Effect of L-Citrulline on Creatine Kinase MM (CK-MM) Isoenzymes in Mice: An In Vivo Study Focusing on Immunohistochemistry Analysis by Dhoni Akbar Ghozali, Annisa Aghnia Rahma, Shafira Nur Hanifa, Muhana Fawwazy Ilyas

“…This study contributes valuable insights into the multifaceted benefits of L-citrulline supplementation for supporting overall muscle health and performance by identifying its protective effects under different mechanisms, including improved blood flow, antioxidant activity, enhanced mitochondrial function, and promotion of muscle protein synthesis.   …”
Get full text

Model for predicting risk of developing drug-induced liver injury during remdesivir therapy: observational prospective open case-control study by Yu. V. Shevchuk, A. V. Kryukov, I. I. Temirbulatov, I. V. Sychev, K. B. Mirzaev, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, V. I. Vechorko, O. V. Averkov, D. A. Sychev

“…According to a number of studies, the incidence of adverse reactions during remdesivir therapy reaches 66%, with the most common is an increase in liver function tests.The aim of the work was to study the influence of clinical, demographic and pharmacogenetic factors on the development of drug-induced liver damage during remdesivir therapy in COVID-19 patients.Materials and methods. …”
Get full text

People’s Behavior of North Indralaya of Ogan Ilir Against Wetland Fires by Dany Hernowo, Mona Lestari, Novrikasari Novrikasari, Widya Lionita, Adisyah Fitrah Rahmadini, Titi Nurhaliza

“…ABSTRACT Land conversion from its original function resulted in negative impacts in the form of fires due to logging activities to clear land by humans. …”
Get full text

Silicone kyphoplasty (elastoplasty) versus traditional cement kyphoplasty for osteoporotic vertebral fractures. Does this new technique reduce the complications? by R. Luque, D. Garríguez, P. Checa Betegon, M. Sanchez, J.L. Perez Gonzalez, I. Dominguez Esteban

“…Clinical, radiological and functional results (Oswestry) and quality of life and (EQ-5D) were analyzed and compared between both groups, focusing on differences in subsequent fractures in adjacent levels. …”
Get full text

ZYGOMYCOSIS IN IMMUNOCOMPROMISED NON-HAEMATOLOGICAL PATIENTS by George Petrikkos, Miranda Drogari-Apiranthitou

“…<span style="mso-spacerun: yes;">  </span>The most important risk factors include neutropenia or functional neutropenia, diabetic ketoacidosis, iron overload, major trauma, prolonged use of corticosteroids, illicit intravenous drug use, neonatal prematurity, malnourishment, and pre-exposure to antifungal agents with no activity against zygomycetes, such as voriconazole and caspofungin.…”
Get full text

Hypoxia-Induced Differences in the Expression of Pyruvate Dehydrogenase Kinase 1-Related Factors in the Renal Tissues and Renal Interstitial Fibroblast-like Cells of Yak (Bos Grunn... by Manlin Zhou, Jun Wang, Ruirui Cao, Fan Zhang, Xuehui Luo, Yiyuan Liao, Weiji Chen, Haie Ding, Xiao Tan, Zilin Qiao, Kun Yang

“…Hypoxia is one of the factors severely affect renal function, and, in severe cases, it can lead to renal fibrosis. …”
Get full text

miR‐92a aggravates metabolic syndrome via KLF2/miR‐483 axis by Zhe Zhao, Chaofeng Ma, Longzhi Wang, Yuhang Xia, Jun Li, Wei Yang, Juan Pang, Hui Ding, Haifeng Wang, Liang Bai, Fenqing Shang, Feng Zhang

“…KLF2 is the target gene of miR‐92a, which can increase the production of miR‐483, miR‐483 acts on its target genes CTGF, ET‐1, and β‐catenin to protect cell function. EC miR‐92a is secreted out of cells into the blood, circulates through the blood to the liver, and continues to exert its biological effects after being absorbed by hepatocytes. …”
Get full text

Yield performance and optimal nitrogen and phosphorus application rates in wheat and faba bean intercropping by Jing-xiu XIAO, Ying-an ZHU, Wen-lian BAI, Zhen-yang LIU, Li TANG, Yi ZHENG

“…Thus, it was concluded that modulated N and P rates could maximize the economic and ecological functions of intercropping. Based on the results, rates of 150 kg Nha–1 and 60 kg P2O5 ha–1 are recommended for IW production in southwestern China and places with similar conditions.…”
Get full text

Novel Algorithm to Estimate Fat‐Free Muscle Volumes in Women Using the Urinary Deuterated‐Creatine Dilution Method by Darren Yuen Zhang Tan, Wei Fun Cheong, Shanshan Ji, Amaury Cazenave‐Gassiot, Jane Cauley, Liang Shen, Eu‐Leong Yong

“…ABSTRACT Background Muscle mass declines after menopause and is a key risk factor for frailty, falls and poor physical function as women age. The deuterated creatine (D3Cr) dilution method provides a direct assessment of muscle mass, but its accuracy in Asian women has not been evaluated. …”
Get full text

Evaluation of MODIS and VIIRS BRDF Parameter Differences and Their Impacts on the Derived Indices by Chenxia Wang, Ziti Jiao, Yaowei Feng, Jing Guo, Zhilong Li, Ge Gao, Zheyou Tan, Fangwen Yang, Sizhe Chen, Xin Dong

“…Currently, the Moderate Resolution Imaging Spectroradiometer (MODIS) and Visible Infrared Imaging Radiometer Suite (VIIRS) teams have successively applied the Ross–Li kernel-driven bidirectional reflectance distribution function (BRDF) model to integrate multi-angle observations to produce long time series BRDF model parameter products (MCD43 and VNP43), which can be used for the inversion of various surface parameters and the angle correction of remote sensing data. …”
Get full text

Association between SGLT-2 inhibitors and suicide risk in type 2 diabetes and bipolar: a real-world cohort study by En-Wei Chang, Jing-Yang Huang, Shih-Chang Lo, Chien-Ning Huang, Chien-Ning Huang, Chien-Ning Huang, Yi-Sun Yang, Yi-Sun Yang, Edy Kornelius, Edy Kornelius

“…Subgroup analyses stratified by age, sex, race, glycemic control (HbA1c), kidney function (eGFR), and baseline lithium use revealed no evidence of increased suicide risk in any subgroup. …”
Get full text

Evaluasi Sistem Informasi Menggunakan Technology Acceptance Model dengan Penambahan Variabel Eksternal by Ria Andriani, Arief Setyanto, Asro Nasiri

“…KRS (Study Plan Card) functions to manage courses that will be taken in the relevant semester by students, filling in KRS using the account given by the campus by entering using an identity in the form of a Student Identification Number and password, students can fill in the Card Study Plan from anywhere with information that has been provided on the website, so that it can be said that the Card Study Plan System is a bridge between students and managers in this case the academic section at the University of Amikom. …”
Get full text

Novel predictive biomarkers for atonic postpartum hemorrhage as explored by proteomics and metabolomics by Jiangxue Qu, Hai Jiang, Huifeng Shi, Nana Huang, Jiawen Su, Yan Zhang, Lian Chen, Yangyu Zhao

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) functional enrichment analysis of significantly differentially expressed proteins revealed that atonic PPH was associated with T cell- and macrophage-related immune inflammatory responses. …”
Get full text

The dynamics of the content of immunoglobulins in the blood serum of piglets according to the actions of immunostimulating agents by N. Yu. Krempa, O. V. Kozenko, B. V. Gutyj, I. V. Dvyliuk, N. V. Magrelo, H. V. Sus, V. V. Voroniak, A. O. Vysotskyi, U. M. Vus, T. V. Martyshuk

“…The effectiveness, specificity, and mechanism of action of these agents is based on the ability of their components, particularly Ig Y, to bind to pathogens or their fragments, to neutralize and safely remove them from the body, which helps to increase the barrier function of the intestinal mucosa. The obtained research results confirm the practicality of using Globigen® Pig Doser and Globigen® Jump Start immunostimulants during single-phase rearing of piglets to increase the level of non-specific resistance and obtain healthy young animals with a high level of viability.…”
Get full text

Virtual reality-assisted rehabilitation for postoperative C5 palsy: a pilot exploratory randomized controlled trial by Kyung-Soo Suk, Jinyoung Park, Taeyeon Choi, Byung Ho Lee, Yongjin Ahn, Sunung Yun, Si Young Park, Hak Sun Kim, Seoung-Hwan Moon, Ji-Won Kwon

“…Depression scores (HADS-D) and anxiety scores (HADS-A) also trended lower in the VR group, particularly at 24 weeks (HADS-D: 4.0 vs. 9.5; p = 0.067). Functional metrics, including maximum arm elevation (from 90.0 cm to 145.0 cm) and apple placement count (from 25 to 55 per session), improved markedly in the VR group. …”
Get full text

Hypoxic cancer-associated fibroblast exosomal circSTAT3 drives triple negative breast cancer stemness via miR-671-5p/NOTCH1 signaling by Lu Yang, Siyuan Zhao, Xu Liu, Yuchen Zhang, Shaorong Zhao, Xuan Fang, Jin Zhang

“…Exosomes were characterized via transmission electron microscopy (TEM), dynamic light scattering (DLS), and marker profiling (CD63⁺/TSG101⁺/Alix⁺, calnexin⁻). Functional effects of hypoxic CAF exosomes on TNBC cells (MDA-MB-231, SUM159) were assessed through proliferation/migration assays, stemness/epithelial-mesenchymal transition (EMT) marker analysis, and siRNA-mediated circSTAT3 knockdown. …”
Get full text

A New Formulation and Code to Compute Aerodynamic Roughness Length for Gridded Geometry—Tested on Lidar-Derived Snow Surfaces by Rachel A. Neville, Patrick D. Shipman, Steven R. Fassnacht, Jessica E. Sanow, Ron Pasquini, Iuliana Oprea

“…By calculating <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>z</mi><mn>0</mn></msub></semantics></math></inline-formula> as a function of these two parameters, we demonstrate the sensitivity of the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>z</mi><mn>0</mn></msub></semantics></math></inline-formula> value to these parameter choices. …”
Get full text

Digital Therapeutics in China: Comprehensive Review by Nan Jiang, Xiru Yu, Yuxi Yang, Guanqiao Li, Chanchan He, Man Ping Wang, Yih Chung Tham, Tien Yin Wong, Keqin Rao

“…Meta-analysis for cognitive disorder DTx showed significant improvement in global cognitive function in DTx-treated participants (SMD 0.65, 95% CI 0.37-0.94), despite notable heterogeneity (I²=71.7%). …”
Get full text

Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs by Aidan C. Manning, Mahmoud M. Bashir, Kyle Rapchak, Calyssa J. Huff, Ariana R. Jimenez, Sheila Gonzalez, Courtney L. Woodruff, Heather E. Upton, Kathleen Collins, Todd M. Lowe, Jessica M. Tucker

“…In addition, mounting evidence supports the biological function for tRNA cleavage products, including the control of gene expression during conditions of stress and infection. …”
Get full text

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption by Marta Ferraresso, Shivani Bailey, Luz Alonso‐Crisostomo, Dawn Ward, Christos Panayi, Zachary G. L. Scurlock, Harpreet K. Saini, Stephen P. Smith, James C. Nicholson, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray

“…Here, we investigated the causes and consequences of downregulated miR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p levels in malignant GCTs regardless of age, site, or subtype. …”
Get full text