Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach by Yujia Wang, Yan Di, Yongqi Li, Jing Lu, Bofan Ji, Yuxia Zhang, Zhiqing Chen, Sijie Chen, Bicheng Liu, Rining Tang, Yuanyuan Ji

“…RNA-seq was utilized to profile gene expression changes of ROD. We elucidated the functions of differentially expressed genes (DEGs) using gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and gene set enrichment analysis (GSEA). …”
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Role of Amide Proton Transfer Weighted MRI in Predicting MGMTp Methylation Status, p53-Status, Ki-67 Index, IDH-Status, and ATRX Expression in WHO Grade 4 High Grade Glioma by Faris Durmo, Jimmy Lätt, Anna Rydelius, Elisabet Englund, Tim Salomonsson, Patrick Liebig, Johan Bengzon, Peter C. M. van Zijl, Linda Knutsson, Pia C. Sundgren

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Angiopoietin II in Critically Ill Septic Patients: A Post Hoc Analysis of the DRAK Study by Veronika Bucher, Helen Graf, Johannes Zander, Uwe Liebchen, Danilo Hackner, Caroline Gräfe, Martin Bender, Michael Zoller, Christina Scharf

“…Conclusion: Increased CRP, positive fluid balance, and impaired kidney function were associated with higher Ang-II concentrations in critically ill patients in the early stage of sepsis in this post hoc analysis. …”
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Hilbert–Huang transform and spectrum-weighted reconstruction integration for millimeter wave radar-based heart rate detection by Hao CUI, Luyao LIU, Hao CHEN, Wendong XIAO

“…By extracting the intrinsic mode functions corresponding to the HR range and designing a spectral weighting reconstruction method, we segment and enhance the HR range, because of which respiratory harmonics and noise interference in the heartbeat signal are further suppressed, thereby improving the resolution of HR detection. …”
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Anti-idiotypic antibodies specific to steroid hormones and proliferative activity of tumor in breast cancer patients by A. N. Glushkov, E. G. Polenok, S. A. Mun, L. A. Gordeeva, A. V. Antonov, P. V. Bairamov, N. E. Verzhbitskaya, G. I. Kolpinsky

“…Antiidiotypic antibodies against monoclonal antibodies, specific to estradiol, showed similar agonist activity. However, the function of auto-antibodies against progesterone receptor (PR) remained unknown. …”
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Tae-miR396b regulates TaGRFs in spikes of three wheat spike mutants by Ziping Yao, Qi Wang, Ying Xue, Zhiheng Liang, Yongjing Ni, Yumei Jiang, Peipei Zhang, Ting Wang, Qiaoyun Li, Lei Li, Jishan Niu

“…This study laid foundation for further elucidating functions of tae-miR396b and TaGRFs underlying wheat spike development. …”
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Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics by Christine Ecker, Charlotte M. Pretzsch, Johanna Leyhausen, Lisa M. Berg, Caroline Gurr, Hanna Seelemeyer, Grainne McAlonan, Nicolaas A. Puts, Eva Loth, Flavio Dell’Aqua, Luke Mason, Tony Charman, Bethany Oakley, Thomas Bourgeron, Christian Beckmann, Jan K. Buitelaar, Celso Arango, Tobias Banaschewski, Andreas G. Chiocchetti, Christine M. Freitag, Elke Hattingen, Dilja Krueger-Burg, Michael J. Schmeisser, Jonathan Repple, Andreas Reif, Declan G. Murphy

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Nuclear factor erythroid 2-related factor 1 regulates the expression of proteasomal genes in ketotic cows and protects mammary cells against free fatty acid–induced endoplasmic ret... by Taiyu Shen, Shijie Xia, Muhammad Usman, Xinyi Xu, Juan J. Loor, Chuang Xu

“…In nonruminants, loss of nuclear factor erythroid 2-related factor 1 (NFE2L1) results in ER stress. The physiological functions and molecular mechanisms controlled by NFE2L1 in bovine mammary tissue are poorly understood. …”
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Excess costs of transgender and gender-diverse people with gender incongruence and gender dysphoria compared with people from the general population in Germany: a secondary analysi... by Judith Dams, Hans-Helmut König, Thomas Grochtdreis, Peer Briken, Alexander Konnopka, Janis Renner, Arne Dekker, Timo Nieder

“…Self-reported healthcare services utilisation was valued by standardised unit costs for the German healthcare system, and absenteeism from work and unemployment were valued with the gross hourly wage of persons in manufacturing and services sectors.Settings TGD people with GIC/GD living at least 50 km outside Hamburg in the federal state Bremen, Mecklenburg-Western Pomerania, Lower Saxony or Schleswig Holstein and the German general adult population.Participants Treatment-seeking TGD people with GIC/GD (n=167) and people of the general German population (n=2811).Primary and secondary outcome measures 6-month excess healthcare costs and indirect costs from a societal perspective were calculated for the year 2020 using two-part models with logit specification for the first part and a generalised linear model with gamma family and log link function for the second part.Results The total 6-month excess costs associated with GIC/GD from a societal perspective were estimated to be €672 (95% CI: €−3315 to €4657; p=0.741) per person. …”
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Development of a Customizable Web-Based Dashboard for Remote Blood Pressure Monitoring: Feasibility and Usability Implementation Study by Joshua Wollen, Thuy Nguyen, Charles Coton, Gina DeWildt, Gabretta Cooksey, Audrey Cohen, Nicholas Hoang, Munachi Okpala, Michael Gonzalez, Mengxi Wang, Chigozirim Izeogu, Elmer Bernstam, Charles Green, Sean Savitz, Jose-Miguel Yamal, Anjail Sharrief

“…The system demonstrated high functionality in addressing patient-, provider-, and system-specific needs, supporting effective BP monitoring and intervention delivery. …”
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Evaluating the Influence of Different Artificial Diets on <i>Apis mellifera</i> L. Using Health Biomarkers and Performance Metrics by Shams Ul Islam, Muhammad Anjum Aqueel, Muhammad Usman Yousuf, Asim Abbasi, Muhammad Yasin, Rashid Iqbal, Muhammad Fahim Raza, Aqsa Parvaiz, Nazih Y. Rebouh

“…To address this issue, three previously evaluated diets (selected from seven) were tested to assess their effects on <i>A. mellifera</i> using key health biomarkers (immune function, stress response) and performance metrics (foraging activity, honey quality, and social interactions). …”
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Unsupervised machine learning to identify subphenotypes among cardiac intensive care unit patients with heart failure by Jacob C. Jentzer, Yogesh N.V. Reddy, Sabri Soussi, Ruben Crespo‐Diaz, Parag C. Patel, Patrick R. Lawler, Alexandre Mebazaa, Shannon M. Dunlay

“…These differences in mortality between phenotypes were consistent when patients were stratified based on demographics, aetiology, admission diagnoses, mortality risk scores, shock severity and systolic function. One‐year mortality occurred in 31.5% and differed between the phenotypes: uncomplicated, 11.9% (reference); inflamed, 26.8% [adjusted hazard ratio (HR) 1.56 (1.27–1.92), P < 0.001]; iron‐deficient, 33.8% [adjusted HR 2.47 (2.00–3.04), P < 0.001]; cardiorenal, 41.2% [adjusted HR 2.41 (1.97–2.95), P < 0.001]; and hypoperfused, 52.3% [adjusted HR 3.43 (2.82–4.18), P < 0.001]. …”
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COMPARATIVE EVALUATION OF THE LABORATORY STUDY RESULTS OF THE ADHESION STRENGTH OF A-SILICONE LINING MATERIAL IN THE PRODUCTION OF TWO-LAYER REMOVABLE PROSTHESES by I. Yanishen, P. Zapara, О. Fedotova

“…The risk of negative influence of unsuccessful selection of dental materials reveals the urgent need to use modern approaches in professional activity in order to provide the necessary quality of structures and their clinical and functional properties. The purpose of the study is to improve the quality of orthopedic treatment of patients with removable structures with an obturating part with two-layer bases due to the scientific substantiation of the selection of both soft substrates and acrylic plastics. …”
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A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression by Hongxia Zhao, Hongxia Zhao, Lingge Huang, Jian Liu, Min Feng, Yeqian Liu, Hong Li, Shan Gong, Chunming Chen, Shuiqing Zeng, Weiqiong Ren

“…Vascular endothelial function and inflammatory levels were assessed using fluorescent probes and enzyme-linked immunosorbent assays. …”
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Comparative Transcriptome Analysis of Two Types of Rye Under Low-Temperature Stress by Haonan Li, Jiahuan Zhao, Weiyong Zhang, Ting He, Dexu Meng, Yue Lu, Shuge Zhou, Xiaoping Wang, Haibin Zhao

“…For example, genes in the “hydrogen catabolic process” pathway may be involved in regulating cellular redox balance, which is crucial for maintaining cell function under cold stress.…”
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Effect of Resistance Training on Hepatic Bile Acid, beta-Klotho Protein and Expression of Farnesoid X Receptor, Fibroblast Growth Factor 15 and Fibroblast Growth Factor Receptor 4... by Mehri Gholipour, Najme Rezaeian, Mohammad Karimi, Sadegh Cheragh-Birjandi

“…Recent studies describe bile acids as messenger molecules with diverse functions that have a wide range of receptors in the body. …”
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hNIS-based imaging to monitor treatment with the novel oncolytic virus CF33-hNIS-antiPDL1 in humans with advanced triple negative breast cancer by Jamie Rand, Dave Yamauchi, Shyambabu Chaurasiya, Jianying Zhang, Supriya Deshpande, Leslie Chong, Amanda Seiz, Hans Meisen, Yuman Fong, Yuan Yuan

“…CF33-hNIS-antiPDL1-infected tumor cells express functional human sodium iodide symporter (hNIS) and are visible by single-photon emission computed tomography (SPECT) or positron emission tomography (PET). …”
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KiKli Fit: Investigating the Implementation of a Physical Activity Program in Pediatric Cancer by Lars Rehbein, Ann Christin Schneider, Christina Hillebrech, Christina Schindera, Amika Singh, Katharina Eva, Valentin Benzing

“…The mediational role of executive functions for the relationship between motor ability and academic performance in pediatric cancer survivors. …”
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THE IMMUNOCOMPETENCE OF THE LYMPHOCYTIC POOL OF PERIPHERAL BLOOD IN ACUTE PURULENT LYMPHADENITIS IN CHILDREN by P.I. Tkachenko, S.O. Bilokon, N.M. Lokhmatova, O.B. Dolenko, K.Yu. Rezvina, Yu.V. Popelo

“… The substantial prevalence of different nosological forms of lymphadenitis in children is due to morpho-functional immaturity and age-related features of the structural components of the lymph node. …”
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Tracking Clinical Competency Growth: A Longitudinal Study of Medical Students in a Multidisciplinary Emergency Department Internship Program by Sung TC, Shih HI, Kawaguchi T, Chi CH, Hsu HC

“…These findings underscore the importance of sustained, structured clinical experiences in preparing students to function effectively within interdisciplinary healthcare teams. …”
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