Response‐adapted zanubrutinib and tislelizumab as a potential strategy to enhance CD19 CAR T‐cell therapy in relapsed/refractory large B‐cell lymphoma: A retrospective observationa... by Rong Shen, Wei‐Guo Cao, Li Wang, Ling‐Shuang Sheng, Yi‐Lun Zhang, Wen Wu, Peng‐Peng Xu, Shu Cheng, Meng‐Ke Liu, Yan Dong, Yue Wang, Xiang‐Qin Weng, Xu‐Feng Jiang, Qi Song, Hong‐Mei Yi, Lei Li, Sheng Chen, Zi‐Xun Yan, Wei‐Li Zhao

“…Highlights Response‐adapted zanubrutinib plus tislelizumab potentially enhances the efficacy of CAR T‐cell therapy for R/R LBCL with acceptable safety profile. This regimen functions independently of genetic subtypes, rendering it more applicable for clinical practice with CAR T‐cell therapy. …”
Get full text

Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes by Bozhi Ye, Diyun Xu, Lingfeng Zhong, Yi Wang, Wei Wang, Haowen Xu, Xue Han, Julian Min, Gaojun Wu, Wenhai Huang, Guang Liang

“…In addition, cardiomyocyte‐specific USP25 overexpression in NLRP3−/− mice with AAV9 vectors was used to validate the biological function of USP25 and NLRP3 interaction. Results We found that the expression level of USP25 was significantly decreased in I/R‐induced mouse heart tissues and primary cardiomyocytes in a time‐dependent manner. …”
Get full text

Contribuciones al conocimiento sobre la Ecología y distribución geográfica de Phrynops (Batrachemys) Dahli; (Testudinata, Pleurodira, Chelidae) Contribuciones al conocimiento sobre... by Medem Federico

“…Since movements and sounds produce vibrations in the water, this behavior may possibly be connected with some biological function, as e. g., to facilitate the meeting of the two sexes during mating season, or to announce the presence of an individual within a fixed territory, already occupied; the function could also be a combined one.…”
Get full text

Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…We found that by the time participants received their diagnosis, they were already dealing with functional limitations and were highly distressed and anxious. …”
Get full text

Oral–gut microbiome axis in a Korean cohort with inflammatory bowel disease and ankylosing spondylitis (INTEGRATE): a prospective and observational study protocol by June-Young Lee, Tae-Hwan Kim, Sungsin Jo, Yeon-Ah Lee, Sang Won Lee, Chang Kyun Lee, Bora Nam, Soo-Kyung Park, Hyun Sik Kim, Bo-Hyung Kim, Shin Ju Oh, Jae-Yun Lee, Dong Il Park

“…Metabolomic analyses will be conducted on saliva, stool and plasma samples to assess functional metabolic profiles. Culturomics will be used to isolate, identify and characterise the diversity of microbial species, including rare or previously unrecognised species, to provide a comprehensive understanding of the microbiota associated with these diseases.Ethics and dissemination Ethical approval was obtained from the Ethics Committee of Kyung Hee University Hospital, Hanyang University Hospital, Kangbuk Samsung Hospital, Yeungnam University Hospital, Kyungpook National University Hospital, Chonnam National University Hospital, Wonkwang University Hospital, Catholic University Daejeon St. …”
Get full text

Penilaian Daur Hidup Proses Distribusi BBM di PT Pertamina (Persero) Fuel Terminal Parepare by Putri Alifa Kholil, Mochamad Arief Budihardjo, Fuad Muhammad, Ketut Karno

“…The calculation of impact assessment is carried out using Microsoft Excel software with the CML IA Baseline method with the function unit used is 1 KL BBM.  Categories including global warming potential, ozone depletion potential, acid rain potential, and eutrophication potential were selected based on relevance to the company's activities and which included the impact of the main categories based on the Minister of Environment and Forestry Regulation No. 1 of 2021 concerning the Company Performance Rating Assessment Program and Environmental Management.  …”
Get full text

Genetic Variation and Assessment of Seven Salt-Tolerance Genes in an <i>Indica</i>/<i>Xian</i> Rice Population by Yuanhang Cheng, Tao Wang, Yeying Wen, Xingfei Zheng, Haifeng Liu, Xiangsong Chen, Ying Diao, Zhongli Hu, Wenjie Feng, Zhaohui Chu

“…<i>OsHKT1;1</i>^94K showed no function with salt treatment for 7 d, but showed a 37.9% rSFW improvement with salt treatment for 14 d. …”
Get full text

Out-of-home care placement, psychiatric disorders, and risk of homelessness: a population-based cohort studyResearch in context by Sandra Feodor Nilsson, Thomas Munk Laursen, Anne Ranning, Anne A.E. Thorup, Merete Nordentoft, Seena Fazel

“…We estimated the cumulative incidence function using an Aalen-Johansen estimator. Hazard ratios (HRs) for the association between out-of-home placement, psychiatric disorder, and homelessness were estimated by sex using Cox proportional-hazard regression analyses, adjusted for birth year, parental sociodemographic factors and psychiatric disorders. …”
Get full text

Upstream therapy of reperfusion disorders of hemodynamics, rhythm and conduction in patients with acute myocardial infarction with diabetes mellitus and metabolic syndrome (second... by M.I. Shved, I.O. Yastremska, R.M. Ovsiychuk, L.P. Martyniuk, O.A. Prokopovych, Ya.M. Kitsak

“…In patients with STEMI combined with T2DM and MS, hyperglycemia, insulin resistance and severe abnormalities of morphological and functional parameters of the heart with its systolic-diastolic dysfunction are observed at baseline, which are triggers of the complicated course of this pathology, with the deve­lopment of heart failure syndrome, rhythm and conduction disorders. …”
Get full text

More than just mud: the importance of wallows to Javan rhino ecology and behaviour by Steven G. Wilson, Georgina Hockings, Jo-Anne M. Deretic, Salit Kark

“…We discovered that Javan rhino utilise wallows not only for thermoregulatory function, but also as sites of interaction and communication. …”
Get full text

Preparasi Karbon Aktif Sekam Padi dan Serbuk Gergaji Kayu Jati melalui Proses Refluks sebagai Adsorben Larutan Multi Ion Fe(II)/Cu(II) by Cucun Alep Riyanto, Yohanes Ariesto, Fidelis Tertius Aluh Christyawardana, Yehez Kiel Sandy Pradana, Nicho Vernanda Wina Puspita, Iga Permata Sari, Jose D Michael Yonggulemba, Marturia Ester Tumbelaka, Sarawinda Hutagalung, Fuady Hanief, Wawan Rustyawan

“…The results showed that the RHAC and TSAC had O-H, C–H stretching, C≡C, C=C/C=O, C-H, and P=O functional groups with the dominance of C (~53%wt) and O (~48.1%wt) elements. …”
Get full text

PD-1/PD-L1 Axis Downregulation in Guillain-Barré Syndrome: A Potential Mechanism Driving the Autoimmune Pathogenesis by Mr Rasel Ahmed, Mrs Israt Jahan, Mrs Pritha Biswash, Miss Mehjabeen Haque, Miss Sarah Khurshid, Mr Jigishu Ahmed, Mr Sayed Akib Hossain, Dr Zhahirul Islam

“…This aligned with prior research, which hinted that PD-1/PD-L1′s influences on immune tolerance and plays a potential role in autoimmune diseases via Treg function regulation. Further investigation with a larger sample size with different time points is warranted to confirm the significance of PD-1/PD-L1 gene expression in the disease progression of GBS patients. …”
Get full text

Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…The miR-6894-3p mimic regulated the activity of lnc-MAP3K13-3:1. Functional assays showed that lnc-MAP3K13-3:1 overexpression inhibited proliferation in HuH-7 and Li-7 cells, promoted apoptosis, reduced migration in Li-7 cells, but enhanced migration in HuH-7 cells. …”
Get full text

Safety of Extended Sedation with Sevoflurane in Patients with Severe Traumatic Brain Injury by D. R. Safiullin, A. K. Shabanov, A. A. Grin, R. A. Cherpakov, A. K. Evseev, A. I. Evdokimov, S. S. Petrikov, O. A. Grebenchikov

“…In conditions of increased sensitivity of damaged brain tissue to disruption of homeostasis, it is important to achieve stabilization of the vital functions of the body as soon as possible. Given the excess afferent impulse, adequate sedation and analgesia are an integral component of intensive care for patients with traumatic brain injury. …”
Get full text

Dynamics of thioredoxin 1, thioredoxin reductase 1 and glutathione-S-transferase Pi content in the spleen and liver of rats during the latent period of growth and metastasis of sar... by E. I. Surikova, E. M. Frantsiyants, I. V. Kaplieva, I. V. Neskubina, E. G. Shakaryan, A. V. Snezhko, E. N. Kolesnikov, V. A. Bandovkina, L. K. Trepitaki, Yu. A. Petrova, N. S. Lesovaya, M. A. Engibaryan, V. L. Volkova

“…During the latent period of C45 growth and metastasis, the antioxidant and redox regulating functions of the Trx system were activated in the spleen, while in the liver, it was inhibited, disrupting the antioxidant and redox homeostasis of the organ. …”
Get full text

Agama sebagai produk: membedah komodifikasi Agama Islam dalam industri media perfilman dan periklanan by Aisyah Humaira

“…This approach allows for a thorough understanding of the key players' functions, regulations, and market dynamics. The theories used in this study are Political Economy Theory and Semiotic Theory. …”
Get full text

Prepregnancy Obesity Reprograms Offspring Skeletal Muscle Fibre Transition Through H3K9me3 by Yichi Wu, Sujuan Li, Jingyi Zhang, Anran Tian, Xiangyao Wang, Xi Yang, Fucheng Meng, Qing Li, Yuan Gao, Yingying Li, Furong Liang, Minglan Yao, Xiaoping Luo, Cai Zhang

“…Given that skeletal muscle plays a crucial role in systemic metabolism, we investigated how maternal prepregnancy high‐fat diet (HFD) influences muscle fibre composition and metabolic function in offspring. Methods We established mouse models with a prepregnancy chow diet (CD) and a prepregnancy high‐fat diet (HFD) for 8 weeks to compare metabolic phenotypes in offspring. …”
Get full text

Cord blood-derived iNK T cells as a platform for allogeneic CAR T cell therapy by Maison Grefe, Abel Trujillo-Ocampo, Jelita Clinton, Hong He, Ling Yu, Dan Li, Qing Ma, Elizabeth J. Shpall, Jeffrey J. Molldrem, Jin S. Im, Jin S. Im

“…However, the phenotypic and functional heterogeneity of iNK T cells from adult donors (AD) may lead to the inconstant CAR-iNK T cell products. …”
Get full text

RESULTS OF COMPREHENSIVE STUDIES OF THE UNDERGROUND HYDROSPHERE WITHIN THE WESTERN SHOULDER OF THE BAIKAL RIFT (AS EXEMPLIFIED BY THE BAYANDAI – KRESTOVSKY CAPE SITE) by Konstantin Zh. Seminsky, Marina A. Tugarina

“…With the detail data on the Bayandai – Krestovsky Cape site, the above conclusions are more precisely determined, and it is generally concluded that the structural tectonic factor controls the hydrogeology of the region.The analysis of mineralization, composition, temperature and other characteristics of the underground waters (Fig. 3–6) show that at the low hierarchic level the NW boundary of the Obruchev interblock zone performs a function of a distinct hydrogeological barrier which represents the marginal suture of the Siberian platform. …”
Get full text

ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury by Yan Bai, Xinyu Zhan, Qing Zhu, Xingyue Ji, Yingying Lu, Yiyun Gao, Fei Li, Zhu Guan, Haoming Zhou, Zhuqing Rao

“…Macrophages are essential for maintaining normal lung physiological functions and are implicated in various pulmonary diseases. …”
Get full text