BIO101 in Sarcopenic Seniors at Risk of Mobility Disability: Results of a Double‐Blind Randomised Interventional Phase 2b Trial by Roger A. Fielding, Michael M. Dao, Kevin Cannon, Moise Desvarieux, Sam S. Miller, Michael Paul Gimness, Donald M. Brandon, Dennis T. Villareal, Olivier Bruyere, Ivan Bautmans, Kyle Rickner, Robert Perry, Stephen B. Kritchevsky, Nicolas Musi, Joe M. Chehade, Judith L. Kirstein, Evelien Gielen, Paul Pickrell, Pierre Dilda, Rene Lafont, Carole Margalef, Yves Rolland, Susanna Del Signore, Jean Mariani, Samuel Agus, Cendrine Tourette, Waly Dioh, Rob vanMaanen, Stanislas Veillet

“…The aim of SARA‐INT was to investigate whether BIO101 (20‐hydroxyecdysone), an activator of the MAS receptor, is safe and improves muscle function and physical performance of community dwelling older sarcopenic patients. …”
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Cardiac remodeling and global longitudinal strain in young male competitive athletes: A comparative study across different training modes by Damirbek A.Abibillaev, Fuat Kocyigit, Aida K.Baatyrbekova, Aisanam K. Abdurasulova, Kudaibergen R. Osmonaliev, Samatbek A. Satybaldyev, Zhenishbek K. Ismailov, Ryskul B.Kydyralieva, Oskon A.Salibaev, Taalaibek Z.Kudaiberdiev

“…Objective: Athletic heart (AH) is the structural, and functional cardiac alterations depending on a training type, intensity and number of sports-related factors (SRF) in an athletic cohort. …”
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Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights by Lei Shi, Ziying Zhang, Song Mei, Zerui Wang, Zhe Xu, Weiqi Yao, Limin Liu, Mengqi Yuan, Yuefei Pan, Kaidi Zhu, Kai Liu, Fanglin Meng, Jiao Sun, Wenying Liu, Xiaohui Xie, Tengyun Dong, Lei Huang, Fanping Meng, Jun-Liang Fu, Yuanyuan Li, Chao Zhang, Xing Fan, Ming Shi, Yu Zhang, Yonggang Li, Wei-Fen Xie, Peng Zhang, Fu-Sheng Wang

“…Preliminary clinical signals included improvements in Child–Pugh scores, Model for End-Stage Liver Disease scores, liver function markers, and quality-of-life metrics, particularly in the higher-dose and multiple-dose groups. …”
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Pre-existing oncohematological disease in kidney transplant recipients: impact on graft survival, acute rejection, and long-term clinical outcomes by Alberto Mella, Alberto Mella, Roberta Clari, Roberta Clari, Valeria Deiana, Valeria Deiana, Roberta Giraudi, Roberta Giraudi, Gloria Giovinazzo, Gloria Giovinazzo, Ester Gallo, Ester Gallo, Caterina Dolla, Caterina Dolla, Antonio Lavacca, Antonio Lavacca, Ana Maria Manzione, Ana Maria Manzione, Fabrizio Fop, Fabrizio Fop, Anna Allesina, Anna Allesina, Federica Cavallo, Sara Bringhen, Dario Ferrero, Roberto Mina, Corrado Tarella, Corrado Tarella, Benedetto Bruno, Filippo Mariano, Filippo Mariano, Luigi Biancone, Luigi Biancone

“…Secondary endpoints included the risk of hematological disease recurrence and infection, patient survival rates, and graft function.ResultsThirty out of 2871 patients (1.04%) receiving 31/3019 KTs have a pre-existing oncohematological disease (hematological cohort): 7/30 (23.3%) PCDs, 4/30 (13.3%) acute leukemia, 8/30 (26.7%) high-grade lymphomas/PTLDs, 4/30 (13.3%) MPNs, 2/30 (6.7%) MDS/MPNs, and 5/30 (16.7%) AA/familiar amyloidosis. …”
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Conserving biodiversity, carbon, and community values in a fragmented landscape by A. Susilowati, Y. Lisnawati, H.H. Rachmat, H. Kurniawan, W.C. Adinugroho, R. Imanuddin, D.J. Sudrajat, I.W.S. Dharmawan, M. Iqbal, S. Fahmi, L.M. Nugraha, E. Novriyanti, E. Sutrisno, A.B. Siswanto

“…The goal is to support the sustainable management of customary fragmented forests by providing scientific and social insights to maintain their ecological functions and community benefits.METHODS: The research was conducted in the Imbo Putui Customary Forest in Petapahan Village, Kampar Regency, Riau Province, Indonesia. …”
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Genetic evolution, epidemic trends, and recombination dynamics of PRRSV-1 in China by Chengzhen Weng, Chengzhen Weng, Chengzhen Weng, Xinxin Huang, Xinxin Huang, Xinxin Huang, Zhian Chen, Zhian Chen, Minjia He, Minjia He, Minjia He, Beiwen Zhang, Beiwen Zhang, Beiwen Zhang, Hongxi Li, Hongxi Li, Hongxi Li, Jingrui Xie, Jingrui Xie, Meichun Chen, Meichun Chen, Meichun Chen, Longxin Qiu, Longxin Qiu, Xiaobing Li, Xiaobing Li, Chong Cao, Chong Cao, Hongbo Chen, Hongbo Chen

“…The results indicated that mutations had occurred at amino acid sites within the antigenic epitopes and functional domains of GP5. Additionally, the prediction of potential N-glycosylation sites identified five locations in GP5: positions 35, 37, 38, 46, and 53. …”
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Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation by Keyin Zheng, Aimin Jiang, Zhengrui Li, Li Chen, Kailai Li, Junyi Shen, Hank Z. H. Wong, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo

“…For HCV‐related HCC, we focus on exploring the following oncogenic mechanisms: oncogenic mechanisms of viral proteins, virus infection‐mediated metabolic disorders, functional dysregulation of immune cells in the microenvironment, and virus‐induced hepatic fibrosis. …”
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Circular RNA CDR1as/ciRS-7– a novel biomarker in solid tumors by Yun Zhang, Yun Zhang, Chanyu Xiong, Zhilin Jiang, Xiao Wang, Juanjuan Ji, Yan Pan, Tianshu Yu, Zihao Wang, Lin Zhu, Yumei Yue, Qiong Li, Haizhen Wang, Shikai Zhu, Yu Zhou

“…IntroductionCircular RNA CDR1as/ciRS-7 has been reported to function as an oncogenic regulator in various cancers. …”
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Associations of elevated cardiac biomarkers with hyperuricemia and mortality in US adults without prevalent cardiovascular disease by Haitao Xie, Le Shen, Le Shen, Peng Yu, Peng Yu, Shi Wang, Shi Wang, Tong Sun, Xueqian Liu, Mengxi Wang, Li Qian, Jiayi Hua, Nan Chen, Xiaohu Chen, Xiaohu Chen, Shuhua Tang, Shuhua Tang

“…Multivariate Cox regression model and Kaplan-Meier curve, risk competition model and Cumulative Incidence Function(CIF) were used respectively to examine the associations between elevated cardiac biomarkers with all-cause and cardiovascular mortality.ResultsIn general US adults without known cardiovascular disease, the prevalence of hyperuricemia was 16.35%. …”
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Insight into rifampicin resistance behind discordant mutations in RpoB of Mycobacterium tuberculosis: A molecular dynamics simulations study by Muhammad Tahir Khan, Elise Dumont, Jialou Zhu, Kashif Iqbal Sahibzada, Madeeha Shahzad Lodhi, Mehmood Qadir, Dongqing Wei

“…Each mutant exhibited some unique interactions that were not present in the WT, potentially altering the protein's structure and function. In the presence of RIF, the WT exhibits 42 DNA-residue interactions, one weak DNA-residue interaction, a total binding surface area of 1658 Å2, 27 hydrogen bonds, and 140 van der Waals interactions, with a hydrophobicity score of −1.348 which was significantly lower than the MTs. …”
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Associations of serum and bronchoalveolar immunoglobulins with lung microbiota diversity, B-cell memory phenotypes, and COPD morbidity and exacerbations by Vickram Tejwani, Nirupama Putcha, Han Woo, Chen Liu, David Lafon, Neil E. Alexis, Antoine Azar, R. Graham Barr, Igor Barjaktarevic, Russell P. Bowler, Alejandro Comellas, David J. Couper, Ashraf Fawzy, MeiLan K. Han, Nadia N. Hansel, Robert J. Kaner, Jerry A. Krishnan, Nathaniel Marchetti, Fernando J. Martinez, Jill Ohar, Wanda O’Neal, Victor E. Ortega, Robert Paine III, Tess D. Pottinger, Martin Stämpfli, Lisa Ruvuna, Prescott G. Woodruff, Christine M. Freeman, Yvonne J. Huang, Jeffrey L. Curtis

“…Neither BAL IgG nor IgA were associated with lung function or exacerbations. Conclusions These results demonstrate an association of low serum IgG with reduced lung bacterial diversity, a feature of dysbiosis that may predispose to exacerbation. …”
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In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…We implemented an assay which allowed us to isolate functional antigen-specific CD4+T cells in an HLA-independent manner. …”
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Rational Approach to New Chemical Entities with Antiproliferative Activity on Ab1 Tyrosine Kinase Encoded by the <i>BCR-ABL</i> Gene: An Hierarchical Biochemoinformatics Analysis by Vitor H. da S. Sanches, Cleison C. Lobato, Luciane B. Silva, Igor V. F. dos Santos, Elcimar de S. Barros, Alexandre de A. Maciel, Elenilze F. B. Ferreira, Kauê S. da Costa, José M. Espejo-Román, Joaquín M. C. Rosa, Njogu M. Kimani, Cleydson B. R. Santos

“…This stability is a positive indicator that LMQC01 and LMQC04 can potentially inhibit enzyme function. Synthetic accessibility (SA) analysis performed on the AMBIT and SwissADME webservers showed that LMQC01 and LMQC04 can be considered easy to synthesize. …”
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Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis by Kornelius Schulze, Tim Daniel Rose, Lorenz Adlung, Manuela Peschka, Francesca Pagani, Joao Gorgulho, Thorben W. Fründt, Ismail Labgaa, Philipp K. Haber, Carolin Zimpel, Darko Castven, Arndt Weinmann, Teresa Garzia-Lezana, Moritz Waldmann, Thomas Renné, Hannah Voß, Manuela Moritz, Dorian Orlikowski, Hartmut Schlüter, Jan Baumbach, Myron Schwartz, Ansgar W. Lohse, Samuel Huber, Bruno Sangro, Rocio I.R. Macias, Laura Izquierdo-Sanchez, Jesus M. Banales, Henning Wege, Jens U. Marquardt, Augusto Villanueva, Josch Konstantin Pauling, Johann von Felden

“…In vitro knockdown confirmed a functional role in proliferation and migration, as exemplified for PYCR2. …”
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IL-28A/IL-10Rβ axis promotes angiogenesis via eNOS/AKT signaling and AP-1/NF-κB/MMP-2 network by regulating HSP70-1 expression by Jun-Hui Song, Byungdoo Hwang, Sung Lyea Park, Hoon Kim, Soontag Jung, Changsun Choi, Hwan Myung Lee, Seok-Joong Yun, Yung Hyun Choi, Eun-Jong Cha, Cam Patterson, Wun-Jae Kim, Sung-Kwon Moon

“…Gene expression changes in HUVECs following IL-28A treatment were analyzed by NGS. The functional role of HSP70-1 and IL-10Rβ in IL-28A-induced angiogenic responses was evaluated using PCR and siRNA knockdown. …”
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Incident Heart Failure in Atherosclerotic Renal Artery Stenosis: A Post Hoc Analysis of the CORAL Trial by Rajesh Gupta, Michelle M. Estrella, Rebecca Scherzer, Pamela S. Brewster, Lance D. Dworkin, Hanh T. Nguyen, Yanmei Xie, Joachim H. Ix, Michael G. Shlipak, Timothy P. Murphy, Donald E. Cutlip, Eldrin F. Lewis, Christopher J. Cooper

“…Participants who experienced incident HF had greater kidney function decline before HF events. Limitations: This is a post hoc analysis of a RCT. …”
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Whole genome sequencing reveals virulence–mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria by Nubwa Medugu, Nubwa Medugu, Mabel Kamweli Aworh, Mabel Kamweli Aworh, Kenneth Iregbu, Philip Nwajiobi-Princewill, Dawn M. Hull, Lyndy Harden, Pallavi Singh, Stephen Obaro, Abiodun Egwuenu, Faith Adeboye, Ruth Egah, Leonard Uzairue, Yahaya Mohammed, Nwafia Ifeyinwa, Siddhartha Thakur

“…BackgroundMultidrug-resistant Escherichia coli poses a critical public health threat in Nigeria, where limited genomic surveillance hinders the understanding of virulence-resistance interplay.MethodsThis cross-sectional study employed whole-genome sequencing to characterize 107 MDR-E isolates from a Nigerian tertiary hospital (2019–2020), analyzing virulence genes, mobile genetic elements (MGEs), phylogroups, sequence types (STs), pathotypes, and antimicrobial resistance (AMR).ResultsWe identified 2,021 virulence genes across nine functional categories, dominated by immune evasion (terC, 96.3%), adherence (fimH, 86%), and iron acquisition (fyuA, 63.6%). …”
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Effective cellular and neutralizing immunity against SARS-CoV-2 after mRNA booster vaccination is associated with pDC and B cell activation by Dorit Fabricius, Carolin Ludwig, Carolin Ludwig, Matthias Proffen, Matthias Proffen, Janina Hägele, Janina Hägele, Judith Scholz, Judith Scholz, Christiane Vieweg, Christiane Vieweg, Immanuel Rode, Immanuel Rode, Simone Hoffmann, Simone Hoffmann, Sixten Körper, Sixten Körper, Hubert Schrezenmeier, Hubert Schrezenmeier, Bernd Jahrsdörfer, Bernd Jahrsdörfer

“…Cellular immunity was assessed by IFN-γ release assays, and flow cytometry was employed to analyze B cell and pDC frequencies, viability, and activation markers. Functional pDC-mediated T cell activation was evaluated in mixed lymphocyte cultures.ResultsmRNA booster vaccination stabilized high anti-SARS-CoV-2 IgG titers and neutralizing activity against wildtype virus across all regimens, with the homologous mRNA group showing the highest antibody titers and Omicron neutralization capacity. …”
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Future liver remnant hypertrophy and postoperative outcomes: a retrospective comparison between segmental and main right portal vein embolization by Elif Can, Aboelyazid Elkilany, Sophia Paparoditis, Bernhard Gebauer, Dominik Geisel, Felix Krenzien, Anne Pohrt, Wibke Uller, Michael Doppler, Sebastian Ebel, Holger Gößmann, Uli Fehrenbach

“…Future research should focus on conducting large, prospective, multicenter trials to further compare the long-term outcomes of this technique, particularly with regard to liver regeneration, postoperative liver function, complications and overall survival.…”
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Poor glycaemic control in type 2 diabetes compromises leukocyte oxygen consumption rate, OXPHOS complex content and neutrophil-endothelial interactions by Julia Cacace, Clara Luna-Marco, Alberto Hermo-Argibay, Catherine Pesantes-Somogyi, Omar A. Hernández-López, María Pelechá-Salvador, Celia Bañuls, Nadezda Apostolova, Luis de Miguel-Rodríguez, Carlos Morillas, Milagros Rocha, Susana Rovira-Llopis, Víctor M. Víctor

“…The mitochondrial electron transport chain becomes overloaded in type 2 diabetes (T2D), which increases ROS (Reactive Oxygen Species) production and impairs mitochondrial function. Peripheral blood mononuclear cells (PBMCs) are critical players in the inflammatory process that underlies T2D. …”
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