dVP_FAM—development and evaluation of a transsectoral digital care platform for individuals with familial cancer risks: study protocol for a multi-centre, cluster-randomised, mixed... by K. Klein, F. Kendel, S. Schüürhuis, K. Neumann, C. Kowalski, P. Thomas, T. Reinhold, U. Felbor, S. Stegen, C. Schmid, N. Mehrhof, S. Asmussen, F. Diel, M.A. Feufel, D. Speiser

“…Secondary outcomes include improvements in care efficiency, patient empowerment, and health-related quality of life. …”
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Applications of machine learning in potentially toxic elemental contamination in soils: A review by Yan Li, Bao Xiang, Tianyang Wang, Yinhai He, Xiaoyang Liu, Yancheng Li, Shichang Ren, Erdan Wang, Guanlin Guo

“…From these findings, ML techniques, through their powerful data processing capabilities, provide new perspectives and tools for the efficient assessment and management of soil PTEs contamination.…”
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AlphaBind, a domain-specific model to predict and optimize antibody–antigen binding affinity by Aditya A. Agarwal, James Harrang, David Noble, Kerry L. McGowan, Adrian W. Lange, Emily Engelhart, Miranda C. Lahman, Jeffrey Adamo, Xin Yu, Oliver Serang, Kyle J. Minch, Kimberly Y. Wellman, David A. Younger, Randolph M. Lopez, Ryan O. Emerson

“…These models enable efficient in silico prescreening and optimization of antibody candidates. …”
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LLM in the Loop: A Framework for Contextualizing Counterfactual Segment Perturbations in Point Clouds by Veljka Kocic, Niko Lukac, Dzemail Rozajac, Stefan Schweng, Christoph Gollob, Arne Nothdurft, Karl Stampfer, Javier del Ser, Andreas Holzinger

“…By leveraging the reasoning capabilities of LLMs, we generate perturbations that are not only computationally efficient but also semantically meaningful. The proposed framework undergoes rigorous evaluation, combining human inspection of LLM-generated suggestions with quantitative analysis of semantic classification model performance across different LLM variants. …”
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Orchestrated Cu2+-coordinated tetracycline-porphyrin self-assembly remodels tumor microenvironment for photo-enhanced immuno-chemodynamic therapy by Xianbin Sun, Xinyi Wang, Xudong Li, Ya Wang, Ruofei Xu, Xinyi Shen, Ding Tan, Jingjing Liao, Haijun Chen, Yu Gao, Jianping Zheng

“…These findings provide key insights into developing orchestrated metal-coordinated nanotherapeutics by repurposing existing therapeutic agents, enabling the design of multifunctional systems that integrate efficient chemodynamic activity, TME remodeling, and immune activation for effective nanodynamic therapy.…”
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A promoter library for tuning gene expression in Cupriavidus necator under autotrophic conditions by Wataru Kitagawa, Wataru Kitagawa, Kensuke Igarashi, Ryo Nagasawa, Shigeyuki Kakizawa, Mizuki Horino, Kosuke Fujishima, Kosuke Fujishima, Toshiaki Fukui, Souichiro Kato, Souichiro Kato, Souichiro Kato

“…This advancement lays the groundwork for more efficient CO2-based biomanufacturing platforms, contributing to the development of sustainable bioprocesses.…”
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The value of using patient‐reported outcomes for health screening during long‐term follow‐up after paediatric stem cell transplantation for nonmalignant diseases by Joëll E. Bense, Nicole Guilonard, Femke Zwaginga, Anne M. Stiggelbout, Marloes Louwerens, Hilda Mekelenkamp, Arjan C. Lankester, Arwen H. Pieterse, Anne P. J. dePagter

“…Results From the patient‐interviews (N = 15) four themes were extracted: use of PROs (1) help to discuss topics; (2) make the patients feel understood; (3) create a moment of self‐reflection; and (4) make consultations more efficient. Pre‐ and postimplementation analysis of PREMs (N = 40) did not show significant differences in terms of patient‐centeredness. …”
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CRISPR-Cas12a/Aurora Deoxyribozyme Cascade: A Label-Free Ultrasensitive Platform for Rapid <i>Salmonella</i> Detection by Cong Shi, Huimin Tan, Zhou Yu, Weilin Li, Yan Man, Qinghai Zhang

“…This cascade ultimately enables quantitative target analysis through fluorescence signal attenuation. …”
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Risk assessment of an Aedes flavivirus and its effect on pathogenic flavivirus replication in mosquitoes by Yumei Fu, Wan Zhao, Shaohui Wu, Jinqian Li, Qing Liu, Feng Jiang, Hong Lu, Le Kang, Qianfeng Xia, Feng Cui

“…Abstract Background Mosquitoes are efficient vectors of medically significant flaviviruses and serve as hosts for insect-specific flaviviruses (ISFs). …”
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Secondary impacts of the COVID-19 pandemic at a tertiary children’s hospital in Canada: a mixed-methods study by Catherine Diskin, Annie Fecteau, Eyal Cohen, Arpita Parmar, Jeremy Friedman, Blossom Dharmaraj, Tanvi Agarwal, Kelly McNaughton, Alia Sunderji, David Faraoni, Jason Fischer, Jason Maynes

“…Themes including (1) timeliness of care, (2) disruption of patient-centred care, (3) new pressures in the provision of safe and efficient care and (4) inequity in the experience of the COVID-19 pandemic emerged, each impacting patients, their families and healthcare providers.Conclusion Being aware of the breadth of the impact of the COVID-19 pandemic across all of the identified themes is important to enable the delivery of timely, safe, high-quality, family-centred paediatric care moving forward.…”
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Dietary creatine improves the growth performance, antioxidant capacity and energy metabolism of common carp (Cyprinus carpio) by activating glucose metabolism and the Nrf2-Keap1 pa... by Meiqi Xing, Xinchi Shang, Longwu Geng, Haijun Wei, Xinghua Che, Xiaodan Shi, Zhengwei Li, Hailong He, Wei Xu

“…The growth data revealed that the addition of 0.5 g/kg creatine significantly increased the weight gain rate (WGR), specific growth rate (SGR), feed efficiency ratio (FER), and protein efficiency ratio (PER) of common carp (P < 0.05). …”
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QTL mapping of seedling biomass and root traits under different nitrogen conditions in bread wheat (Triticum aestivum L.) by Meng-jiao YANG, Cai-rong WANG, Muhammad Adeel HASSAN, Yu-ying WU, Xian-chun XIA, Shu-bing SHI, Yong-gui XIAO, Zhong-hu HE

“…Plant nitrogen assimilation and use efficiency in the seedling's root system are beneficial for adult plants in field condition for yield enhancement. …”
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Heptad green metrics and quality by design tool evaluated chromatography method for content determination of Bexagliflozin in formulation product by Satyajit Raj Nethekar, Phani Raja Kanuparthy, Leela Prasad Kowtharapu, Vishnuvardhana Kishore Polisetti, Pankaj Kumar Lahoti, Sreekantha B Jonnalagadda, Naresh Kumar Katari

“…The study created an eco-friendly, rapid, sensitive, cost-efficient, stability-assessing method for analyzing Bexagliflozin in pharmaceuticals using a RP-UPLC approach. …”
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Anomaly Field Extraction Based on Layered-Earth Model and Equivalent Eddy Current Inversion: A Case Study of Borehole zk506 in Baishiquan, Xinjiang by Yi Yang, Jie Zhang, Qingquan Zhi, Yang Ou, Xingchun Wang, Lei Wang, Junjie Wu, Xiaohong Deng

“…Based on the concept of an equivalent eddy current, anomaly field inversion provides an efficient and rapid inversion method for borehole transient electromagnetic (BHTEM) measurements. …”
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RGB and RGNIR image dataset for machine learning in plastic waste detectionZENODO by Owen Tamin, Ervin Gubin Moung, Jamal Ahmad Dargham, Samsul Ariffin Abdul Karim, Ashraf Osman Ibrahim, Nada Adam, Hadia Abdelgader Osman

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What should be publicly funded in the Colombian health system? A mixed methods study of citizens’ perceptions by Juan Carlos Velasquez, Claudia Marcela Vélez, Diana Patricia Díaz-Hernández, Pamela Velázquez-Salazar, Gilma Hernández-Herrera, Daniel Felipe Patiño-Lugo, Olga Francisca Salazar-Blanco, Leydi Camila Rodríguez-Corredor, Viviana María Vélez-Marín, Anny Julieth Jaramillo-García

“…We performed a content analysis of the interviews, and, for the quantitative strand, we performed a principal component analysis and varimax rotation to identify view patterns. …”
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Suppress or Not to Suppress … CRAFT It: A Targeted Metabolomics Case Study Extracting Essential Biomarker Signals Directly from the Full ¹H NMR Spectra of Horse Serum Sa... by James Chen, Ayelet Yablon, Christina Metaxas, Matheus Guedin, Joseph Hu, Kenith Conover, Merrill Simpson, Sarah L. Ralston, Krish Krishnamurthy, István Pelczer

“…Relatively complicated, yet very efficient experimental methods have been introduced recently (DIRE, JEDI) to suppress the rest of the spectrum, thus allowing measurement of these integrals of interest. …”
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Electrocatalytic detection of Acetaminophen by sodium ferrite by Saima Perveen, Jameel Ahmed Baig, Mohammad Nur-e-Alam, Mohsin Kazi, Shahabuddin Memon, Tasneem Gul Kazi, Khalil Akhtar, Sajjad Hussain

“…The developed electrochemical sensor was found to be efficient for selective and sensitive detection of APN in real samples with quantitative recoveries (> 90 %).…”
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Numerical assessment of ICRF-specific plasma-wall interaction in the new ITER baseline using the SSWICH-SW code by L. Colas, W. Helou, G. Urbanczyk, V. Bobkov, F. Calarco, N. Fedorczak, D. Milanesio, J. Hillairet

“…The simulated target plasma contains 2% of neon ions. These are efficient at sputtering W, already at low accelerating voltages. …”
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Superior biomechanical stability of pedicle screws compared to lateral mass screws: recommendations for bicortical positioning and enhancing bone contact in geriatric C1 vertebrae by Leon-Gordian Leonhardt, Leonie Rörup, Anna Lena Kammal, Michael Hahn, Marc Dreimann, Benjamin Ondruschka, Felix Nikolai von Brackel, Tim Rolvien, Lennart Viezens, Simon von Kroge

“…Conclusions This study suggests that mono- and bicortical positioning of PS is similarly efficient in creating a stable basis for screw fixation in the atlas. …”
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