The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immun... by Hualin Sun, Jifei Yang, Zhonghui Zhang, Mengli Wu, Zhancheng Tian, Ying Liu, Xiaoqiang Zhang, Jianhao Zhong, Songlin Yang, Yikang Chen, Jianxun Luo, Guiquan Guan, Hong Yin, Qingli Niu

“…Multigene family (MGF) virulence genes have been shown to be crucial for ASFV’s ability to evade host innate immune responses. However, the functions of most MGF genes remain unknown, which poses significant challenges for the development of ASFV vaccines and antiviral drugs. …”
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Hybrid Integration of a Beam-Steering Leaky-Wave Antenna and Power Amplifier MMIC Using UPD Printing in 220 to 325 GHz Range by Georg Gramlich, Elizabeth Bekker, Luca Valenziano, Joel Dittmer, Martin Roemhild, Holger Baur, Fabian Thome, Axel Tessmann, Michael Kuri, Tom Neerfeld, Andreas Stohr, Sebastian Randel, Christian Koos, Norbert Fruehauf, Thomas Zwick, Akanksha Bhutani

“…The hybrid assembly achieves a reflection coefficient of less than -10 dB and a peak gain of up to 26 dBi across the sub- THz range. The beamsteering functionality of the hybrid assembly is successfully validated only in the forward quadrant due to measurement restrictions in the backward quadrant. …”
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Effects of previous steroid treatment on ischemic stroke outcomes: a propensity score-matched hospital analysis by Yasser Alatawi, Eman A. Alraddadi, Eman A. Alraddadi, Abdullah A. Alhifany, Faisal E. Alzahrani, Faisal E. Alzahrani, Saud M. Alknawy, Saud M. Alknawy, Nawaf M. Aljohani, Nawaf M. Aljohani, Husun K. Kecheck, Husun K. Kecheck, Alanoud K. Alaslab, Alanoud K. Alaslab, Aser F. Alamri, Aser F. Alamri, Ahmed Aljabri, Daniyah A. Almarghalani, Daniyah A. Almarghalani, Faisal F. Alamri, Faisal F. Alamri

“…Secondary outcomes included stroke severity and functional independence on admission and discharge, hemorrhagic transformation within 30 days, and mortality rate within 365 days of the index stroke.ResultsOut of 925 patients, 85 (9.19%) received steroids. …”
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Study of anti-inflammatory, antioxidant, antimicrobial and mineralizing effects of an N-isopropenylimidazole zinc metal complex derivative in experimental endodontic-periodontal le... by Pavel A. Galenko-Yaroshevsky, Ivan I. Pavlyuchenko, Olga V. Shelemekh, Boris A. Trofimov, Lidiya N. Parshina, Viktor L. Popkov, Svetlana A. Demyanenko, Oleg V. Tsymbalov, Andrey V. Zadorozhniy, Anait V. Zelenskaya, Irina B. Nektarevskaya, Alina V. Sergeeva, Nikolay E. Korovaykin, Svetlana A. Lebedeva

“…This necessitates search for and development of new molecules with a wide range of therapeutic effects aimed to block the infectious and inflammatory process and to restore the functional ability of teeth in EPLs as much as possible (depending on a lesion severity). …”
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Consortium of <i>Lactobacillus crispatus</i> 2029 and <i>Ligilactobacillus salivarius</i> 7247 Strains Shows In Vitro Bactericidal Effect on <i>Campylobacter jejuni</i> and, in Com... by Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Evgenia I. Deryusheva, Tatiana V. Priputnevich, Alexander N. Panin, Irina O. Chikileva, Tatiana N. Abashina, Ashot M. Manoyan, Olga E. Ivanova, Tigran T. Papazyan, Ilia N. Nikonov, Nataliya E. Suzina, Vyacheslav G. Melnikov, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, Andrey V. Karlyshev

“…<b>Conclusions:</b> These data highlight the potential of using a synergistic synbiotic as a preventive strategy for creating feed additives and functional nutrition products based on it to combat the prevalence of campylobacteriosis caused by MDR strains in animals and humans.…”
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Transcriptomic analysis reveals that selenium-enriched Lactobacillus plantarum alleviates high -salinity stress in common carp through lipid metabolism and ferroptosis signalling p... by Xinchi Shang, Xinghua Che, Longwu Geng, Qing Zhang, Haijun Wei, Wang Li, Xiaodan Shi, Wei Xu

“…Salinity stress disrupts antioxidant defences in aquatic animals and results in oxidative stress, damaging body functions. As an important constituent of glutathione, selenium has been shown to play an important role in improving antioxidant defences and regulating metabolism. …”
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Multi-omics unveils BCAA metabolism markers L-leucine and HMGCS1 as prognostic marker for immunotherapy efficacy in non-small cell lung cancer by Liyuan Dai, Xinzheng Wang, Ning Lou, Lin Li, Liling Huang, Le Tang, Jiarui Yao, Yuankai Shi, Xiaohong Han

“…And our cell and animal function experiments found HMGCS1 overexpression promotes metabolic pathways and accelerates tumor growth, whereas HMGCS1 knockdown suppresses tumor progression in a mouse model treated with PD-1 monoclonal antibody (P < 0.05). …”
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Comparative transcriptome reveals genes regulating root hair length of barley(基于比较转录组发掘控制大麦根毛长度的基因) by 贺小彦(HE Xiaoyan), 王永梅(WANG Yongmei), 何东(HE Dong), 吴港(WU Gang), 孙庆译(SUN Qingyi), 孙雪莲(SUN Xuelian), 刘文星(LIU Wenxing), 曾建斌(ZENG Jianbin)

“…Further analyses via Gene Ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, MapMan metabolic pathway analysis, and protein-protein interaction (PPI) network prediction led to the identification of a set of genes regulating root hair length, with higher expression levels in long root hair genotypes than in short ones. …”
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Impact of Institutional Monthly Volume of Transcatheter Edge-to-Edge Repair Procedures for Significant Mitral Regurgitation: Evidence from the GIOTTO-VAT Study by Nicola Corcione, Paolo Ferraro, Filippo Finizio, Michele Cimmino, Michele Albanese, Alberto Morello, Giuseppe Biondi-Zoccai, Paolo Denti, Antonio Popolo Rubbio, Francesco Bedogni, Antonio L. Bartorelli, Annalisa Mongiardo, Salvatore Giordano, Francesco De Felice, Marianna Adamo, Matteo Montorfano, Francesco Maisano, Giuseppe Tarantini, Francesco Giannini, Federico Ronco, Emmanuel Villa, Maurizio Ferrario, Luigi Fiocca, Fausto Castriota, Angelo Squeri, Martino Pepe, Corrado Tamburino, Arturo Giordano

“…Several baseline differences were found, with some features disfavoring less busy centers (e.g., functional class and surgical risk, both <i>p</i> < 0.05), and others suggesting a worse risk profile in those treated in busier institutions (e.g., frailty and history of prior mitral valve intervention, both <i>p</i> < 0.05). …”
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miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthmaResearch in context by Rinku Sharma, Kevin Mendez, Sofina Begum, Su Chu, Nicole Prince, Julian Hecker, Rachel S. Kelly, Qingwen Chen, Craig E. Wheelock, Juan C. Celedón, Clary Clish, Robert Gertszen, Kelan G. Tantisira, Scott T. Weiss, Jessica Lasky-Su, Michael McGeachie

“…These findings imply that the indirect regulation of metabolism and cellular functions by miRNA influences Th2 inflammation, AHR, and airflow obstruction in childhood asthma. …”
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Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study by Joel Räsänen, Seppo Helisalmi, Sami Heikkinen, Joose Raivo, Ville E. Korhonen, Henna Martiskainen, Antti Junkkari, Benjamin Grenier-Boley, Céline Bellenguez, Minna Oinas, Cecilia Avellan, Janek Frantzen, Anna Kotkansalo, Jaakko Rinne, Antti Ronkainen, Mikko Kauppinen, Mikael von und zu Fraunberg, Kimmo Lönnrot, Jarno Satopää, Markus Perola, Anne M. Koivisto, Valtteri Julkunen, Anne M. Portaankorva, Arto Mannermaa, Hilkka Soininen, Juha E. Jääskeläinen, Jean-Charles Lambert, Per K. Eide, FinnGen, Aarno Palotie, Mitja I. Kurki, Mikko Hiltunen, Ville Leinonen, Anssi Lipponen

“…Abstract Background Heterozygous CWH43 loss-of-function (LOF) variants have been identified as iNPH risk factors, with 10–15% of iNPH patients carrying these variants in cohorts from the US. …”
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Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement by Xinyu Wang, Qianye Chen, Jiping Sun, Zihan Huang, Zijian Zhang, Tingwei Lu, Xiangru Huang, Siyuan Sun, Yuanqi Liu, Houwen Pan, Li Mei, Paul R. Cooper, Qinggang Dai, Lei Shen, Lingyong Jiang

“…Although most investigations have centered on mesenchymal stem cells (MSCs) from long bones, the distinct properties and immunoregulatory functions of craniofacial bone marrow derived MSCs remain largely unexplored. …”
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In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China by Weilun Zuo, Weilun Zuo, Chen Wei, Meiyan He, Mengyao Zhang, Jiangli Liang, Xiao Ma, Na Gao, Qin Gu, Yan Ma, Jingyan Li, Shuyuan Liu, Yan Huang, Mingbo Sun, Li Shi

“…In vivo RNA-seq results revealed that BP-L2 significantly upregulated relA (log2FC = 2.1, FDR P-value = 0.019) and sodA (log2FC =2.4, FDR P-value = 8.61E-06) compared to BP-L1, functionally linked to enhanced stringent response and oxidative stress defense. …”
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Effects of Tofacitinib Therapy on Circulating Tumour-Associated Antigens and Their Relationship with Clinical, Laboratory and Vascular Parameters in Rheumatoid Arthritis by Enikő Sebestyén, Dóra Csige, Péter Antal-Szalmás, Ágnes Horváth, Edit Végh, Boglárka Soós, Zsófia Pethő, Nóra Bodnár, Attila Hamar, Levente Bodoki, Dorottya Kacsándi, Róza Földesi, Edit Kalina, Gábor Nagy, György Kerekes, Béla Nagy, Katalin Hodosi, Szilvia Szamosi, Péter Árkosy, Gabriella Szűcs, Zoltán Szekanecz, Éva Szekanecz

“…Patients and methods: Altogether, 26 RA patients received 5 mg bid or 10 mg bid tofacitinib treatment for 12 months. Ultrasound-based functional vascular assessments, such as common carotid intima-media thickness (ccIMT), brachial artery flow-mediated vasodilation (FMD) and carotid-femoral pulse-wave velocity (cfPWV), were determined at various timepoints. …”
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Probiotic Bacillus subtilis QST713 improved growth performance and enhanced the intestinal health of yellow-feather broilers challenged with coccidia and Clostridium perfringens by Lu Sun, Yangbin Liu, Pan Xiao, Keying Zhang, Shiping Bai, Jianping Wang, Qiufeng Zeng, Huanwei Peng, Yadong Mu, Yue Xuan, Shanshan Li, Xuemei Ding

“…Dietary supplementation with B. subtilis can alleviate the damage to intestinal morphology and intestinal barrier function, as well as the altered cecal flora structure in broilers caused by Coccidia and C. perfringens infections.…”
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Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways by Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie

“…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted to elucidate the functions of pivotal targets within the protein–protein interaction network. …”
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Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease. by Randall L Barbour, Harry L Graber, San-Lian S Barbour

“…<h4>Summary</h4>In this report we introduce a weak-model approach for examination of the intrinsic time-varying properties of the hemoglobin signal, with the aim of advancing the application of functional near infrared spectroscopy (fNIRS) for the detection of breast cancer, among other potential uses. …”
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Study the effect of Lactobacillus plantarum ATCC 14917 for caries prevention and anti-obesity by Wei Yang, Wei Yang, Mingxin Jiang, Bairu Chen, Bairu Chen, Kongzhao Jiang, Nan Ma, Nan Ma, Yimin Li, Yimin Li, Meng Wang, Meng Wang, Meihua Bao, Meihua Bao, Chengyue Wang, Chengyue Wang, Xiaopeng Yang, Xiaopeng Yang

“…Support the management of dental caries and obesity, and establish a foundation for future functional food research and development.…”
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Muscle Fat and Volume Differences in People With Hip‐Related Pain Compared With Controls: A Machine Learning Approach by Chris Stewart, Evert O. Wesselink, Zuzana Perraton, Kenneth A. Weber II, Matthew G. King, Joanne L. Kemp, Benjamin F. Mentiplay, Kay M. Crossley, James M. Elliott, Joshua J. Heerey, Mark J. Scholes, Peter R. Lawrenson, Chris Calabrese, Adam I. Semciw

“…These changes may facilitate greater muscular efficiency for a given load, enabling the athlete to maintain their normal level of function. In addition, the CNNs for muscle segmentation was more efficient and demonstrated excellent reliability in comparison to manual segmentations.…”
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Preliminary study on the effects of dry powder and water extract of Neolamarckia cadamba on growth performance, immunity, and intestinal health of yellow-feathered broilers by Yuxuan Wang, Guoping Chen, Changsong Liu, Yunxin Liao, Limin Wei, Hailong Wang, Junyi Luo, Jiajie Sun, Qianyun Xi, Yongliang Zhang, Ting Chen

“…Conclusions These results suggest that the dietary supplementation with Nc can enhance immune function, improve small intestinal barrier integrity, and reduce intestinal inflammation to a certain extent. …”
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