Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007... by Leo Anthony Celi, Jonathan Shaffer, Marie-Laure Charpignon, Liam G McCoy, Luis Filipe Nakayama, Jack Gallifant, Urvish Jain, Joao Matos, Pia Gabrielle I Alfonso, Marisa Cobanaj, Amelia Morel Fiske, Alexander J Gates, Frances Dominique V Ho, Mohammad Kashkooli, Naira Link

“…The Genderize.io Application Programming Interface was then used to infer each author’s likely gender based on their extracted first name. …”
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Evidence-based prevention and management of febrile neutropenia in patients undergoing chemotherapy for breast cancer (基于循证的乳腺癌化疗患者粒细胞减少性发热的预防与管理)... by BIAN Guanyue (边关月), CHEN Qian (陈茜), SUN Ling (孙玲)

“…Conclusion The evidence-based quality review program has significantly improved nursing practice in the prevention and management of febrile neutropenia in breast cancer patients undergoing chemotherapy, but it still needs to be reviewed and improved to improve the quality of nursing. …”
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Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trialResearch in... by Sean W.X. Ong, Ruxandra Pinto, Asgar Rishu, Steven Y.C. Tong, Robert J. Commons, John M. Conly, Gerald A. Evans, Michael Fralick, Christopher Kandel, Philippe R.S. Lagacé-Wiens, Todd C. Lee, Sylvain A. Lother, Derek R. MacFadden, John C. Marshall, Valérie Martel-Laferrière, Michael Mayette, Emily G. McDonald, John D. Neary, Josef Prazak, Edward Raby, Adrian Regli, Benjamin A. Rogers, Stephanie Smith, Linda R. Taggart, Han Ting Wang, Terence Wuerz, Dafna Yahav, Paul J. Young, Robert A. Fowler, Nick Daneman, Nick Daneman, Asgar Rishu, Ruxandra Pinto, Benjamin Rogers, Yahya Shehabi, Rachael Parke, Deborah J. Cook, Yaseen Arabi, John Muscedere, Steven Reynolds, Richard Hall, Dhiraj Bhatia Dwivedi, Colin McArthur, Shay McGuinness, Dafna Yahav, Bryan Coburn, Anna Geagea, Pavani Das, Phillip Shin, Michael Detsky, Andrew Morris, Michael Fralick, Jeff E. Powis, Christopher Kandel, Wendy Sligl, Sean M. Bagshaw, Nishma Singhal, Emilie Belley-Cote, Richard Whitlock, Kosar Khwaja, Susan Morpeth, Alex Kazemi, Tony Williams, Derek R. MacFadden, Lauralyn McIntyre, Jennifer L.Y. Tsang, Francois Lamontagne, Alex Carignan, John Marshall, Jan O. Friedrich, Robert Cirone, Mark Downing, Christopher Graham, Joshua Davis, Erick Duan, John Neary, Gerald Evans, Basem Alraddadi, Sameera Al Johani, Claudio Martin, Sameer Elsayed, Ian Ball, François Lauzier, Alexis F. Turgeon, Henry Thomas Stelfox, John Conly, Todd C. Lee, Emily G. McDonald, Richard Sullivan, Jennifer Grant, Ilya Kagan, Paul Young, Cassie Lawrence, Kevin O'Callaghan, Matthew Eustace, Keat Choong, Pierre Aslanian, Ulrike Buehner, Tom Havey, Alexandra Binnie, Josef Prazak, Brenda Reeve, Edward Litton, Sylvain Lother, Anand Kumar, Ryan Zarychanski, Tomer Hoffman, David L. Paterson, Peter Daley, Robert J. Commons, Emmanuel Charbonney, Jean-Francois Naud, Sally Roberts, Ravindranath Tiruvoipati, Sachin Gupta, Gordon Wood, Omar Shum, Spiros Miyakis, Peter Dodek, Clement Kwok, Linda R. Taggart, Stephanie Smith, Karen Doucette, Robert A. Fowler

“…VML is supported by Clinical Research Scholar—Junior 2 program (FRQ-S).…”
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Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v by Ulrich Moebius, Radek Špíšek, David Béchard, Zuzana Antosova, Nada Podzimkova, Irena Adkins, Klara Danova, Ekaterina Simonova, Katerina Behalova, Petr Danek, Matej Fabisik, Kamila Hladikova, Lucie Kosinova, Pavel Marasek, Vladyslav Mazhara, Katerina Sajnerova, Milada Sirova, Marek Kovar, Martin Steegmaier, Hana Matuskova, Iva Malatova, Klara Hrabankova, Denise Greco, Ondrej Martinec, Romana Mikyskova, Milan Reinis, Lenka Palova Jelinkova

“…Background SOT201 and its murine surrogate mSOT201 are novel cis-acting immunocytokines consisting of a humanized/murinized/, Fc-silenced anti-programmed cell death protein 1 (PD-1) monoclonal antibody (mAb) fused to an attenuated human interleukin (IL)-15 and the IL-15Rα sushi+ domain. …”
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Echocardiographic evaluation of myocardial structural and functional changes in patients with stage 5 chronic kidney disease before and after kidney transplantation by M. Sh. Khubutiya, E. V. Shuvalova, O. N. Rzhevskaya, L. T. Khamidova, A. A. Ivannikov, Kh. G. Alidzhanova, A. G. Balkarov, I. V. Dmitriev

“…A retrospective cross-sectional study included 111 individuals of whom 36 patients underwent evaluation for kidney transplant waiting list placement program (Group I), and 51 patients received kidney transplants from deceased donors (Group II). …”
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Possibilities of rehabilitation of the psychological state of children over 10 years old, suffering from acute respiratory diseases, in conditions of war in Ukraine by I.O. Mityuryayeva-Kornijko, Ie.A. Burlaka, T.D. Klets, O.A. Panchenko, A.V. Kabantseva, R.V. Terletskiy

“…The study was carried out as part of the program of outpatient observation of children with various acute manifestations of acute respiratory infections against the background of stress damage to the nervous system due to the war in Ukraine. …”
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Evaluation of Immunogenicity of Inactivated Whole-Virion Booster Vaccine against SARS-CoV-2 in a phase I, II Clinical Trial by I. O. Stoma, E. V. Voropaev, E. I. Mikhailova, K. S. Korsak, O. V. Osipkina, A. V. Molchanova, A. A. Kovalev, D. M. Los, A. A. Ziatskov, A. S. Shaforost, M. N. Yatsuk, A. Yu. Braga, N. V. Trofimova, A. M. Dronina, E. L. Gasich, V. A. Gorbunov, A. Ev. Hancharou

“…Statistical processing of the data was performed using the R programming language.Results. The values of fold change in IgG concentration to SARS-CoV-2 on day 42 and 90 in subjects who received «BelCovidVac» vaccine were significantly higher than those of subjects who received placebo (p=0,05, p=0,02, respectively). …”
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Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation by Pengyu Wang, Weihua Guo, Shuyue Liu, Shouyi Li, Jiaqi Li, Bowen Ding, Fengyi Yin, Yang Yang, Xingjiang Li, Pei Cao, Chaozhe Ma, Wanying Zhang, Yidan Song, Yating Geng, Lantao Liu, Jing Hu, Jihui Hao, Yukuan Feng

“…Recent studies have highlighted the critical role of intratumoral copper levels in regulating the expression of programmed cell death ligand-1 (PD-L1), suggesting that copper-induced cuproptosis not only enhances cancer cell death but may also amplify the effects of anti-PD-L1 antibodies (αPD-L1). …”
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Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study by Aricca D Van Citters, Megan M Holthoff, Colleen Young, Sarah M Eck, Amelia M Cullinan, Stephanie Carney, Elizabeth A O'Donnell, Joel R King, Malavika Govindan, David Gustafson, Stephanie C Tomlin, Anne B Holmes, Ann D Bradley, Brant J Oliver, Matthew M Wilson, Eugene C Nelson, Amber E Barnato, Kathryn B Kirkland

“…Additional work is needed to identify the impact of the network on distress, social connectivity, and support programming.…”
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Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy by Ke Xu, Qingfeng Zhu, Suzanne L Topalian, Robert A Anders, Janis M Taube, Mark Yarchoan, Keziban Ünsal-Kaçmaz, Logan L Engle, Tracee L McMiller, Sepideh Besharati, Junghwa Lee, Feriyl Bhaijee, Alan E Berger

“…Background Gastric carcinomas (GC) are aggressive malignancies, and only ~15% of patients respond to anti-programmed cell death (ligand) 1 (PD-(L)1) monotherapy. …”
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Development, validation, and clinical application of a machine learning model for risk stratification and management of cervical cancer screening based on full-genotyping hrHPV tes... by Binhua Dong, Zhen Lu, Tianjie Yang, Junfeng Wang, Yan Zhang, Xunyuan Tuo, Juntao Wang, Shaomei Lin, Hongning Cai, Huan Cheng, Xiaoli Cao, Xinxin Huang, Zheng Zheng, Chong Miao, Yue Wang, Huifeng Xue, Shuxia Xu, Xianhua Liu, Huachun Zou, Pengming Sun

“…Funding: National Natural Science Foundation of China; Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province, China; Fujian Province Central Government-Guided Local Science and Technology Development Project; Fujian Province's Third Batch of Flexible Introduction of High-Level Medical Talent Teams; Fujian Provincial Natural Science Foundation of China; Fujian Provincial Science and Technology Innovation Joint Fund.…”
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First-line treatment options for PD-L1-negative lung adenocarcinoma: a real-world analysis by Lijuan Chen, Lijuan Chen, Jie Liu, Jie Liu, Junfeng Lu, Junfeng Lu, Xiufeng Hu, Xiufeng Hu, Erjing An, Erjing An, Yanqiu Zhao, Yanqiu Zhao

“…ObjectiveTo evaluate the optimal first-line treatment options for programmed death-ligand 1 (PD-L1) negative lung adenocarcinoma (LUAD) patients without common gene-alterations.MethodsA total of 159 PD-L1-negative LUAD patients without common gene-alterations were included. …”
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Novel imaging biomarkers predict outcomes in stage III unresectable non-small cell lung cancer treated with chemoradiation and durvalumab by Amit Gupta, Pingfu Fu, Nathan A Pennell, Mohamed Gad, Mohammadhadi Khorrami, Anant Madabhushi, Anas Saad, Pradnya Patil, Khalid Jazieh, Vidya Sankar Viswanathan, Prabhakar Rajiah, Charles J Nock, Michael Gilkey

“…In clinical practice in the USA, durvalumab continues to be used in patients across all levels of programmed cell death ligand-1 (PD-L1) expression. While immune therapies have shown promise in several cancers, some patients either do not respond to the therapy or have cancer recurrence after an initial response. …”
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AI-based pelvic floor surface electromyography reference ranges and high-precision pelvic floor dysfunction diagnosisResearch in context by Juan Chen, Jiahui Yao, Wei Chen, Feng Zhang, Heyuan Wang, Xiaoying Xu, Huan Ge, Hongmei Zhou, Jin Cen, Dan Li, Bengui Jiang, Li He, Tingting Fu, Zhengxian Xu, Lei Chu, Shuxia Zhang, Dongmei Yao, Linyi Wei, Liu Huang, Anjing Ge, Cuiping Jin, Zimu Fu, Qin Liu, Xuefeng Yu, Chengmao Zhao, Tengjiao Wang, Lan Zhu

“…Funding: This study was supported by grants from the National Key R&D Program of China: The Establishment of a Comprehensive Network for PFD Prevention, Rehabilitation, Pelvic Floor Surgery and Related Complications (2021YFC2701300), Perception and Analysis of the Situation of Major Infectious Disease Outbreaks Based on Internet Big Data (2021ZD0111202), Research on New Models for Forecasting Major Infectious Diseases and Policy Evaluation (2021ZD0111205); Beijing Natural Science Foundation (7212073), National High-Level Hospital Clinical Research Funding (2022-PUMCH-B-087) and the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2021-I2M- C&T-B- 021).…”
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The comparison of efficacy and safety between cadonilimab (PD-1/CTLA-4) and anti-PD-1 inhibitors in patients with recurrent or metastatic cervical cancer: a retrospective real-worl... by Baoyue Pan, He Huang, Ting Wan, Qidan Huang, Shanyang He, Shijie Xu, Siyu Chen, Jiaxin Yin, Jundong Li, Min Zheng

“…However, the efficacy of cadonilimab in patients with prior failure of anti- programmed death receptor-1 (PD-1) inhibitors, as well as a direct comparison of its efficacy and safety with anti-PD-1 inhibitors, has not been reported in real-world settings.MethodsWe conducted a retrospective study at our hospital, including two R/M CC patient cohorts. …”
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Tumour extracellular vesicle surface Protein-mRNA integration assay for early detection of epithelial ovarian cancerResearch in context by Ying-Tzu Yen, Chen Zhao, Tian Gao, Jacqueline Ziqian Yang, Ning Kang, Jiahui Pu, Lei Qiu, Qixin Hu, Hyoyong Kim, Anmin Wang, Junseok Lee, Ryan Y. Zhang, Na Liu, Yue Ma, You-Ren Ji, Yong Ju, Lynn L. Zheng, James Lee-South, Vivian X. Zuo, Audrey Qian, Aaron Kwan, Yating Zhang, Shenghua Zhang, Zhili Wang, Jing Ren, Huaichao Liu, Zihan Wang, Yang Yue, Jina Kim, Jennifer Sun, Gabriella A. DiBernardo, Laura B. James-Allan, Ying Chen, Weipei Zhu, Guoyun Wang, Renjun Pei, Sanaz Memarzadeh, Sungyong You, Bobbie J. Rimel, Kate Lawrenson, Beth Y. Karlan, Myung Shin Sim, Shaohua Lu, Jipeng Wan, Na Sun, Hsian-Rong Tseng, Yazhen Zhu

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Genetic variants in immune mediators as potential molecular biomarkers for oral cancer evaluation: Insights from a systematic revaluation by computational analyses and Bayesian app... by Juliana Campos Botelho, Samuel Arcebispo Brasileiro, André Victor Oliveira Monteiro, Alessandro Luiz Araújo Bentes Leal, Naum Neves da Costa dos Santos, Gabrielly Ribeiro Alves, Reyce Santos Koga, Haline Alves da Silva, José Rogério Souza Monteiro, Denis Vieira Gomes Ferreira, Adenilson Leão Pereira, Ana Carolina Alves de Oliveira, Márcia Socorro Silva Lima Duarte, Felipe Rodolfo Pereira da Silva

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An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten by Lisa Leinhos, Paul Robinson, Giulia Poloni, Sophie Broadway-Stringer, Julia Beglov, Adam B. Lokman, Gillian Douglas, Sajjad Nuthay, Oveena Fonseka, Manuel Schmid, Evie Singer, Charlotte Hooper, Kate Thomson, Richard D. Bagnall, Jodie Ingles, Christopher Semsarian, Elizabeth Ormondroyd, Christopher N. Toepfer, Benjamin Davies, Charles Redwood, Hugh Watkins, Katja Gehmlich

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Climate science for 2050 by Guy Brasseur, Guy Brasseur, Detlef Stammer, Pierre Friedlingstein, Pierre Friedlingstein, Gabriele Hegerl, Tiffany Shaw, Kevin Trenberth, Kevin Trenberth, Jadwiga Richter, Carolina Vera, André Berger, Helen Cleugh, Steve Easterbrook, Paul Edwards, Daniela Jacob, Michael Mann, Valérie Masson-Delmotte, Gavin Schmidt, Mary Scholes, Thomas Stocker, Martin Visbeck, Guoxiong Wu

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Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height by A. Papadopoulou, E. M. Litkowski, M. Graff, Z. Wang, R. A. J. Smit, G. Chittoor, I. Dinsmore, N. S. Josyula, M. Lin, J. Shortt, W. Zhu, S. L. Vedantam, L. Yengo, A. R. Wood, S. I. Berndt, I. A. Holm, F. D. Mentch, H. Hakonarson, K. Kiryluk, C. Weng, G. P. Jarvik, D. Crosslin, D. Carrell, I. J. Kullo, O. Dikilitas, M. G. Hayes, W. -Q. Wei, D. R. V. Edwards, T. L. Assimes, J. N. Hirschhorn, J. E. Below, C. R. Gignoux, A. E. Justice, R. J. F. Loos, Y. V. Sun, S. Raghavan, P. Deloukas, K. E. North, E. Marouli

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