Cardiovascular status and echocardiographic changes in survivors of COVID-19 pneumonia three months after hospital discharge by D. V. Krinochkin, E. I. Yaroslavskaya, N. E. Shirokov, E. P. Gultyaeva, I. R. Krinochkina, I. O. Korovina, A. V. Mamarina, N. A. Osokina, N. N. Melnikov, T. A. Trifanova, E. A. Gorbatenko, T. I. Petelina

“…Coronavirus disease 2019 (COVID-19) affects the function of all organs and systems. Today, studying the effect of COVID-19 on cardiovascular system, including on echocardiographic characteristics, is relevant.Aim. …”
Get full text

A real-world study on the clinicopathological profile, treatment outcomes and health-related quality of life, anxiety and depression among patients with desmoid tumor at two tertia... by Ghazal Tansir, Aparna Sharma, Bivas Biswas, Suryadev Narayan Sah, Somnath Roy, S. V. S. Deo, Sandeep Agarwala, Shah Alam Khan, Sameer Bakhshi, Deepam Pushpam

“…Anxiety, depression and QoL were prospectively measured among 30 patients using Hospital Anxiety and Depression (HADS) and Functional Assessment of Cancer Therapy-General (FACT-G) scales respectively between 2022 to 2023.Results200 patients were included with a male-predominant (n=111, 55.5%) population and median age 26.5 (2.5-75) years. …”
Get full text

Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…A Genome-wide association study (GWAS) was conducted to identify candidate genes associated with the five indicators of body conformation traits, thereby establishing a foundation for subsequent investigations into the biological functions of these genes. Results A total of 19.89 Tb of raw data was generated with an average sequencing depth of about 20×. …”
Get full text

Can Endothelin-1 Help Address the Diagnostic and Prognostic Challenges in Multimorbid Acute Heart Failure Patients? by Bianca-Ana Dmour, Minerva Codruta Badescu, Cristina Tuchiluș, Corina Maria Cianga, Daniela Constantinescu, Nicoleta Dima, Ștefania Teodora Duca, Awad Dmour, Alexandru Dan Costache, Maria-Ruxandra Cepoi, Adrian Crișan, Sabina Andreea Leancă, Cătălin Loghin, Ionela-Lăcrămioara Șerban, Irina Iuliana Costache-Enache

Get full text

Mediating role of psychological resilience between depression and humoral immunological biomarkers in medical staff by Yunyun MA, Yanshuan WEI, Lili QIAN, Xiufeng ZUO, Dechao WANG, Shanfa YU

“…BackgroundAt present, high level of depression is a serious problem in medical staff and may affect their immune function. The role of psychological resilience between depression and immunity cannot be ignored. …”
Get full text

The intestinal microbiota modulates the visceral sensitivity involved in IBS induced by restraint combined with tail clustering by Na Deng, Na Deng, Siqin Xie, Qin Liu, Huiyi Peng, Leyao Fang, Junxi Shen, Xiaoyuan Lin

“…The gut microbiota of the mice in the BM, CTM, and BCTM groups all exhibited dysbiosis, with changes in the diversity, structural composition, and function of the microbial community. Specific bacterial taxa were enriched in each stress group, and their corresponding KEGG pathways were also significantly altered. …”
Get full text

HCAR2 Exerts Anti-Depressive Effects on Corticosterone-Induced Depression in Mice by Modulating Microglial Activity by Zhao Pan, Li Jiang, Jiacheng Chen, Sicong Xu, Ping Zhang, Yili Yi, Yangzhi Xie, Yongjun Chen

“…Hydroxy-carboxylic acid receptor 2 (HCAR2) functions as a receptor for various diet-derived metabolites. …”
Get full text

ASIATIC SMELT OSMERUS DENTEX STEINDACHNER ET KNER, 1870 OF THE UDA RIVER (NORTHWESTERN OKHOTSK SEA) — BIOLOGY, ECOLOGY, FISHERY by V. P. Ovsyannikov, A. Yu. Nemchenko, A. N. Kanzeparova

“…The body weight depends on age as the function: Wt = 2.974t 2.136. Individual absolute fecundity of the smelt in the Uda varies from 11300 to 141300 eggs, on average 52500 eggs in 2016 and 50400 eggs in 2007; these values are close to the smelt fecundity in the Ulbeya and Inya rivers. …”
Get full text

Chronic kidney disease in patients with long-term type 1 diabetes mellitus by M. I. Yevloyeva, M. S. Arutyunova, A. S. Severina, N. P. Trubitsyna, N. V. Zaitseva, M. S. Shamhalova, M. V. Shestakova

“…BACKGROUND: Patients with type 1 diabetes mellitus (T1D) have an earlier age of onset and a longer course of the disease, already by middle age they have the development of microand macrovascular diabetic complications that reduce the quality and duration of life.AIM: To evaluate the prevalence of chronic kidney disease (CKD) and other late complications of T1D depending on renal dysfunction in the population of patients with T1D with disease duration of 20 and more years, who underwent examination and treatment in Endocrinology Research Centre.MATERIALS AND METHODS: A one-stage single-center epidemiological non-randomised study was conducted using the database of Endocrinology Research Centre with the study of 500 patients’medical histories with long-term T1D (20 years and mores), without kidney damage and with CKD at different stages (CKD C1–C5, C5D, after transplantation), examined and treated from 2011 to 2023.RESULTS: Normal renal function was observed in 10.8% of patients (n=54). …”
Get full text

CRYPTO-RESISTANT METHODS AND RANDOM NUMBER GENERATORS IN INTERNET OF THINGS (IOT) DEVICES by Petro Klimushyn, Tetiana Solianyk, Oleksandr Mozhaiev, Yurii Gnusov, Oleksandr Manzhai, Vitaliy Svitlychny

“…Research methods: method of structural and functional analysis of RNG and IoT devices, cryptographic methods of information protection, methods of random sequence generation, method of stability analysis of systems, methods of construction of autonomous Boolean networks and Boolean chaos analysis, methods of quality assessment of random sequences. …”
Get full text

Genicular Nerve Ultrasound-Guided Cryoanalgesia for the Treatment of Chronic Knee Joint Pain: An Observational Retrospective Study by Giuliano Lo Bianco, Francesco Paolo D’angelo, Guillherme Ferreira Dos Santos, Agnes Stogicza, Matteo Luigi Giuseppe Leoni, Andrea M. Trescot, Robert Jason Yong, Christopher L. Robinson

“…Outcome measures included the Visual Analog Scale (VAS, 0–10) for pain intensity, the Western Ontario and McMaster Universities Arthritis Index (WOMAC, 0–100) for assessing pain, stiffness, and physical function related to OA, the Douleur Neuropathique en 4 Questions (DN4, 0–10) for neuropathic pain, and the EuroQol 5-Dimension (EQ-5D, 0–100) for quality of life. …”
Get full text

Proteomic Landscape of Small Extracellular Vesicles Derived From Gastric Juice and Identified TFF2 as a Specific Biomarker by Fan R, Wu K, Yang J, Zhu B, Jiang T, Liu Y, Yuan B, Liu L, Sun Y, Sun X, Liu L, Luo W, Zhou C, Guo Y, Liu L

“…Multi-omics analysis indicated that the functions of gsEVs carrying TFF2 were primarily associated with inflammation and cancer.Conclusion: The UC method is suitable for isolating gsEVs, particularly for mass spectrometry-based proteomic analysis. …”
Get full text

Analisis Kualitas Website Balai Besar Taman Nasional Gunung Gede Pangranggo (BBTNGGP) menggunakan Metode Webqual 4.0 by Muhammad Syahid Qadhafi, Atit Pertiwi

“…In carrying out its duties and functions, the Gunung Gede Pangranggo National Park Center (BBTNGGP) continues to strive to provide services, information and education to the public and visitors. …”
Get full text

Metabolomics and proteomics insights into hepatic responses of weaned piglets to dietary Spirulina inclusion and lysozyme supplementation by Cátia Falcão Martins, Manolis Matzapetakis, David M. Ribeiro, Josipa Kuleš, Anita Horvatić, Nicholas Guillemin, Peter David Eckersall, João P. B. Freire, André M. Almeida, José A. M. Prates

“…Together, Spirulina and lysozyme demonstrate potential as functional dietary components, but further optimization is needed to fully realize their benefits without compromising growth performance.…”
Get full text

FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma by Yuan Hepei, Zeng Jun, Khan Muhammad, Wang Baiyao, Hu Xiaoshan, Wei Hao, Wang Zhaotong, Yuan Yawei

“…FNDC5 was markedly upregulated in cancer cells, and western blot confirmed its elevated protein levels (p < 0.001). Functional assays following FNDC5 knockdown in SW480 and HCT116 cells demonstrated efficient silencing by qPCR and western blot, significantly reduced cell viability (CCK-8 assay), and impaired colony formation, supporting its role as a potential oncogene in colorectal cancer. …”
Get full text

Primary heart failure with preserved ejection fraction: The intertwined pathophysiology and treatment of some of the most relevant phenotypes by Ryohei Ono, Luiz Menezes Falcão

“…Some of the main pathophysiological mechanisms for each phenotype of primary HFpEF are as follows: arterial hypertension, which promotes left ventricular hypertrophy and fibrosis; obesity, which contributes through systemic inflammation and metabolic dysregulation; aging, which leads to ventricular-vascular stiffening; gender differences, with women experiencing changes due to smaller heart size and hormonal shifts; ID, which affects mitochondrial function; CAD, which impairs myocardial blood flow; diabetes, which is associated with hyperglycemia, lipotoxicity, insulin resistance, and microvascular rarefaction; CKD, which leads to hypertension, metabolic disturbance, systemic inflammation, and endothelial dysfunction; sleep apnea, which induces cardiac changes through pressure swings and hypoxia; and chronotropic incompetence, which is due to reduced cardiac β-receptor responsiveness. …”
Get full text

Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes by Wenxu Wang, Wenxu Wang, Jincheng Lu, Jincheng Lu, Ningyun Pan, Ningyun Pan, Huiying Zhang, Jingcen Dai, Jie Li, Cheng Chi, Liumei Zhang, Liang Wang, Mengying Zhang, Mengying Zhang

“…We further performed gene set variation analysis (GSVA), functional enrichment analysis, and immune cell infiltration analysis to investigate differences between the identified AD subtypes. …”
Get full text

The Paleochrono-1.1 probabilistic model to derive a common age model for several paleoclimatic sites using absolute and relative dating constraints by F. Parrenin, M. Bouchet, C. Buizert, E. Capron, E. Corrick, R. Drysdale, K. Kawamura, A. Landais, R. Mulvaney, I. Oyabu, S. O. Rasmussen

“…Paleochrono-1.1 is based on the inversion of an archiving model: a varying deposition rate (also named growth rate, sedimentation rate or accumulation rate) and also (for ice cores) a lock-in depth of air (since, in the absence of significant surface melt, the air is trapped in the ice at about 50–120 m below the surface) and a thinning function (since glacier ice undergoes flow). Paleochrono-1.1 integrates several types of chronological information: prior knowledge of the archiving process, independently dated horizons, depth intervals of known duration, undated stratigraphic links between records, and (for ice cores) <span class="inline-formula">Δ_depth</span> observations (depth differences between events recorded synchronously in the gas and solid phases of a certain core). …”
Get full text

Differential Expression Characteristics of Two Isoforms <i>nr5a2f</i> and <i>nr5a2m</i> in Gonadal Differentiation of Chinese Giant Salamanders, <i>Andrias davidianus</i> by Dan Hu, Guanglve Li, Guohua Zou, Jiaqing Xu, Wenyin Luo, Qiaomu Hu

“…These results suggested that <i>Nr5a2</i>f and <i>Nr5a2m</i> exhibited different expression patterns in the process of sex differentiation, which provided a foundation for further functional characterizations.…”
Get full text

Comparative Study of Fish Diversity in Wanquan River Based on Environmental Technology and Traditional Fishing Gear Survey Methods by Jun LEI, Yuanyuan SU, Lianzheng YIN, Ruohan ZENG, Ping LI, Yongqiang QIN, Xingwei CAI, Xiaoping DIAO

“…The rapid economic development of the Wanquan River basin has seriously affected the ecological function of fish in the basin owing to human activities such as dam dredging and highways. …”
Get full text