Comparative proteomics of biofilm development in Pseudoalteromonas tunicata discovers a distinct family of Ca2+-dependent adhesins by Sura Ali, Alexander Stavropoulos, Benjamin Jenkins, Sadie Graves, Atiyeh Ahmadi, Vania Marzbanrad, Geoffrey Che, Jiujun Cheng, Huagang Tan, Xin Wei, Suhelen Egan, Brian Ingalls, Josh D. Neufeld, Ulrich Eckhard, Trevor C. Charles, Andrew C. Doxey

“…However, the pathways responsible for P. tunicata biofilm formation are not fully understood, in part due to a lack of functional information for a large proportion of its proteome. …”
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Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-r... by Adhithiya Charli, Yuan-Teng Chang, Jie Luo, Bharathi Palanisamy, Emir Malovic, Zainab Riaz, Cameron Miller, Manikandan Samidurai, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, Anumantha G. Kanthasamy

“…Collectively, our data reveal that PKCδ functions as a Lamin B1 kinase to disassemble the nuclear membrane during mitochondrial stress-induced neuronal death. …”
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Inflammatory cytokine-primed MSC-derived extracellular vesicles ameliorate acute lung injury via enhanced immunomodulation and alveolar repair by Jongwon Jeong, Jun-Kook Park, Jiwon Shin, Inseong Jung, Hyun-Woo Kim, Anyeseu Park, Hanchae Cho, Sung-Min Kang, Sanghee Shin, Eunju Park, Jisuk Kim, Soojeong Noh, Yongdeok Ahn, Do-Kyun Kim, Jeong Yoon Lee, Daeha Seo, Moon-Chang Baek, Kyungmoo Yea

“…We characterized unprimed control MSC-EVs (C-MEVs) and primed MSC-EVs (P-MEVs) by transmission electron microscopy, nanoparticle tracking analysis, and western blotting for EV markers. Functional assays in THP-1 and A549 cells examined anti-inflammatory potency and barrier regeneration against lipopolysaccharide (LPS)-induced damage. …”
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Identification of SNPs and INDELS associated with duck egg quality traits through a genome-wide association analysis by Min Zhang, Lizhi Lu, Yan Li, Qiong Wu, Yanhui Liu, Hongfei Liu, Hehe Tang, Rulong Lin, Hongping Chen, Tao Zeng, Yong Tian, Yuting Yan, Yanning Wei, Chenyu Ren, Wenfu Li, Min Liu, Jie Yu, Jiawen Liu, Xin Lin, Guanghua Zeng, Chunmei Cheng, Xiaobing Jiang, Yanfa Sun

“…Of the 46 genes, the molecular functions of 22 are related to protein binding, indicating important roles in the formation of egg quality traits. …”
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Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling by Rui-Qiang Qi, Yu-Fei Chen, Jing Cheng, Jia-Wei Song, Yi-Hang Chen, Si-Yuan Wang, Ying Liu, Kai-Xin Yan, Xiao-Yan Liu, Jing Li, Jiu-Chang Zhong

“…Elabela, a recently identified peptide, has emerged as a significant player in the regulation of cardiovascular function and homeostasis. However, the effects and underlying mechanisms of Elabela on age-related vascular calcification remain largely unexplored. …”
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B and T lymphocyte attenuator (BTLA) and PD-1 pathway dual blockade promotes antitumor immune responses by reversing CD8+ T-cell exhaustion in non-small cell lung cancer by Yang Zhang, Yang Zhang, Yang Yang, Yang Yang, Yuanyuan Zeng, Yuanyuan Zeng, Qiuxia Qu, Dan Shen, Chuanyong Mu, Wei Lei, Meiqin Su, Jingyu Mao, Lirong Gao, Zeyi Liu, Zeyi Liu, Cheng Chen, Jian-an Huang, Jian-an Huang

“…In addition, distribution and function of immune cells were analyzed by flow cytometry. …”
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VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway by Liu-liu Shi, Yu-ting Sun, Jia-nan Sun, Jing Yue, Wei Chen, Kun Meng, Long Chen, Chang-qing Hu, Rui Chen, Dong-sheng Sun, Cheng-bao Xu, Wei Yuan, Xin-li Li, Dan Zhao, Yan Wu, Shi-bing Xi, Xiao-ying Zhao, Jun-ming Tang

“…Furthermore, high-dose VEGF-B186 decreased the expression of glucose transporter type 4, glucose utilization, and mitochondrial function in a unique myoblast cell model, effects that were reversed by PKA activators and NFATc1/c2 overexpression. …”
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Validation of Strategic Memory Advanced Reasoning Training as an efficient and effective approach to treating warfighters with persistent cognitive complaints associated with mild... by Andrew J. Darr, Andrew J. Darr, Andrew J. Darr, Angela Basham, Angela Basham, Angela Basham, Jessica L. Ryan, Melissa Caswell, Melissa Caswell, Melissa Caswell, Juan Lopez, Juan Lopez, Juan Lopez, Jennifer Zientz, Erin Venza, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Chapman, Jason M. Bailie, Jason M. Bailie, Jason M. Bailie

“…Additionally, treatment improved patient perceived functionality (KBCI) from T1 to T2 and these gains remained stable at T3 (p < 0.001, ηp2 = 0.377). …”
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Metabolomic signatures in liquid biopsy are associated with overall survival in metastatic melanoma patients treated with immune checkpoint inhibitor therapy by Susan Costantini, Gabriele Madonna, Mariaelena Capone, Elena Di Gennaro, Palmina Bagnara, Federica Renza, Domenico Mallardo, Roberta Affatato, Carlo Vitagliano, Marilena Romanelli, Marilena Tuffanelli, Ester Simeone, Gennaro Ciliberto, Paolo A. Ascierto, Alfredo Budillon

“…Peripheral metabolomics was performed using baseline sera from 132 patients via 600 MHz Nuclear Magnetic Resonance (NMR) spectroscopy. Enriched functional analysis was conducted to identify the metabolic pathways in which significant metabolites were involved. …”
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Effects of a novel synbiotics-enzyme complex as a replacement for antibiotics on growth performance, slaughter and meat characteristics, immune organ index, and intestinal morpholo... by Zihao Zhao, Zihao Zhao, Simushi Liswaniso, Simushi Liswaniso, Ning Qin, Ning Qin, Shengxiao Cao, Shengxiao Cao, Xin Wu, Xin Wu, Chang Ma, Chang Ma, Chunchi Yan, Chunchi Yan, Rifu Xu, Rifu Xu, Xue Sun, Xue Sun

“…SEC inclusion at 0.1% significantly (P < 0.05) increased the spleen, bursal, and thymus indexes, respectively.ConclusionSupplementation of broilers with 0.1% SEC can be used as an antibiotic alternative because it increases the F/G, improves the carcass and meat quality, increases the body conformation, improves the small intestines' functions, and immune organ size.…”
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Genetic Variations of Three Kazakhstan Strains of the SARS-CoV-2 Virus by Bekbolat Usserbayev, Kulyaisan T. Sultankulova, Yerbol Burashev, Aibarys Melisbek, Meirzhan Shirinbekov, Balzhan S. Myrzakhmetova, Asankadir Zhunushov, Izat Smekenov, Aslan Kerimbaev, Sergazy Nurabaev, Olga Chervyakova, Nurlan Kozhabergenov, Lesbek B. Kutumbetov

“…According to PROVEAN data, the loss-of-function mutations identified in strains KAZ/Britain/2021, KAZ/B1.1/2021, and KAZ/Delta020/2021 include 5 mutations (P218L, T716I, W149L, R52I, and Y73C), 2 mutations (S813I and Q992H), and 8 mutations (P77L, L452R, I82T, P45L, V82A, F120L, F120L, and R203M), respectively. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…While epilepsy and psychiatric behaviors increase in severity with age, communication abilities and motor function tend to improve. iPSCs, which were differentiated into GABAergic neurons, represent the first in vitro neuronal model of SSADHD and express the neuronal marker microtubule-associated protein 2 (MAP2), as well as GABA. …”
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Cloud-scale Gas Properties, Depletion Times, and Star Formation Efficiency per Freefall Time in PHANGS–ALMA by Adam K. Leroy, Jiayi Sun, Sharon Meidt, Oscar Agertz, I-Da Chiang, Jindra Gensior, Simon C. O. Glover, Oleg Y. Gnedin, Annie Hughes, Eva Schinnerer, Ashley T. Barnes, Frank Bigiel, Alberto D. Bolatto, Dario Colombo, Jakob den Brok, Mélanie Chevance, Ryan Chown, Cosima Eibensteiner, Damian R. Gleis, Kathryn Grasha, Jonathan D. Henshaw, Ralf S. Klessen, Eric W. Koch, Elias K. Oakes, Hsi-An Pan, Miguel Querejeta, Erik Rosolowsky, Toshiki Saito, Karin Sandstrom, Sumit K. Sarbadhicary, Yu-Hsuan Teng, Antonio Usero, Dyas Utomo, Thomas G. Williams

“…Then we test how ${\tau }_{{\rm{dep}}}^{{\rm{mol}}}$ and ${\epsilon }_{{\rm{ff}}}^{{\rm{mol}}}$ vary as functions of the regional mass-weighted mean molecular gas properties on cloud scales (60–150 pc): gas surface density, $\langle {{\rm{\Sigma }}}_{{\rm{mol}}}^{{\rm{cloud}}}\rangle $ , velocity dispersion, $\langle {\sigma }_{{\rm{mol}}}^{{\rm{cloud}}}\rangle $ , virial parameter, $\langle {\alpha }_{{\rm{vir}}}^{{\rm{cloud}}}\rangle $ , and gravitational freefall time, $\langle {\tau }_{{\rm{ff}}}^{{\rm{cloud}}}\rangle $ . …”
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Histopathologic Progression and Metastatic Relapse Outcomes in Small Cell Neuroendocrine Carcinomas of the Urinary Tract by Mohammad Jad Moussa, Georges C. Tabet, Arlene O. Siefker‐Radtke, Lianchun Xiao, Nathaniel R. Wilson, Jianjun Gao, Christopher J. Logothetis, Petros Grivas, Byron Lee, Amishi Y. Shah, Pavlos Msaouel, Roger Li, Leticia Campos Clemente, Jianping Zhao, Nizar M. Tannir, Ashish M. Kamat, Donna E. Hansel, Charles C. Guo, Matthew T. Campbell, Omar Alhalabi

“…Relapse event was the time‐to‐event outcome, and relapse probabilities were estimated using a competing risk method with cumulative incidence functions (CIFs). Fine‐Gray distribution models assessed covariate associations. …”
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Effect of acupuncture on patients with chronic obstructive pulmonary disease: A multicenter randomized controlled trial by Jiansheng Li, Yang Xie, Yanjun Wang, Lei Wu, Xuefeng Yu, Li Bai, Suju Shao, Miao Zhou, Mingli Zhang, Xueqing Yu, Weihong Han, Xuanlin Li, Tao Chen

“…George’s Respiratory Questionnaire (SGRQ), and the secondary outcomes included the modified Medical Research Council dyspnea scale (mMRC), acute exacerbation, lung function, and quality of life (COPD assessment test). …”
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Outcomes of transcatheter aortic valve replacement in younger low-risk patients: a comprehensive meta-analysis of efficacy and safety by António Rocha de Almeida, António Rocha de Almeida, António Rocha de Almeida, Maria Rita Lima, Maria Rita Lima, Daniel A. Gomes, Renato Fernandes, Eduardo Infante Oliveira, Eduardo Infante Oliveira, Pedro Araújo Gonçalves, Pedro Araújo Gonçalves, Rui Campante Teles, Rui Campante Teles, Manuel de Sousa Almeida, Manuel de Sousa Almeida, Lino Patrício

“…Secondary endpoints included all-cause mortality, disabling stroke, atrial fibrillation (AF), permanent pacemaker implantation (PPI), bleeding, functional class (NYHA), and quality-of-life (KCCQ score) improvements.ResultsFour RCTs were included with 4,252 patients (2,125 TAVI and 2,127 SAVR). …”
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Immunotherapy combining tumor and endothelium cell lysis with immune enforcement by recombinant MIP-3α Newcastle disease virus in a vessel-targeting liposome enhances antitumor imm... by Lei Li, Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Guang-Hong Tan, Hengyu Chen, Cai-Chun Wang, Wu-Ping Zheng

“…Moreover, iNDV3α-LP treatment could significantly suppress tumor angiogenesis and reverse the tumor immune suppressive microenvironment in both B16-bearing and 4T1-bearing mice.Conclusions In this study, iNDV3α-LP had several functions, such as tumor and vessel lysis, MIP-3α immunotherapy, and binding to αvβ3-expressing tumor and its neovasculature. iNDV3α-LP treatment significantly suppressed tumor angiogenesis and reversed the tumor immunosuppressive microenvironment. …”
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Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia by Kai Jiang, Fanghua Su, Ruhua Deng, Yue Xu, Anqi Qin, Xun Yuan, Dongmei Xing, Yang Chen, Dandan Wang, Lan Shen, John Hwa, Lei Hou, Yaozu Xiang

“…Graphical abstract NHE1 activation emerges as a novel therapeutic strategy to reduce infarct size and preserve cardiac function in hyperglycemia-associated myocardial infarction (MI). …”
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Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury—a randomized, double-blind, and placebo-control... by Dana M. Otzel, Dana M. Otzel, Larissa Nichols, Christine F. Conover, Stephen A. Marangi, Jayachandra R. Kura, Dominic K. Iannaccone, David J. Clark, David J. Clark, Chris M. Gregory, Christopher F. Sonntag, Anita Wokhlu, Anita Wokhlu, Hans K. Ghayee, Michael J. McPhaul, Charles E. Levy, Charles A. Plumlee, Charles A. Plumlee, Robert B. Sammel, Robert B. Sammel, Kevin T. White, Joshua F. Yarrow, Joshua F. Yarrow, Joshua F. Yarrow, Joshua F. Yarrow

“…The participant retention, drug compliance, and incidence and severity of adverse events were similar among the groups.ConclusionThese data provide proof-of-concept and rationale for larger RCTs aimed at discerning the impact of TRT + finasteride on body composition, musculoskeletal health, and physical function in men with SCI, along with effect sizes and variance of responses to assist in planning subsequent trials.Clinical trial registrationClinicalTrials.gov, identifier NCT02248701.…”
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Effects of Soybean Meal Substitution in Finishing Pig Diet on Carcass Traits, Meat Quality, and Muscle Antioxidant Capacity by Shuai Liu, Zhentao He, Xiaolu Wen, Xianliang Zhan, Lei Hou, Dongyan Deng, Kaiguo Gao, Xuefen Yang, Shuting Cao, Zongyong Jiang, Li Wang

“…These results can help develop further mixed meals as a functional alternative feed ingredient for soybean meals in pig diets.…”
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