Dual inhibition of HERs and PD-1 counteract resistance in KRASG12C-mutant head and neck cancer by Ofra Novoplansky, Sankar Jagadeeshan, Manu Prasad, Ksenia M. Yegodayev, Divyasree Marripati, Raghda Abu Shareb, Yariv Greenshpan, Sooraj Mathukkada, Talal Ben-Lulu, Baisali Bhattacharya, Angel Porgador, Dexin Kong, Johannes Brägelmann, J. Silvio Gutkind, Moshe Elkabets

“…Immunohistochemistry (IHC) and Immunoflourescence (IF) analyses were performed to profile the TME and programmed death-ligand 1 (PD-L1) expression in tumors. …”
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Efficacy and safety of Tofacitinib in patients with active rheumatoid arthritis resistant to conventional therapy: Preliminary results of an open-label clinical trial by E. L. Luchikhina, D. E. Karateev, N. V. Demidova, A. S. Musiyuk, E. N. Aleksandrova, A. A. Novikov, A. V. Smirnov, E. L. Nasonov

“…This ongoing open-label trial is a part of the scientific program «Russian Investigation of Methotrexate and Biologics in Early Active Inflammatory Arthritis» (REMARCA) that explores the possibility of adapting the «treat-to-target» strategy in real prac-tice in Russia. …”
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Real-World Efficacy and Safety of Anti-PD-1 Antibody Plus Apatinib and Temozolomide for Advanced Acral Melanoma by Zhang J, Tian H, Mao L, Li C, Wei X, Gu J, Wang X, Zhou L, Lian B, Tang B, Yan X, Li S, Cui C, Chi Z, Sheng X, Guo J, Si L

“…Jiaran Zhang,1,* Huichun Tian,1,* Lili Mao,1 Caili Li,1 Xiaoting Wei,1 Junjie Gu,1 Xuan Wang,1 Li Zhou,2 Bin Lian,1 Bixia Tang,1 Xieqiao Yan,2 Siming Li,2 Chuanliang Cui,1 Zhihong Chi,1 Xinan Sheng,2 Jun Guo,1 Lu Si1 1Department of Melanoma and Sarcoma, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, 100142, People’s Republic of China; 2Department of Genitourinary Oncology, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, 100142, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lu Si, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), 52# Fucheng Road, Haidian District, Beijing, 100142, People’s Republic of China, Email silu15_silu@126.comPurpose: The combination of programmed cell death-1 (PD-1) blockade camrelizumab plus apatinib (an antiangiogenic agent) and temozolomide has displayed promising therapeutic effects in patients with advanced acral melanoma (AM) in a non-randomized Phase II clinical trial (NCT04397770). …”
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Agronomic Performance of Newly Developed Elite Cowpea Mutant Lines in Eswatini by Kwazi A. K. Mkhonta, Hussein Shimelis, Seltene Abady, Asande Ngidi

“…The following traits, NPP, NSP, PDL, GYD, and HSW, offered unique opportunities for genotype selection in the cowpea breeding program in Eswatini.…”
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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

“…Background Pembrolizumab monotherapy is an established front-line treatment for advanced non-small cell lung cancer (NSCLC) with programmed cell death-ligand 1 (PD-L1) tumor proportion score (TPS)≥50%. …”
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Effects of maternal blood beta-hydroxybutyrate on brown adipose tissue functions and thermogenic and metabolic health in neonatal calves by Yang Gai, Guiling Ma, Shuyan Yang, Zhiyong Hu, Yulin Ma, Rui He, Yu Zhang, Shilong Huang, Hossam H. Azzaz, Zhaobing Gu, Shengyong Mao, Morteza H. Ghaffari, Yanting Chen

“…Overall, this study demonstrates that calves born from elevated maternal BHB levels (∼0.64 mM) within the normal physiological range in the dry period significantly had impaired perinatal BAT development, thermogenesis, and glucose metabolism, highlighting the roles of maternal metabolic health in programming metabolic and thermoregulatory capacity in offspring.…”
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Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of a randomized clinical trialResearch in context by Jiejie Li, Jing Jing, Xia Meng, Fu-Dong Shi, Hong-Qiu Gu, Aoming Jin, Yong Jiang, Hao Li, S. Claiborne Johnston, Graeme J. Hankey, J. Donald Easton, Xuewei Xie, Wei-Na Jin, Liguo Chang, Penglai Shi, Lihua Wang, Xianbo Zhuang, Haitao Li, Yingzhuo Zang, Jianling Zhang, Zengqiang Sun, Dongqi Liu, Ying Li, Hongqin Yang, Jinguo Zhao, Weiran Yu, Anxin Wang, Yuesong Pan, Jinxi Lin, Shuya Li, Siying Niu, Yilong Wang, Xingquan Zhao, Zixiao Li, Liping Liu, Huaguang Zheng, Yongjun Wang, Xingquan Zhao, Liguo Chang, Minghua Cao, Yanliang Miao, Dali Li, Xiafeng Yang, Aimei Wu, Penglai Shi, Jianghua Si, Hongqin Yang, Naian Xiao, Na Guo, Ling Ma, Youren Li, Tianming Pan, Yingzhuo Zang, Fangqi Tian, Youjun Liu, Xiaopeng Feng, Dongqi Liu, Xianwen Han, Yi Zhao, Xueling Zhang, Mei Hong, Airen Lu, Haichao Liu, Zhonghai Jia, Kai Li, Xiaosong Li, Ziyan Li, Dongli Chen, Lifeng Lei, Jingwen Jiao, Baohua Zhao, Peiduo Yuan, Xingchi Wang, Qiang Li, Jianmin Guo, Xin Wang, Cunrui Wang, Haifeng Huang, Yanhua Zhang, Yefang Feng, Baojun Wang, Weifeng Lu, Huqing Li, Bojun Han, Jianghuan Zheng, Jianhua Li, Hongtian Zhang, Yu Che, Yuhai Liu, Jianli Cheng, Ni Wang, Yunshu Zhang, Dongyun Li, Dongwei Zhang, Haitao Li, Baolong Wang, Xintong Liu, Tianhui He, Duanling Ye, Ping Sun, Anqiang Chen, Weimin Hong, Hongbin Liang, Yanqiu Du, Jinguo Zhao, Min Zhang, Weifeng Chen, Xiting Zhang, Hongguo Dai, Junfeng Shi, Ke Li, Junfeng Zhao, Qian Wang, Yuqing Zhang, Yajun Liu, Xiangming Wang, Bin Li, Bingqi Zhang, Xiaomin Mei, Mingqing Zhen, Jinhui Qin, Yanling Hu, Cunju Guo, Li Ji, Zengqiang Sun, Yunyi Dai, Yong You, Bo Wang, Changhao Jiang, Rong Zou, Runting Jing, Di Pu, Pida Hao, Defeng Tian, Qian Xue, Zhigang Liang, Aisheng Wu, Jingya Jiao, Wei Wu, Dong Wang, Zhen Jiao, Jianping Niu, Xiangbin Wu, Jing Wang, Ping Shen, Zhao Li, Huihai Du, Liqin He, Xinhui Kou, Jing Chen, Quping Ouyang, Youquan Ren, Chunjie Yang, Hailian Jin, Yongming Chen, Chunlei Li, Qiuwu Liu, Hongliang Wang, Hao Hu, Ying Li, Gongping Zhu, Shaofa Li, Hongyun Chang, Huixiang Tang, Sumin Bai, Weidong Jia, Wensheng Tian, Shuzhen Yang, Zhenhua Xi, Degang Sun, Can Jiang, Yueqiang Gao, Xia Wei, Jianling Zhang, Rongfang Ma, Fujian Chen, Yanan Zhu, Hongjuan Chang, Houqin Chen, Guoyou Zhao, Junyong Zhao, Jing Ding, Shoucheng Zhang, Rui Wang, Panbing Huang, Jingyuan Jiang, Haipeng Li, Wei Zhang, Qingcheng Yang, Chen Niu, Ke Deng, Guoping Zou, Zhongfeng Yu, Yongqian Lei, Yan Wei, Tao Sun, Diwen Zhang, Hongliang Wang, Jiafeng Dong, Xinbo Deng, Dong Chen, Hongyan Ni, Lujun Zhang, Guofeng Li, Shifeng Guo, Dan He, Lie Wu, Guoqiang Yang, Ying Hai, Dongjing Song, Yan Han, Chaoqun Li, Li Wang, Xiue Wei, Runxiu Zhu, Haiyan Xu, Xinsheng Han, Wen Shangguan, Ailian Zhang, Jun Gu, Peng Guo, Hairong Sun, Baoguo Xue, Lihua Wang, Wanyong Yang, Shihao You, Mingjie Liu, Huijuan Sun, Anding Xu, Nengwei Yu, Yafei Shangguan, Lianmei Zhong, Xinqiang Wang, Hejun Chen, Juan Feng, Xiangqing Xu, Xiaoxuan Zhang, Jianguo Ge, Meirong Zhu, Dongbo Li, Jiajun Huang, Xiaoyan Li, Zhihui Duan, Weiying Di, Jianchao Qin, Fang Li, Guangming Kang, De Yang, Wenfeng Cao, Chunsheng Cai, Xiangqing Li, Yi Wang, Shengfu Yang, Xianghong Liu, Hebin Wan, Muhui Lin, Feng Wang, Ying Xing, Qiangyuan Tian, Wanying Li, Honghao Man, Zhihua Hao, Ziran Wang, Yanhua Zhou, Xinyi Li, Hong Chen, Hongyan Li, Junmei Wang, Jinfeng Shi, Dali Li, Juan Tang, Di Zhong, Bin Liu, Chuanzhen Qu, Haiying Wang, Chen Chen, Xiangyu Pu, Yukai Wang, Yangmei Chen, Yang Xu, Fei Wang

“…Funding: National Key R&D Program of China, National Natural Science Foundation of China, the Capital's Funds for Health Improvement and Research and Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences. …”
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The state of the biogeometric profile of the posture of young athletes specializing in hand-to-hand combat as a prerequisite for the development of corrective and preventive measur... by Vitalii Kashuba, Аndrii Radchenko, Yuri Radchenko, Ilia Vako, Vitaly Usychenko

“…The problems identified during the study were solved using generally accepted methods: theoretical analysis of scientific literature on the chosen research topic; the Torso program was used to determine the types of posture, visual screening of the state of the biogeometric profile of the posture of young athletes specializing in hand-to-hand combat included a focus on the tribal system and the use of a method for comparing individual posture on a photogram and methods of mathematical statistics. …”
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Experiences Receiving and Delivering Virtual Health Care For Women: Qualitative Evidence Synthesis by Karen M Goldstein, Sharron Rushton, Allison A Lewinski, Abigail Shapiro, Tiera Lanford-Davey, Jessica N Coleman, Neetu Chawla, Dhara B Patel, Katherine Van Loon, Megan Shepherd-Banigan, Catherine Sims, Sarah Cantrell, Susan Alton Dailey, Jennifer M Gierisch

“…Quality assessment was conducted using the Critical Appraisal Skills Program and certainty of evidence using Confidence in the Evidence from Reviews of Qualitative Research approaches. …”
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Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inferenceResearch in context by Jinxin Guo, Tiansheng Wang, Zhike Liu, Weihong Zeng, Peng Shen, Yexiang Sun, Siyan Zhan, Yang Xu

“…Funding: National Natural Science Foundation of China; Science and Technology Project of Science and Technology Bureau of Yinzhou District, Ningbo City; Zhejiang Provincial Centre for Disease Control and Prevention Science and Technology Program; Bill & Melinda Gates Foundation.…”
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Mapping of quantitative trait loci and mining of candidate genes for seed viability in soybean [Glycine max (L.) Merr.] by Manisha Saini, Raju R. Yadav, Rahul Kumar, Rahul Kumar, Subhash Chandra, N. Krishna Kumar Rathod, Meniari Taku, Manu Yadav, Sudipta Basu, Ambika Rajendran, S. K. Lal, Akshay Talukdar

“…Understanding inheritance and mapping of quantitative trait loci (QTLs) for seed viability would help in designing breeding program for developing varieties with higher viability of the seeds. …”
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Evaluating exercise therapies in adolescent idiopathic scoliosis: a systematic review with Bayesian network meta-analysis by Yang Jiang, Hao Peng, Yanping Song, Li Huang, Hongbo Chen, Pengcheng Li, Guoshun Yang, Yueyu Song, Qigang Chen, Na Yao

“…A Bayesian network meta-analysis was performed utilizing the R programming language (version 4.3.4) and MetaInsight tool (version V6.0.1). …”
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Prevalence of dyslipidemia and its association with blood pressure control in Iranian hypertensive patients: insights from STEPS 2021 by Shervin Mossavarali, Yosra Azizpour, Ali Golestani, Nazila Rezaei, Sepehr Khosravi, Mina Mirzad, Pouria Khashayar, Ozra Tabatabaei-Malazy

“…Lipid markers, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), Non-HDL-C, and triglycerides (TG), were evaluated using the National Cholesterol Education Program Adult Treatment Panel III 2004 criteria. Associations between lipid markers and uncontrolled hypertension were assessed using a multivariable modified Poisson regression model, with results presented as adjusted prevalence ratio (APR) and 95% confidence interval (CI). …”
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Synergy of rehabilitation for stress-related disorders and ARIs in school-age children under the war condition in Ukraine by I.O. Mityuryayeva-Kornijko, Ie.A. Burlaka, T.D. Klets, O.A. Panchenko, A.V. Kabantseva, E.S. Sukhodolska

“…The study was carried out as part of the program of outpatient observation of children with various acute manifestations of ARIs against the background of stress damage to the nervous system due to the war in Ukraine, and taking naturopathic drugs with immunocorrective properties (scheme (1)): 1) affinity-purified antibodies to human interferon gamma (6 mg), histamine (6 mg) and CD4 (6 mg) — a mixture of homeopathic dilutions C12, C30 and C50; or in combination with a drug with a sedative effect (scheme (1+2)): 1) affinity-purified antibodies to human gamma interferon (6 mg), histamine (6 mg) and CD4 (6 mg) — a mixture of homeopathic dilutions C12, C30 and C50; 2) affinity-purified antibodies to brain-specific protein S100 (3 mg) — a mixture of homeopathic dilutions C12, C30 and C50. …”
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Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/Jak/Stat3 in PD-L1-high lung cancer by Bhumsuk Keam, Se-Hoon Lee, Yingying Li, Yoon Kyung Jeon, Hye Young Kim, Sehui Kim, Hyein Jeong, Soo Hyun Lee, Jaemoon Koh, Jeemin Yim, Seung Geun Song, Hanbyeol Kim, Yeon Kyu Chung, Hongsoon Kim, Chul-Hwan Lee, Doo Hyun Chung

“…Background Some patients with non-small-cell lung cancer (NSCLC) benefit from immune checkpoint inhibitors (ICIs) despite programmed death-ligand 1 (PD-L1) expression. To address the mechanism of ICI resistance in PD-L1-positive NSCLC, we investigated the role of tumor-cell-intrinsic function of PD-L1 in interleukin (IL)-6-mediated immunosuppression.Methods Cohorts of NSCLC patients treated with ICI and public datasets were analyzed. …”
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Characteristic of herd immunity among the population of Stavropol region amid the COVID-19 epidemic by A. Yu. Popova, E. B. Ezhlova, A. A. Melnikova, V. S. Smirnov, L. V. Lyalina, A. V. Ermakov, N. I. Solomashchenko, I. V. Kovalchuk, E. A. Vasilenko, E. N. Romanenko, A. V. Zvoliborskaya, A. V. Ryabykh, L. I. Dmitrienko, N. A. Mezhlumyan, A. A. Sharova, V. V. Vetrov, A. A. Totolian

“…The SARS-CoV-2 study was carried out according to a unified methodology within the framework of the program for assessing the population immunity of the population of the Russian Federation, developed by Rospotrebnadzor with the participation of the St. …”
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A Novel Splice Site Variant in COL6A1 Causes Ullrich Congenital Muscular Dystrophy in a Consanguineous Malian Family by Alassane Baneye Maiga, Ibrahim Pamanta, Salia Bamba, Lassana Cissé, Salimata Diarra, Sidi Touré, Abdoulaye Yalcouyé, Seydou Diallo, Salimata Diallo, Fousseyni Kané, Seybou Hassane Diallo, Hamidou Oumar Ba, Cheick Oumar Guinto, Kenneth Fischbeck, Guida Landoure, Idrissa Ahmadou Cissé, The H3Africa Consortium

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SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers by Jin Zhou, Austin Hepperla, Jeremy M. Simon, Kangsan Kim, Qing Hu, Chuanhai Zhang, Lei Dong, Lianxin Hu, Cheng Zhang, Chengheng Liao, Alice Fang, Yayoi Adachi, Haoyong Fu, Tao Wang, Qian Liang, Fangzhou Zhao, Hongyi Liu, Masashi Takeda, Jun Fang, Hua Zhong, Peter Ly, Lu Wang, Payal Kapur, Lin Xu, Liwei Jia, Srinivas Malladi, James Brugarolas, M. Celeste Simon, Bo Li, Qing Zhang

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Insights into ancestral diversity in Parkinson’s disease risk: a comparative assessment of polygenic risk scores by Paula Saffie-Awad, Spencer M. Grant, Mary B. Makarious, Inas Elsayed, Arinola O. Sanyaolu, Peter Wild Crea, Artur F. Schumacher Schuh, Kristin S. Levine, Dan Vitale, Mathew J. Koretsky, Jeffrey Kim, Thiago Peixoto Leal, María Teresa Periñán, Sumit Dey, Alastair J. Noyce, Armando Reyes-Palomares, Noela Rodriguez-Losada, Jia Nee Foo, Wael Mohamed, Karl Heilbron, Lucy Norcliffe-Kaufmann, the 23andMe Research Team, Mie Rizig, Njideka Okubadejo, Mike A. Nalls, Cornelis Blauwendraat, Andrew Singleton, Hampton Leonard, Global Parkinson’s Genetics Program (GP2), Ignacio F. Mata, Sara Bandres-Ciga

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Life course socioeconomic position, alcohol drinking patterns in midlife, and cardiovascular mortality: Analysis of Norwegian population-based health surveys. by Eirik Degerud, Inger Ariansen, Eivind Ystrom, Sidsel Graff-Iversen, Gudrun Høiseth, Jørg Mørland, George Davey Smith, Øyvind Næss

“…<h4>Methods and findings</h4>From 3 cohorts (the Counties Studies, the Cohort of Norway, and the Age 40 Program, 1987-2003) containing data from population-based cardiovascular health surveys in Norway, we included participants with self-reported information on alcohol consumption frequency (n = 207,394) and binge drinking episodes (≥5 units per occasion, n = 32,616). …”
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