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Amentoflavone Impedes NF-κB Activation and Mediates Apoptosis Induction in Lung Cancer Cells: An in vitro and in silico exploration
Published 2025-07-01“…Chronic activation of NF-κB triggers activation of its target genes involved in promoting malignancy, metastasis, irregular proliferation of cells, and/or their resistance to programmed cell death. Amentoflavone (AMF) is a biflavonoid with intrinsic ability to modulate key signaling pathways associated with homeostatic and non-homeostatic conditions impels its exploration as therapeutic candidate against non-small cell lung carcinoma (NSCLC) A549 cells.Objective: This study investigates the anticancer potential of AMF in A549 cells, focusing on its unique dual role in NF-κB suppression and apoptosis induction, and compares its efficacy to the standard drug doxorubicin.Materials and Methods: A549 cells were treated with varying concentrations of AMF for 24 h. …”
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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context
Published 2025-02-01“…Funding: The Boneca laboratory was supported by the following programmes: Investissement d’Avenir program, Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases” (ANR-10-LABX-62-IBEID) and by R&D grants from Danone and MEIJI. …”
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Hepatic immune environment differences among common mouse strains in models of MASH and liver cancer
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Onset of strong Iceland-Scotland overflow water 3.6 million years ago
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Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycinResearch in context
Published 2025-07-01“…Funding: Funding for this study was provided by the National Key Research and Development Program of China (Grant no. 2021YFA1300901).…”
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