HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread by Omolara O. Baiyegunhi, Kensane Mthembu, Ann-Kathrin Reuschl, Doty Ojwach, Omotayo Farinre, Murunwa Maimela, Sheila Balinda, Matt Price, Madeleine J. Bunders, Marcus Altfeld, Clare Jolly, Jaclyn Mann, Thumbi Ndung’u

“…Virus cell-to-cell spread efficiency was measured through flow cytometry-based detection of p24, while nutrient uptake assays and mitotracker dye detection served as surrogate markers for T-cell metabolism and mitochondrial function. Chimeric subtype C viruses exhibited significantly lower RC compared to subtype B viruses (P = 0.0008). …”
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Thermal Decomposition and Kinetic Analysis of Amazonian Woods: A Comparative Study of <i>Goupia glabra</i> and <i>Manilkara huberi</i> by Mark Dany Veloso Junior, Fidel Guerrero, Felipe Moura Araújo da Silva, Glenda Quaresma Ramos, Robert Saraiva Matos, Ștefan Țălu, Dung Nguyen Trong, Henrique Duarte da Fonseca Filho

“…FTIR-ATR analysis highlighted the presence of key functional groups in both species, with strong absorption bands in the 3330–3500 cm⁻¹ region corresponding to O-H stretching vibrations, indicative of hydroxyl groups in cellulose and hemicellulose. …”
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Early high nutrition enhances grass-fed beef productivity through epigenetically regulated muscle metabolism, altered early adipogenesis, and rumen fermentation dynamics by D. Nishino, S. Khounsaknalath, K. Saito, A. Saito, T. Abe, E. Kobayashi, F. Ebara, S. Maak, E. Albrecht, M.W. Pfaffl, R. Saneshima, S. Shimamoto, D. Ijiri, S. Koike, S. Yasuo, T. Gotoh

“…These findings suggest that the increase in LM IMF might be the result of early adipocyte hyperplasia, greater nutrient supply through rumen programming of high propionate production, and epigenetic regulation of metabolism, involving decreased muscle mitochondrial function inducing a shift towards myofibres that consume less lipids.…”
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Evaluation on Carbon Sequestration Capacity of 30 Common Landscaping Tree Species in Beijing by Jing QIAN, Sidong SHEN, Shuxin FAN, Li DONG

“…On the basis of fulfilling other functional needs, from the perspective of carbon sink, landscaping tree species with high carbon sequestration capacity should be fully applied. …”
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Immune mechanism of n-butanol extract of Clerodendrum bungei against loach infected with Aeromonas hydrophila by Ya-Jie Li, Xin-Ya Dong, Hong-Hui Li, Hong-Hui Li, Jin-Guo Luo, Xing-Yu Chen, Xu-Dong Zhou

“…The Unique Reads were aligned with the non-coding RNA sequences in the Rfam 13 database using Blast to screen out the non-coding RNAs and identify their types and numbers for further analysis of their functions and regulatory mechanisms. The Reads Count value of miRNA was calculated, and the expression data of the conserved miRNA in each sample were sorted out. …”
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Effect of Astragalus polysaccharide combined with Ginsenoside Rg3 on PD-1/PD-L1 in colon cancer by Wang Ya’nan, Zhang Zhikuan, Gao Feng

“…[Conclusion] APS combined with Ginsenoside Rg3 can inhibit the growth of colon cancer and PD-L1, improve the immune function of colon cancer mice, and reduce the expression levels of IL-6, TNF-α and IFN-γ.…”
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Cálculo de estructuras para semirremolques de pasajeros de grandes dimensiones // Calculation of structures for semi - trailers of large dimensions using in passengers transportati... by L Otero Pereiro, C. Novo Soto, M. Fernández Salgado

“…</p><p>____________________________________________________________________</p><p>Abstract<br />The Finite Elements Method (FEM) developed until the present time is a powerful computerized calculation system applied in<br />the tensions and deformations analysis of solids and structures and much literature has been published on FEM as calculation<br />method,<br />The need of solving the problems of passengers transportation, mainly in Havana City, in the difficult conditions of Cuban<br />special period, conducted to the development of a semi - trailer with the necessary characteristics to fulfil this function , which<br />by their attributes constitutes the only one in his gender for this purpose.…”
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Application of wax therapy combined with traditional Chinese medicine directional drug penetration in patients undergoing open reduction and internal fixation for intertrochanteric... by YAO Fang (姚芳)

“…Conclusion Wax therapy combined with Traditional Chinese Medicine directional drug penetration is effective to reduce the postoperative pain of open reduction and internal fixation and improve the recovery of hip joint function and patient satisfaction. (目的 探讨蜡疗联合中医定向透药疗法在股骨粗隆间骨折切开复位内固定术后患中的应用效果。…”
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Nonlocal Nonlinear Fractional-Order Sequential Hilfer–Caputo Multivalued Boundary-Value Problems by Sotiris K. Ntouyas, Bashir Ahmad, Jessada Tariboon

“…The problem considered in the present study is of a more general nature as the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>(</mo><msub><mi>k</mi><mn>1</mn></msub><mo>,</mo><msub><mi>ψ</mi><mn>1</mn></msub><mo>)</mo></mrow></semantics></math></inline-formula>-Hilfer fractional derivative operator specializes to several other fractional derivative operators by fixing the values of the function <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>ψ</mi><mn>1</mn></msub></semantics></math></inline-formula> and the parameter <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>β</mi></semantics></math></inline-formula>. …”
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How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study by Joshua Dissemond, Tim Havers, Steffen Held, Stephan Geisler, Tihomir Kostov, Patrick Diel, Svea Türschmann, Maria K. Parr, Eduard Isenmann

“…M. vastus lateralis and M. vastus intermedius). Liver and kidney function, along with endocrine parameters, were measured via blood samples pre- and post-intervention. …”
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International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB) by John A. Rathmacher, Lisa M. Pitchford, Jeffrey R. Stout, Jeremy R. Townsend, Ralf Jäger, Richard B. Kreider, Bill I. Campbell, Chad M. Kerksick, Patrick S. Harty, Darren G. Candow, Brandon M. Roberts, Shawn M. Arent, Douglas S. Kalman, Jose Antonio

“…HMB supplementation may be important in a non-exercising sedentary and aging population to improve muscle strength, functionality, and muscle quality. The effects of HMB supplementation with exercise are varied, but the combination may have a beneficial effect on the treatment of age-associated sarcopenia under select conditions. 11. …”
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Neutralizing antibody test supports booster strategy for young individuals after SARS-CoV-2 Omicron breakthrough by Yichuan Yao, Yunru Yang, Qiqin Wu, Mengyao Liu, Wei Bao, Qiutong Wang, Meijun Cheng, Yunuo Chen, Yiting Yu, Yuan Cai, Mei Zhang, Jingxue Yao, Hongliang He, Changjiang Jin, Changcheng Zheng, Tengchuan Jin, Dali Tong

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Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis by Ling Lei, Yilei Cheng, Anqi Yin, Jian-Min Han, Gang Wu, Fumin Yang, Qi Wang, Jian-Zhi Wang, Rong Liu, Hong-Lian Li, Xiaochuan Wang

“…Injection of AAV9-YAP1 in the brains of SAMP8 mice partially alleviated neuronal senescence and enhanced cognitive function. Notably, genetic knockdown and chemical inhibition of Nr4a1 significantly ameliorated cognitive deficits as well as AD-like pathology in these subjects. …”
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Prophetie und Bekenntnis Eine Untersuchung aus sozialethischer Sicht by Sándor FAZAKAS

“…A social ethical inquiry in a current phenomena The Hungarian Reformed Church and its theological reflexions of the last few de- cades are in a state of crisis, suffering from the lack of the confessing and prophetic function of its theological thinking. While the reformed church is challenged by un- precedented global economical, social and political changes, it is not surprising that a strong need arose to give a valid and relevant response to these changes, both in theological reflexions and declarations from the worldwide Reformed Church bod- ies and organizations. …”
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Maternal MitoQ Treatment Is Protective Against Programmed Alterations in CYP Activity Due to Antenatal Dexamethasone by Millicent G. A. Bennett, Ashley S. Meakin, Kimberley J. Botting-Lawford, Youguo Niu, Sage G. Ford, Michael P. Murphy, Michael D. Wiese, Dino A. Giussani, Janna L. Morrison

“…CYP activity and protein abundance were assessed using functional assays and Western blot. <b>Results</b>: Dex decreased the hepatic activity of fetal CYP3A (−56%, <i>P</i>_Dex = 0.0322), and 9 mo lamb CYP1A2 (−22%, <i>P</i>_Dex = 0.0003), CYP2B6 (−36%, <i>P</i>_Dex = 0.0234), CYP2C8 (−34%, <i>P</i>_Dex = 0.0493) and CYP2E1 (−57%, <i>P</i>_Dex = 0.0009). …”
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Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies. by Dongshan Zhu, Hsin-Fang Chung, Nirmala Pandeya, Annette J Dobson, Janet E Cade, Darren C Greenwood, Sybil L Crawford, Nancy E Avis, Ellen B Gold, Ellen S Mitchell, Nancy F Woods, Debra Anderson, Daniel E Brown, Lynnette L Sievert, Eric J Brunner, Diana Kuh, Rebecca Hardy, Kunihiko Hayashi, Jung Su Lee, Hideki Mizunuma, Graham G Giles, Fiona Bruinsma, Therese Tillin, Mette Kildevæld Simonsen, Mette Kildevæld Simonsen, Hans-Olov Adami, Elisabete Weiderpass, Marianne Canonico, Marie-Laure Ancelin, Panayotes Demakakos, Gita D Mishra

“…If the toxic impact of cigarette smoking on ovarian function is irreversible, we hypothesized that even former smokers might experience earlier menopause, and variations in intensity, duration, cumulative dose, and age at start/quit of smoking might have varying impacts on the risk of experiencing earlier menopause.…”
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A bioinformatics-driven approach to identify biomarkers and elucidate the pathogenesis of type 2 diabetes concurrent with pulmonary tuberculosis by Yan Liu, Yonglan Pu, Jie Wang, Zhiyong Li, Songliang Liu, Shenjie Tang

“…Weighted gene co-expression network analysis (WGCNA) and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were employed to identify key gene modules and functions related to PTB + T2DM. Immune cell infiltration and drug sensitivity were compared between PTB + T2DM patients and healthy controls (HCs), with a bioinformatic approach. …”
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Studi In Silico Senyawa 1,4-Naphthalenedione-2-Ethyl-3-Hydroxy sebagai Antiinflamasi dan Antikanker Payudara by Richa Mardianingrum, Kamiel Roesman Bachtiar, Susanti Susanti, Aas Nuraisah Aas Nuraisah, Ruswanto Ruswanto

“…Inflammation is a response from the body to injury or infection which is characterized by redness, fever, swelling, pain, and loss of function. Inflammation contributes to the imbalance of cytokine secretion which will inhibit apoptosis in cancer cells, causing cell hyperproliferation. …”
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Relationships Among In-Line Milk Fat-to-Protein Ratio, Metabolic Profile, and Inflammatory Biomarkers During Early Stage of Lactation in Dairy Cows by Karina Džermeikaitė, Justina Krištolaitytė, Neringa Sutkevičienė, Toma Vilkonienė, Gintarė Vaičiulienė, Audronė Rekešiūtė, Akvilė Girdauskaitė, Samanta Arlauskaitė, Árpád Csaba Bajcsy, Ramūnas Antanaitis

“…Moreover, high serum NEFA levels adversely affect immune function, increasing vulnerability to infections such as mastitis. …”
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Comparative analysis of the integration of autologous and allogeneic cryopreserved tendons in the femoral canal on a model of laboratory animals by A. A. Budaev, N. S. Tropskaya, N. V. Borovkova, A. M. Fayn, G. P. Titova, M. S. Makarov, A. Yu. Vaza, I. V. Ponomarev, E. A. Kislyakova, O. S. Kislitsyna, A. A. Offitserov, D. A. Kisel', M. V. Storozheva, V. V. Slastinin, A. A. Kanibolotskiy

“…Cryopreserved allogeneic tendons were able to integrate into the body's own tissues without pronounced structural and functional disorders. According to the treadmill test, the distance covered by the animals of both experimental groups did not differ statistically significantly from the values in the control group (without tendon transplantation) after 3 and 6 weeks…”
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