EP-430 - INFECÇÕES DE SÍTIO CIRÚRGICO EM TRANSPLANTES RENAIS EM UM HOSPITAL DE ENSINO: UMA ANÁLISE DE SÉRIE TEMPORAL. by Miguel Rubira Telles, Flávio Pasa Brandt, Luis Gustavo Modelli de Andrade, Ricardo de Souza Cavalcante, Ricardo Augusto Monteiro Barros Almeida, Gabriel Berg de Almeida

“…As séries temporais foram analisadas utilizando o software R versão 4.3.2 (R Core Team, 2023) e as mudanças de tendência o software Joinpoint Regression Program, versão 5.1.0.0 (National Cancer Institute, 2024). …”
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Application of continuous quality improvement in promoting the cooperative development of district-level Central Sterile Supply Department (持续质量改进在促进区级消毒供应中心合作发展中的应用)... by SONG Gang (宋钢), MA Qiong (马琼), DUAN Yanxiang (段艳香)

“…Objective To explore the application effect of continuous quality improvement (CQI) in promoting regional cooperation and development of district-level Central Sterile Supply Department (CSSD). Methods The CQI program had been carried out based on the cooperative development of district-level Central Sterile Supply Department science 2020. …”
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Predictors of patients with advanced pancreatic cancer undergoing conversion surgery via chemoimmunotherapy with a multifunctional Wilms’ tumor 1 (WT1) peptide cocktail-pulsed dend... by Nobuhiro Sato, Shigetaka Shimodaira, Masayuki Saruta, Yoko Shimizu, Shigeo Koido, Junichi Taguchi, Masamori Shimabuku, Tuuse Bito, Zensho Ito, Kan Uchiyama, Toshifumi Ohkusa, Haruo Sugiyama, Soyoko Morimoto, Yusuke Oji, Yoshihiro Oka, Masaki Ito

“…Therefore, the memory CD8+T cell subpopulations in WT1-specific cytotoxic T lymphocytes (WT1-CTLs), titers of antibodies against the WT1 epitopes, infiltration of CD103+tissue-resident memory T cells and CD20+cells in the pancreatic TME, gene mutations in plasma circulating tumor DNA (ctDNA) obtained via liquid biopsy, and PDAC cell characteristics were evaluated.Results Prior to treatment, patients with a relatively low number of WT1-specific CD8+naive T (Tn) cells, high levels of WT1-specific IgM antibodies, no mutations in any key genes (KRAS and TP53) in plasma ctDNA that were different in each patient (ie, neoantigens), and low levels of programmed death-ligand 1 expression in PDAC cells presented a markedly superior prognosis compared with patients with alternative patterns. …”
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Impact of Hypoalbuminemia on Outcomes Following Hepatic Resection: A NSQIP Retrospective Cohort Analysis of 26,394 Patients by Dunavan Morris-Janzen, Sukhdeep Jatana, Kevin Verhoeff, A. M. James Shapiro, David L. Bigam, Khaled Dajani, Blaire Anderson

“…<b>Methods:</b> The American College of Surgeons–National Surgical Quality Improvement Program (2017–2021) database was used to extract the data of patients who underwent a hepatic resection. …”
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Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…ObjectiveTo evaluate the efficacy and safety of programmed cell death protein 1 or its ligand (PD-1/L1) inhibitors as first-line therapy in advanced or metastatic urothelial carcinoma (mUC) who are ineligible for platinum-based chemotherapy.MethodA systematic search was conducted in four databases (Pubmed, Embase, Web of Science, and the Cochrane Library) to find articles that evaluate the effectiveness of first-line PD-1/L1 inhibitors for mUC, from the establishment of the databases to 22 November 2023. …”
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The AURORA Survey: A New Era of Emission-line Diagrams with JWST/NIRSpec by Alice E. Shapley, Ryan L. Sanders, Michael W. Topping, Naveen A. Reddy, Danielle A. Berg, Rychard J. Bouwens, Gabriel Brammer, Adam C. Carnall, Fergus Cullen, Romeel Davé, James S. Dunlop, Richard S. Ellis, N. M. Förster Schreiber, Steven R. Furlanetto, Karl Glazebrook, Garth D. Illingworth, Tucker Jones, Mariska Kriek, Derek J. McLeod, Ross J. McLure, Desika Narayanan, Pascal Oesch, Anthony J. Pahl, Max Pettini, Daniel Schaerer, Daniel P. Stark, Charles C. Steidel, Mengtao Tang, Leonardo Clarke, Callum T. Donnan, Emily Kehoe

“…We present results on the emission-line properties of z  = 1.4–7.5 star-forming galaxies in the Assembly of Ultradeep Rest-optical Observations Revealing Astrophysics (AURORA) Cycle 1 JWST/NIRSpec program. Based on its depth, continuous wavelength coverage from 1 to 5 μ m, and medium spectral resolution ( R  ∼ 1000), AURORA includes detections of a large suite of nebular emission lines spanning a broad range in rest-frame wavelength. …”
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Characterising the effects of displacement on gender-based violence among women living with HIV in Ukraine: a cross-sectional study by Stefan David Baral, Carrie Lyons, Althea Wolfe, Mary Anne Roach, Gnilane Turpin, Omar Syarif, Pim Looze, Katarzyna Lalak, Jean de Dieu Anoubissi, Yi-Chi Chiu, Alexandra Volgina, Sophie Brion, Keren Dunaway, Olena Stryzhak, Daria Ocheret, Laurel Sprague, Carlos Garcia de Leon Moreno, Katherine B Rucinski

“…Displaced WLHIV were significantly more likely to have experienced sexual violence (aPR: 2.74, 95% CI: 1.67 to 4.51), violence in healthcare (aPR: 2.57, 95% CI: 1.49 to 4.43), pregnancy coercion (aPR: 2.60, 95% CI: 1.41 to 4.78), sterilisation coercion (aPR: 4.26, 95% CI: 1.17 to 15.43) and contraception coercion (aPR: 2.48, 95% CI: 1.00 to 6.15) compared with non-displaced WLHIV.Conclusion As the war in Ukraine continues, humanitarian and health systems can use these findings to guide integration of GBV referrals and scale-up of trauma-informed care and antiexploitation training into Ukrainian programming. Moreover, additional surveillance methods, including community-led monitoring, can support routine documentation of experiences of coercion and abuse in healthcare settings. …”
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Evaluation of the HIV-1 drug resistance to elsulfavirine and the effectiveness of it among Russian treatment-naïve patients by A. A. Kirichenko, D. E. Kireev, A. V. Kravchenko, A. V. Pokrovskaya, U. A. Kuimova, N. V. Sizova, S. O. Mayorova, D. A. Gusev, V. V. Pokrovsky

“…To clarify the results of subtyping, phylogenetic analysis of nucleotide sequences was carried out using the MEGA program (v. 6.0).Results. The prevalence of mutations associated with decreased susceptibility to elsulfavirine among HIV-infected treatment-naïve patients was 1.7% and 4.5% for the first and second groups of patients, respectively. …”
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Fingolimod synergizes with anti-PD-1 radioimmunotherapy in an experimental multiple sclerosis model through enhanced lymph node retention and CD8+ T cell depletion by Connor Frank, Kevin J. H. Allen, Wojciech Dawicki, Michael C. Levin, Michael C. Levin, Michael C. Levin, Michael C. Levin, Ekaterina Dadachova

“…A targeted approach aimed at depleting only activated T lymphocytes, which play a key role in disease progression, would be optimal. Programmed cell death protein 1 (PD-1) is an inhibitory receptor expressed on exhausted and recently activated T cells. …”
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Differential safety profiles of durvalumab monotherapy and durvalumab in combination with tremelimumab in adult patients with advanced cancers by Mayur Patel, John Kurland, Claire Morgan, Cathy O’Brien, Pamela Concepcion, Gary J Doherty, Stephan Hois, Alejandra Negro, Dejan Pavlovic, Karen A Robbins

“…Background Durvalumab (D; anti-programmed cell death ligand 1 (PD-L1)) monotherapy or in combination with tremelimumab (T; anti-cytotoxic T lymphocyte antigen-4 (CTLA-4)) have demonstrated efficacy in advanced cancers. …”
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Diagnosis of tuberculosis in buffaloes in Argentina: intradermoreaction, compatible lesions and bacteriological culture by Emilia Irina Martínez, Fabiana Cipolini Galarza, Nolly María Monzón, Ana Gabriela Espasandin, José Luis Konrad, Elvira Falzoni, Soledad Barandiaran, Jimena Marfil, Marcela Martínez Vivot, Diana Elina Martínez

“…In Argentina, bovine and buffalo cattle are under a tuberculosis control and eradication program, which includes tuberculin purified protein derivative bovine (PPDB) diagnosis and slaughter of positive reagents. …”
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Impact of isotype on the mechanism of action of agonist anti-OX40 antibodies in cancer: implications for therapeutic combinations by Junping Jing, Laura Bover, C Ian Mockridge, Kerry L Cox, Mark S Cragg, Tatyana Inzhelevskaya, Chris A Penfold, Vikki English, Jane E Willoughby, Hong Shi, Peter J Morley, Heather Jackson, Roopa Srinivasan, Tom Murray, Axel Hoos, Paul Bojczuk, James Smothers, Niranjan Yanamandra, Lang Dou, Sabyasachi Bhattacharya, Laura Seestaller-Wehr, David Kilian, Kui S Voo, Mel John, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Sara J Brett, Christopher Hopson, Elaine Paul, Stephen L Martin

“…Additionally, combination studies using anti-mouse programmed cell death protein-1 (mPD-1) were assessed. …”
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Deletional Alpha-Thalassemia Alleles in Amazon Blood Donors by Fernanda Cozendey Anselmo, Natália Santos Ferreira, Adolfo José da Mota, Marilda de Souza Gonçalves, Sérgio Roberto Lopes Albuquerque, Nelson Abrahim Fraiji, Ana Carla Dantas Ferreira, José Pereira de Moura Neto

“…Knowing the frequency of thalassemia and the prevalence of responsible mutations is, therefore, an important step in the understanding and control program. Hematological and molecular data, in addition to serum iron and serum ferritin, from 989 unrelated first-time blood donors from Amazonas Hemotherapy and Hematology Foundation (FHEMOAM) were collected. …”
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Clinical significance of the phenotype of immune cells of the tumor stroma of prostate cancer by P. A. Podlesnaya, O. V. Kovaleva, M. A. Rashidova, D. V. Samoilova, A. A. Petrenko, V. V. Mochalnikova, A. N. Gratchev

“…The expression of CD3, CD8, FoxP3, CD68, PU.1, CD204, CD163, IDO1, PD-L1 (programmed death-ligand 1) was assessed by immunohistochemistry. …”
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Chronic immune checkpoint inhibitor pneumonitis by Julie R Brahmer, Patrick M Forde, Evan J Lipson, Jarushka Naidoo, Joanne Riemer, Daphne Wang, Janis M Taube, Cheng Ting Lin, Peter B Illei, Tricia R Cottrell, Lonny B Yarmus, K Ranh Voong, David Feller-Kopman, Hans Lee, Sonye K Danoff, Franco R D'Alessio, Karthik Suresh

“…Background Pneumonitis from immune checkpoint inhibitors (ICI) is a potentially fatal immune-related adverse event (irAE) from antiprogrammed death 1/programmed death ligand 1 immunotherapy. Most cases of ICI pneumonitis improve or resolve with 4–6 weeks of corticosteroid therapy. …”
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Radiomic analysis of patient and interorgan heterogeneity in response to immunotherapies and BRAF-targeted therapy in metastatic melanoma by Riyue Bao, Yana G Najjar, Diwakar Davar, John M Kirkwood, Jason John Luke, Sarah Newman, Hassane M Zarour, Afsaneh Amouzegar, Rivka R Colen, Murat Ak, Priyadarshini Mamindla, Serafettin Zenkin, Vishal Peddagangireddy, Sarah Behr, Alexandra G Tompkins, Zane N Gray, Rebekah E Dadey, Nasim Batavani, Nursima Ak, Taha Yasin Pak, Mohammadreza Amjadzadeh, Amy Goodman, Darcy L Ploucha, Curtis Tatsuoka

“…We queried the UPMC Hillman Cancer Center registry for patients with metastatic melanoma (MEL) treated with immune checkpoint inhibitors (ICI) (anti-programmed cell death protein-1 (PD-1)/cytotoxic T-lymphocyte associated protein 4 (CTLA-4) (ipilimumab+nivolumab; I+N) or anti-PD-1 monotherapy) or BRAF-targeted therapy. …”
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Engineering of CD8+ T cells with an HIV-specific synthetic notch receptor to secrete broadly therapeutic antibodies for combining antiviral humoral and cellular immune responses by Lina Meng, Haichi Zhao, Shangkun Chang, Weiting Li, Yinghui Tian, Ruihong Wang, Libian Wang, Tiejun Gu, Jiaxin Wu, Bin Yu, Chu Wang, Xianghui Yu

“…The synNotch receptor (SNR) system serves as a versatile tool, enabling customized programming of input and output functions in mammalian cells. …”
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Early and long-term effects of prophylactic and post-excision human papillomavirus vaccination on recurrent high-grade cervical intraepithelial neoplasia relative to margin status:... by Marek Petráš, Danuše Lomozová, Vladimír Dvořák, Vladimír Dvořák, Jr., Jana Malinová, Markéta Trnková, Ivan Fišer, Pavel Dlouhý, Jozef Rosina, Ivana Králová Lesná

“…It included women treated for CIN2+ between 2010 and 2024 who had received either prophylactic HPV vaccination (available through the national immunisation program since 2011) or post-conisation vaccination (recommended by the Czech Gynaecological and Obstetrical Society since 2008). …”
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Impact of different concurrent training sequencing schemes on overnight systemic immunological regulation in adolescent athletes by Thomas Steidten, Urs Granacher, Holger Gabriel, Simon Haunhorst, Simon Haunhorst, Philipp Reuken, Diana Dudziak, Christian Puta, Christian Puta, Christian Puta

“…., judo, rowing) characterized by high training volumes and/or intensities. CT can be programmed in different sequencing schemes including strength/power before endurance training or vice versa. …”
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Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer by Mingjie Zhang, Lifeng Huang, Guoping Ding, Huilian Huang, Guoliang Cao, Xu Sun, Neng Lou, Qiang Wei, Tao Shen, Xiaodong Xu, Liping Cao, Qiang Yan

“…Tumor immune escape plays an important role in PC progression. Programmed death 1 (PD1) blockade therapy is a promising treatment for patients with PC, but is yet to achieve significant clinical effects so far. …”
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