Newborn screening facilitates early theranostics and improved spinal muscular atrophy outcome: five-year real-world evidence from Taiwan by Chen-Hua Wang, Ting-Rong Hsu, Mei-Ying Liu, Li-Yun Wang, I-Jun Chou, Wang-Tso Lee, Wen-Chen Liang, Inn-Chi Lee, Hsiao-Jan Chen, Shu-Min Kao, Hui-Chen Ho, Dau-Ming Niu, Kwang-Jen Hsiao, Ming-Yuh Chang, Hui-Min Hsieh, Yuh-Jyh Jong

“…This study aimed to investigate the long-term outcomes of a 5-year SMA NBS program in Taiwan. Results From September 2017 to August 2022, two NBS centers screened patients for SMN1 homozygous deletion using quantitative real-time polymerase chain reaction (RT-PCR) or the Sequenom MassARRAY platform and subsequently confirmed the findings using multiplex ligation-dependent probe amplification (MLPA). …”
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Impact of baseline left ventricular ejection fraction and body mass index on the effect of 24-week Ipragliflozin treatment on left ventricular diastolic function in patients with t... by Hiroki Teragawa, Atsushi Tanaka, Kanae Takahashi, Chikage Oshita, Yuko Uchimura, Nozomu Kamei, Hiroyuki Hirai, Michio Shimabukuro, Isao Taguchi, Yosuke Okada, Koichi Node

“…In this sub-analysis of the Program of Ipragliflozin for Endothelial Dysfunction in Chronic Kidney Disease and Type 2 Diabetes (PROCEED) trial—including patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD)—we examined the effect of ipragliflozin compared with non-SGLT2 inhibitor standard therapy (control) on changes in the maximum early diastolic velocity to average early diastolic peak velocity (E/e’) ratio (an index of LV diastolic function) via echocardiography. …”
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Impact of Negative Pressure Wound Therapy on Outcomes Following Pancreaticoduodenectomy: An NSQIP Analysis of 14,044 Patients by Jeremy Peabody, Sukhdeep Jatana, Kevin Verhoeff, A. M. James Shapiro, David L. Bigam, Blaire Anderson, Khaled Dajani

“…<b>Methods</b>: Utilizing the National Surgical Quality Improvement Program database, we included patients undergoing a pancreaticoduodenectomy between 2017 and 2021 and divided patients into the NPWT and non-NPWT cohorts. …”
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Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18 by Yu Liu, Yichi Zhang, Yayi Hou, Yan Cheng, Mengyu Zhang, Yuanhui Zhao, Dongge Xu, Weikang Sun, Yuqing Miao, Susu He, Dwayne Stupack, Erguang Li

“…Antitumor memory and synergistic effect with an anti-programmed cell death protein-1 (PD-1) antibody was evaluated. …”
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Metabolomic signatures in liquid biopsy are associated with overall survival in metastatic melanoma patients treated with immune checkpoint inhibitor therapy by Susan Costantini, Gabriele Madonna, Mariaelena Capone, Elena Di Gennaro, Palmina Bagnara, Federica Renza, Domenico Mallardo, Roberta Affatato, Carlo Vitagliano, Marilena Romanelli, Marilena Tuffanelli, Ester Simeone, Gennaro Ciliberto, Paolo A. Ascierto, Alfredo Budillon

“…Abstract Background Immune checkpoint inhibitors (ICIs), such as anti-Cytotoxic T-Lymphocyte Antigen 4(CTLA-4) and anti-Programmed cell death protein 1 (PD-1) agents, have improved the prognosis of patients with metastatic melanoma. …”
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Assessment of microvascular flow in human atherosclerotic carotid plaques using ultrasound localization microscopyResearch in context by Henri Leroy, Louise Z. Wang, Anatole Jimenez, Nassim Mohamedi, Clément Papadacci, Pierre Julia, Salma El Batti, Jean-Marc Alsac, Jonas Sitruk, Armelle Arnoux, Patrick Bruneval, Emmanuel Messas, Tristan Mirault, Guillaume Goudot, Mathieu Pernot

“…Co-funding by ART (Technological Research Accelerator) biomedical ultrasound program of INSERM, France.…”
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Spatially resolved analysis of the T cell immune contexture in lung cancer-associated brain metastases by Richa Gupta, Sarah B Goldberg, Kurt A Schalper, Harriet M Kluger, Lucia B Jilaveanu, Adebowale J Adeniran, Benjamin Y Lu, Adam Aguirre-Ducler, Nicole Gianino, Hailey Wyatt, Matthew Ribeiro, Veronica L Chiang, Joseph N Contessa

“…In particular, the expression of coinhibitory receptors, such as programmed cell death 1 (PD-1), T cell immunoglobulin mucin receptor 3 (TIM-3), and lymphocyte activation gene 3 (LAG-3), within BrMs is unknown. …”
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Age-stratified associations between radiotherapy and SPMs for FPHNC: a population-based cohort study by Yuan-Yuan Li, Qiong Liu, Si-Qi Ying, Xiu-Quan Wu, Xiao-Hui Zhang, Xiao-Mei Xie, Bing-Dong Sui, Yan Jin, Yang Jiao, Franklin R. Tay

“…Methods Using data from the Surveillance, Epidemiology, and End Results program (2004−2015), incidence rate ratios (IRRs) and standardized incidence ratios (SIRs) were evaluated for solid and hematologic SPMs associated with radiotherapy within different age groups. …”
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A cluster-randomized trial of interventions for adolescent mental disorders in Zimbabwe by Rhulani Beji-Chauke, Victoria Simms, Melanie Abas, Kelly Muzariri, Webster Mavhu, Collin Mangenah, Ruth Verhey, Ephraim Chiriseri, Jermaine M. Dambi, Ricardo Araya, Helen A. Weiss, Frances M. Cowan, Dixon Chibanda

“…Among 528 trial participants, adjusting for baseline score, gender, education, marital status, employment and HIV status, the proportion of participants with SSQ-14 score ≥ 8 was similar by arm after six months, adjusted odds ratio = 0.65 (95% CI: 0.36–1.17). Total program costs were higher in the YouFB arm. Process evaluation found the YouFB to be highly acceptable. …”
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WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape by Jennifer L Waller, Chunwan Lu, Kebin Liu, John D Klement, Dafeng Yang, Zhuoqi Liu, Alyssa D Merting, Dakota Poschel, Thomas Albers, Huidong Shi

“…Background Despite PD-L1 (Programmed death receptor ligand-1) expression on tumor cells and cytotoxic T lymphocytes tumor infiltration in the tumor microenvironment, human pancreatic cancer stands out as one of the human cancers that does not respond to immune checkpoint inhibitor (ICI) immunotherapy. …”
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Role of ARRB1 in prognosis and immunotherapy: A Pan-Cancer analysis by Yingquan Ye, Yingquan Ye, Haili Jiang, Haili Jiang, Yue Wu, Yue Wu, Gaoxiang Wang, Gaoxiang Wang, Yi Huang, Yi Huang, Weijie Sun, Mei Zhang, Mei Zhang

“…Furthermore, putative correlations between ARRB1 and tumor-infiltrating immune cells, the signatures of T-cell subtypes, immunomodulators, the tumor mutation burden (TMB), Programmed cell death ligand 1 (PD-L1), and microsatellite instability (MSI) were also explored. …”
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MRI based volumetric lung nodule assessment - a comparison to computed tomography by Tatjana Dell, Andreas Feisst, Olga Ramig, Yannik Layer, Narine Mesropyan, Alexander Isaak, Claus Pieper, Patrick Kupczyk, Julian Luetkens, Daniel Thomas, Daniel Kuetting

“…The study aimed to assess the feasibility and accuracy of in-vivo magnetic resonance imaging (MRI)-based volumetric assessment of lung nodules larger than 6 mm, in comparison to the current gold standard, CT.Materials and methodsThis study involved a subgroup analysis of 233 participants from a prospective, single-center lung cancer screening program using CT and MRI. Patients were included if foci ≥6 mm were detected in CT during the initial screening round, resulting in 23 participants with 47 pulmonary nodules. …”
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Prediabetes: prevalence, associations with cardiovascular risk factors and contribution to survival in the Russian population by Yu. A. Balanova, S. A. Shalnova, A. E. Imaeva, V. A. Kutsenko, A. V. Kapustina, S. E. Evstifeeva, G. A. Muromtseva, R. V. Ievlev, R. N. Shepel, O. M. Drapkina

“…Statistical processing was performed using the open-source statistical programming language and R environment (version 4.1). …”
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Phosphate Peritoneal Equilibration Test, Hypothesizing New Parameters to Classify Peritoneal Phosphate Handling Through the Peritoneal Membrane by Francesca K. Martino, Chiara Ciotti, Anna Basso, Ruggero Zanella, Lucia F. Stefanelli, Dorella Del Prete, Federico Nalesso

“…Standardizing a phosphate removal propensity marker could optimize the peritoneal dialytic program. Our preliminary report aims to evaluate a simple model of phosphate handling and to assess which marker during the peritoneal equilibration test (PET) could better describe the propensity of phosphate removal through the peritoneal membrane. …”
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A Pharmacokinetic Study of the Interaction Between Regorafenib and Paracetamol in Male Rats by Agnieszka Karbownik, Danuta Szkutnik-Fiedler, Filip Otto, Anna Wolc, Tomasz Grabowski, Zuzanna Maciejewska, Aleksandra Borycka, Edyta Szałek

“…The statistical evaluation was performed in the SAS program. <b>Results</b>: After the administration of PA, the C_max and AUC_0–∞ of REG increased by 890% and 1140%, respectively; for M-2, they increased by 220% and 170%, and for M-5, by 2130% and 1730% (C_max and AUC_0–∞, respectively). …”
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Genetic surveillance shows spread of ACT resistance during period of malaria decline in Vietnam (2018-2020) by Johanna Helena Kattenberg, Mathijs Mutsaers, Van Hong Nguyen, Thi Hong Ngoc Nguyen, Arlette Umugwaneza, Maria Lara-Escandell, Xuan Xa Nguyen, Thi Huong Binh Nguyen, Anna Rosanas-Urgell

“…The central highlands, particularly Gia Lai province, have the highest residual malaria burden but exhibit low diversity and clonal populations, likely due to the pressures from the antimalarial drugs and targeted national malaria control program (NMCP) efforts.DiscussionIn conclusion, examining a broad panel of full-length resistance genes and SNPs provided high-resolution insights into genetic diversity and resistance evolution in Vietnam, offering valuable information to inform local treatment and intervention strategies.…”
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The content of sEMMPRIN/CD147 in the blood serum of patients with bone tumors and its relationship with the clinical and morphological characteristics of the disease by N. E. Kushlinskii, O. V. Kovaleva, Yu. B. Kuzmin, E. V. Samoilova, P. L. Prishchep, E. S. Gershtein, S. R. Varfolomeeva, D. V. Rogozhin, N. Yu. Sokolov, K. A. Borzov, E. A. Sushentsov, A. K. Valiev, I. S. Stilidy

“…The obtained data were processed using the GraphPad Prizm 9.4 program. When comparing indicators and analyzing their relationships, we used the nonparametric Mann–Whitney and Kruskal–Wallis tests. …”
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Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes by Wenxu Wang, Wenxu Wang, Jincheng Lu, Jincheng Lu, Ningyun Pan, Ningyun Pan, Huiying Zhang, Jingcen Dai, Jie Li, Cheng Chi, Liumei Zhang, Liang Wang, Mengying Zhang, Mengying Zhang

“…PANoptosis represents an emerging paradigm in programmed cell death, integrating three critical processes: pyroptosis, apoptosis, and necroptosis. …”
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Determination of 13 Halogenated Organic Additives in Plastics of Electronic Products by Liquid Chromatography-High Resolution Mass Spectrometry by Rui-fen ZHENG, Yi-zhe ZHU, Ling LIU, Shi-rong MA, Jun-xian HE, Cai-ming TANG

“…Chromatographic separation was conducted with an ACQUITY UPLC BEH C18 column. A gradient elution program was performed with the mobile phases of acetonitrile and H2O containing 2 mmol/L ammonium acetate. …”
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Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using s... by Zhaorui Cheng, Xiangyu Yang, Yi Ren, Huimin Wang, Qi Zhang, Sailing Lin, Wenhao Wu, Xiaolu Yang, Jiahan Zheng, Xinzhu Liu, Xin Tao, Xiaoyong Chen, Yuxin Qian, Xiushen Li

“…Introduction: PANoptosis is a newly identified form of programmed cell death that integrates elements of pyroptosis, apoptosis, and necroptosis. …”
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