Endothelial damage and complement dysregulation in fetuses from pregnancies complicated by preeclampsia by Alex Ramos, Lina Youssef, Patricia Molina, Julia Martinez‐Sanchez, Ana Belen Moreno‐Castaño, Miquel Blasco, Blanca De Moner, Marta Tortajada, Marta Camacho, Maria Borrell, Francesca Crovetto, Marc Pino, Gines Escolar, Enric Carreras, Eduard Gratacos, Maribel Diaz‐Ricart, Marta Palomo, Fatima Crispi

“…Abstract Introduction Our objective was to evaluate the endothelial function profile and complement system in fetuses from preeclamptic pregnancies using ex vivo and in vitro approaches. …”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype by Nadia Cobo‐Vuilleumier, Silvia Rodríguez‐Fernandez, Livia López‐Noriega, Petra I. Lorenzo, Jaime M. Franco, Christian C. Lachaud, Eugenia Martin Vazquez, Raquel Araujo Legido, Akaitz Dorronsoro, Raul López‐Férnandez‐Sobrino, Beatriz Fernández‐Santos, Carmen Espejo Serrano, Daniel Salas‐Lloret, Nila vanOverbeek, Mireia Ramos‐Rodriguez, Carmen Mateo‐Rodríguez, Lucia Hidalgo, Sandra Marin‐Canas, Rita Nano, Ana I. Arroba, Antonio Campos Caro, Alfred CO Vertegaal, Alejandro Martín‐Montalvo, Franz Martín, Manuel Aguilar‐Diosdado, Lorenzo Piemonti, Lorenzo Pasquali, Roman González Prieto, Maria Isabel García Sánchez, Decio L. Eizirik, Maria Asuncion Martínez‐Brocca, Marta Vives‐Pi, Benoit R. Gauthier

“…BL001‐target gene expression levels were confirmed by quantitative PCR. Mitochondrial function was evaluated through the measurement of oxygen consumption rate using a Seahorse XF analyser. …”
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Selective neoadjuvant therapy of rectal cancer patients (SELREC): study protocol for a European randomised controlled, open, multicentre non-inferiority trial by Markus W Büchler, Lukas Baumann, Peter Schirmacher, Christoph W Michalski, Markus K Diener, Dirk Jäger, Pascal Probst, Mohammed Al-Saeedi, Martin Schneider, Alexis Ulrich, Constantin Schwab, Anja Sander, Christina Klose, Christoph Kahlert, Hans-Ulrich Kauczor, Jürgen Debus, Rosa Klotz, Solveig Tenckhoff, Cosima Engerer, Kristin Uzun-Lang, Caroline Wild, Bruno C Köhler

“…However, n(C)RT has demonstrated no significant impact on overall survival but is associated with adverse effects, including impaired sphincter and sexual function. We hypothesise that omitting n(C)RT in selected patients with a clear circumferential resection margin (CRM) >1 mm as determined through preoperative MRI is not inferior regarding local recurrence rate within 3 years after surgery. …”
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Expert consensus for the management of patients with achondroplasia in treatment with vosoritide by Ana-Coral Barreda-Bonis, Josep Maria de Bergua Domingo, Enrique Galán-Gómez, Encarna Guillén-Navarro, Isabel Leiva-Gea, Isolina Riaño-Galán

“…This interdisciplinary team should be involved in the planning of vosoritide treatment (including the education of patients and caregivers, with management of their expectations, and their training in the practical aspects of vosoritide administration), treatment initiation and close monitoring with regular assessment of anthropometric, biochemical, functional or patient-reported variables. Conclusions: This protocol for the administration of vosoritide will allow standardised implementation and optimization of treatment outcomes. …”
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Demand and Influencing factors for community health services during chemotherapy of patients with advanced cancer by Qianqian Li, Xunrui Chen, Wenying Zhang, Haihua Yuan, Yanjie Zhang, Bin Jiang, Feng Liu

“…The top five demands were “preparation for pathological tests such as routine blood, liver and kidney functions before chemotherapy” (2.48 points), “education on chemotherapy knowledge” (2.48 points), “care for peripherally inserted central catheter(PICC) catheterization during chemotherapy” (2.45 points), “management of myelosuppression after chemotherapy” (2.43 points) and ''providing updated information on treatment, examination and rehabilitation” (2.42 points), primarily focusing on the medical care demand dimension. …”
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Serum extracellular vesicle microRNAs as potential biomarkers to predict pembrolizumab response and prognosis in metastatic non-small cell lung cancer patients by Daniela Lamorte, Luciana De Luca, Alfredo Tartarone, Stefania Trino, Irene Giulivo, Angelo De Stradis, Maddalena Maietti, Antonella Caivano, Ilaria Laurenzana

“…All data were associated with immunotherapy response, Progression Free Survival (PFS), Overall Survival (OS), Eastern Cooperative Oncology Group Performance Status (ECOG-PS) and metastases.ResultsTwelve NSCLC-related microRNAs have been found, for the first time, in serum cEVs from a specific cohort of metastatic advanced stage NSCLC patients. Through a functional analysis, these microRNAs are found to be connected to each other and involved in the pathology of NSCLC, particularly in IGF/P53/VEGF/NOTCH/PI3K pathways, in cytokine/interleukin signaling and in the immune system. …”
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<i>Bifidobacterium adolescentis PRL2019</i> in Pediatric Irritable Bowel Syndrome: A Multicentric, Randomized, Double-Blind, Placebo-Controlled Trial by Valentina Giorgio, Giovanna Quatrale, Maurizio Mennini, Marisa Piccirillo, Silvia Furio, Giuseppe Stella, Alessandro Ferretti, Pasquale Parisi, Melania Evangelisti, Enrico Felici, Paolo Quitadamo, Giovanni Di Nardo

“…The gut microbiota plays a pivotal role in gastrointestinal inflammation and immune response since changes in microbiota may result in abnormal neurotransmitter expression, inducing changes in gastrointestinal sensory–motor function and leading to symptom onset in irritable bowel syndrome (<i>IBS</i>) patients. …”
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Fibroblasts‐specific p16INK4a exacerbates inflammageing‐mediated post‐infarction ventricular remodelling through interacting with STAT3 to regulate NLRP3 transcription by Xin Gu, Yingqiang Du, Jin'ge Zhang, Jiyu Li, Haiyun Chen, Yujie Lin, Yue Wang, Chunli Zhang, Shiyu Lin, Nannan Hao, Chengyi Peng, Jiacheng Ge, Jin Liu, Yan Liang, Yongjie Zhang, Xiaoyan Wang, Fang Wang, Jianliang Jin

“…POSTN‐driven p16INK4a knockout improved cardiac function, and reduced ventricular remodelling, myocardial inflammation and NLRP3 signalling activation following MI through downregulating STAT3‐mediated NLRP3 inflammasome and upregulating glutathione metabolism pathway in fibroblasts. …”
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Deciphering the interaction between the expression of LRP2 served as a mitochondrial metabolism-related gene and prognosis in colon cancer integrating multi-omics analysis by Jie Zhang, Ziyun Liu, Xiaoqing Ma, Zhenyu Shi, Jing Zhao, Yongjie Xie, Xiaobin Shang, Xia Zhang

“…We validated survival outcome and biological function of the target gene leveraging single-cell sequencing and transcriptomics datasets from Gene Expression Omnibus (GEO), and evaluated the value of the target gene in the clinical pathology stage of COAD patients. …”
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Serum FGF21 as a predictor of response to atezolizumab and bevacizumab in HCC by Risako Kohya, Goki Suda, Masatsugu Ohara, Shunichi Hosoda, Takuya Sho, Makoto Chuma, Atsumasa Komori, Yuki Kugiyama, Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Joji Tani, Shun Kaneko, Mina Nakagawa, Yasuhiro Asahina, Shinya Maekawa, Nobuyuki Enomoto, Yoshiya Yamamoto, Masaru Baba, Ren Yamada, Takashi Sasaki, Tomoka Yoda, Sonoe Yoshida, Qingjie Fu, Zijian Yang, Osamu Maehara, Shunsuke Ohnishi, Yoshimasa Tokuchi, Takashi Kitagataya, Naoki Kawagishi, Masato Nakai, Mitsuteru Natsuizaka, Koji Ogawa, Naoya Sakamoto

“…Tumour-secreted FGF21 has shown immune-checkpoint factor functions, and high FGF21 levels are associated with a poor prognosis for patients. …”
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Changes in Protein Metabolism and Early Development of Sarcopenia in Mice With Cholestatic Liver Disease by Ottavia Agrifoglio, Solvig Görs, Quentin Sciascia, Zeyang Li, Elke Albrecht, Sophie Achilles, Meike Statz, Manuela Bastian, Tobias Lindner, Karen Friederike Gauß, Sarah Rohde, Karen Rischmüller, Peggy Berlin, Georg Lamprecht, Robert Jaster, Cornelia C. Metges, Luise Ehlers

“…The quadriceps muscle of BDL mice contained higher mRNA levels of atrophy‐associated genes (Trim63: p < 0.0001, Fbxo32: p < 0.01) and Mstn (p < 0.05), but lower levels of genes involved in mitochondrial function (Cpt‐1b: p < 0.05, Pgc‐1α: p < 0.01; each vs. sham). …”
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Next-generation sequencing in early-stage multiple primary lung cancer: The prognostic significance of genomic accumulation status and BCL2L11del by Mu-Ting Wang, Chen-Hui Ni, Yan-Qi Lu, Wei Zheng, Shu-Liang Zhang, Mao-Hui Chen, Bin Zheng, Chun Chen

“…Additionally, the study sought to explore the biological functions and prognostic significance of PRMT8 in BCL2L11del lung cancer. …”
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Validation of the PsAID-12 Russian questionnaire in patients with psoriatic arthritis by L. D. Vorobyeva, E. Yu. Loginova, Yu. L. Korsakova, E. E. Gubar, P. O. Tremaskina, T. V. Korotaeva

“…It was revealed that in groups I and II there was a statistically significant difference on all scales of questionnaires, in group III, “non-responders” to therapy, there were no statistically significant improvements in the scales “Pain” (p=0.37), “Fatigue” (p=0.15), “Skin problems” (p=0.23), “Work and/or leisure activities” (p=0.056), “Functional capacity” (p=0.44). Thus, during treatment, it was noted that the PsAID-12 questionnaire may reflect the dynamics depending on the activity of the disease during treatment, which proves its good sensitivity.Conclusion. …”
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The analgesic effect and ATP release at acupuncture points in response to acupuncture with different parameters on arthritis rats by Jie LIN, Kai-yu CUI, Yu-jia LI, Wei-min ZUO, Jing-wen XU, Xue-yong SHEN, Guang-hong DING, Xiao-long TANG, Li-na WANG

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Comparative analysis of patients transplanted due to hepatocellular carcinoma. Are there survival differences between those who meet the Milan criteria and those who exceed them? by M.H. Mohamed-Chairi, A.B. Vico-Arias, N. Zambudio-Carroll, M.T. Villegas-Herrera, J.M. Villar-del-Moral

“…The Student’s t test or Mann–Whitney U test were applied for the quantitative variables and the Fisher’s exact test for the categorical variables. The survival function was estimated through the Kaplan–Meier method and the log-rank test was applied for comparing the groups. …”
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Phenotypic evaluation of worldwide germplasm of arugula (Eruca sativa Mill.) and identification of underlying latent factors contributing to phenotypic variation under indoor farmi... by Seam Choon Law, Ting Xiang Neik, Ethan Tze Cherng Lim, Adrian Ming Jern Lee, Yi Lin Lim, Wan Zu Tang, Shuang Song, Pei-Wen Ong, Sin Joe Ng, Fook Tim Chew

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A Delphi Consensus Project to Capture Greek Experts&rsquo; Opinion on the Position of Triple Therapies in COPD: Why, When and to Whom by Papaioannou AI, Loukides S, Vassilakopoulos T, Tzanakis N, Kostikas K, Hillas G

“…The questionnaire was developed by a 6-member steering committee, included 54 statements, and divided into 3 domains: (A) triple therapy as initial treatment (divided into subdomains examining the impact of exacerbations based on lung function, bronchodilation reversibility and/or blood eosinophil count, smoking, symptoms, and comorbidities), (B) escalation to triple therapy from dual bronchodilation and (C) de-escalation from triple therapy to dual bronchodilation. …”
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Effects of direct moxibustion on antigen-presenting cells in gastric tissue of rat models with gastric cancer: Understanding the immunological mechanisms by Tian-yu GAO, Fei-cheng ZHANG, Ru-fang PAN, Shu-ya MA, Xiao-qi ZHANG, Li-jia PAN, Chun-sheng JIA

“…Its mechanisms may involve effects on the state of antigen-presenting cells, thereby promoting T cell activation and enhancing immune function.…”
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Requirements for Becoming a Startup: A Study with an Economic Sociology Approach (Case Study: Managers of Startups in Isfahan City) by Rahmatollah Torkan, Seyed Samad Beheshty, Ramin Moradi

“…This innovative ecosystem functioned as a coordinated and synergistic system.The key organizing themes within this ecosystem included:Startup Ecosystem: Encompassing innovative policymaking structures, startup legislation, supportive government initiatives, internationalization, and the startup communityStrategic Idea: Serving as an innovative and market-reality-based foundationStartup Mentality: Reflecting the leadership, entrepreneurial spirit, and risk-taking attributes of foundersAffinity of Strategic Financial Approach: Manifested in funding strategies and the alignment between investors and foundersTeam Dynamics: Emphasizing the importance of teamwork and specialized division of laborMarket Realism: Informed by accurate analyses of customer needsStartup Networking: Focusing on creating and strengthening connectionsAccording to the managers of Isfahan startups, the formation, strengthening, and sustainability of these ventures relied on the interaction and synergy of these organizing themes at various levels. …”
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Study of the effect of human placenta hydrolysate in a new model of metabolic-associated fatty liver disease with iron overload by T. E. Bogacheva, O. A. Gromova, I. Yu. Torshin, V. I. Demidov, A. G. Kalacheva, A. A. Garanin, I. V. Gogoleva, L. E. Fedotova, O. A. Limanova, А. N. Mnatsakanyan, N. Yu. Zhidomorov, T. R. Grishina

“…The model was used to test the effectiveness of using standardized HPH and to characterize complex changes in more than 20 biomarkers of liver and kidney functions, hematopoiesis, inflammation, and thrombus formation.Results. …”
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