated in this study demonstrated a strong capability to detect and classify various retinal diseases with high accuracy. …”
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An Improved Convolutional Neural Networks: Quantum Pseudo-Transposed Convolutional Neural Networks by Li Hai, Chen Liang, Hao Yaming, Yu Wenli, Shi Fengquan

“…The results demonstrate that both Model A and Model B achieve strong performance across the datasets. However, Model A outperforms Model B, achieving higher classification accuracy and lower loss compared to earlier models. …”
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Attention-enhanced residual U-Net: lymph node segmentation method with bimodal MRI images by Juping Qiu, Chunxia Chen, Ming Li, Jingde Hong, Binhua Dong, Shangyue Xu, Yongping Lin

“…Results The experimental results demonstrated that the ERU-Net network showed strong segmentation performance, which was significantly better than other segmentation networks. …”
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Stochastic Differential Games and a Unified Forward–Backward Coupled Stochastic Partial Differential Equation with Lévy Jumps by Wanyang Dai

“…The coupling between forward and backward SPDEs essentially corresponds to the interaction between noise encoding and noise decoding in the current hot diffusion transformer model for generative AI.…”
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GPE-DNeRF:Neural radiance field method for surface geological bodies reconstruction by Xinyi Wang, Weihua Hua, Xiuguo Liu, Peng Li, Guohe Li

“…The GPE-DNeRF method demonstrates a strong capability to eliminate artifacts and retain detailed terrain features, thereby enhancing reconstruction quality and ensuring a closer alignment with actual surface geological conditions.…”
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