Prognostic Value of KRAS/TP53 Status for Overall Survival in First-Line Monoimmunotherapy and Chemoimmunotherapy Treated Patients With Nonsquamous NSCLC in the Netherlands: A Brief... by Vincent D. de Jager, MD, Léon C. van Kempen, PhD, Betzabel N. Cajiao Garcia, MSc, T. Jeroen N. Hiltermann, MD, PhD, Anthonie J. van der Wekken, MD, PhD, Ed Schuuring, PhD, Stefan M. Willems, MD, PhD

“…Introduction: Programmed death-ligand 1 (PD-L1) is the main predictive biomarker used to identify patients with NSCLC who are eligible for treatment with immune checkpoint inhibitors. …”
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Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myel... by Diwakar Davar, Yujia Liu, Jason Laporte, Prajna Guha, Steven C Katz, Chandra C Ghosh, Lauren Cournoyer, Alizee Ballarin, Ilan B Layman, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha

“…After a week, fluorescently labeled nelitolimod (10 µg/mouse) was delivered via PEDD and co-administered anti-programmed cell death-1 (α-PD-1) either via Sys or SQ. …”
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Biomarkers of tumor-reactive CD4+ and CD8+ TILs associate with improved prognosis in endometrial cancer. by Xavier Matias-Guiu, Ana Vivancos, Jordi Ponce, Ignacio Melero, Alena Gros, Josep María Piulats, Carlos E De Andrea, Maria Lozano-Rabella, Jara Palomero, August Vidal, Carla Panisello, Ricky Tirtakasuma, Judit Díaz-Gómez, Daniela Grases, Helena Pasamar, Laura Arregui, Eduard Dorca Duch, Esther Guerra Fernández

“…In addition, CD8+ and CD4+ TIL subpopulations were isolated based on the differential expression of programmed cell death protein-1 (PD-1) (negative, dim and high) and CD39 (positive or negative) by fluorescence activated cell sorting (FACS), expanded in vitro, and screened for autologous tumor recognition. …”
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Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing by Dirk Schadendorf, Ralf Gutzmer, Thomas Eigentler, Israel Lowy, Vladimir Jankovic, Elizabeth Stankevich, Anna C Pavlick, Danny Rischin, Michael R Migden, Annette M Lim, Chrysalyne D Schmults, Nikhil I Khushalani, Brett G M Hughes, Lara A Dunn, Leonel Hernandez-Aya, Anne Lynn S Chang, Badri Modi, Axel Hauschild, Claas Ulrich, Brian Stein, Jessica L Geiger, Murad Alam, Emmanuel Okoye, Melissa Mathias, Jocelyn Booth, Siyu Li, Matthew G Fury, Alexander Guminski

“…Background Cemiplimab, a high-affinity, potent human immunoglobulin G4 monoclonal antibody to programmed cell death-1 demonstrated antitumor activity in a Phase 1 advanced cutaneous squamous cell carcinoma (CSCC) expansion cohort (NCT02383212) and the pivotal Phase 2 study (NCT02760498). …”
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Phase 1 first-in-human dose-escalation study of IMSA101, a novel cyclic di-nucleotide STING agonist, for patients with advanced solid tumor malignancies by Syed Kazmi, Lijun Sun, Justin Moser, Angela Alistar, Timothy A Yap, Edward Garmey, Teresa Mooneyham, Peter Vu, Jay Jacoby, Deva Mahalingam

“…Preclinical studies demonstrate antitumor activity of IMSA101 alone and in combination with immune-checkpoint inhibitors (ICIs).Methods IMSA101-101 was an open-label, multicenter, phase 1 first-in-human dose-escalation study to establish a recommended phase 2 dose (RP2D) of IMSA101 both as monotherapy and in combination with a programmed death ligand 1 (PD-(L)1)-ICI. Secondary objectives were to evaluate safety, tolerability and antitumor activity, and to characterize pharmacokinetics. …”
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Radiomic Model Associated with Tumor Microenvironment Predicts Immunotherapy Response and Prognosis in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma by Jie Sun, Xuewei Wu, Xiao Zhang, Weiyuan Huang, Xi Zhong, Xueyan Li, Kaiming Xue, Shuyi Liu, Xianjie Chen, Wenzhu Li, Xin Liu, Hui Shen, Jingjing You, Wenle He, Zhe Jin, Lijuan Yu, Yuange Li, Shuixing Zhang, Bin Zhang

“…Background: No robust biomarkers have been identified to predict the efficacy of programmed cell death protein 1 (PD-1) inhibitors in patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). …”
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Herd Immunity to the Measles, Mumps and Rubella Viruses Among the Belgradian Population in May, 2024 by Anna Y. Popova, Vyacheslav S. Smirnov, Svetlana A. Egorova, Luka Dragačević, Angelica M. Milichkina, Jelena Protić, Ekaterina M. Danilova, Irina V. Drozd, Marija Petrušić, Ojuna B. Zhimbaeva, Elizaveta S. Glazkova, Nataša Gutić, Valeri A. Ivanov, Edward S. Ramsay, Oleg V. Kotsar, Vyacheslav Y. Smolensky, Areg A. Totolian

“…<b>Background/Objectives:</b> In the Republic of Serbia, measles vaccination was first introduced in 1971, while combined vaccination (measles, mumps, rubella) was made mandatory in 1996 as part of the national vaccination program. Reported prevalence values for 2023 were <0.75 cases per 100K population for measles, 0.09 cases per 100K for mumps, and no cases of rubella. …”
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Adult-plant resistance to leaf scald and net form net blotch in food barley genotypes at a hot spot location in Ethiopia by Girma Ababa, Wami Hailu, Tigist Shiferaw, Wondimu Fekadu, Sentayehu Alamerew

“…Plant height and the severity of both diseases showed an adverse association (r = −0.1), suggesting that barley breeders should take these two factors into account when designing targeted their breeding program.…”
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Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality by Jiansen Lu, Zhiqiang Hu, Huaji Jiang, Zebin Wen, Hongyu Li, Jian Li, Ke Zeng, Yingchao Xie, Huadan Chen, Xin-zhuan Su, Chunmei Cai, Xiao Yu

“…On the contrary, a late IFN-α/β induction through toll-like receptor 9 (TLR9)-IRF7/ stimulator of interferon genes (STING)- interferon regulatory factor 3 (IRF3) dependent pathways expands programmed cell death protein 1 (PD-1)+CD8+ T cells and impairs host immunity during PbANKA infection. …”
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Using Human‐Centred Design to Codesign Patient Engagement Tools With a Patient Advisory Council: Successes and Challenges by Madelyn Knaub, Santiago Leon, Surakshya Pokharel, Veronika Kiryanova, Kim Giroux, Prachi Khanna, Anna Rychtera, D'Arcy Duquette, Pamela Mathura, Nancy Verdin, Anshula Ambasta

“…Methods A HCD working group was formed from a Patient Advisory Council (PAC) that supports a research program to optimize laboratory test ordering in hospitalized patients. …”
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Efficacy and safety of trastuzumab deruxtecan in gastrointestinal malignancies: a systemic review and meta-analysis by Ali Hussain, Qamar Iqbal, Sangeetha Isaac, Faisal Shariff, Ezza Tariq, Hassan Awais, Nayan Mainkar, Heidi Lynn Reis, Aakriti Arora, Akshay Deotare, Azka Tasleem, Srijan Valasapalli, Munizay Paracha, Maya Hashmi, Hamdi Battah, Mahvish Muzaffar

“…Pooled analyses were performed using the ‘meta’ package (Schwarzer et al., R programming language), and proportions with 95% confidence intervals (CIs) were calculated.ResultsWe identified 653 patients treated with T-DXd for HER2-positive GI malignancies in 10 studies. …”
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COMMUNITY-ACQUIRED PNEUMONIA IN HIV-INFECTED SUBJECTS: MICROFLORA, ANTIBIOTIC RESISTANCE: DEPENDENCE ON THE LEVELS OF CD4 LYMPHOCYTES by D. N. Akusheva, О. Е. Khokhlova, V. V. Kamshilova, A. I. Motova, О. V. Peryanova, A. A. Upirova, N. К. Potkina, Tatsuo Yamamoto

“…The results were processed with WHONET digital program (WHO). The significance level was p &lt; 0.05. …”
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Discussion of the correlation between HIV-1 gp120-induced intestinal dysbiosis and intestinal barrier loss by Ms Jiachun Luo, Anyun Wang, Yuqi Wang, Yuyi Che, Xingyu Wan, Qiuming Peng, Dr Xuefeng Gao, Mr. Xuefeng Gao

“…Undergraduate Training Program for Innovation and Entrepreneurship of SMU, China)…”
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Two decades of Lloviu virus in Europe: knowns and unknowns about the European filovirus by Dr Gábor Kemenesi, Dr Zsófia Lanszki, Ágota Ábrahám, Dr Sándor A Boldogh, Dr Simon Scott, professor Nigel Temperton, Dr Edward Wright, Dr Pierre Nouvellet, Dr Stefania Leopardi, Dr Paola Di Benedictis, Dr Adam Hume, Dr Elke Mühlberger, Levente Sipos-Szabó, Dr Dávid Bajusz, Dr Heliana Dundarova, Dr Szilárd L Bücs, Dr Branka Bajić, Dr Ivana Budinski, Dr Štefan Matis, Dr Tamás Görföl

“…Methods &amp; Materials: We initiated a complex monitoring program for Lloviu virus in 2013. During the last decade we collected and screened more than 2000 blood samples with PCR and serology from eight countries. …”
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Serum sPD-1 as a marker of T cell exhaustion in ART-naïve, ART-experienced, and intestinal parasite co-infected HIV-positive adults at the university of Gondar comprehensive specia... by Tadelo Wondmagegn, Wubet Birhan, Eseye Derb, Mulualem Lemma, Hana Yohannes, Degsew Ewunetie Anteneh, Alembante Bazezew, Kebebe Tadesse, Bewuketu Belete Alemu

“…While serum soluble programmed death protein 1 (sPD-1) may serve as a marker for immune exhaustion, its role in antiretroviral therapy (ART) and intestinal parasite (IP) co-infections remains underexplored, especially in developing countries like Ethiopia with high HIV and IP prevalence. …”
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Effect of water-based aerobic training on anthropometric, biochemical, cardiovascular, and explosive strength parameters in young overweight and obese women: a randomized controlle... by Imen Ben Cheikh, Hamza Marzouki, Okba Selmi, Bilel Cherni, Siwar Bouray, Ezdine Bouhlel, Anissa Bouassida, Beat Knechtle, Yung-Sheng Chen

“…Conclusions Our findings indicate that water-based aerobic training could be a useful program to enhance anthropometric, biochemical, cardiovascular, and explosive strength parameters in young overweight and obese women compared to inactive persons.…”
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Evaluation of treadmill cardiopulmonary exercise testing and field measurement results in women’s youth and adult national team water polo players by Mark Zamodics, Mate Babity, Attila Mihok, Csaba Bognar, Agnes Bucsko-Varga, Panka Kulcsar, Dora Boroncsok, Regina Benko, Alexandra Fabian, Balint Lakatos, Hajnalka Vago, Attila Kovacs, Bela Merkely, Orsolya Kiss

“…Comparing the youth (<18y) and the adult (≥18y) players, no differences in relative maximal aerobic capacity (44.4 ± 4.8vs.44.9 ± 5.5 ml/kg/min, p = 0.72) and in peak lactate values (8.2 ± 2.7vs.8.7 ± 1.9 mM, p = 0.48) were observed in CPET examinations, while maximal heart rates were higher in the youth group (200.7 ± 7.2vs.190.1 ± 9.6 BPM, p < 0.001).Similarly, maximal lactate levels showed no differences (9.1 ± 2.6vs.10.4 ± 2.7 mM, p = 0.13), while maximal heart rates were higher in the youth group during swimming examinations (197.7 ± 10.0vs.181.4 ± 8.9 BPM, p < 0.001).The combined use of both exercise tests enables the assessment of maximal physiological parameters (heart rate, lactate, aerobic capacity) during different types and intensities of physical exercise and identifies differences across age groups, facilitating the design of a more personalized and effective training program.…”
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Natural lung-tropic TH9 cells: a sharp weapon for established lung metastases by Tao Chen, Hao Zhou, Shuming Li, Nong Lin, Yixuan Feng, Zhijian Cai, Chenxiao Qiao, Eloy Yinwang, Shengdong Wang, Xuehuan Wen, Xiangang Jin, Yucheng Xue, Wenkan Zhang, Xianchang Zeng, Zenan Wang, Hangxiang Sun, Lifeng Jiang, Hengyuan Li, Binghao Li, Zhaoming Ye

“…Ultimately, we analyzed the tumor immune composition after TH9 cell transfusion and evaluated the therapeutic efficacy of adjunctive anti-programmed cell death protein-1 (PD-1) therapy in conjunction with TH9 cells.Results In this study, we provide evidence that TH9 cells exhibit higher lung tropism than TH1 and TH17 cells, thereby exhibiting exceptional efficacy in combating established lung metastases. …”
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Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcino... by Lei Yu, Lan Zhang, Xin Xu, Zheng Wang, Jian Zhou, Jia Fan, Wentao Wang, Zhenggang Ren, Lixing Li, Peiran Huang

“…The study aims to evaluate the efficacy and safety of this treatment strategy for such patients.Methods In this single-arm, prospective, phase II study, we enrolled eligible patients with HCC who were treated with TACE plus programmed cell death protein 1 (PD-1) inhibitors (sintilimab) from April 2021 to February 2023. …”
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The contribution of personalized video feedback to robotic partial nephrectomy training in realistic 3D tumor kidney models: design, production and implementation by Ahmet Furkan Sarıkaya, Kayhan Tarım, Ersin Köseoğlu, Arif Özkan, İbrahim Can Aykanat, Baris Esen, Umut Can Karaarslan, Mustafa Müdüroğlu, Şevval Kanlı, Murat Can Kiremit, Yakup Kordan, Mevlana Derya Balbay, Tarık Esen, Serdar Aydın, Serdar Aydın, Abdullah Erdem Canda, Abdullah Erdem Canda

“…After completing a standardized theoretical and simulation-based training program, they performed partial nephrectomy on 3D-printed kidney models. …”
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