Predictive potential of combined secretomics and image-based morphometry as a non-invasive method for selecting implanting embryos by Andrea Palomar, Roberto Yagüe-Serrano, Juan Vicente Martínez-Sanchis, Ignacio Iniesta, Alicia Quiñonero, Pedro José Fernández-Colom, Ana Monzó, José María Rubio, Inmaculada Molina, Francisco Domínguez

“…Ninety-two proteins involved in embryonic developmental programming were measured in spent blastocyst media (SBM) using a protein extension assay. …”
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Investigating the Role of GDF-15 in Diabetes and Obesity: A Comprehensive Analysis of a Cohort from the KDEP Study by Jehad Abubaker, Mohamed Abu-Farha, Ahmed N. Albatineh, Irina Al-Khairi, Preethi Cherian, Hamad Ali, Ibrahim Taher, Fahad Alajmi, Mohammed Qaddoumi, Muhammad Abdul-Ghani, Fahd Al-Mulla

“…<b>Methods:</b> In a cross-sectional study, plasma GDF-15 concentrations were measured in 2083 participants enrolled in the Kuwait Diabetes Epidemiology Program (KDEP). The dataset included anthropometric, clinical, biochemical, and glycemic markers. …”
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High and low body mass index increases the risk of short-term postoperative complications following total shoulder arthroplasty by Salvatore Capotosto, MD, Matthew Kim, MD, Kenny Ling, MD, Alireza Nazemi, MD, Ryan Tantone, MD, Elizabeth Wang, MD, David E. Komatsu, PhD, Edward D. Wang, MD

“…Methods: All patients undergoing TSA, both anatomic and reverse, between 2015 and 2019 were queried from the American College of Surgeons National Surgical Quality Improvement Program database. The study population was stratified into 6 cohorts: BMI < 18.5 kg/m2 (underweight), BMI of 18.5-24.9 kg/m2 (reference cohort), BMI of 25.0-29.9 kg/m2 (overweight), BMI of 30.0-39.9 kg/m2 (obese), BMI of 40.0-49.9 kg/m2 (morbidly obese), and BMI ≥ 50.0 kg/m2 (super-morbidly obese). …”
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Effect of timing of artificial insemination with conventional or sex-sorted semen on fertility of lactating dairy cows by V.G. Santos, P.D. Carvalho, A.H. Souza, S. Priskas, J.A.L. Castro, A.M.F. Pereira, P.J. Ross, J. Moreno, M.C. Wiltbank, P.M. Fricke

“…ABSTRACT: The effect on pregnancy per artificial insemination (P/AI) of interval from induction of ovulation to timed artificial insemination (TAI) for cows submitted to a fertility program and the interval from the onset of estrous alert to artificial insemination (AI) for cows inseminated to estrous alert was analyzed in 3 experiments. …”
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Lymph Node Involvement Prediction Using Machine Learning: Analysis of Prostatic Nodule, Prostatic Gland, and Periprostatic Adipose Tissue (PPAT) by Eliodoro Faiella, Giulia D’amone, Raffaele Ragone, Matteo Pileri, Elva Vergantino, Bruno Beomonte Zobel, Rosario Francesco Grasso, Domiziana Santucci

“…A three-year resident manually segmented the prostate nodule, prostatic gland, and periprostatic tissue using an open-source segmentation program. A random forest (RF) machine learning model was developed and tested using Chat-GPT version 4.0 software. …”
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Systems analysis and improvement to optimize opioid use disorder care quality and continuity for patients exiting jail (SAIA-MOUD) by Sarah Gimbel, Anirban Basu, Emily Callen, Abraham D. Flaxman, Omeid Heidari, Julia E. Hood, Anna Kellogg, Eli Kern, Judith I. Tsui, Ericka Turley, Kenneth Sherr

“…Clinic teams with study team support will deliver the SAIA-MOUD intervention at the jail-based MOUD program and three referral clinics over a two-year intensive phase, followed by a one-year sustainment phase where SAIA implementation will be led by King County Jail MOUD staff without study support to enable pragmatic evaluation of sustained implementation. …”
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Effects of whole-body cryostimulation on spinal and shoulder range of motion in individuals with obesity by Serena Cerfoglio, Serena Cerfoglio, Federica Verme, Jacopo Maria Fontana, Angelo Alito, Manuela Galli, Paolo Capodaglio, Paolo Capodaglio, Veronica Cimolin, Veronica Cimolin

“…This study evaluates the acute and short-term effects of WBC combined with rehabilitation on spinal and shoulder ROM in individuals with obesity.MethodsThis non-randomized controlled trial included 42 adults with obesity undergoing a 4-week multidisciplinary rehabilitation program consisting of nutritional intervention, psychological support, physiotherapy, and physical activity. …”
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Worlds Next Door: A Candidate Giant Planet Imaged in the Habitable Zone of α Centauri A. I. Observations, Orbital and Physical Properties, and Exozodi Upper Limits by Charles Beichman, Aniket Sanghi, Dimitri Mawet, Pierre Kervella, Kevin Wagner, Billy Quarles, Jack J. Lissauer, Max Sommer, Mark Wyatt, Nicolas Godoy, William O. Balmer, Laurent Pueyo, Jorge Llop-Sayson, Jonathan Aguilar, Rachel Akeson, Ruslan Belikov, Anthony Boccaletti, Elodie Choquet, Edward Fomalont, Thomas Henning, Dean Hines, Renyu Hu, Pierre-Olivier Lagage, Jarron Leisenring, James Mang, Michael Ressler, Eugene Serabyn, Pascal Tremblin, Marie Ygouf, Mantas Zilinskas

“…However, if S 1 is the counterpart of the object C 1, seen by the Very Large Telescope/New Earths in Alpha Centauri Region program in 2019, we find that there is a 52% chance that the S 1 +  C 1 candidate was missed in both follow-up JWST/MIRI observations due to orbital motion. …”
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Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer by Lin Shen, Xiaochen Zhao, Zhenghang Wang, Yuezong Bai, Feilong Zhao, Zhi Peng, Jinping Cai, Tong Xie, Shuang Tong, Xiaofan Wei

“…Patients with EBVaGC with a high cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) level were less responsive to anti-programmed death-1/ligand 1 (PD-1/L1) monotherapy, and the combination of anti-CTLA-4 plus anti-PD-1/L1 checkpoint blockade benefited patients with EBVaGC more than anti-PD-1/L1 monotherapy with a trend close to significance (p=0.074). …”
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Psychosocial risk factors for cardiovascular disease: vital exhaustion and its associations with biochemical markers of inflammation among persons 25-44 years old by V. V. Gafarov, E. A. Gromova, E. V. Kashtanova, D. V. Denisova, I. V. Gagulin, Y. V. Polonskaya, A. V. Gafarova, Yu. I. Ragino

“…General examination and history collection were carried out according to standard methods included in the WHO program "MONICA-psychosocial (MOPSY)". All study participants completed the Maastricht Vital Exhaustion Questionnaire (MQ).Results. …”
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Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer by Jinlong Tian, Yanlei Li, Yu Tong, Yuan Zhang, Tingxiao Zhao, Yao Kang, Qing Bi

“…This study aims to shed light on the role and possible mechanism of UCK2 in pan-cancer.MethodsWe used the R programming language for pan-cancer bulk sequencing data analysis, which were obtained from the University of California, Santa Cruz (UCSC) datasets. …”
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Persistent anti-NY-ESO-1-specific T cells and expression of differential biomarkers in a patient with metastatic gastric cancer benefiting from combined radioimmunotherapy treatmen... by Deepak Kumar, Said Dermime, Maysaloun Merhi, Afsheen Raza, Varghese Philipose Inchakalody, Kodappully S Siveen, Fairooz Sahir, Sarra Mestiri, Shereena Hydrose, Niloofar Allahverdi, Munir Jalis, Allan Relecom, Lobna Al Zaidan, Mohamed Sir Elkhatim Hamid, Mai Mostafa, Abdul Rehman Zar Gul, Shahab Uddin, Mohammed Al Homsi

“…Combined radioimmunotherapy is currently being investigated to treat patients with cancer. Anti-programmed cell death-1 (PD-1) immunotherapy offers the prospect of long-term disease control in solid tumors. …”
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Deciphering the structural and dynamic effects of SHP2-E76 mutations: mechanistic insights into oncogenic activation by Humaira Rafiq, Lu Han, Ashfaq Ur Rehman, Pei He, Ali Saber Abdelhameed, Eman S. G. Hassan, Hongxia Fu, Abdul Wadood, Junjian Hu

“…This protein is essential for the regulation of cell growth, differentiation, programed cell death, and survival. This regulation is achieved through the release of intramolecular autoinhibition and the modulation of several signaling pathways, including the signaling cascade of Ras-MAPK. …”
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Alcohol consumption, high-sensitivity C-reactive protein, and estimated glomerular filtration rate: tripartite predictors of 10-year cardiovascular risk progression in patients wit... by Yizhe Wang, Yizhe Wang, Yu Duan, Yongcheng Zhang, Yongcheng Zhang, Na Li, Ying Hu, Liping Gu, Yanfang Hou, Yuhang Ma

“…ObjectivesTo investigate the predictors influencing the advancement of 10-year cardiovascular disease (CVD) risk after infection with Corona Virus Disease 2019 (COVID-19) in type 2 diabetes patients, and to provide a theoretical basis for an early intervention program for the cardiovascular dimension of the cardiovascular-kidney-metabolic syndrome (CKM syndrome).MethodsA cohort of 378 individuals diagnosed with type 2 diabetes was analyzed retrospectively. …”
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Revolutionizing oncology care: pioneering AI models to foresee pneumonia-related mortality by Qunzhe Ding, Yi Zhang, Zihao Zhang, Peijie Huang, Rui Tian, Zhigang Zhou, Ruilan Wang, Yun Xie

“…This study aimed to determine the incidence of pneumonia as a cause of death in patients with cancer, analyze trends and risk factors associated with mortality, and develop corresponding predictive models.MethodsWe included 26,938 cancer patients in the United States who died from pneumonia between 1973 and 2020, as identified through the Surveillance, Epidemiology, and End Results (SEER) program. Cox regression analysis was used to ascertain the prognostic factors for patients with cancer. …”
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Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer by Meng Zhang, Guiling Li, Jing Peng, Keqin Hua, Yumeng Wang, Congwen Wang, Junjun Qiu, Xinyu Qu, Chong Lu, Mingxing Zhang, Xingling Qi

“…Although therapies targeting the programmed cell death protein 1 (PD-1) pathway have been approved for CC, a large subset of patients exhibit innate resistance. …”
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Impact of pharmaceutical and non-pharmaceutical interventions on COVID-19 in Tunisia by Hela Abroug, Cyrine Bennasrallah, Manel Ben Fredj, Meriem Kacem, Manel Ben Belgacem, Wafa Dhouib, Amel Gara, Amani Maatouk, Imen Zemni, Donia Ben Hassine, Syrine Gallas, Ines Bouanene, Asma Sriha Belguith

“…Since the start of the immunization program, the risk of COVID-19 death has consistently decreased. …”
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Inhibitory Fcγ receptor deletion enhances CD8 T cell stemness increasing anti-PD-1 therapy responsiveness against glioblastoma by Won Hyung Park, In Kang, Keun Bon Ku, Chae Won Kim, Yumin Kim, Byeong Hoon Kang, Jeongwoo La, Stephen Ahn, Sung Ki Lee, Heung Kyu Lee

“…In this study, we investigate a target that triggers stem-like properties in CD8 T cells to enhance the response to ICB in a murine GBM model.Methods Using Fcgr2b−/− mice and a murine GL261 GBM model, we confirmed the efficacy of anti-programmed cell death protein-1 (PD-1) immunotherapy, observing improved survival. …”
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M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer by Eva M Garrido-Martin, Toby W P Mellows, James Clarke, Anusha-Preethi Ganesan, Oliver Wood, Angelica Cazaly, Gregory Seumois, Serena J Chee, Aiman Alzetani, Emma V King, Gareth Thomas, Peter S Friedmann, Pandurangan Vijayanand, Tilman Sanchez-Elsner

“…Thus, therapeutic approaches to re-program TAMs to an M1hot phenotype are likely to augment the adaptive antitumor responses.…”
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Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma by Ge Zhang, Zhenfa Zhang, Lianmin Zhang, Guangyao Zhou, Pengpeng Zhang, Dingli Wang, Shuai Jiang

“…Significantly, suppression of B4GALT2 was found to enhance CD8+ T lymphocyte populations and their functional status, thereby potentiating anti-programmed cell death protein 1 immunotherapeutic efficacy in animal studies. …”
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