Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.) by Junxuan Zhu, Ming An, Weiting Wang, Jingjing Guo, Mengting Chen, Longlong Fang, Cen Wang, Dong Zhang, Guodong Wu

“…At the molecular level, RT-qPCR analysis demonstrated that Zhicaowu significantly suppressed hepatic CYP1a2, CYP2d2, CYP3a1, and CYP2c11 mRNA expression, while Hezi co-treatment restored their expression to normal or elevated levels.ConclusionHezi dose-dependently induced CYP450 enzyme activity, reversing Zhicaowu’s inhibition of CYP1a2/2d2/3a1/2c11 and markedly improving liver function and histopathology. These results elucidate the scientific basis for toxicity reduction in Zhicaowu-Hezi herb pair through metabolic enzyme regulation, supporting its traditional use. …”
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ACTIVE, ACTUATED, AND ASSISTIVE: A SCOPING REVIEW OF EXOSKELETONS FOR THE HANDS AND WRISTS by Angel Galbert, Arjan Buis

“…The design and method of device function of 121 devices were analysed. Muscle and joint movement detection were highly used to control device movement. …”
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Usnic acid and tannic acid as inhibitors of coccidia and Clostridium perfringens: alleviating necrotic enteritis and improving intestinal health in broiler chickens by Huiping Xu, Minghao Yang, Jianyang Fu, Huiyuan Lv, Jiang Guo, Changji Lu, Zengpeng Lv, Yuming Guo

“…Both usnic acid alone and in combination with tannic acid alleviate NE-induced adverse effects in broilers by modulating intestinal immunity, altering the microbial composition, and improving intestinal barrier function. Compared with usnic acid alone, the combination of usnic acid and tannic acid had superior effects, providing a promising basis for the development of effective feed additive combinations.…”
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CO13 | Genetic background in hypercholesterolemic patients framing cardiovascular risk

“…Many FH subjects (about 60%) did not demonstrate functional mutations in major candidate genes (LDLR, APOB, PCSK9, LDLRAP1). …”
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Harnessing metabolomics for enhanced crop drought tolerance by Ali Raza, Muhammad Anas, Savita Bhardwaj, Rakeeb Ahmad Mir, Sidra Charagh, Minhas Elahi, Xinyue Zhang, Reyazul Rouf Mir, Wolfram Weckwerth, Alisdair R. Fernie, Kadambot H.M. Siddique, Zhangli Hu, Rajeev K. Varshney

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Epidemiology of Disability of Adult Population in the Russian Federation by S. N. Puzin, M. A. Shurgaya, N. V. Dmitrieva, G. E. Pogosyan, I. V. Lyalina, A. M. Mammaraeva, T. A. Ivanova, L. S. Idrisova

“…The accumulation of impaired functions of organs and systems helps to reduce the adaptive capacity of the body and is associated with limited life, which entails an increase in the risks of disability in the elderly and the need for medical and social rehabilitation. …”
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Vascular access and survival of patients with hemodialysis: features of cause-effect relationship by A. B. Zulkarnaev, N. M. Fominykh, Z. B. Kardanakhishvili

“…Within the patients with diabetes mellitus, the use of CVC is associated with a deterioration of the adjusted survival rate even with subsequent successful conversion to functional AVF. Patients with systemic processes (vasculitis, myeloma, HIV-associated nephropathy, renal neoplasms, etc.) have low predicted survival rate disregarding the type of vascular access (there are no significant differences between the types of vascular access). …”
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Network and systems biology approaches help investigate gene regulatory interactions between Salmonella disease and host in chickens: Model‐based in silico evidence combined with g... by Reza Tohidi, Hoda Javaheri Bargourooshi, Arash Javanmard

“…To start, we used free computational tools and online bioinformatics resources, including predicting gene function using a multiple association network integration algorithm (geneMania), the Kyoto Encyclopedia of Genes and Genomes, the Annotation, Visualization and Integrated Discovery (DAVID) database and the stimulator of interferon genes. …”
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Development of an interpretable machine learning model for frailty risk prediction in older adult care institutions: a mixed-methods, cross-sectional study in China by Weizi Wu, Li Jing, Qing Peng, Peng Hua, Zeng Shumei, Luofang Lv, Liqing Yue, Hu Jian zhong, Huang Weihong

“…Hyperparameter optimisation was performed using stratified fivefold cross-validation with grid search, incorporating class-weighted loss functions to address class imbalance and model-specific regularisation techniques to maximise performance while preventing overfitting. …”
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Novel pyrochlores in the Bi2O3–MgO–Ta2O5 (BMT) system: Synthesis optimisation, phase equilibria and dielectric properties by K.B. Tan, P.Y. Tan, Y. Feng, C.C. Khaw, V. Raman, H.C. Ananda Murthy, R. Balachandran, S.K. Chen, O.J. Lee, K.Y. Chan, D. Zhou, M. Lu

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Enhancing access to specialist appointments in tertiary healthcare in Shanghai, China: a structured reservation pathway using digital health technologies by Li Li, Tao Zheng, Enhong Dong, Minjie Chen, Xiaojing Zhao, Binyuan Zhang, Xuji Zhao, Weijun Shao, Yiling Fan

“…Objective The aim of this study is to develop, implement the precise reservation path (PRP) and investigate its prediction function for scheduling shunting patients for specialist appointment registration in Shanghai, China.Design The PRP system was built on the hospital’s existing information system, integrated with WeChat (WeCom) for user convenience. …”
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Molecular Profiling, Characterization and Antimicrobial Efficacy of Silver Nanoparticles Synthesized from <em>Calvatia gigantea</em> and <em>Mycena leaiana</em> Against Multidrug-R... by Sayab Khan, Muhammad Fiaz, Iqbal Ahmad Alvi, Muhammad Ikram, Humaira Yasmin, Junaid Ahmad, Amin Ullah, Zeeshan Niaz, Shubana Hayat, Ajaz Ahmad, Prashant Kaushik, Arshad Farid

“…In addition, SEM results showed the cubic morphology of <i>C. gigantea</i> with a diameter of 65 nm, and the FTIR spectra of fruiting body revealed the presence of functional groups—carboxyl, nitro, and hydroxyl—in AgNPs, which catalyzed the reduction of Ag+ to Ag0. …”
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Evaluating the Possibility of Replacing Non-Wood Core in the Make of Wooden Sandwich Panel to Reduce the Consumption of Wood Resources, Preserve the Environment and Human Health by Pantea Omrani, Hosein Rangavar, Afshin Rahmati Tula Rud-e Pain

“…On the other hand, due to the very high physical and mechanical properties of cross-linked polyethylene foam, its use in the core of a wood sandwich panel creates a wide variety of functionalities for the made sandwich panels. The various properties of cross-linked polyethylene foam, such as thermal strength (against heat and cold), chemical strength, strength to the growth of fungi and insects, non-toxicity, proper dimensional stability, moisture and sound insulation, compatibility with the environment and being free from harmful gases, quick and easy installation, and ease of transportation, have led to its many applications in various industries. …”
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Flavor formation and phospholipids degradation of crayfish meat treated by boiling combined air-frying during accelerated storage by Mingzhu Zhou, Dongyin Liu, Hongyuan Tan, Chao Wang, Wei Yu, Guangquan Xiong, Lan Wang, Wenjin Wu, Yu Qiao

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Prevalence of hitherto unknown brain meningioma detected on 68Ga-DOTATATE positron-emission tomography/computed tomography in patients with metastatic neuroendocrine tumor and expl... by Rahul V Parghane, Sanjay Talole, Sandip Basu

“…Following177Lu-DOTATATE PRRT, posttreatment functional and structural imaging response evaluation of the meningiomas were undertaken by 68Ga-DOTATATE PET/CT, MRI, or CT brain, respectively, along with clinical neurological evaluation. …”
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HilD-regulated chemotaxis proteins contribute to Salmonella Typhimurium colonization in the gut by Kendal G. Cooper, Laszlo Kari, Audrey Chong, Naman Tandon, Kathleen Doran, Lidiane Gomes Da Silva, Diane C. Cockrell, Arden Baylink, Olivia Steele-Mortimer

“…We found that the conserved cysteine is required for McpA function in the mouse gut, thus demonstrating a virulence role for the CZB Zn2+-binding site during infection.IMPORTANCEThe gut-adapted bacterium Salmonella Typhimurium causes inflammatory diarrhea via a process that involves active invasion of intestinal epithelial cells, secretion of inflammatory molecules, and recruitment of immune cells. …”
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Effects of Incremental Shuttle Walk Test on Maximal Oxygen Consumption and Comfort in Patients with Coronary Artery Disease Undergoing Phase 3 Cardiac Rehabilitation by Mutarobin Mutarobin, Tutiany Tutiany

“…Coronary artery disease (CAD) is a condition characterized by impaired cardiac function due to a reduced blood supply to the myocardial tissue, resulting from narrowing or obstructing of the coronary arteries. …”
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Groundwater level effects on greenhouse gas emissions from undisturbed peat cores by Erne Blondeau, Gerard L. Velthof, Marius Heinen, Rob F.A. Hendriks, Anneke Stam, Jan J.H. van den Akker, Monne Weghorst, Jan Willem van Groenigen

“…Groundwater level (GWL) management has been proposed to mitigate peat oxidation, but may lead to increased emissions of nitrous oxide (N2O) and methane (CH4).The aim of this experiment was to study trade-offs between greenhouse gas emissions from peat soils as a function of GWL. We incubated 1 m deep, 24 cm diameter undisturbed bare soil cores, after removal of the grass layer, from three contrasting Dutch grassland peat sites for 370 days at 16 °C. …”
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Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors by Kai Wang, Xin Zhang, Yufei Fan, Liang Zhou, Yajun Duan, Su Li, Zhongkan Sun, Chunqian Zhang, Haoyu Yang, Wenxiu Yuan, Linyuan Peng, Xiaoyu Ma, Siliang Xiang, Tianzhi Wang, Mei Yang, Zhenyuan Zhang, Jiaxuan Wang, Zhongyuan Wang, Minxian Qian

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Lipozyme TLIM催化大豆磷脂乙醇解制备溶血磷脂 "Preparation of lysophospholipids through ethanolysis of soybean phospholipids catalyzed by Lipozyme TLIM" by 许晓欣，杨国龙，孟鹏程，杨瑞楠，刘伟 XU Xiaoxin, YANG Guolong, MENG Pengcheng, YANG Ruinan, LIU Wei

“…In order to improve the functional properties of soybean phospholipids and expand their applications, lysophospholipids was prepared by Lipozyme TLIM catalyzed ethanolysis of soybean phospholipids, the effects of reaction time and substrate mass concentration on ethanolysis reaction were examined by single factor test,and the optimal process conditions were obtained using response surface methodology. …”
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