Efficiency and safety of the Russian-made KERATOLINK device used to treat patients with stage I–II keratoconus and pellucid marginal corneal degeneration by A. T. Khandzhyan, E. N. Iomdina, A. V. Ivanova, A. S. Sklyarova, N. V. Khodzhabekyan, I. V. Manukyan

“…The analysis of various UVCL programs revealed no difference in the recovery period and showed comparable clinical and functional results. Conclusion. The new KERATOLINK device is shown to be effective and safe in the treatment of stage I–II keratoconus and PMCD. …”
Get full text

Assessing the role of Chemokine (C–C motif) ligand 14 in AKI: a European consensus meeting by Jay L. Koyner, Christian Arndt, Jaume Baldira Martinez de Irujo, Sílvia Coelho, Manuel Garcia-Montesinos de la Peña, Luca di Girolamo, Michael Joannidis, Pablo Jorge-Monjas, Christian Koch, Steven Lobaz, Alain Meyer, Marlies Ostermann, Nicoletta Pertica, John R. Prowle, Jon Silversides, Alexander Zarbock, Jorge Echeverri, Kai Harenski, Lui G. Forni

Get full text

Predictive value of urinary triggering receptors expressed on myeloid cells-1 on contrast-induced nephropathy after percutaneous coronary intervention by Lai Dong-yan, Wei Yin, Mo Chang-gan, Bei Xiao-na, Wei Guang-suo, Sun Wei-dong, Wei Gang, Liang Cheng-yuan

“…ObjectiveTo evaluate the predictive value of urinary soluble triggering receptors expressed on myeloid cells-1 （sTREM-1） on contrast-induced nephropathy （CIN） after percutaneous coronary intervention （PCI）.MethodsPatients undergoing PCI were divided into two groups of CIN （<italic>n</italic>=21） and non-CIN （<italic>n</italic>=179） according to the occurrence of CIN.Serum creatinine，estimated glomerular filtration rate （eGFR） and urinary sTREM-1 were compared between two groups.The correlation between urinary sTREM-1，serum creatinine and eGFR were analyzed.And early diagnostic value of urinary sTREM-1 in CIN was examined.ResultsAge ［（71.48±8.51）year <italic>vs</italic>（62.92±9.16）year］ and diabetic rate （57.15% <italic>vs</italic> 34.64%） of CIN group were significantly higher than those in non-CIN group （<italic>P</italic>&lt;0.05）.At 4 h、24 h、48 h post-operation，urinary sTREM-1 ［（111.02±14.73） ng/L <italic>vs</italic> （47.45±10.36） ng/L，（123.81±28.51） ng/L <italic>vs </italic>（49.29±12.46） ng/L，（134.69±30.37） ng/L <italic>vs </italic>（45.31±9.48） ng/L］ of CIN group was significantly higher than that of non-CIN group （<italic>P</italic>&lt;0.05）.At 4 h、24 h post-operation，serum creatinine and eGFR showed no significant inter-group differences （<italic>P</italic>&gt;0.05）.At 48 h post-operation，serum creatinine ［（89.05±21.13） <italic>vs</italic> （63.42±12.42） μmol/L］ of CIN group was significantly higher than that of non-CIN group （<italic>P</italic>&lt;0.05）； eGFR ［（76.28±21.89） mL·min^-1·（1.73m²）^-1<italic>vs </italic>（112.94±30.46） mL·min^-1·（1.73m²）^-1］ of CIN group was significantly less than that of non-CIN group （<italic>P</italic>&lt;0.05）.Urinary sTREM-1 was positively correlated with serum creatinine （<italic>P</italic>&lt;0.05） while urinary sTREM-1 negatively correlated with eGFR （<italic>P</italic>&lt;0.05）.Receiver operator characteristic （ROC） analysis showed that AUC of urinary sTREM-1 was 0.740 （95% <italic>CI</italic>：0.482-0.998） at 4 h post-operation； the sensitivity and specificity for diagnosing CIN were 62.6% and 73.5% at a cut-off level of 89.0 ng/L.AUC of urinary sTREM-1 was 0.931（95% <italic>CI</italic>：0.868-0.994） at 24 h post-operation and the sensitivity and specificity diagnosing CIN were 86.6% and 73.8% at a cut-off level of 98.0 ng/L.AUC of urinary sTREM-1 was 0.948 （95% <italic>CI</italic>：0.894-1.001） at 48 h post-operation and the sensitivity and specificity for diagnosing CIN were 87.9% and 88.4% at a cut-off level of 108.0 ng/L.ConclusionUrinary sTREM-1 may reflect the early changes of renal function after PCI.It has an excellent value in the early diagnosis of CIN.…”
Get full text

El Flujo espiratorio Máximo y la Fuerza de prensión Manual predicen la salud ósea de niños y adolescentes (Maximum expiratory flow and handgrip strength predict bone health in chi... by Fernando Alvear-Vasquez, Rossana Gomez-Campos, Paz Pezoa-Fuentes, Camilo Urra-Albornoz, Javiera Caceres-Bahamondes, Cristian Luarte-Rocha, Jose Sulla-Torres, Marco Antonio Cossio-Bolaños

“…These results suggest that both parameters can serve as indicators of functional aptitude to identify bone fragility among children and adolescents. …”
Get full text

Isolated “on-pump” tricuspid valve repair through right-sided anterolateral thoracotomy by modified femoral-monocaval cannulation in patients with repeated heart intervention – a s... by V. V. Osaulenko, V. O. Hubka, K. O. Chmul, R. I. Budahov

“…Indications for isolated surgery on the tricuspid valve should be based on reliable echocardiographic parameters of the right heart function.…”
Get full text

The genetic history of Portugal over the past 5,000 years by Xavier Roca-Rada, Roberta Davidson, Matthew P. Williams, Vanessa Villalba-Mouco, António Faustino Carvalho, Shyamsundar Ravishankar, Evelyn Collen, Christian Haarkötter, Leonard Taufik, Daniel R. Cuesta-Aguirre, Catarina Tente, Álvaro M. Monge Calleja, Rebecca Anne MacRoberts, Linda Melo, Gludhug A. Purnomo, Yassine Souilmi, Raymond Tobler, Eugénia Cunha, Sofia Tereso, Vítor M. J. Matos, Teresa Matos Fernandes, Anne-France Maurer, Ana Maria Silva, Pedro C. Carvalho, Bastien Llamas, João C. Teixeira

Get full text

Multifunctional Poly(Acrylic Acid)-Coated EuBiGd2O3 Nanocomposite as an Effective Contrast Agent in Spectral Photon Counting CT, MRI, and Fluorescence Imaging by Ibrahim YO, Maalej N, Raja AY, Qurashi A, Rahmani M, Venkatachalam T, Abdullah O, Paterson HJ, Das G, Bradley CC, Nasser RA, Pitsalidis C

“…Yusuf O Ibrahim,1,2 Nabil Maalej,1,2 Aamir Younis Raja,1 Ahsanulhaq Qurashi,3 Mohamed Rahmani,4,8 Thenmozhi Venkatachalam,4 Osama Abdullah,5 Haidee J Paterson,5 Gobind Das,1 Curtis C Bradley,1 Rasha A Nasser,6 Charalampos Pitsalidis1,7,8 1Department of Physics, Khalifa University of Science and Technology, Abu Dhabi, 127788, United Arab Emirates; 2Functional Biomaterials Group, Khalifa University of Science and Technology, Abu Dhabi, 127788, United Arab Emirates; 3Department of Chemistry, Khalifa University of Science and Technology, Abu Dhabi, 127788, United Arab Emirates; 4Department of Biological Sciences, College of Medicine & Health Sciences, Khalifa University, Abu Dhabi, 127788, United Arab Emirates; 5Core Technology Platform Operations, New York University Abu Dhabi, Abu Dhabi, 129188, United Arab Emirates; 6Department of Biomedical Engineering and Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, 127788, United Arab Emirates; 7Advanced Research and Innovation Center (ARIC) Khalifa University, Abu Dhabi, 127788, United Arab Emirates; 8Center for Biotechnology, Khalifa University, Abu Dhabi, 127788, United Arab EmiratesCorrespondence: Nabil Maalej, Email nabil.maalej@ku.ac.aeIntroduction: Recently, diagnostic methods based on multimodal and non-invasive imaging, such as MRI and CT scanners, have been developed for accurate cancer diagnosis. …”
Get full text

Antioxidant, Anti-Alzheimer’s, anticancer, and cytotoxic properties of peanut oil: in vitro, in silico, and GC-MS analysis by Hanène Djeghim, Hanène Djeghim, Djamila Benouchenne, Djamila Benouchenne, El Hassen Mokrani, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum

Get full text

miRNA let-7f-5p-encapsulated labial gland MSC-derived EVs ameliorate experimental Sjögren’s syndrome by suppressing Th17 cells via targeting RORC/IL-17A signaling axis by Yufei Xie, Maosheng Chai, Yixiao Xing, Peiru Zhou, Pan Wei, Hong Hua

“…These small RNAs are essential for EV-mediated functions, particularly in regulating gene expression and modulating the immune microenvironment. …”
Get full text

Dermatoglifia y Somatotipo en Jugadores de Voleibol del Departamento del Huila en los XX Juegos Deportivos Nacionales Colombia (Dermatoglyphia and Somatotype in Volleyball Players... by Oscar Alfredo Montenegro Arjona, Oscar Leonardo Cordoba Urriago, Angie Carolina Calderón Sterling, Cristian Javier Mendez Parra, Gian Carlos Tovar Osso

“…The volleyball team is classified in class IV of the dermatoglyphic and somatic functional index; where, the low presence of arches and a higher count of loops are typical of sports due to the dominance of power, coordination, and endurance. …”
Get full text

The family caregiver’s discourse on the hospitalization of the elderly with Alzheimer’s disease O discurso do cuidador familiar sobre a hospitalização do idoso com doença de Alzhei... by Gabriela Pizelli Mocco Grillo, Aline Miranda da Fonseca Marins, Rosâne Mello

“…Results: Two summary central ideas emerged: worsening of cognitive function in the elderly with Alzheimer disease during the process of hospitalization and the lack of health staff to take care of an elderly with dementia. …”
Get full text

M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer by Eva M Garrido-Martin, Toby W P Mellows, James Clarke, Anusha-Preethi Ganesan, Oliver Wood, Angelica Cazaly, Gregory Seumois, Serena J Chee, Aiman Alzetani, Emma V King, Gareth Thomas, Peter S Friedmann, Pandurangan Vijayanand, Tilman Sanchez-Elsner

“…Protein expression of genes characteristic of M1-like (chemokine (C-X-C motif) ligand 9) or M2-like (matrix metallopeptidase 12) functions was confirmed by confocal microscopy. Immunohistochemistry related the distribution of TAM transcriptomic signatures to density of CD8+ tissue-resident memory T cells (TRM) in tumors and survival data from an independent cohort of 393 patients with lung cancer.Results TAMs have significantly different transcriptomic profiles from NTAMs with &gt;1000 differentially expressed genes. …”
Get full text

Diegetic Invisible/Vanishing in Silent Cinema and its Origins / Диегетическое исчезающее/невидимое в немом кино и его корни by SALNIKOVA EKATERINA V. / САЛЬНИКОВА Е.В.

“…In adventure and adventure-fantasy films, this motif performs a whole set of functions. Using the example of several films, I uncover its rich semantic potential. …”
Get full text

Dexamethasone effects on the expression and content of glycosylated components of mouse brain tissue by S. D. Aladev, D. K. Sokolov, A. V. Strokotova, G. M. Kazanskaya, A. M. Volkov, M. O. Politko, A. I. Shahmuradova, E. E. Kliver, A. Y. Tsidulko, S. V. Aidagulova, E. V. Grigorieva

“…However, even a single use of Dex significantly increased the content of total as well as highly sulfated glycosaminoglycans in the mouse brain tissue, which can lead to the changes in the composition and structure of the brain tissue, as well as its functional characteristics.…”
Get full text

Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma by Ge Zhang, Zhenfa Zhang, Lianmin Zhang, Guangyao Zhou, Pengpeng Zhang, Dingli Wang, Shuai Jiang

“…Significantly, suppression of B4GALT2 was found to enhance CD8+ T lymphocyte populations and their functional status, thereby potentiating anti-programmed cell death protein 1 immunotherapeutic efficacy in animal studies. …”
Get full text

Leveraging RRT^*: Probabilistically Interpreted Mechanisms Enhanced With P-HOPE and FLEX-OPT for Complex Path Planning by Yujie Miao, Haiyang Liu, Ziqiang Zhang, Yanju Liang

“…Second, a flexible mechanism FLEX-OPT is developed to adaptively and dynamically adjust the search strategy through real-time feedback and monitoring of the cost function to tackle the above-mentioned local minima problem, which significantly improves the convergence speed and path quality of the algorithm. …”
Get full text

A Cost Effectiveness Analysis of Spinal Cord Stimulation versus Conventional Medical Management for the Treatment of Low Back Pain Using Data from DISTINCT RCT and Medical Claims f... by Deer T, Heros R, Scarfo K, Gilligan C, Jameson J, Pilitsis JG, Desai MJ, Panchalingam T, Goates S, Benison AM, Okaro U, Falowski S

“…HCU data covered physical therapy, chiropractic therapy, massage therapy, occupational therapy, acupuncture, injection treatments, radiofrequency ablation procedures, and opioid and anticonvulsant usage.Results: The DISTINCT study demonstrated superior outcomes in pain relief, function, and other symptoms with SCS compared to CMM in the treatment of persistent (at least 6 months) low back pain. …”
Get full text

Modelo de aprendizaje para la selección de un proyecto diseño-construcción (llave en mano) en el sector público A learning model for design-build project selection in the public se... by Alfonso Bastias, Keith R Molenaar

“…This model adjusts parameters and functions using artificial intelligence as the main knowledge engine. …”
Get full text

Development and Validation of a Risk Prediction Model Based on Inflammatory and Nutritional Composite Indicators for Posthepatectomy Liver Failure Following Radical Resection of He... by Li J, Chen M, Cai W, Yin D

“…A comparison was made of the predictive efficacy of the nomogram prediction model and the associated composite liver function score. ROC curves were plotted for the nomogram prediction model, Child-Pugh score and ALBI score, and AUC values were calculated, which were 0.686 (95% CI 0.635– 0.737) for the prediction model, 0.558(95% CI 0.512– 0.603) for the Child-Pugh score. …”
Get full text

Decision-Making Process of Home and Social Care Professionals Using Telemonitoring of Activities of Daily Living for Risk Assessment: Embedded Mixed Methods Multiple-Case Study by Renée-Pier Filiou, Mélanie Couture, Maxime Lussier, Aline Aboujaoudé, Guy Paré, Sylvain Giroux, Hubert Kenfack Ngankam, Patricia Belchior, Carolina Bottari, Kevin Bouchard, Sébastien Gaboury, Charles Gouin-Vallerand, Faustin Armel Etindele Sosso, Nathalie Bier

“… BackgroundOlder adults with cognitive deficits face difficulties in recalling daily challenges and lack self-awareness, impeding home care clinicians from obtaining reliable information on functional decline and home care needs and possibly resulting in suboptimal service delivery. …”
Get full text