Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model by Wei PS, Chou PY, Hsu HY, Chen M, Chen YJ, Tsai TH, Wen BY, Sheu MT, Chuang KH, Lin HL

“…Meanwhile, in vivo pharmacokinetics, anti-tumor efficacy studies, and T-cell tracking studies were conducted to analyze the advantages of nsTPPgels included D2gel and DTgels.Results: The cytotoxicity of BiPTE against PSMA-overexpressing tumor cells and the drug release functionality of nsTPPgels were validated in vitro. Rheological studies showed that both D2gel and DTgels remained in solution below 27 °C for easy injection and solidified at physiological temperatures to form localized depots for sustained BiPTE release. …”
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Relationship between different methods of visualization of hip joint lesions in patients with axial spondyloarthritis during a two-year observational study by E. M. Agafonova, Sh. Erdes

“…As for other clinical manifestations of the disease at the time of inclusion in the study, among 77 patients, 75% had peripheral arthritis, and after 2 years – only about 39% (p<0.05). The patient’s functional index (BASFI) was initially 3.3, and after 2 years it decreased down to 1.3 (p<0.05).Results. …”
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Analysing the contribution of trees and green spaces to household nutrition security in eThekwini, KwaZulu-Natal, South Africa by Qhelile Ntombikayise Bhebhe, Qhelile Ntombikayise Bhebhe, Muthulisi Siwela, Temitope O. Ojo, Temitope O. Ojo, Simphiwe Innocentia Hlatshwayo, Simphiwe Innocentia Hlatshwayo, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi, Rob Slotow, Mjabuliseni S. C. Ngidi, Mjabuliseni S. C. Ngidi, Mjabuliseni S. C. Ngidi

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FATAL CASE OF DENGUE HEMORRHAGIC FEVER DURING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION by ACM Coli, LGD Paolo, AC Cordeiro, VDA Bovolenta, JS Filho, JS Filho, MV Batista, MV Batista

“…The patient developed anisocoria, worsening of renal function, acute hepatitis, high fever, and exams were requested to investigate hemophagocytic lymphohistiocytosis triggered by Dengue. …”
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EEG-fMRI neurofeedback versus motor imagery after stroke, a randomized controlled trial by Simon Butet, Mathis Fleury, Quentin Duché, Elise Bannier, Giulia Lioi, Lou Scotto di Covella, Emilie Lévêque-Le Bars, Anatole Lécuyer, Pierre Maurel, Isabelle Bonan

“…Thirty stroke survivors, exhibiting partial upper-limb motor impairment with a Fugl-Meyer Assessment Upper Extremity score (FMA-UE) > 21 and partially functional corticospinal tract (CST) were randomly allocated to the NF and MI groups. …”
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AIM2 activation mediated by RIPK1/3-dependent mitochondrial DNA release drives Aβ1−40-Induced retinal pigment epithelium injury by Xiaoxu Huang, Tongqi Li, Guanran Zhang, Jieqiong Chen, Tong Li, Shiqi Yang, Qiyu Bo, Xiaohuan Zhao, Xiaoling Wan, Xinyue Zhu, Bo Yu, Xiaodong Sun, Junran Sun

“…Fundus photography, electrophysiology and hematoxylin-eosin staining were used to evaluate the morphological and functional RPE damage. Transcriptome sequencing was used to detect the differentially expressed genes between Aβ1-40 group and control group. …”
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Ameliorative Effects of Selenium-Containing Proteins and Peptides from Selenium-Enriched Cardamine L. against Ulcerative Colitis in Mice by MENG Yao, HE Ziyan, LUO Ying, ZHANG Zhong, LI Jianke, YUAN Li

“…Conclusion: SePro and SePP have preventive and ameliorative effects against DSS-induced ulcerative colitis in mice by repairing colonic mucosal injury, inhibiting inflammatory response, enhancing colonic barrier function, and regulating the balance of gut microbiota. …”
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CH25H Promotes Autophagy and Regulates the Malignant Progression of Laryngeal Squamous Cell Carcinoma Through the PI3K‐AKT Pathway by Zhenfei Xiang, Senquan Yu, Yuxin Xu, Huacai Xiong, Danfei Hu, Qun Li, Zhenhua Wu

“…Intersection genes were taken from the above three datasets. To confirm the function of genes, we overexpressed and knocked down genes in cells and treated them with autophagy agonist Rapamycin and PI3K‐AKT pathway inhibitor. …”
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On Rough Parametric Marcinkiewicz Integrals Along Certain Surfaces by Mohammed Ali, Hussain Al-Qassem

“…We establish the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mi>L</mi><mi>p</mi></msup></semantics></math></inline-formula>-boundedness of these integrals when the kernel functions lie in the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mi>L</mi><mi>q</mi></msup><mrow><mo>(</mo><msup><mi mathvariant="double-struck">S</mi><mrow><mi>m</mi><mo>−</mo><mn>1</mn></mrow></msup><mo>)</mo></mrow></mrow></semantics></math></inline-formula> space. …”
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Analyzing power errors in the optical pumping system of atomic spin comagnetometers by Jiale QUAN, Ye LIU, Longyan MA, Wenfeng FAN, Wei QUAN

“…The study concludes that the magneto-optical nonorthogonality of the comagnetometer introduces a differential component into the power transfer function. As a result, within the device’s operational bandwidth, the output signal is approximately proportional to the pumping power. …”
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Effects of Electroacupuncture Preconditioning at Baihui and Zusanli Acupoints on the Expression of Inflammatory Factors in Brain and Intestines of Rats with Cerebral Ischemia/Reper... by ZHANG Jiyao, TANG Qiang, ZHU Luwen

“…Before surgery for one day, after reperfusion for 12 h and after reperfusion for 1,3,7 days, the grip tester was used to measure the forelimb grasping strength; after reperfusion for 7 days, ELISA methods was used to determine the content of IL-17A and IL-10 in serum, Western blot method was used to detect the expression of IL-17A and IL-10 protein in ischemic cortex and colon tissue, immunohistochemistry method was used to calculate the average optical density (AOD) value of IL-17A and IL-10 in ischemic cortex and colon tissue, and HE staining method was used to observe the pathological change of ischemic cortex.Results① Forelimb grasping strength: compared with the S-con group, the forelimb grasping strength of rats in the M-con group after reperfusion for 12 h, 1 d, 3 d, 7 d was decreased significantly (<italic>P</italic>&lt;0.05); compared with the M-con group, the forelimb grasping strength of rats in the EP group was increased significantly (<italic>P</italic>&lt;0.05). ② Content of IL-17A and IL-10 in serum: after reperfusion for 7 days , compared with the S-con group, the content of serum IL-17A and IL-10 of rats in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the content of serum IL-17A in the EP group were significantly decreased (<italic>P</italic>&lt;0.05), and IL-10 in the EP group were significantly increased (<italic>P</italic>&lt;0.05). ③ Expression of IL-17A and IL-10 protein: after reperfusion for 7 days, compared with the S-con group, the expression of IL-17A and IL-10 protein in ischemic cortex and colon tissue in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the expression of IL-17A in the EP group was significantly decreased (<italic>P</italic>&lt;0.05), and the expression of IL-10 protein in the EP group was significantly increased (<italic>P</italic>&lt;0.05). ④ AOD value of IL-17A and IL-10: after reperfusion for 7 days, compared with the S-con group, the AOD value of IL-17A and IL-10 in ischemic cortex and colon tissue in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the AOD value of IL-17A in the EP group was significantly decreased (<italic>P</italic>&lt;0.05), the AOD value of IL-10 in the EP group was significantly increased (<italic>P</italic>&lt;0.05). ⑤ Pathological change of ischemic cortex: after reperfusion for 7 days, compared with the M-con group, the pathological change of ischemic cortex in EP group was significantly decreased (<italic>P</italic>&lt;0.05).ConclusionElectroacupuncture preconditioning at Baihui and Zusanli acupoints can reduce the pathological damage degree of the ischemic cortex and intestinal-central inflammation, improve neurobehavioral function, which may be related to brain-gut protection.…”
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Reversing cardiac hypertrophy and heart failure using a cardiac targeting peptide linked to miRNA106a by Ming Lu, Siqi Cai, Kyle Korolowicz, Claire Deng, Kaan Taskintuna, Gerard Ahern, Raymond B. Yurko, Kazi R. Islam, Bryn Schoonover, Jack B. Lopuszynski, Hongkun Wang, Maliha Zahid, G. Ian Gallicano

“…., hypertension, diabetes mellitus, coronary artery disease, etc.) lead to structural and functional changes in cardiomyocytes, resulting in HF. …”
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Garlic-Derived Exosome-Like Nanovesicles: A Promising Natural Nanotherapy for Periodontitis via PHGDH/PI3K/AKT-Mediated Metabolic and Inflammatory Regulation by Yu C, Liu Y, Yu X, Liu J, Cao P, Liu G, Cai Y, Zhang Y, Luan Q

“…These therapeutic effects were mediated by upregulation of PHGDH, activation of the PI3K/AKT signaling pathway, increased expression of mTOR and Nrf2, and inhibition of NF-κB activity, which together contributed to improved mitochondrial function and metabolic reprogramming under inflammatory conditions.Conclusion: GaELNs demonstrate potent anti-inflammatory, antioxidative, and metabolism-enhancing properties, offering significant therapeutic potential for the treatment of periodontitis by modulating the PHGDH/PI3K/AKT pathway. …”
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Can a New, Satellite Inpatient Hospital Maintain the Efficiency of an Ambulatory Surgery Center with No Difference in Patient-reported Outcomes? A Prospective Study by Vineet M. Desai, BS, Christopher J. DeFrancesco, MD, Morgan E. Swanson, BA, Divya Talwar, PhD, Alexandra Stevens, BS, Nathan Chaclas, BS, David P. VanEenenaam, Jr., BS, Kevin M. Landrum, BS, Akbar N. Syed, MD, Brendan A. Williams, MD, Theodore J. Ganley, MD

“…Key Concepts: (1) A satellite inpatient hospital and ambulatory surgery centers are more time-efficient for adolescent ACL reconstruction than a main, inpatient hospital. (2) There were no differences in patient-reported functional outcomes after adolescent ACL reconstruction among ASCs, a main inpatient hospital, and a satellite inpatient hospital. (3) A satellite inpatient hospital can be as efficient as an ASC, with no significant difference in quality. …”
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Seguimiento de trayectorias de un robot móvil (3,0) mediante control acotado by J.F. Guerrero-Castellanos, M.G. Villarreal-Cervantes, J.P. SaÌnchez-Santana, S. Ramírez-Martínez

“…., Keywords: Mobile robot (3,0), bounded control, nested function, nonlinear control, trajectory tracking.…”
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Combining prelamin A accumulation and oxidative stress: A strategy to target glioblastoma by Maria Vittoria Marvi, Camilla Evangelisti, Camilla Bruna Cerchier, Antonietta Fazio, Irene Neri, Foteini-Dionysia Koufi, William Blalock, Vittoria Cenni, Matteo Zoli, Sofia Asioli, Luca Morandi, Enrico Franceschi, Lucia Manzoli, Cristina Capanni, Stefano Ratti

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The Influence of Zero‐Profile Implant Selection on the Outcomes of Anterior Cervical Discectomy and Fusion by Xing‐Jin Wang, Jun‐Bo He, Ting‐Kui Wu, Bei‐Yu Wang, Xin Rong, Quan Gong, Hao Liu

“…In addition, radiographical analysis encompassed cervical lordosis (CL), functional spinal unit (FSU) angle, range of motion (ROM) of the total cervical spine and the FSU, anterior and posterior FSU height, C1–C7 sagittal vertical axis (SVA), C2–C7 SVA, the center of gravity of the head (CGH)‐C7 SVA as well as T1 slope (T1S) measurements. …”
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Efficacy and acceptability of different blood flow restriction training interventions during the rehabilitation of military personnel with lower limb musculoskeletal injuries: prot... by Alexander N Bennett, Peter Ladlow, Luke Hughes, Nick Caplan, Robert Barker-Davies, Luke Gray, Russ J Coppack, Robyn P Cassidy, Gavin Atkinson, Lauren Bradshaw, Janisha Chauhan, Kieran M Lunt

“…Secondary outcomes include blood biomarkers for inflammation and pain (Phase Two only), injury-specific outcome measures, lower extremity function scale, objective measures of muscle strength and neuromuscular performance, and pressure pain threshold testing.Ethics and dissemination The study is approved by the Ministry of Defence Research Ethics Committee (2318/MODREC/24) and Northumbria University. …”
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Association and shared biological bases between birth weight and cortical structure by Lu Zhang, Qiaoyue Ge, Zeyuan Sun, Rui Zhang, Xinxi Li, Xiaoli Luo, Run Tian, Yuheng Cao, Chunyan Pu, Lin Li, Dongsheng Wu, Ping Jiang, Chuan Yu, Chiara Nosarti, Chenghan Xiao, Zhenmi Liu

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Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation by Ying Zhuge, Gonghao Li, Mingyue Sun, Jiajia Zhang, Jiafeng Zou, Feng Gao, Fang Wang

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