Lipidomics-based plasma signature of alcohol-related hepatitis linked to short-term mortality by Florent Artru, Stephen Atkinson, Francesca Trovato, Luke D. Tyson, Vishal C. Patel, Nikhil Vergis, Noora Kano, Robert Goldin, Alberto Quaglia, Alexandros Pechlivanis, Phillip Morgan, Salma Mujib, Anna Cavazza, Ellen Jerome, Marc Zentar, Roosey Sheth, Maura Morrison, Evangelos Triantafyllou, Elaine Holmes, María Gómez-Romero, Mark J. McPhail, Mark Thursz

“…Conclusions: Untargeted lipidomics identified a glycerophospholipid and sphingolipid signature distinguishing sAH from DC, implicating lipid species involved in liver regeneration and immune function. Acylcarnitine accumulation in patients with sAH and poor prognosis suggests mitochondrial dysfunction and warrants further investigation into therapeutic potential. …”
Get full text

Application of platelet-rich plasma therapy combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis (富血小板血浆联合5E康复护理模式在膝骨性关节炎患者中的应用)... by AN Linjing (安林静), ZHAO Chen (赵晨), CHANG Yueyuan (常月圆), PAN Yaying (潘亚英), CHEN Yanqi (程艳琪), ZHANG Bing (张兵), CHEN Weinan (陈炜楠), GAO Bei (高蓓), NIU Jing (牛静), ZHANG Ting (张婷)

“…Conclusion Platelet-rich plasma therapy combined with 5E rehabilitation nursing model can effectively relieve pain and improve knee joint function in patients with knee osteoarthritis. …”
Get full text

A Telephone-based Physiotherapy Intervention for Patients with Osteoarthritis of the Knee by Adesola C Odole, Oluwatobi D. Ojo

“…<p>This study assessed the effects of a 6-week telephone based intervention on the pain intensity and physical function of patients with knee osteoarthritis (OA), and compared the results to physiotherapy conducted in the clinic. …”
Get full text

A phase I, open-label, multicentre, first-in-human study to evaluate safety, pharmacokinetics and efficacy of AMG 404, a PD-1 inhibitor, in patients with advanced solid tumours by Yasutoshi Kuboki, Hendrik-Tobias Arkenau, Vivek Subbiah, Timothy Price, Gerald Falchook, Hans Prenen, Rafal Dziadziuszko, Hansen Wong, Iwona Lugowska, Daniel Tan, Weibing Shi, Ryota Shibaki, Min Hee Hong, Sant P Chawla, Jose G Monzon, Mun Hui, Caio Max Rocha Lima, Kejia Wang, Antreas Hindoyan, Mira Kistler

“…The inclusion criteria included a life expectancy of &gt;3 months, ≥1 measurable or evaluable lesion per modified Response Evaluation Criteria in Solid Tumours (RECIST) V.1.1, an Eastern Cooperative Oncology Group performance status of ≤2 and adequate haematological, renal and hepatic function. Patients with prior treatment with checkpoint inhibitors, primary brain tumour or untreated or symptomatic brain metastases and leptomeningeal disease and history of other malignancy within the past 2 years were excluded.Interventions The planned doses were 240 mg, 480 mg and 1050 mg of AMG 404 administered every 4 weeks (Q4W).Primary and secondary outcome measures Primary endpoints were dose-limiting toxicities (DLTs), treatment-emergent adverse events, treatment-related adverse events, changes in vital signs and clinical laboratory tests. …”
Get full text

Activity and mechanism of naringin in the treatment of post-infectious cough by Yinghan Chen, Dong Wang, Meng Song, Weiqi Pan, Wenda Guan, Zifeng Yang, Shan Zhong

“…GO (Gene Ontology) functional annotation and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analyses were performed with Metascape. …”
Get full text

SPARCL1 and NT‐proBNP as biomarkers of right ventricular‐to‐pulmonary artery uncoupling in pulmonary hypertension by Oliver Dörr, Stanislav Keranov, Paulina vanWickern, Holger Nef, Christian Hamm, Pascal Bauer, Christian Troidl, Samuel Sossalla, Sandra Voss, Christoph Liebetrau, Manuel J. Richter, Henning Gall, Werner Seeger, Ardeschir Ghofrani, Athiththan Yogeswaran, Khodr Tello

“…The present study investigated whether NT‐proBNP and SPARCL1 concentrations are associated with load‐independent parameters of RV function and RV‐to‐pulmonary artery (RV–PA) coupling as measured using invasive pressure–volume (PV) loops in the RV. …”
Get full text

Real‐world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED–HEART study by Umut Kocabas, Isil Ergin, Veysel Yavuz, Cihan Altın, Mehmet Kaplan, Gülsüm Meral Yılmaz Öztekin, Mustafa Doğduş, Selda Murat, Bektaş Murat, Tarık Kıvrak, Dilay Karabulut, Ersin Kaya, İbrahim Halil Özdemir, Cennet Yıldız, Fatma Özge Salkın, Emre Özçalık, Şeyda Günay Polatkan, Fahri Çakan, Taner Şen, Umut Karabulut, Sinem Çakal, Ersan Oflar, Ümit Yaşar Sinan, Mustafa Yenerçağ, Uğur Önsel Türk

“…Higher education level [odds ratio (OR): 1.80; 95% confidence interval (CI): 1.06–3.05; P = 0.027], higher household income (OR: 3.46; 95% CI: 1.27–9.42; P = 0.015), New York Heart Association functional class IV (OR: 2.72; 95% CI: 1.16–6.35; P = 0.021), diabetes (OR: 9.42; 95% CI: 6.72–13.20; P < 0.001), the use of angiotensin receptor–neprilysin inhibitors (ARNis) (OR: 4.09; 95% CI: 2.39–7.01; P < 0.001), the use of mineralocorticoid receptor antagonists (MRAs) (OR: 2.02; 95% CI: 1.49–2.75; P < 0.001), the use of loop diuretics (OR: 1.62; 95% CI: 1.18–2.22; P = 0.003) and the use of thiazide diuretics (OR: 1.72; 95% CI: 1.30–2.29; P < 0.001) were independently associated with the use of SGLT2is. …”
Get full text

Atrial Fibrillation Risk Scores as Potential Predictors of Significant Coronary Artery Disease in Chronic Coronary Syndrome: A Novel Diagnostic Approach by Alexandru-Florinel Oancea, Paula Cristina Morariu, Maria Godun, Stefan Dorin Dobreanu, Miron Mihnea, Diana Gabriela Iosep, Ana Maria Buburuz, Ovidiu Mitu, Alexandru Burlacu, Diana-Elena Floria, Raluca Mitea, Andrei Vâță, Daniela Maria Tanase, Antoniu Octavian Petris, Irina-Iuliana Costache-Enache, Mariana Floria

“…While clinical scores commonly used in AF—such as CHA₂DS₂VA (which includes congestive heart failure, hypertension, age ≥ 75, diabetes, stroke/TIA, vascular disease, and age 65–74), HAS-BLED (which incorporates hypertension, abnormal renal/liver function, stroke, bleeding history, labile INR, elderly age, and drug/alcohol use), and C₂HEST (incorporating coronary artery disease, COPD, hypertension, elderly age ≥ 75, systolic heart failure, and thyroid disease)—are traditionally applied to rhythm or bleeding risk prediction, their value in estimating the angiographic severity of coronary artery disease (CAD) remains underexplored. …”
Get full text

Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis by Menglin Liu, Jingmin Gu, Chenchen Zhao, Jinxia Li, Fanrong Kong, Xinyu Du, Dandan Qi, Enzhu Li, Jie Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Wenwen Gao, Xinwei Li, Lin Lei

“…ABSTRACT: Dairy cows with ketosis frequently exhibit impaired liver function and inflammation. Necroptosis, a form of programmed cell death associated with cellular lysis, releases damage-associated molecular patterns (DAMP) into injured tissues, thereby amplifying inflammatory responses and tissue damage. …”
Get full text

Dual targeting of the mitochondrial Lon peptidase 1 and the chymotrypsin-like proteasome activity as a potential therapeutic strategy in malignant astrocytoma models by Christopher Douglas, Shashi Jain, Naomi Lomeli, Javier Lepe, Kaijun Di, Nitesh Kumar Nandwana, Adil Shareef Mohammed, Thao Vu, James Pham, Maria Cristina Kenney, Bhaskar Das, Daniela A. Bota

“…Using gain- and loss-of-function genetic models, we discovered that LonP1 is both necessary and sufficient to drive BT317 drug sensitivity in established and patient-derived glioma stem-like cells by generating ROS and inducing apoptosis. …”
Get full text

Characteristics of patients prescribed SGLT-2i and/or GLP-1RA among cardiology clinics in the US: insights from the COORDINATE-diabetes trial by Adam J Nelson, Lisa A. Kaltenbach, Hussein R. Al-Khalidi, Monica Leyva, Laura Webb, Darren K. McGuire, Rodica Pop-Busui, Matthew A Cavender, Vanita R. Aroda, Melissa L. Magwire, Caroline R. Richardson, Ildiko Lingvay, Julienne K. Kirk, Ambarish Pandey, Tanya Gaynor, Jonathan Pak, Alana Washington, Cagri Senyucel, Renato D. Lopes, Jennifer B. Green, Christopher B. Granger, Neha J Pagidipati

“…A trend towards significance was observed for the association of preserved kidney function (OR 1.47, 0.99–2.19) and higher Charlson comorbidity index (OR 1.54, 0.97–2.44) with higher odds of SGLT-2i prescription. …”
Get full text

Association of Musculoskeletal Indexes With 1-Year Outcomes After ≥ 7 Days of Mechanical VentilationTake-Home Points by Hannah Wozniak, MD, Erminio Santangelo, Micheal McInnis, Laura Dragoi, Priscila Robles, Leslie M. Chu, Andrea Matte, Margaret S. Herridge, Margaret S. Herridge, Leslie M. Chu, Andrea Matte, George Tomlinson, Linda Chan, Claire Thomas, Jan O. Friedrich, Sangeeta Mehta, Francois Lamontagne, Melanie Levasseur, Niall D. Ferguson, Neill K.J. Adhikari, Jill C. Rudkowski, Hilary Meggison, Yoanna Skrobik, John Flannery, Mark Bayley, Jane Batt, Claudia dos Santos, Susan E. Abbey, Adrienne Tan, Vincent Lo, Sunita Mathur, Matteo Parotto, Denise Morris, Linda Flockhart, Eddy Fan, Christie M. Lee, M. Elizabeth Wilcox, Najib Ayas, Karen Choong, Robert Fowler, Damon C. Scales, Tasnim Sinuff, Brian H. Cuthbertson, Louise Rose, Priscila Robles, Stacey Burns, Marcelo Cypel, Lianne Singer, Cecelia Chaparro, Chung-Wai Chow, Shaf Keshavjee, Laurent Brochard, Paul Hebert, Arthur S. Slutsky, John C. Marshall, Deborah Cook, Jill I. Cameron, Margaret S. Herridge, Leslie M. Chu: Andrea Matte, George Tomlinson, Linda Chan, Claire Thomas, Jan O. Friedrich, Sangeeta Mehta, Francois Lamontagne, Melanie Levasseur, Niall D. Ferguson, Neill K.J. Adhikari, Jill C. Rudkowski, Hilary Meggison, Yoanna Skrobik, John Flannery, Mark Bayley, Jane Batt, Claudia dos Santos, Susan E. Abbey, Adrienne Tan, Vincent Lo, Sunita Mathur, Matteo Parotto, Denise Morris, Linda Flockhart, Eddy Fan, Christie M. Lee, M. Elizabeth Wilcox, Najib Ayas, Karen Choong, Robert Fowler, Damon C. Scales, Tasnim Sinuff, Brian H. Cuthbertson, Louise Rose, Priscila Robles, Stacey Burns, Marcelo Cypel, Lianne Singer, Cecelia Chaparro, Chung-Wai Chow, Shaf Keshavjee, Laurent Brochard, Paul Hebert, Arthur S. Slutsky, John C. Marshall, Deborah Cook, Jill I. Cameron

“…Are these indexes also associated with 7-day post-ICU functional independence measure (FIM) and discharge disposition? …”
Get full text

Sepsis-Associated Acute Kidney Disease Incidence, Trajectory, and Outcomes by Hsiu-Yin Chiang, Chih-Chia Liang, Ya-Luan Hsiao, Uyen-Minh Le, Yi-Ching Chang, Pei-Shan Chen, David Ray Chang, I-Wen Ting, Hung-Chieh Yeh, Chin-Chi Kuo

“…Limitations: Selection bias and information bias could be present because of limiting population to sepsis survivors and because of no standardized follow-up protocol for kidney function. Conclusions: SA-AKD without recovery is associated with increased and long-term risks of KRT initiation, mortality, and increased risk of de novo CKD-ND for patients initially free of CKD. …”
Get full text

Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa by Fredros Okumu, Sarah J. Moore, Prashanth Selvaraj, Arnon Houri Yafin, Elijah O. Juma, GloriaSalome G. Shirima, Silas Majambere, Andy Hardy, Bart G. J. Knols, Betwel J. Msugupakulya, Marceline Finda, Najat Kahamba, Edward Thomsen, Ayman Ahmed, Sarah Zohdy, Prosper Chaki, Peter DeChant, Kimberly Fornace, Nicodem Govella, Steven Gowelo, Emmanuel Hakizimana, Busiku Hamainza, Jasper N. Ijumba, William Jany, Hmooda Toto Kafy, Emmanuel W. Kaindoa, Lenson Kariuki, Samson Kiware, Eliningaya J. Kweka, Neil F. Lobo, Dulcisária Marrenjo, Damaris Matoke-Muhia, Charles Mbogo, Robert S. McCann, April Monroe, Bryson Alberto Ndenga, Halfan S. Ngowo, Eric Ochomo, Mercy Opiyo, Richard Reithinger, Chadwick Haadezu Sikaala, Allison Tatarsky, David Takudzwa, Fedra Trujillano, Ellie Sherrard-Smith

“…In this paper, we argue that the heavy reliance on large-scale cluster-randomized controlled trials (CRTs) to generate evidence on epidemiological endpoints restricts the recommendation of approaches to only those interventions that can be measured by functional units and deliver relatively uniform impact and, therefore, are more likely to receive financial support for conducting these trials. …”
Get full text

Integrating plot-based methods for monitoring biodiversity in island habitats under the scope of BIODIVERSA + project BioMonI: Tree monitoring in Terceira, Tenerife and Réunion Isl... by Paulo Borges, Leila Morgado, Rosalina Gabriel, Rui Elias, Mirana Gauche, Claudine Ah-Peng, Rüdiger Otto, Lea de Nascimento, Dominique Strasberg, Nathaly Guerrero-Ramírez, Holger Kreft, José María Fernández-Palacios

“…Such data underpin the detection of subtle shifts in community composition, functional diversity and species distributions, which are critical for assessing the effectiveness of conservation actions and predicting future ecological scenarios.In summary, plot-based data are indispensable for targeted and effective biodiversity monitoring on islands. …”
Get full text

Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Methods: Three novel transgenic mouse models were engineered to investigate the functional contribution of Gpr45 to body weight and appetite regulation: 1) a global Gpr45 knockout, 2) a conditional floxed Gpr45 allele, and 3) a Gpr45-CreERT2 knock-in. …”
Get full text

Accuracy of tracer-based methane flux quantification: underlying impact of calibrating acetylene measurements by A. Shah, O. Laurent, P. Kumar, G. Broquet, L. Loigerot, T. Depelchin, M. Lozano, C. Yver Kwok, C. Philippon, C. Romand, E. Allegrini, M. Trombetti, P. Ciais

“…Methane fluxes were derived by integrating the methane and acetylene mole fraction plumes, as a function of distance along the sampling road. This resulted in a <span class="inline-formula">±56</span> % flux variability between different transects which was principally due to errors associated with the tracer release location and downwind sampling positioning. …”
Get full text

Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer by Lin-Ting Zhang, Yuejia Zhou, Tiantian Wang, Boran Chen, Zhigao Cai, Shubin Wang, Gangling Tong

“…This research aims to investigate the expression levels of a novel circRNA, hsa_circ_0002238, in CRC and to explore its association with alterations in CRC functional phenotypes.MethodsHigh-throughput RNA sequencing identified abnormal circRNA expressions, and qRT-PCR validated hsa_circ_0002238 expression. …”
Get full text

Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mech... by Yi-Chun Chen, Nils E. Bäck, Jenicia Zhen, Lena Xiong, Mitsuhiro Komba, Anna L. Gloyn, Patrick E. MacDonald, Richard E. Mains, Betty A. Eipper, C. Bruce Verchere

“…Despite these changes in beta cell function, βPamKO mice were not more susceptible to diet-induced hyperglycemia. …”
Get full text

Identifying Heat Adaptability QTLs and Candidate Genes for Grain Appearance Quality at the Flowering Stage in Rice by Lei Chen, Weiwei Chen, Jin Li, Yu Wei, Dongjin Qing, Juan Huang, Xinghai Yang, Maoyan Tang, Zhanying Zhang, Jianping Yu, Guofu Deng, Gaoxing Dai, Chao Chen, Tianfeng Liang, Yinghua Pan

“…Based on RNA-seq, qRT-PCR and functional annotations analysis, LOC_Os05g06920, LOC_Os05g06970, and LOC_Os11g28104 were highly expressed, identifying them as the high-priority candidate genes for QTLs linked to grain appearance quality (GL, GW, and GC) under heat stress. …”
Get full text