Clinical Profile of Elderly Patients with COVID-19 hospitalised in Indonesia’s National General Hospital by Muhammad Khifzhon Azwar, Siti Setiati, Aulia Rizka, Ika Fitriana, Siti Rizny F Saldi, Eka Dian Safitri

“…We postulated that immunosenescence and sex-specific immunoregulatory function play an important role in causing death in this study cohort.   …”
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Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy by Ke Xu, Qingfeng Zhu, Suzanne L Topalian, Robert A Anders, Janis M Taube, Mark Yarchoan, Keziban Ünsal-Kaçmaz, Logan L Engle, Tracee L McMiller, Sepideh Besharati, Junghwa Lee, Feriyl Bhaijee, Alan E Berger

“…In contrast, EBV(−) tumors overexpressed several functionally-related gene groups associated with myeloid cells (CD163, IL1A, NOS2, RIGI), immunosuppressive cytokines/chemokines (CXCL2, CXCR4, IL10, IL32), coinhibitory molecules (HAVCR2/TIM-3 and VSIR/VISTA), and adenosine pathway components (ENTPD1/ CD39 and NT5E/CD73). …”
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Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models by Pooreum Lim, Sang Woo Woo, Jihye Han, Young Lim Lee, Jin Ju Lim, Yeong Hoon Kang, Ji Wook Moon, Jeong Min Nam, Jeong Hyeon Kim, Donghun Kim, Jae Ho Shim, Hyeon Soo Kim

“…Conclusion Our findings demonstrate that KIC improves muscle function in CAC‐induced muscle atrophy by regulating myostatin expression in skeletal muscle via the Akt–FoxO3a pathway. …”
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Exploration of Practical Experience in Socialized Operation of the Chaoyang Section of Wenyu River Park by Zehui SUN, Yudi LIU, Jiali WU, Xiao FENG

“…On the one hand, the construction and maintenance of large park green spaces require a large amount of continuous investment; on the other hand, the current urbanization development in China has shifted from incremental construction to stock renewal, which requires the improvement of the quality and efficiency of park green spaces and the enhancement of their service functions. Through relatively thorough operation, Beijing Wenyu River Park has not only maintained the quality of the park’s green space and improved the quality of park services, but also alleviated the financial pressure on the management and maintenance of the park’s green space, becoming a model of park operation in Beijing. …”
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Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule by Fanfan Wang, Fanfan Wang, Jianting Wen, Jianting Wen, Jian Liu, Jian Liu, Ling Xin, Yanyan Fang, Yanyan Fang, Yue Sun, Mingyu He, Mingyu He

“…Additionally, FISH, luciferase reporter assays, and rescue experiments were performed to validate the regulatory role of ENST00000619282 and its sponge-like function in RA-FLS. Clinical samples were analyzed to determine the correlation between FTO/YTHDF1/ENST00000619282/Bax/Bcl-2 and immune-inflammatory markers. …”
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Developments in Legal Education: Beyond the Primary School Model by William Twining

“…Two other recent publications perform similar functions for legal scholarship: the now venerable Modern Law Review marked its fiftieth birthday with an illuminating survey of the state of legal scholarship in the common law world; this exhibits the wry acceptance of lowering of sights by an ageing radical. …”
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SIRT6 Ameliorates Cancer Cachexia–Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice by Kang Xu, Yida Wang, Fang Wang, Yannan Guo, Yu Ren, Vivien Low, Sungyun Cho, Qingfei Liu, Ying Qiu, Xue Li, Kang Yu, Zhongchi Li, Zhao Wang

“…Conclusion We found an unexpected beneficial function of SIRT6 in cancer cachexia, demonstrating that increased SIRT6 expression or activity is capable of protecting the host against cachexia‐associated tissue wasting, providing a concept of future therapies for cachexia.…”
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Donation after circulatory death heart transplantation using normothermic regional perfusion:The NYU ProtocolCentral MessagePerspective by Les James, MD, MPH, V. Reed LaSala, MD, Fredrick Hill, RN, CCP, Jennie Y. Ngai, MD, Alex Reyentovich, MD, Syed T. Hussain, MD, Claudia Gidea, MD, Greta L. Piper, MD, Aubrey C. Galloway, MD, Deane E. Smith, MD, Nader Moazami, MD

“…Meticulous intraoperative management of donation after cardiac death donors with a specific focus on improving their metabolic milieu may lead to improved graft function in transplant recipients.…”
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Prognoses and risk stratification of thrombus‐associated events in heart failure patients without atrial fibrillation by Yanxuan Li, Zihan Li, Daoyuan Si, Ping Yang

“…Methods and results This retrospective study included 450 patients (median age 64.0 years, interquartile range [55.0, 75.0]; 31.6% women) hospitalized for HF without AF and atrial flutter, but with a left ventricular ejection fraction (LVEF) ≤ 55% and New York Heart Association (NYHA) functional class of III–IV. A median follow‐up of 47 months was conducted. …”
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Ovidius moralizatus by Pierre Bersuire: target audience, exegetical and ideological context by Ludmilla Evdokimova

“…In my opinion, this term is appropriate in the analysis of various medieval texts including those that have evident pragmatic and communicative functions. It points to the link between the author’s intentions and the initial circle of readers; thus, it allows us to contrast the primary reception of the work with its later interpretations. …”
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Effect of Traditional Chinese Medicine fumigation combined with acupoint massage in the prevention of deep venous thrombosis of lower limbs in elderly hospitalized patients in the... by DONG Fangfang (董芳芳), ZHANG Linying (张林英), HE Yan (贺艳), XU Man (许曼), LIU Zijing (刘紫荆), XIONG Qiuwan (熊秋婉)

“…The incidence of DVT, the change of D-dimer index in blood coagulation function and the satisfaction of patients with nursing were compared between the two groups. …”
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Proinflammatory Cytokines in Women with PCOS in Atypical Pathogen Infections by Izabela Chudzicka-Strugała, Iwona Gołębiewska, Grzegorz Brudecki, Wael Elamin, Beata Banaszewska, Marta Chudzicka-Adamczak, Dominik Strugała, Barbara Zwoździak

“…<b>Conclusions:</b> Invasion of host cells by atypical pathogens such as C. trachomatis and infections with “genital mycoplasmas” can disrupt the function of these cells and lead to many complications, including infertility. …”
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An Attention‐Aware Multi‐Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia by Md Selim Reza, Chuan Qiu, Xu Lin, Kuan‐Jui Su, Anqi Liu, Xiao Zhang, Yun Gong, Zhe Luo, Qing Tian, Martin Nwadiugwu, Shaung Liang, Hui Shen, Hong‐Wen Deng

“…Gene Ontology and KEGG pathways analysis highlighted five key functions and signalling pathways relevant to skeletal muscle. …”
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Prioritizing direct heart procurement in organ donors after circulatory death does not jeopardize lung transplant outcomesCentral MessagePerspective by Stefan Schwarz, MD, PhD, Johannes Gökler, MD, Roxana Moayedifar, MD, Clemens Atteneder, MD, Giovanni Bocchialini, MD, Alberto Benazzo, MD, PhD, Thomas Schweiger, MD, PhD, Peter Jaksch, MD, Andreas O. Zuckermann, MD, Arezu Z. Aliabadi-Zuckermann, MD, Konrad Hoetzenecker, MD, PhD

“…Whether this negatively impacts lung allograft function is unclear. Methods: A retrospective analysis of cDCD lungs transplanted between 2012 and February 2022 at the Medical University of Vienna was performed. …”
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Research Progress on the Impact of Nighttime Outdoor Environments on Residents’ Health by Chongxian CHEN, Xinrui XIONG, Guangsi LIN, Jingyi LIU

“…Additionally, nighttime recreational activities function as a vital medium for interaction between individuals and their environment, with the realization of health benefits depending on the combined influence of multiple environmental factors. …”
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Does Mirabegron the β3 Agonist Frequently Used in the Treatment of Overactive Bladder Really Affect the Respiratory System Negatively ? A Prospective Study by Şenol Adanur, Ahmet Gedik, Ömer Araz, Elif Yılmazel Ucar, Kadir Ozmen, Fatih Akkaş, Tugay Aksakalli, Adem Utlu, Ahmet Cinislioğlu

“…Spirometry and body plethysmography were performed to objectively evaluate the respiratory functions of patients with OAB.ResultsThe spirometry and body plethysmography showed that the FVC value was 102.51 ± 16.99 L before, 101.77 ± 14.17 L at the first month, and 100.52 ± 15.98 L at the third month after mirabegron treatment. …”
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Immune Profile of COVID-19 Survivors and Contacts During 9 Months: A Cohort Study by Valentina V. Tatarnikova, Natalya O. Kiseleva, Valentina I. Dubrovina, Vladimir A. Vishnyakov, Darya D. Bryukhova, Anna B. Pyatidesyatnikova, Konstantin M. Korytov, Munko B. Sharakshanov, Sergey V. Balakhonov, Haijuan Wang

“…Little is known about the possible long-term effects of COVID-19 on circulating leukocyte kinetics and functional T-cell activity after recovery. To investigate immune system changes, we designed a cohort study. …”
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RESULTS OF PREVENTIVE WORK IN CHILDREN WITH DIFFERENT FREQUENCY OF ACUTE RESPIRATORY VIRAL INFECTIONS FOLLOWING PREVENTIVE MEASURES IMMEDIATELY AND IN 5 YEAR LONG PERIOD by O.S. Pavlenkova

“…There are many etiological factors, which can cause the carious process, namely: endogenous or general (poor nutrition, low fluoride content in drinking water, the state of the child's overall health, adverse environmental living conditions, genetic predisposition, etc.) and exogenous, or local (poor oral hygiene, excessive use of refined carbohydrates, changes in the composition and properties of oral fluid (saliva), reduced resistance of dental tissues, insufficient functional load of the maxillofacial system, etc.). …”
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Allelic variants of genes of the main histocompatibility complex in children with type 1 diabetes mellitus who became ill at preschool age by D. N. Laptev, I. A. Eremina, E. S. Shubina, T. E. Yankevich, E. A. Sechko, N. A. Goncharova, V. A. Peterkova

“…GADAs were associated with the predisposing haplotype DR3-DQ2 (55.0% vs. 34.5%, p=0.03).CONCLUSION: Predisposing and protective HLA haplotypes of class I and II associated with the manifestation of DM1 in preschool age and the reserve function of beta cells have been established in the Russian population. …”
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Abstract 129: Endovascular Therapy in Cerebral Venous Thrombosis: Nationwide Insights and Implications for Mortality by Liqi Shu, Elizabeth M. Lee, Piers Klein, Mohamad Abdalkader, Thanh Nguyen, Shadi Yaghi, Thalia Field, Lily Zhou

“…Introduction Cerebral Venous Thrombosis (CVT) is a rare cerebrovascular condition causing death or functional dependency in 10‐15%. Although Endovascular Therapy (EVT) is deployed variably across centers for managing CVT, the determinants and consequences of such use remain under‐explored. …”
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