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4861
Advances in application of ultrasound in diagnosis of diabetic nephropathy
Published 2025-06-01“…Ultrasound elastography provides a new dimension for assessing renal fibrosis by quantitatively measuring tissue stiffness. In DN patients, shear wave velocity (SWV) exhibits a characteristic pattern of "initial increase followed by decrease", which may correlate with histopathological staging. …”
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4862
“Sensitive and sustainable stability-indicating RP-HPLC method for simultaneous assay and impurity profiling of amitriptyline HCl: green metric, RGB model and forced degradation st...
Published 2025-06-01“…The method showed excellent linearity for amitriptyline hydrochloride, with a quantitation range of 0.12–1.67 μg/mL for impurity determination and 255.49–766.48 μg/mL for assay linearity. …”
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4863
Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells
Published 2025-04-01“…Results The application of RA facilitated the efficient generation of NNE within a six-day period. …”
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4864
Overexpression of the apple expansin-like gene MdEXLB1 accelerates the softening of fruit texture in tomato
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4865
TransLIBS-CRS: Integrating LIBS with transfer learning for accurate cross-regional soil total nitrogen detection
Published 2025-12-01“…This approach offers a feasible solution for large-scale and efficient soil TN detection.…”
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4866
A comprehensive review of diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) techniques in protonic ceramic cells (PCCs): Current status and future perspective
Published 2025-09-01“…Protonic ceramic cells (PCCs) have emerged as a promising technology for power generation, energy storage, and value-added chemical synthesis, offering benefits such as fuel flexibility, low emissions, and efficient operation at intermediate temperatures (300–600 °C). …”
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4867
Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters
Published 2025-09-01“…ASO-N1 induced a sustained reduction in viral RNA and inflammatory cytokine expression in the nasal mucosa and efficiently decreased infectious viral titers in nasal swabs at day 3 post infection. …”
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4868
Talent Management Pattern Finding with a Succession Approach Using the Met-asynthesis Method
Published 2025-03-01“…Technology and data-related job positions, such as data scientists and quantitative analysts, are among the most in demand, which means that large banks, for example, will face new competition for talent (Whysall et al, 2019). …”
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4869
AI-based carbon peak prediction and energy transition optimization for thermal power industry in energy-intensive regions of China
Published 2025-01-01“…Leveraging multi-source data-driven AI models, this study efficiently provided reliable quantitative support for measuring policies with various priorities, emphasizing the necessity of implementing balanced energy transition strategies. …”
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4870
Assessment of the global healthcare industry during COVID-19 pandemic: A content analysis approach [version 2; peer review: 2 approved]
Published 2024-04-01“…Therefore, there is need for the development of a more efficient technology-driven healthcare management system. …”
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4871
A two-parameter damage-controlled strength model to predict the fracturing of brittle rock mass at great depth
Published 2025-12-01“…This study provides a significant benchmark for predicting the progressive fracturing of brittle rock masses in deep tunnels, as well as for regulating safe and efficient site construction progress.…”
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4872
An effective fluorescence strategy based on xanthine oxidase catalysis and the carbon dots’ specific response to ·OH for aminophylline pharmacokinetic studies
Published 2025-08-01“…Aminophylline (AMP), a xanthine-derived bronchodilator with a narrow therapeutic window, requires timely plasma concentration monitoring and pharmacokinetic (PK) studies for safe medication. However, efficient and sensitive detection methods remain limited. …”
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4873
Influence of the Processing Method on the Nano-Mechanical Properties and Porosity of Dental Acrylic Resins Fabricated by Heat-Curing, 3D Printing and Milling Techniques
Published 2025-07-01“…<b>Methods:</b> The hardness, elasticity, and stiffness measurements were performed by the nano-metric indentation method (nanoindentation), and the quantitative morphological characterization of the porosity of the acrylic resin samples obtained by 3D printing and CAD/CAM milling was performed by micro-computed tomography. …”
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4874
N-Glycoside of Indolo[2,3-<i>a</i>]pyrrolo[3,4-<i>c</i>]carbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking S...
Published 2024-12-01“…<b>Background/Objectives:</b> Indolo[2,3-<i>a</i>]pyrrolo[3,4-<i>c</i>]carbazole scaffold is successfully used as an efficient structural motif for the design and development of different antitumor agents. …”
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4875
Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enabl...
Published 2025-08-01“…In this review, we highlight how biophysics-inspired prediction tools combined with advanced deep learning algorithms, such as AlphaFold2 (AF2), can help efficiently infer the conformational heterogeneity and dynamics of RdRps. …”
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4876
Effects of a Complex Feed Additive on Productivity and Blood Parameters of Laying Hens Using Stochastic Fractal-based Neural Network Model
Published 2025-06-01“…It also contributed to the calculation of bioconsolidation index values for each variant, i.e., a quantitative assessment of the physiological/biochemical blood descriptors, depending on diet. …”
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4877
Random forest algorithm integrated with an initial basic feasible solution in buckling analysis of a two-dimensional functionally graded porous taper beam
Published 2025-01-01“…The proposed method offers a scalable, accurate, and computationally efficient tool for analyzing complex functionally graded porous taper beam, overcoming the limitations of classical beam theories and numerical solvers. …”
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4878
An Optimization Method for Multi-Robot Automatic Welding Control Based on Particle Swarm Genetic Algorithm
Published 2024-10-01“…The results demonstrated that the optimized production line significantly improved efficiency while maintaining safety standards.…”
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4879
Heterogeneous expression of long noncoding RNA RP11-109D20.2: Insights into regulatory gene expression roles in colon cancer
Published 2025-05-01“…Objective(s): Colorectal cancer is one of the deadliest cancers worldwide, which can be prevented and even cured by early diagnosis and more efficient treatment modalities. Comprehensive transcriptional analysis has highlighted the importance of lncRNAs in CRC tumorigenesis. …”
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4880
Numerical Simulation of Dynamic Response of Slab-Column Structures under Fire-Explosion Coupled Effects
Published 2025-01-01“…A critical knowledge gap exists in quantitatively understanding these coupled effects and the governing parameters that influence the structural behavior. …”
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