Experiences and outcomes of older adults with obesity transitioning from gym- to home-based resistance training due to COVID-19 lockdowns: a mixed-methods analysis of a RCT by Costas Glavas, Jakub Mesinovic, Anoohya Gandham, Mavil May Cervo, Carrie-Anne Ng, Peter R. Ebeling, Elena S. George, Robin M. Daly, Belinda R. Beck, Paul Jansons, David Scott

“…Results Participants’ experiences and perspectives regarding the HOME program encompassed various elements including accessibility, accountability, maintaining physical activity levels, motivation, support from health care professionals, openness to telehealth videoconferencing for support, engagement, lack of equipment, supervision and a structured routine. …”
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Synthesis and Evaluation of [¹⁸F]AlF-NOTA-iPD-L1 as a Potential Theranostic Pair for [¹⁷⁷Lu]Lu-DOTA-iPD-L1 by Guillermina Ferro-Flores, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Nallely Jiménez-Mancilla, Nancy Lara-Almazán, Rigoberto Oros-Pantoja, Clara Santos-Cuevas, Erika Azorín-Vega, Laura Meléndez-Alafort

“…<b>Background/Objective</b>: Programmed cell death ligand-1 (PD-L1), which is overexpressed in certain tumors, inhibits the body’s natural immune response by providing an “off” signal that enables cancer cells to evade the immune system. …”
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Emergence and characterization of a ST852 Klebsiella quasipneumoniae clinical isolate coharboring blaNDM-1 and blaKPC-2 in China by Chongmei Tian, Yaping Zhao, Su Dong, Zhixin You, Jingbai Chen, Hongfeng Xu, Yuejuan Fang, Yapei Zhang

“…Antimicrobial resistance determinants were identified using the ABRicate program in the ResFinder database. Insertion sequences (ISs) were identified using ISFinder. …”
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Secular trends in physical fitness and cardiovascular risks among Chinese college students: an analysis of five successive national surveys between 2000 and 2019Research in context by Shan Cai, Yihang Zhang, Ziyue Chen, Yunfei Liu, Jiajia Dang, Jiaxin Li, Tianyu Huang, Ziyue Sun, Yanhui Dong, Jun Ma, Yi Song

“…Funding: The present study was funded by National Key R&D Program of China (Grant No. 2024YFC2707901 to Yi Song), National Natural Science Foundation of China (Grant No. 82273654 to Yi Song), and Beijing Office for Education Sciences Planning (Grant No. …”
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Obesity phenotypes and the risk of myocardial infarction: a prospective cohort study by S. V. Mustafina, D. A. Vinter, O. D. Rymar, L. V. Scherbakova, V. V. Gafarov, D. O. Panov, E. A. Gromova, A. V. Gafarova, E. G. Verevkin, T. I. Nikitenko, M. Bobak, S. K. Malyutina

“…New cases of myocardial infarction have been collected according to the data of the WHO “Register of Acute Myocardial Infarction” program, held at the Research Institute of Therapy and Preventive Medicine; the results of two repeated examinations (2006-2008 and 2015-2017) and repeated postal interview of cohort during 13-year follow-up. …”
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Surgical stabilization of rib fractures improves survival in functionally dependent trauma patients by Yi-Yu Lin, Yi-Jung Chen, Chih-Po Hsu, Jen-Fu Huang, Ya-Chiao Lin, Ling-Wei Kuo, Chi-Tung Cheng, Chien-Hung Liao

“…Methods A retrospective cohort analysis was conducted using the American College of Surgeons-Trauma Quality Improvement Program dataset from 2020 to 2022. Patients with three or more rib fractures and AIS (Abbreviated Injury Scale) greater than 3 for the rib and thoracic wall, along with documented functional dependency, were included. …”
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Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches by Ingunn Olea Lund, Laurie J. Hannigan, Helga Ask, Adrian D. Askelund, Laura Hegemann, Elizabeth C. Corfield, Robyn E. Wootton, Yasmin I. Ahmadzadeh, George Davey Smith, Tom A. McAdams, Eivind Ystrom, Alexandra Havdahl

“…Nonetheless, our research contributes to identifying boundary conditions of the fetal programming and developmental origins of health and disease hypotheses, which may not be as universal as sometimes assumed.…”
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PD-L1 Testing, Treatment Patterns, and Clinical Outcomes Among Patients with Metastatic NSCLC at an Academic Medical Center, 2017–2021 by Mehmet Altan, Dawen Sui, Cai Xu, George R. Simon, Saliha T. Sulihem, Donna Malveaux, Darcy Ponce, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, J. Jack Lee, Jianjun Zhang, Don L. Gibbons, Ara A. Vaporciyan, John V. Heymach, Melissa L. Santorelli, Thomas Burke, Loretta A. Williams

“…Methods This single-center observational study was conducted to describe programmed death-ligand 1 (PD-L1) testing, choice of therapy, and outcomes for adult patients with stage IV NSCLC initiating first-line therapy from 2017 through 2020, with follow-up through June 2021. …”
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High matrix metalloproteinase-2 expression predicts poor prognosis of colon adenocarcinoma and is associated with PD-L1 expression and lymphocyte infiltration by Yiyi Xiao, Guangming Li, Yongjie Xie, Bo Shao, Jingpeng Hao, Yanglin Zhu, Dejun Kong, Yafei Qin, Hong Qin, Shaohua Ren, Hongda Wang, Chenglu Sun, Hao Wang

“…Background Colon adenocarcinoma (COAD) is a prevalent and aggressive malignancy with limited treatment options, particularly for advanced stages. While programmed death-ligand 1 (PD-L1) inhibition, has emerged as an appealing therapeutic approach for COAD, its effectiveness as a monotherapy is hindered by high tumor heterogeneity. …”
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Chronical kidney disease in clinical practice: non progredi est regredi (lat. not to go forward is to go back) by A. L. Vertkin, N. A. Burakova, Yu. V. Sedyakina, S. S. Kurdzhieva, M. M. Shamuilova, E. M. Ledeneva

“…Upon stabilization of the patient’s condition, she was discharged from the hospital with recommendations to continue the program hemodialysis. However, even upon admission to the hospital, the patient’s creatinine level was 260 μmol/L, which may indicate that chronic kidney disease had been developing for a long time before myocardial infarction and before the administration of X-ray contrast medium during coronary angiography.Conclusion. …”
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A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome by Xiaoxiao Wang, Yingxue Liu, Guanghui Yuan, Jingjie Yang, Xiaowen Liu, Shuyuan Chen, Huaiqian Dou, Panpan Lu, Linfang Han, Duan Li, Cuifang Hao

“…We emphasize the importance of genetic analysis in the diagnosis and prognosis of “genuine” EFS (GEFS) and recommend that EFS patients strive for a successful pregnancy through an oocyte donation program.…”
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Neoadjuvant chemoradiotherapy combined with sequential perioperative toripalimab in locally advanced esophageal squamous cell cancer by Qiang Liu, Qing Ye, Xin Xu, Lei Shen, Yao Zhang, Bin Hu, Haiyan Chen, Xiaojing Zhao, Zhiyong Sun, Haiping Lin, Ling Rong, Xiaohang Wang, Yong-Rui Bai, Xiumei Ma

“…Background Programmed death 1 (PD-1) inhibitor demonstrated durable antitumor activity in advanced esophageal squamous cell carcinoma (ESCC), but the clinical benefit of perioperative immunotherapy in ESCC remains unclear. …”
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Phase I study of the safety and clinical activity of the interleukin-8 inhibitor AMY109 combined with atezolizumab in patients with advanced solid cancers by Yasutoshi Kuboki, Masafumi Ikeda, Shigehisa Kitano, Takafumi Koyama, Noboru Yamamoto, Yuki Yamaguchi, Yuki Nakagawa, Takaaki Ishida, Hidenori Mizugaki, Takatsugu Narikiyo, Ryoko Takubo, Chika Ogami, Mayuko Sekiya

“…Background Immunosuppressive conditions within the tumor microenvironment (TME) can allow tumors to evade the immune system, including by hampering programmed death ligand 1 (PD-L1) inhibitor activity. …”
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PrEP choice in the real world: Results of a prospective cohort study describing uptake and use patterns of oral PrEP and the dapivirine vaginal ring among women in sub‐Saharan Afri... by Virginia A. Fonner, Elizabeth Irungu, Mark Conlon, Carolyne A. Akello, Emily Gwavava, Kevin K'Orimba, Nicolette P. Naidoo, Patriciah Jeckonia, Imelda Mahaka, Saiqa Mullick, Mamatli Chabela, Roisin Drysdale, Jacqueline Kabongo, Millicent Kiruki, Ivan Segawa, Munyaradzi Dobbie, Nthuseng Marake, Peter Mudiope, Hasina Subedar, Rose Wafula, Andrew Kazibwe, Jason Reed, Katharine Kripke, Douglas Taylor, Mu‐Tien Lee, Glory Chidumwa, Adatia Chivafa, Ramatsoai Soothoane, Margaret Eichleay, Ashley Mayo, Courtney McGuire, Tara McClure, Tatenda Yemeke, Kristine Torjesen, the CATALYST study team

“…With expanding biomedical prevention options, understanding PrEP use patterns when women are offered choice can inform HIV prevention programming in Africa. Methods The CATALYST study offers informed PrEP choice through an enhanced service delivery package for women in 27 public health sites across Kenya, Lesotho, South Africa, Uganda, and Zimbabwe. …”
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Predictive value of ENLIGHT-DP in patients with metastatic lung adenocarcinoma treated with immune checkpoint inhibitors and platinum chemotherapy directly from histopathology slid... by Eli Pikarsky, Anna Elia, Gal Dinstag, Omer Tirosh, Tuvik Beker, Ranit Aharonov, Hovav Nechushtan, Leon Gugel, Yaron Kinar, Michael Tabi, Tzivia Gottlieb, Aron Popovtzer, Johnathan Arnon, Yakir Rottenberg, Philip Blumenfeld

“…We then unblinded the clinical outcomes and evaluated the predictive value of ENLIGHT-DP in comparison to programmed death ligand (PD-L)-1 and tumor mutational burden (TMB).Results ENLIGHT-DP is predictive of response to treatment with receiver operating characteristic (ROC) area under the curve (AUC) of 0.69 (p=0.01) and outperforms both TMB and PD-L1 expression with ROC AUC of 0.52 and 0.46, respectively. …”
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Clinicians’ attitudes and knowledge of medicinal cannabis in opioid dependence treatment clinics in New South Wales, Australia by Laila Parvaresh, Llewellyn Mills, Jaleh Gholami, Louisa Jansen, Nazila Jamshidi, Kate Baker, Christopher Tremonti, Marguerite Tracy, Adrian Dunlop, Nicholas Lintzeris

“…Abstract Background There are no prior studies investigating the attitudes and knowledge of opioid treatment program (OTP) clinicians on prescribed medicinal cannabis in OTP clients. …”
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Thymic characteristics in patients with autoimmune diseases: a multicentre radiological observational studyResearch in context by Haoxiao Chang, Junqiang Yan, Anxin Wang, Ningning Wang, Peng Liu, Yemin Shi, Xin Zhao, Jinqiao Zhu, Yuan Cai, Xue Xia, Yunyi Hao, Shiyi Yin, Jing Wang, Xinli Wang, Lina Sun, Jia Ma, Xiaoyu Huang, Haonan Guan, De-Cai Tian, Kaibin Shi, Ganqin Du, Wenhao Huang, Guoyan Qi, Hao Li, Yongjun Wang, Fu-Dong Shi, Zhang Zhang, Wei-Na Jin

“…Funding: The National Key R&D Program of China, the National Science Foundation of China, and the Tianjin Key Medical Discipline (Specialty) Construction Project.…”
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Schistosomiasis in Ghana from baseline to now: the impact of fifteen years of interventions by Joseph Opare, Tei Hervie, Ernest Mensah, Charles Brown-Davies, Odame Asiedu, Bright Alomatu, Ebenezer Padi Ako, John Frederick Dadzie, Irene Dzathor, Vance Harris, Julie Ritter, Darin Evans, Anna Elizabeth Phillips

“…The Ghana Health Service launched the Neglected Tropical Disease program in 2008, expanding baseline disease mapping first initiated in 2007 to additional geographic areas in 2008 and 2010 and simultaneously rolling out mass drug administration (MDA). …”
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Targeting the LMP1‐ALIX axis in EBV+ nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity by Fajian He, Yan Gong, Gan Tao, Jianguo Zhang, Qiuji Wu, Yushuang Tan, Yajie Cheng, Chunsheng Wang, Jinru Yang, Linzhi Han, Zhihao Wang, Yanping Gao, Jingyi He, Rui Bai, Peikai Sun, Xiaoyan Yu, Yajuan Zhou, Conghua Xie

“…Abstract Background Immunotherapy has revolutionized the therapeutical regimen for nasopharyngeal carcinoma (NPC), yet its response rate remains insufficient. Programmed death‐ligand 1 (PD‐L1) on small extracellular vesicles (sEVs) mediates local and peripheral immunosuppression in tumors, and the mechanism of PD‐L1 loading into these vesicles is garnering increasing attention. …”
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Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies by Camilla Jandus, Walter Ferlin, Sébastien Calloud, Alizée Viandier, Pauline Malinge, Nicolas Fischer, Limin Shang, Krzysztof Masternak, Julien Montorfani, Eric Hatterer, Laurence Chatel, Adeline Lesnier, Bruno Daubeuf, Lise Nouveau

“…The in vivo antitumor activity was assessed in combination with an anti-mouse programmed cell death protein 1 (mPD-1) monoclonal antibody.Results We demonstrated with two different TAAs (human epidermal growth factor receptor 2 (HER2) and mesothelin (MSLN)) that the CD122×TAA/CD132×TAA bsAb pairs mediate effective activation of immune cells exclusively in the presence of TAA+ tumor cells. …”
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