A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner by Xin-Yu Ding, Hua-Ying Zhang, Jia-Hao Chen, Meng-Jie Yang, Zhi-Xiong Huang, Yi-Hong Lei, Qin-Kun Sun, Jian-Bin Bai, Dian-Chao Lin, Jian-Fa Lan, Lu-Lu Ren, Zheng-Yi Chen, Wei-Dong Zhou, Qiong-Hua Chen

“…A colorimetric assay was used to measure methylation levels in clinical and mouse EMs samples. Functional assays (CCK-8, EdU, Transwell, and wound healing) were used to evaluate phenotypic changes. m6A immunoprecipitation sequencing (MeRIP-seq) identified downstream targets. …”
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Improved representation of soil moisture processes through incorporation of cosmic-ray neutron count measurements in a large-scale hydrologic model by E. Fatima, E. Fatima, R. Kumar, S. Attinger, S. Attinger, M. Kaluza, O. Rakovec, O. Rakovec, C. Rebmann, C. Rebmann, R. Rosolem, R. Rosolem, S. E. Oswald, L. Samaniego, L. Samaniego, S. Zacharias, M. Schrön

“…We included three different approaches to estimate CRNS neutron counts in the mHM as a function of the simulated soil moisture profiles: two methods based on the Desilets equation and one based on the forward operator COSMIC (COsmic-ray Soil Moisture Interaction Code). …”
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Fish scale-based carbon dots with g-C3N4 as a photo-catalyst for oxidation of herbicide 2,4-dichloro phenoxy acetic acid under visible light: Experimental and theoretical studies by Yessenia-Scarlette García-Gutierrez, Cristian-Brayan Palacios-Cabrera, Alan-Javier Santiago-Cuevas, Ivan-Alejandro Reyes-Domínguez, Maria-Teresa Orta-Ledesma, Frank Güell, Eduard Llobet, Edilso Reguera, Carlos Alberto Huerta-Aguilar, Pandiyan Thangarasu

“…The bandgap energy of the samples (2.77–2.91 eV) is consistent with those from the Density Functional Theory (DFT). The adsorption of 2,4-D by S-NCDs/g-C3N4 is highly efficient; for example, qm = 2.85 × 10−5 mol/g for C-NCD/g-C3N4, 2.02 × 10−5 mol/g for S-NCD/g-C3N4 or 2.43 × 10−5 mol/g for g-C3N4. …”
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Effect of Mesenchymal Stem Cell–Derived Extracellular Vesicles Induced by Advanced Glycation End Products on Energy Metabolism in Vascular Endothelial Cells by Jiabin Liang, Sihang Cheng, Qide Song, Yukuan Tang, Qian Wang, Hanwei Chen, Jie Feng, Lin Yang, Shunli Li, Zhiwei Wang, Jinghui Fan, Chen Huang

“…This likely resulted from impaired mitochondrial function, including reduced ATP production, maximal respiration, basal respiration, and spare respiratory capacity (P < 0.05), or increased reactive oxygen species (ROS) (P < 0.05) and glucose-6-phosphate dehydrogenase (G6PD) activity (P < 0.05). …”
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High-Throughput Indirect Monitoring of TORC1 Activation Using the pTOMAN-G Plasmid in Yeast by Melissa Gómez, Guilherme Rocha, Diego Ruiz, Claudio Martínez, Francisco Salinas, Eduardo Kessi-Pérez

“…The target of rapamycin complex 1 (TORC1) is a highly conserved protein complex whose primary function is to link nutrient availability to cell growth in eukaryotes, particularly nitrogen sources. …”
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Eco-friendly innovation: Development of a multifunctional polyaniline-cuttlebone nanocomposite as a synergistic shield against doxorubicin-induced toxicity and a powerful antimicro... by Esraa Salama, Fatma I. Abo El-Ela, Walid Hamdy Hassan, Ahmed A. Farghali, Abdullah A. Eweis, Sarah H.M. Hafez, Rehab Mahmoud

“…The results demonstrated a decrease in oxidative damage and significant improvements in liver and kidney function markers in the polyaniline/cuttlebone-treated groups compared with those in the groups treated with individual components. …”
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Natural compounds targeting inflammation and oxidative stress in intestinal ischemia-reperfusion injury: a comprehensive review by Balaji Venkataraman, Aya A. Touny, Shamanth Neralagundi Harihar gowdru, Bhoomendra A. Bhongade, Rajesh B. Patil, Shreesh Ojha, Mauro Pessia, Sandeep B. Subramanya

“…This pathological process induces oxidative stress, inflammation, and cellular damage, which collectively impair intestinal function. Recent studies have explored natural therapeutic approaches, including the use of plants, herbal formulations, and phytochemicals, to mitigate the detrimental effects of intestinal I/R injury. …”
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GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis by Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, Shuo Yu, Yao Xie, Cheng-Jiang Jin, Yi-Min Shen, Si-Yu Zhou, Xiao-Ce Dai, Sheng-An Su, Lan Xie, Zheng-Xing Huang, Hui Gong, Mei-Xiang Xiang, Hong Ma

“…Overexpression of GSTM1 in post-MI mice improved cardiac function, while significantly reducing infarct size and fibrosis compared with the control group. …”
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A randomised controlled trial of amygdala fMRI-neurofeedback versus sham-feedback in borderline-personality disorder – systematic literature review and introduction to the BrainSTE... by Christian Paret, Miroslava Jindrová, Nikolaus Kleindienst, Judith Eck, Hester Breman, Michael Lührs, Beatrix Barth, Thomas Ethofer, Andreas J. Fallgatter, Rainer Goebel, Andreas Hoell, Denise Lockhofen, Annika S. Reinhold, Simon Maier, Swantje Matthies, Christoph Mulert, Christian Schönholz, Ludger Tebartz van Elst, Christian Schmahl

“…Hyperactivity of the amygdala is assumed to drive exaggerated emotional responses in BPD. Functional Magnetic Resonance Imaging (fMRI)-based neurofeedback is an endogenous neuromodulation method intended to address the imbalance of neural circuits and thus holds the potential as a treatment for BPD. …”
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Assessment of Biodegradation Mechanisms of Ceftiofur Sodium by <i>Escherichia</i> sp. CS-1 and Insights from Transcriptomic Analysis by Meng-Yang Yan, Cai-Hong Zhao, Jie Wu, Adil Mohammad, Yi-Tao Li, Liang-Bo Liu, Yi-Bo Cao, Xing-Mei Deng, Jia Guo, Hui Zhang, Hong-Su He, Zhi-Hua Sun

“…Furthermore, the differentially expressed genes (DEGs) of <i>E. coli</i> CS-1 were functionally annotated using a combination of genomics and bioinformatics approaches. …”
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Exploring the relationship between dietary rapeseed meal, condensed tannin and growth, nutrive metabolism in largemouth bass (Micropterus salmoides) by Peng Kang, Xiaoshuang Xia, Ying Hang, Xueming Hua

“…Therefore, largemouth bass exhibited tolerance to a 5% inclusion of RM in the feed without compromising their growth, digestion and metabolic functions. The incorporation of 5% RM, equivalent to a supplemental 0.062% CT, had regulatory effects on the digestion and metabolism of largemouth bass while improving feed utilization. …”
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Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression by Lei Feng, Yan Chen, Liang Wang, Fei Huang, Yi-Yang Hu, Jun-Long Zhao, Shi-Qian Liang, Lei Dong, Heng-Chao Yu, Jian Bai, Jia-Meng Yang, Jie-Yi Fan, San-Zhong Li, Hua Han, Hong-Yan Qin

“…However, the mechanism underlying the TAM phenotype and function needs to be resolved. Our previous studies have demonstrated that miR-125a can reverse the TAM phenotype toward antitumor. …”
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Prolonged ECMO support in a pediatric patient with complex cardiac conditions during wartime in Kyiv, Ukraine by Rusnak Daniel, Condello Ignazio, Dohtiar Valerii, Varbanets Serhii, Alieksieieva Kristina, Luhovkin Serhii, Palokha Vladyslav, Zhoha Vadym, Bukhnei Neonila, Krashevska Lesia, Kutsenko Olha, Kupina Nataliia, Vnukov Oleksii

“…Weaning tests consistently indicated no recovery of cardiac function. Results: Despite rigorous management, the oxygenators faced performance declines over time, including clotting, reduced oxygen exchange, and lower CO2 removal efficiency, necessitating frequent replacements, with a total of ten changes across the ECMO course. …”
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Bridging Data Silos in Oncology with Modular Software for Federated Analysis on Fast Healthcare Interoperability Resources: Multisite Implementation Study by Jasmin Ziegler, Marcel Pascal Erpenbeck, Timo Fuchs, Anna Saibold, Paul-Christian Volkmer, Guenter Schmidt, Johanna Eicher, Peter Pallaoro, Renata De Souza Falguera, Fabio Aubele, Marlien Hagedorn, Ekaterina Vansovich, Johannes Raffler, Stephan Ringshandl, Alexander Kerscher, Julia Karolin Maurer, Brigitte Kühnel, Gerhard Schenkirsch, Marvin Kampf, Lorenz A Kapsner, Hadieh Ghanbarian, Helmut Spengler, Iñaki Soto-Rey, Fady Albashiti, Dirk Hellwig, Maximilian Ertl, Georg Fette, Detlef Kraska, Martin Boeker, Hans-Ulrich Prokosch, Christian Gulden

“…The pipeline handles diverse IT infrastructures and systems while maintaining privacy by keeping data decentralized for analysis. To assess the functionality and validity of our implementation, we defined a cohort to address two specific medical research questions. …”
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Secular trends in physical fitness and cardiovascular risks among Chinese college students: an analysis of five successive national surveys between 2000 and 2019Research in context by Shan Cai, Yihang Zhang, Ziyue Chen, Yunfei Liu, Jiajia Dang, Jiaxin Li, Tianyu Huang, Ziyue Sun, Yanhui Dong, Jun Ma, Yi Song

“…There is an urgent need to increase the focus on college students’ health and establish a college-based physical examination system to assess their long-term cardiovascular function. Funding: The present study was funded by National Key R&D Program of China (Grant No. 2024YFC2707901 to Yi Song), National Natural Science Foundation of China (Grant No. 82273654 to Yi Song), and Beijing Office for Education Sciences Planning (Grant No. …”
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Fertility preservation by ovarian tissue cryopreservation of children in China——umbilical single-incision surgery and perioperative experience by Zheng Qipeng, Liu Jing, Su Yun, Li Zexi, Cao Zhenhua, Chen Meng, Zhou Yan, Zhang Hua, Wang Zecheng, Tian Yu, Ruan Xiangyan, Wu Yurui

“…BackgroundOvarian tissue cryopreservation and transplantation (OTCT) is an effective method for preserving fertility and endocrine function. This study aims to summarize the surgical techniques and perioperative experiences to provide clinical evidence for pediatric OTCT.MethodsThis retrospective study reviewed the clinical data of 89 children who underwent umbilical single-incision laparoscopic oophorectomy at Children’s Hospital, Capital Institute of Pediatrics between September 2020 and December 2024. …”
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Effectiveness and safety of BCD180, anti-TRBV9⁺ T-lymphocytes monoclonal antibody in patients with active radiographic axial spondyloarthritis: 36-week results of double... by E. L. Nasonov, V. I. Mazurov, A. M. Lila, T. V. Dubinina, I. Z. Gaydukova, S. A. Lapshina, A. A. Klimenko, D. V. Somov, S. A. Lukianov, D. M. Chudakov, I. V. Zvyagin, O. V. Britanova, M. A. Korolev, D. I. Abdulganieva, D. G. Krechikova, A. A. Kastanayan, L. V. Eliseeva, R. R. Samigullina, T. V. Povarova, O. V. Antipova, S. A. Smakotina, V. N. Soboleva, O. B. Nesmeyanova, T. V. Plaksina, N. F. Soroka, I. B. Vinogradova, A. P. Rebrov, T. V. Kropotina, A. L. Maslyanskiy, A. V. Zinkina-Orikhan, Yu. N. Lin’kova, P. S. Pukhtinskaia, M. A. Morozova, G. A. Vinderskaya

“…The dynamics of the disease activity status according to ASDAS-CRP, the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and BASFI (Bath Ankylosing Spondylitis Functional Index) indices, as well as the dynamics of laboratory markers (C-reactive protein anderythrocyte sedimentation rate (ESR)) were analyzed. …”
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Comparison of outcomes of neoadjuvant chemotherapy in BRCA1- versus BRCA2-associated breast and ovarian cancers by Anna Sokolenko, Tatiana Gorodnova, Diana Enaldieva, Anna Shestakova, Alexandr Ivantsov, Anna Nyuganen, Igor Berlev, Petr Krivorotko, Alexey Belyaev, Evgeny Imyanitov

“…However, BRCA1 and BRCA2 genes differ in their function; therefore, a comparison of treatment outcomes in BRCA1 vs. …”
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Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model by Zohreh Sharafian, Zohreh Sharafian, Paula T. Littlejohn, Paula T. Littlejohn, Paula T. Littlejohn, Christina Michalski, Christina Michalski, James A. Sousa, James A. Sousa, Janelle Cheung, Mariana Hill, Mariana Hill, Hannah Piper, Kevan Jacobson, Kevan Jacobson, Pascal M. Lavoie, Pascal M. Lavoie, Joannie M. Allaire, Bruce A. Vallance, Bruce A. Vallance

“…Exactly how this immaturity affects key epithelial functions and their interactions with nearby immune cells remains an understudied area of research, partly due to limited access to non-diseased infant gut tissues. …”
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Efficacy of initial combination with belimumab in newly diagnosed childhood-onset lupus nephritis: a single-centre historical control study by Yu Shi, Jing Chen, Hong Xu, Qian Shen, Yinv Gong, Li Sun, Qijiao Wei, Yifan Li, Xiaomei Zhang, Shuhua Liu, Haimei Liu, Wanzhen Guan, Qiaoqian Zeng, Qianying Lv

“…In the standard immunotherapy group, 4 patients (6.3%) experienced a decline in estimated glomerular filtration rate of 30% or more at 12 months, while no patients in the belimumab group experienced worsening of renal function. There were no serious adverse events reported in two groups, and there was no significant difference in the occurrence of infection between the two groups.Conclusion This study reported for the first time the effectiveness of combined belimumab therapy in a Chinese cohort of patients with cLN. …”
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