Diverse actions of 15 structurally unrelated mitochondrial uncouplers in cells and mice by Divya P. Shah, Calum S. Vancuylenburg, Ellen M. Olzomer, Sing-Young Chen, Robert J. Grams, Martina Beretta, Frances L. Byrne, Webster L. Santos, Kyle L. Hoehn

“…Objective: Mitochondrial uncouplers are used as chemical tools to study mitochondrial function in vitro and in vivo, and some molecules are in development for the treatment of metabolic diseases. …”
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Improvement of the approach to definition of patient release criteria after radionuclide therapy by L. A. Chipiga, I. A. Zvonova, A. V. Vodovatov, A. V. Petryakova, A. A. Stanzhevsky, D. A. Vazhenina, M. A. Smoliarchuk, S. A. Ryzhov

“…Considering the fast-eliminated fraction in the first hours after the administration, it can be assumed that more patients with normal renal function can undergo radionuclide therapy with 177Lu-PSMA in the outpatient hospital. …”
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基于ChatGLM急性缺血性卒中大血管闭塞的识别与诊断 Identification and Diagnosis of Large Vessel Occlusion in Acute Ischemic Stroke Based on ChatGLM by 宋晓微1，尹伟2，李佳褀3，魏宸铭1，王玥明1，邳靖陶1，陈乐1，高策舒1，马为之3，武剑1，4 (SONG Xiaowei1, YIN Wei2, LI Jiaqi3, WEI Chenming1, WANG Yueming1, PI Jingtao1, CHEN Le1, GAO Ceshu1, MA Weizhi3, WU Jian1,4 )

“…Based on the ChatGLM model, the inference processes and diagnosis results were given by using techniques such as prompt function, instruction fine-tuning, and retrieval-augmented generation, and the accuracy, sensitivity, and specificity of different inference processes for determining large vessel occlusion were explored. …”
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Conhecimento dos graduandos de nutrição e enfermagem quanto ao consumo de corantes alimentares e seus efeitos adversos à saúde Knowledge of nursing and nutrition graduate students... by Julia Nascimento Teles, Maria Lúcia Teixeira Polônio

“…SUMMARY: Objective: Evaluate the intestinal function concerning the contingent assisted, associating to the risk factors, from data obtained through the Care Factory Program. …”
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Patient-Reported Outcome Measures in Patients with Rheumatoid Arthritis, Psoriasis, or Psoriatic Arthritis Treated with GP2015, an Etanercept Biosimilar: Results from Two Phase III... by Diamant Thaçi, Sascha Gerdes, Hendrik Schulze-Koops, Yannick Allanore, Arthur Kavanaugh, Charlotte Both, Sreekanth Gattu, Sohaib Hachaichi, Marco Matucci-Cerinic

“…Assessed PROs included Dermatology Life Quality Index (DLQI) and EuroQol five-dimension health status questionnaire (EQ-5D-5L) in EGALITY, Functional Assessment of Chronic Illness Therapy (FACIT)–Fatigue score in EQUIRA, and Health Assessment Questionnaire–Disability Index (HAQ-DI) in both studies. …”
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One arrow two eagles: Multifunctional nano-system for macrophage reprogramming and osteoclastogenesis inhibition against inflammatory osteolysis by Tong Sha, Ze Wang, Jinwei Li, Yahong Wu, Jinbiao Qiang, Zhenming Yang, Yue Hu, Kaijuan Zheng, Shuyu Zhang, Haizhu Sun, Andrew K. Whittaker, Bai Yang, Hongchen Sun, Quan Lin, Ce Shi

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Tratamiento de la fractura luxación radiocarpiana dorsal: resultados clínicos y radiológicos a largo plazo by V. Jiménez-Díaz, L. García-Lamas, I. Auñón-Martín, V. Rodríguez-Vega, D. Cecilia-López

“…Conclusions: In spite of a large number of clinical and radiological complications during follow-up, longterm functional results are good in this kind of wrist injuries.…”
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Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors by Yan Zhang, Di Chen, Qiqi Lu, Yu Yao, Gaopeng Li, Chunxia Ji, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Dave S B Hoon, Liangfu Zhou

“…The distinct B7-H4 pathways modulating T-cell function and immune evasion in glioma patients deserved to be further explored in the future during immunotherapy.…”
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Divergence in physical, chemical, and biological soil properties caused by different long-term bare fallow management and natural succession by Steffen Schlüter, Mengqi Wu, Maxime Phalempin, Lena Philipp, Evgenia Blagodatskaya, Thomas Reitz, Carsten Simon, Oliver Lechtenfeld, Hans-Jörg Vogel, Martin Schädler, Ines Merbach

“…The absence of plants has profound effects on many ecosystem functions of soil. Long-term bare fallow trials are valuable tools for studying the dynamics in soil carbon decline and associated soil degradation. …”
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Exploring the associations between gut microbiota composition and SARS-CoV-2 inactivated vaccine response in mice with type 2 diabetes mellitus by Long Liu, Xianzhen He, Jiaqi Wang, Moran Li, Xiuli Wei, Jing Yang, Gong Cheng, Weixing Du, Zhixin Liu, Xiao Xiao

“…Concurrently, increasing evidence suggests that the composition and diversity of gut microbiota, crucial regulators of immune function, may influence the efficacy of vaccines. Against this backdrop, our study explores the complex interplay among SARS-CoV-2 inactivated vaccination, T2DM, and host microbiota. …”
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Polishing inner wall of crossed deep micropores using magnetic microabrasive jet technology by Zezhi WANG, Jie WANG, Xiaogang MA, Fan LI, Xinya FAN, Yan CHEN

“…In view of the problems of conventional finishing processing of cross deep micro-holes being limited by size, uneven processing, and poor quality, and combined with the characteristics of a stable removal function and strong adaptability of the abrasive jet, the magnetic micro-abrasive jet technology finishing processing method is proposed to improve the quality of the inner wall of cross deep micro-holes.MethodsAn independent magnetic abrasive jet device was used to carry out finishing tests on the cross deep micro-holes, and an electromagnetic device was used to generate a focusing magnetic force near the nozzle outlet. …”
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PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells by Leszek Pączek, Radoslaw Zagozdzon, Karl-Johan Malmberg, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Sébastien Wälchli, Magdalena Winiarska

“…Finally, we have observed that HER-2–CAR T cells stimulate PD-L1 expression on MCF-7 cells and therefore accelerate the functionality of PD-L1–CAR T cells when used in combination.Conclusions In summary, our studies show that CAR-effector cells trigger the expression of PD-L1 on target cells, which in case of PD-L1–CAR results in the unique self-amplification phenomenon. …”
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Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms by Shuzhen Mao, Jiahui Huang, Junyan Li, Fang Sun, Qilian Zhang, Qing Cheng, Wei Zeng, Dongya Lei, Shiyan Wang, Jing Yao

“…IntroductionUlcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by mucosal damage and impaired epithelial barrier function. While glycyl-l-histidyl-l-lysine-copper (GHK-Cu) exhibits known anti-inflammatory properties, its therapeutic mechanisms in UC remain undefined. …”
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The prevention of sodium bicarbonate hydration therapy with contrast-induced nephropathy by TANG Na, YANG Ding-ping

“…Objective To investigate the effects and preventive measures of the improvement of the contrast agent sodium bicarbonate hydrotherapy.Methods 245 cases of cardiology coronary angiography/intervention patients were divided into observation group（n =123） and control group（n =122） from October 2008 to March 2010.The observation group were treatmented with 3 ml·kg^-1 ·h^-1infusion rate of 1.25%sodium bicarbonate injection.The control group were preoperative imaging speed by 3 ml·kg^-1 ·h^-1 intravenous infusion of 0.9%sodium chloride injection.The levels of serum creatinine（SCr）,potassium ion（K⁺）,bicarbonate（HCQT）> glomerular filtration rate（GFR）,urine pH value of two groups were compared before and after preoperative.Results CIN incidence observed in patients,the secondary endpoint occurred and the proportion required hemodialysis were 2.44%,0.00%,0.00%was significantly lower than the control group 11.47%,5.74%,4.92%,and the difference was statistically significant（P<0.05）.Observation group after 24 hours SCr,Cys C,Hcy levels were（82.28 ± 22.16） μmol/L,（1.24 ± 0.21） mg/L,（14.02 ± 3.14） μmol/L,after 48 hours were（82.06 ± 22.79） μmol/L,（0.82 ± 0.11） mg/L,（8.02 ± 2.45） μmol/L was significantly lower than the preoperative（94.58 ± 17.63） μmol/L,（1.98 ± 0.25） mg/L,（17.25±4.28） μmol/L,GFR,HCO₃^-,K⁺,TRF levels after 24 hours were（99.04 ±28.53）ml·min^-1·（1.73 m²_）^-1、（26.09 ± 2.99）mmol/L,（5.22 ± 0.34）mmol/L,（4.82 ± 0.52）mg/L,after 48 hours were（102.34±38.49） ml·min^-1·（1.73 m²）^-1、（25.72 ± 2.30）mmol/L,（6.02 ± 0.50）mmol/L,（5.38 ± 0.64）mg/L was significantly higher than the preoperative（79.93 ±18.14） ml · min^-1 ·（1.73 m²）^-1、（24.03± 4.18）mmol/L,（3.88± 0.31）mmol/L,（2.69 ± 0.48）mg/L,while the control group after 24 hours,SCr,GFR,HCO₃^-,K⁺,TRF levels were（92.79 ± 29.04） μmol/L,（85.64 ± 34.88） ml· min^-1 ·（1.73 m²）^-1、（24.17 ±4.04）mmol/L,（4.02 ± 0.26） mmol/L,（2.92 ± 0.64） mg/L,after 48 hours were（93.89 ± 25.75）μmol/L,（90.88 ±29.39） ml·min^-1 ·（1.73 m²）^-1、（23.81 ± 4.18）mmol/L,（4.25 ±0.33）mmol/L,（3.08 ± 0.71）mg/L remained no significiant change compared with before treatment（94.97 ± 22.79）μmol/L,（79.51 ± 20.34） ml·min^-1·（1.73 m²）^-1、（24.01±3.17） mmol/L,（3.91±0.35） mmol/L,（2.71 ± 0.52） mg/L,the difference was not statistically significant（P>0.05）.Conclusions For coronary angiography/intervention of patients undergoing angiography using sodium bicarbonate hydration intervention can reduce the incidence of CIN,the effective protection of kidney function.…”
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Muscle-derived factor alleviated cognitive impairment caused by intestinal ischemia-reperfusion by Yafang Tan, Guo Mu, Feixiang Wang, Xin Fan, Chengjie Yang, Zuan Shi, Yiping Bai, Bingqing Xie, Xuan Yu, Jianguo Feng, Jing Jia, Xiaobin Wang, Ye Chen, Jun Zhou

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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…This study presents the first evidence that altered liver functions are associated with pathological behaviors arising from genetic SERT deficiency.…”
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Human Capital, Economic Growth and Environmental Quality with Special Emphasis on Public Education Expenditures: An Application of DSGE Models by Yahya Mohaghegh, hashem zare, Mehrzad Ebrahimi

“…Because private and public education expenses complement each other and entered the model in the form of a Cobb-Douglas function. Therefore, education hours, investment in education and subsequently, human capital increased. …”
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Zoning and Identification of Factors Affecting Illegal Livestock Grazing in Golestan National Park Using Logistic Regression by Meysam Madadi, HamidReza Rezaei, Alireza Mohammadi, Bagher Nezami Balochi, Maryam Shahbazi

“…The removal of each independent variable individually and the comparison of sensitivity analysis using statistical indices confirmed the independent variable of distance from the road as the most important factor affecting the occurrence of illegal grazing.Discussion: The results of the logistic regression model provided the best fitting function to describe the relationship between the factors influencing illegal livestock grazing and to predict its occurrence. …”
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The Effects of Sidt2 on the Inflammatory Pathway in Mouse Mesangial Cells by Hui Sun, Jia-ming Ding, Hui-hao Zheng, Kang-jia Lv, Yun-fei Hu, Ying-hui Luo, Xue Wu, Wen-jun Pei, Li-zhuo Wang, Ming-cai Wu, Yao Zhang, Jia-lin Gao

“…In patients with chronic kidney disease, the abnormal activation of inflammatory pathways is usually an important factor leading to renal fibrosis and further deterioration of renal function. Finding effective intervention targets of the inflammatory signaling pathway is an important way to treat chronic kidney disease. …”
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A PAINTING AS A UNIVERSAL MULTIMEDIA LAYER / ЖИВОПИСНОЕ ПРОИЗВЕДЕНИЕ КАК УНИВЕРСАЛЬНЫЙ МУЛЬТИМЕДИЙНЫЙ СЛОЙ by YURGENEVA ALEXANDRA L. / ЮРГЕНЕВА А.Л.

“…They become an emphasis that characterizes a person, informs others of their tastes and interests. They function in a virtual environment in exactly the same way: on personal webpages and within the content published by the user, they exist side by side with photographs from everyday life, shaping a portrait of one’s personality. …”
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