Assessing the direct and spillover protective effectiveness of Wolbachia-mediated introgression to combat dengueResearch in context by Jo Yi Chow, Somya Bansal, Borame S.L. Dickens, Pei Ma, Ary Hoffmann, Yoon Ling Cheong, Nazni Wasi Ahmad, Jue Tao Lim

“…Funding: This research is hosted by CNRS@CREATE and supported by the National Research Foundation, Prime Minister's Office, Singapore, under its Campus for Research Excellence and Technological Enterprise (CREATE) program, and is funded by the Lee Kong Chian School of Medicine—Ministry of Education Start-Up Grant. …”
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Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors by Yan Zhang, Di Chen, Qiqi Lu, Yu Yao, Gaopeng Li, Chunxia Ji, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Dave S B Hoon, Liangfu Zhou

“…Our study was performed to determine coexpression levels of two major B7 immune regulatory molecules programmed death ligand 1 (PD-L1) and B7-H4, both of which have been demonstrated to inhibit antitumor host immunity in gliomas.Methods We assessed tumor tissues from stage II–IV primary gliomas (n=505) by immunohistochemistry (IHC) for protein levels of both PD-L1 and B7-H4. …”
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PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations by Jeffrey Schlom, James W Hodge, Clint T. Allen, Shahrooz Rabizadeh, Patrick Soon-Shiong, John H. Lee, Renee N. Donahue, Kristen Solocinski, Michelle R Padget, Kellsye P Fabian, Yvette Robbins

“…For the first time, we report a novel natural killer (NK) cell line, programmed death-ligand 1 (PD-L1) targeting high-affinity natural killer (t-haNK), which was derived from NK-92 and was engineered to express high-affinity CD16, endoplasmic reticulum-retained interleukin (IL)-2, and a PD-L1-specific chimeric antigen receptor (CAR). …”
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Dendritic cells pulsed with multifunctional Wilms’ tumor 1 (WT1) peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in... by Machi Suka, Hiroyuki Yanagisawa, Nobuhiro Sato, Shigetaka Shimodaira, Masayuki Saruta, Shigeo Koido, Junichi Taguchi, Masamori Shimabuku, Shin Kan, Tuuse Bito, Takeyuki Misawa, Zensho Ito, Kan Uchiyama, Shintaro Tsukinaga, Toshifumi Ohkusa, Haruo Sugiyama

“…These three patients exhibited notable infiltration of T cells and programmed cell death protein-1+ cells within the pancreatic tumor microenvironment (TME). …”
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BMI Association With Treatment Outcomes in Head and Neck Cancer Patients Receiving Immunotherapy: A Comprehensive Review and Meta‐Analysis by Sakditad Saowapa, Natchaya Polpichai, Pharit Siladech, Chalothorn Wannaphut, Manasawee Tanariyakul, Phuuwadith Wattanachayakul, Diego Olavarria Bernal, Hector Garcia Pleitez, Lukman Tijani

“…Additionally, data synthesis was carried out using the Review Manager program, and evaluation of methodological quality was done with the Newcastle Ottawa scale. …”
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The Pléiades Glacier Observatory: high-resolution digital elevation models and ortho-imagery to monitor glacier change by E. Berthier, E. Berthier, J. Lebreton, D. Fontannaz, S. Hosford, J. M.-C. Belart, F. Brun, L. M. Andreassen, B. Menounos, B. Menounos, B. Menounos, C. Blondel

“…Here, we present the Pléiades Glacier Observatory (PGO), a scientific program acquiring Pléiades 0.7 m satellite stereo pairs for 140 sites from Earth's glacierized areas. …”
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Longitudinal Body Composition Identifies Hepatocellular Carcinoma With Cachexia Following Combined Immunotherapy and Target Therapy (CHANCE2213) by Zhi‐Cheng Jin, Jia‐Wei Zhou, Jian‐Jian Chen, Rong Ding, Bernhard Scheiner, Si‐Na Wang, Hai‐Liang Li, Qing‐Xia Shen, Qing‐Yun Lu, Yi Liu, Wei‐Hua Zhang, Biao Luo, Hai‐Bin Shi, Ming Huang, Ye‐Ming Wu, Chun‐Wang Yuan, Ming‐Sheng Huang, Jia‐Ping Li, Jian‐Bing Wu, Xiao‐Li Zhu, Bin‐Yan Zhong, Hai‐Feng Zhou, Yu‐Qing Wang, Shan‐Zhi Gu, Zhi‐Yi Peng, Chuan‐Sheng Zheng, Rui‐Bao Liu, Guo‐Hui Xu, Wei‐Zhu Yang, Ai‐Bing Xu, Dong‐Fang Liu, Xiaolong Qi, Yee Hui Yeo, Hai‐Dong Zhu, Yang Zhao, David J. Pinato, Fanpu Ji, Gao‐Jun Teng

“…Methods This longitudinal, multicentre cohort study included unresectable HCC patients treated with first‐line programmed death‐(ligand)1 inhibitors plus anti‐vascular endothelial growth factor antibody/tyrosine kinase inhibitors between 01/2018–12/2022. …”
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Nonadherence to Diabetes Complications Screening in a Multiethnic Asian Population: Protocol for a Mixed Methods Prospective Study by Amudha Aravindhan, Eva Fenwick, Aurora Wing Dan Chan, Ryan Eyn Kidd Man, Wern Ee Tang, Ngiap Chuan Tan, Charumathi Sabanayagam, Junxing Chay, Lok Pui Ng, Wei Teen Wong, Wern Fern Soo, Shin Wei Lim, Ecosse L Lamoureux

“…Follow-up phases will focus on establishing the rates and associated modifiable predictors of nonadherence to DR, DN, or DFC rescreening, which may inform program initiatives. International Registered Report Identifier (IRRID)DERR1-10.2196/63253…”
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Efficacy of two brands of Mebendazole (500 mg) in the treatment of Ascaris lumbricoides and hookworm infection among school-aged children in South Gondar zone, Northwest Ethiopia:... by Birhanu Malede, Ayalew Jejaw Zeleke, Yenesew Mihret Wondmagegn, Abebaw Setegn, Hailegebriel Wondimu, Ayenew Berhan, Tadesse Misganaw, Gashaw Azanaw Amare, Tegegne Eshetu

“…This trial investigated efficacy of two different brands of mebendazole (Vermox® and X-WORM®) used in the deworming program and available in local pharmaceutical shops. …”
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Factors affecting viral suppression or rebound in people living with HIV and receiving antiretroviral therapy in Ghana by Anthony T. Boateng, Anthony T. Boateng, James O. Aboagye, James O. Aboagye, Helena Lamptey, Christopher Z.-Y. Abana, Christopher Z.-Y. Abana, Araba Abaidoo-Myles, Araba Abaidoo-Myles, Darius N. K. Quansah, Darius N. K. Quansah, Seth Agyemang, Seth Agyemang, Yaw Awuku-Larbi, Gloria Ansa, Joseph Oliver-Commey, Vincent Ganu, George B. Kyei, George B. Kyei, George B. Kyei, Peter Puplampu, Evelyn Y. Bonney

“…IntroductionRegular viral load (VL) testing for people living with HIV (PLWH) is key to attaining the Joint United Nations Program on HIV/AIDS (UNAIDS) Fast-Track 95–95-95 target to end the HIV epidemic by 2030. …”
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Efecto de la concentración de SO2 en las reacciones de calcinación y sulfatación de calcáreos en reactores de lecho fluidizado. // Effect of the SO2 concentration in the calcinatio... by J. E. Lindo Samaniego, M. C. Diniz Costa, F. E. Milioli, J. D. Pagliuso

“…For the recording of this parameters a data adquisition program in<br />LabView was developed. A mathematical model was used to allow the determination of the conversion, the<br />conversion rate and the global coefficient of reaction rate for all the test conditions.…”
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THE TIME COURSE OF CHANGES IN BIOMARKER LEVELS AND THE ULTRASONIC SIGNS OF INFLAMMATION IN PATIENTS WITH RHEUMATOID ARTHRITIS by O. G. Alekseeva, A. A. Novikov, M. V. Severinova, A. S. Avdeeva, E. N. Aleksandrova, E. I. Luchikhina, D. E. Karateev, S. I. Glukhova, A. V. Volkov, E. L. Nasonov

“…Thirty-eight patients with early RA, who were followed up within the framework of the REMARCA program, were examined. All the patients' therapy was started with subcutaneous methotrexate (MTX) with its rapid dose escalation up to 20–30 mg/week and assessment of the achievement of the treatment goal (low disease activity or remission) every 3 months according to the reason why a decision had been made to add biological agents to the therapy. …”
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Timing of intravenous iron for treatment of anaemia in surgical patients: a systematic review and network meta-analysisResearch in context by Chang Liu, Jiashu Han, Renkui Fu, Tianyu Li, Georgios Antonios Margonis, Jaeyun Jane Wang, Kaiqi Ma, Weibin Wang, Chen Lin

“…Funding: National Key Research and Development Program of China, National Natural Science Foundation of China, Beijing Natural Science Foundation, Capital's Funds for Health Improvement and Research, National High Level Hospital Clinical Research Funding, and Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences.…”
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A survey on clinical communication competence of psychiatric nurses in Guangdong Province (广东省精神科护士临床沟通能力调查分析) by LI Xiaochan (李晓婵), ZHUANG Jingyi (庄静仪), ZHANG Huixian (张慧娴), XIE Jiao (谢姣), HAO Li (郝丽), LUO Juanjuan (罗娟娟), ZENG Junfang (曾君芳), ZOU Caimei (邹彩媚)

“…Conclusion Findings of the study indicated a high level of team communication competence of psychiatric nurses , however relatively low level of emotional support and communication in difficult situations were found. Targeted training program should be carried out to improve the clinical communication competence of psychiatric nurses in Guangdong Province (目的 调查广东省精神科护士的临床沟通能力水平并分析其影响因素, 为管理层提高精神科护士沟通能力提供参考依据。…”
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1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells by Peng Li, Hua Zhang, Xiao Wang, Biyun Chen, Ke Li, Zhinan Yin, Xinhai Zhu, Guangchao Cao, Ruan Wu, Wenhui Yuan, Guodong Sun, Xichun Xia, Ligong Lu, Yunfei Gao

“…Vitamin D receptor (VDR) knockout and overexpression CD8+ and Vδ2+ T cells were constructed using Cas9-gRNA targeted and overexpressing approaches to identify 1α,25(OH)2D3/VDR-mediated transcription regulation for ICRs or antitumor activity in T cells.Results We show that serum level of vitamin D is negatively correlated with expression of programmed cell death-1 (PD-1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), but positively correlated with CD28 expression on CD8+ and Vγ9Vδ2+ T cells in patients with NSCLC. 1α,25(OH)2D3, the active form of vitamin D, promotes the nuclear translocation of VDR, which binds to the promoter region of Pdcd1, Tim3, and Tigit genes and inhibits their expression. …”
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Investigating the effect of cochlear implant usage metrics on cortical auditory-evoked potential responses in adult recipients post-implantation by Caris Bogdanov, Caris Bogdanov, Helen Goulios, Wilhelmina H. A. M. Mulders, Dayse Tavora-Vieira, Dayse Tavora-Vieira, Dayse Tavora-Vieira

“…CI usage frequency was defined as the average number of hours per day of audio processor use, which was recorded using the CI programming software.ResultsOverall, 27 participants (65.85%) exhibited detectable eCAEP responses across one or more electrode contacts. …”
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Implementation of the advanced HIV disease package of care using a public health approach: lessons from Nigeria by Williams Eigege, Oche Agbaji, Nere Otubu, Opeyemi Abudiore, Oluwakemi Sowale, Boma Levy-Braide, Asari Inyang, Dinesh Rathakrishnan, Ikechukwu Amamilo, James Conroy, Folu Lufadeju, Carolyn Amole, Owens Wiwa, Dennis Onotu, Khalil Sanni, Peter Nwaokenneya, Mohammed Patiko, Akudo Ikpeazu, Stephen Oguche, Rita Oladele, Sulaimon Akanmu

“…The package includes CD4 + cell count testing to identify People Living with HIV (PLHIV) with AHD, screening and treatment of opportunistic infections, rapid antiretrovirals (ART) initiation, and intensive adherence follow-up. The national program adopted a phased approach in the rollout of the AHD package of care to learn lessons from a few representative health facilities before scaling up across the country. …”
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Changes in muscle performance among older adults with myeloid malignancies engaging in a mobile health (mHealth) exercise intervention: a single arm pilot study by Marielle Jensen-Battaglia, Po-Ju Lin, Chandrika Sanapala, Erin E. Watson, Jason H. Mendler, Jane Liesveld, Ying Wang, Elisabeth Hayward, Marissa LoCastro, Soroush Mortaz, Richard F. Dunne, Karen Mustian, Kah Poh Loh

“…Methods Patients ≥ 60 years old with myeloid malignancies receiving outpatient chemotherapy completed a home-based resistance band and walking exercise program [EXercise for Cancer Patients (EXCAP)©®] delivered via a mobile application with symptom monitoring [(Geriatric Oncology-EXCAP (GO-EXCAP)] lasting 2 cycles of chemotherapy (approximately 8–12 weeks). …”
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Investigating the Relationship between Changes in the Expression Level of the CLU Gene and the Prognosis of Gastric Cancer Patients by Arezoo Farhadi, Erfan Cheraghi, Nastaran Farahani, Fatemeh Khodabandehloo, Mohammad Foad Heidari, Reza Heydari, Mehdi Ghorbani, Mahmood Vahidi, Javad Behroozi

“…The CLU gene, an evolutionarily conserved gene, encodes the protein clusterin, which plays a role in various cellular processes, including cell-cell adhesion and programmed cell death. Clusterin has multiple roles in carcinogenesis and tumor invasion. …”
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BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis by Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard

“…Serum analysis of patients treated with target therapies or IT indicates that soluble forms of NK ligands (MICA, B7H6, programmed cell death ligand 1, and carcinoembryonic antigen cell adhesion molecule 1) may correlate with clinical response.Conclusion These results support strategies combining targeted therapies and NK-based immunotherapies.…”
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