Deciphering the role of acetylation-related gene NAT10 in colon cancer progression and immune evasion: implications for overcoming drug resistance by Xuancheng Zhou, Xun Sang, Lai Jiang, Shengke Zhang, Chenglu Jiang, Yuheng Gu, Yipin Fu, Guanhu Yang, Jieyin Zhang, Hao Chi, Binbin Wang, Xiaolin Zhong

“…Recent studies highlight the significant role of post-transcriptional modifications like acetylation in cancer biology, affecting processes like gene transcription, metabolism, and tumor progression. …”
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Riscos ocupacionais no trabalho de limpeza hospitalar: percepções de especialistas em segurança e saúde do trabalhador [Occupational risks in hospital cleaning work: perceptions fr... by Larissia Admá de Souza Pereira, Marcia Lima da Cunha, Raquel Veiga Baptista, Regina Célia Gollner Zeitoune, Magda Guimarães de Araújo Faria, Cristiane Helena Gallasch

“…ABSTRACT Objective: to characterize occupational risks in the labor context of hospital cleaning service workers and discuss their implications for the work process, as perceived by specialists in occupational safety and health. …”
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CSRP2 promotes the glioblastoma mesenchymal phenotype via p130Cas-mediated NF-κB and MAPK pathways by Jiawei He, Liang Zhang, Hao Xu, Chengtian Gao, Wentao Zhao, Bingchang Zhang, Wanhong Han, Wenpeng Zhao, Guowei Tan, Sifang Chen, Ping Zhong, Zhe Shen, Jian Meng, Ziqian Tang, Hanwen Lu, Xin Gao, Zhangyu Li, Wenhua Li, Jianyao Mao, Bosen Liu, Yun-wu Zhang, Zhanxiang Wang

“…Abstract Background Cysteine-rich protein 2 (CSRP2) plays a role in a variety of biological processes including cell proliferation and differentiation. …”
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Activation of AMP-activated Protein Kinase by Metformin Inhibits Dedifferentiation of Platelet-derived Growth Factor-BB-induced Vascular Smooth Muscle Cells to Improve Arterial Rem... by Guangbo Wu, Qiang Fan, Min Chen, Guqing Luo, Zhenghao Wu, Jinbo Zhao, Jiayun Lin, Chihao Zhang, Hongjie Li, Xiaoliang Qi, Haizhong Huo, Lei Zheng, Meng Luo

“…However, in the advanced stages of cirrhosis, the fibrotic process in the liver becomes irreversible, leading to persistent and intractable increases in intrahepatic vascular resistance. …”
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ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling by Yujia Li, Chenjun Huang, Weiguo Fan, Seddik Hammad, Cyrill Géraud, Lea Berger, Shanshan Wang, Ye Yao, Chenhao Tong, Claudia Rubie, Laura Kim Feiner, Zeribe C. Nwosu, Frederik Link, Pia Erdösi, Weronika Piorońska, Kerry Gould, Christoph Meyer, Rilu Feng, Hui Liu, Chen Shao, Bing Sun, Huiguo Ding, Roman Liebe, Matthias P.A. Ebert, Honglei Weng, Matthias Glanemann, Chunfang Gao, Peter ten Dijke, Steven Dooley, Sai Wang

“…Results: In healthy hepatocytes, epidermal growth factor (EGF)/EGF receptor (EGFR) signalling sustains ECM1 expression through phosphorylating signal transducer and activator of transcription 1 (STAT1) at serine727 (S727), thus enhancing its binding to the ECM1 promoter and boosting gene transcription. This process is disrupted during liver inflammation by interferon gamma (IFNγ), which downregulates EGFR and inhibits EGF/EGFR/STAT1-mediated ECM1 promoter binding. …”
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Timely post-discharge medication reviews to Improve Continuity—the Transitions Of Care stewardship (TIC TOC) study in rural and regional Australia: a parallel-group randomised cont... by Sepehr Shakib, Manya Angley, Jonathan Penm, Charley Budgeon, Kim Nguyen, Rebekah Jane Moles, Faye McMillan, Rohan A Elliott, Paul Yates, Katie Phillips, Jenny Chen, Stephen Ross Carter, Kingston Yeung, Deirdre Criddle, Deborah Rigby, Frank Mario Sanfilippo, Jerry Yik, Deborah Hawthorne, Cristen Fleming, Anna Packer, Linda Krogh, Simon K Poon, Brett Chambers, Shania Liu, Fatemeh Emadi, Klaudia Englezos, Ganga Ratnanayagam, Michelle Penm, Andrew Hawthorne, Alexander Khlentzos, Jilian Khlentzos

“…A Transition of Care Stewardship pharmacist has been proposed to facilitate and coordinate a patient’s discharge process and facilitate a timely post-discharge medication review. …”
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Identification of host serum-responsive microRNAs in the infective larvae of Toxocara canis and their functional analysis(犬弓首蛔虫感染性幼虫宿主血清反应性微RNA的鉴定与功能分析)... by 陈宜(CHEN Yi), 杨一帆(YANG Yifan), 陈学秋(CHEN Xueqiu), 熊志威(XIONG Zhiwei), 杨晨雨(YANG Chenyu), 杨怡(YANG Yi), 马光旭(MA Guangxu), 杜爱芳(DU Aifang)

“…The predicted target genes of 15 miRNAs were linked to biological processes, including host immune cell adhesion and migration and olfactory transduction pathway, suggesting a role in parasite-host interactions. …”
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MiR-383-5p promotes schistosomiasis-induced liver fibrosis by targeting peroxiredoxin-3 by Yi-Xin Li, Xin-Yue Zhang, Ju-Lu Lu, Ying-Ying Yang, Cong-Jin Mei, Pan-Pan Dong, Chuan-Xin Yu, Jian-Feng Zhang, Chun-Rong Xiong, Li-Jun Song, Kun Yang

“…The mechanisms underlying the development of liver fibrosis remain unclear, but microRNAs (miRNAs) are thought to play a crucial role in this process. Our previous study revealed significantly reduced miR-383-5p expression in patients with advanced schistosomiasis, particularly in those with newly developed disease, suggesting a possible association between miR-383-5p and fibrotic progression. …”
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Systematic pan-cancer analysis identified NCOA4 as an immunological and prognostic biomarker and validated in lung adenocarcinoma by An Wang, Yun-ye Mao, Tao Li, Xin Zhou, Yi-bing Bai, Jia-pei Qin, Yi Dong, Ting Wang, Tong Zhang, Zhi-qiang Ma, Yi Hu

“…PPI network and KEGG/GO enrichment analyses implicated NCOA4 in immune-related biological processes and pathways. IHC staining of LUAD tissues confirmed higher NCOA4 expression in tumors versus non-cancerous tissues. …”
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Development of a culture-independent whole-genome sequencing of Nipah virus using the MinION Oxford Nanopore platform by Md. Mahfuzur Rahman, Mojnu Miah, Mohammad Enayet Hossain, Samiur Rahim, Sharmin Sultana, Syed Moinuddin Satter, Ariful Islam, Shannon L. M. Whitmer, Jonathan H. Epstein, Christina F. Spiropoulou, John D. Klena, Tahmina Shirin, Joel M. Montgomery, Maria E. Kaczmarek, Mohammed Ziaur Rahman, Iqbal Kabir Jahid

“…The WGS of 12 NiV-positive samples achieved coverage between 95.71% (Ct 29.54) and 99.3% (Ct 22.34). The entire process, from RNA extraction to finished sequences, took only 24 h. …”
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Pushing Forward West Nile Virus Understanding: An Integrated One Health Genomic Surveillance Journey in Romagna (Italy) by Miss Martina Brandolini, Dr Alessandra Mistral De Pascali, Mr Giorgio Dirani, Ms Silvia Zannoli, Ms Irene Zaghi, Ms Ludovica Ingletto, Dr Antonio Lavazza, Dr Davide Lelli, Dr Michele Dottori, Dr Mattia Calzolari, Mr Massimiliano Guerra, Dr Carlo Biagetti, Prof Francesco Cristini, Dr Paolo Bassi, Dr Rino Biguzzi, Dr Andrea Porcellini, Dr Roberta Chicchi, Prof Monica Cricca, Prof Alessandra Scagliarini, Prof Vittorio Sambri

“…Conclusion: Our approach suggests the importance of adopting an interdisciplinary multistakeholder strategy to integrate the steps from clinical diagnosis to entomological and ornithological monitoring, up to epidemiological and genomic surveillance to create an operational process involving human and animal health suitable for the genomic characterisation of both autochthonous and imported Arboviruses. …”
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Enhanced propionate and butyrate metabolism in cecal microbiota contributes to cold-stress adaptation in sheep by Xindong Cheng, Yanping Liang, Kaixi Ji, Mengyu Feng, Xia Du, Dan Jiao, Xiukun Wu, Chongyue Zhong, Haitao Cong, Guo Yang

“…Following cold exposure, the microbial community of Hulunbuir sheep showed a decrease in the influence of stochastic processes on community assembly, with a corresponding increase in the role of environmental selection. …”
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Cellular SLC35B4 promotes internalization during influenza A virus entry by Guangwen Wang, Li Jiang, Ya Yan, Fandi Kong, Qibing Li, Jie Zhang, Shuangshuang Hou, Bo Wang, Xiurong Wang, Huihui Kong, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Hualan Chen, Chengjun Li

“…Collectively, these findings establish that SLC35B4 is an important regulator of IAV replication and uncover the underlying mechanisms by which SLC35B4 employs UDP-xylose transport activity to promote IAV internalization.IMPORTANCEThe entry process of IAV represents a favorable target for drug development. …”
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TanSat-2: a new satellite for mapping solar-induced chlorophyll fluorescence at both red and far-red bands with high spatiotemporal resolution by D. Zhao, D. Zhao, D. Zhao, S. Du, S. Du, C. Zou, C. Zou, C. Zou, L. Tian, M. Fan, M. Fan, Y. Du, Y. Du, Y. Du, L. Liu, L. Liu, L. Liu

“…First, we simulated the satellite's radiative transfer processes using the Moderate Resolution Atmospheric Transmission 5 (MODTRAN 5) and Soil Canopy Observation of Photosynthesis and Energy (SCOPE) models. …”
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Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients by Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Vicente Zanón-Moreno, Vicente Zanón-Moreno, Carolina García–Villanueva, Alessio Martucci, Cristina Peris-Martínez, Cristina Peris-Martínez, Jorge Vila-Arteaga, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Irene Andrés–Blasco, Irene Andrés–Blasco, Irene Andrés–Blasco, Alex Gallego–Martínez, Alex Gallego–Martínez, Carlo Nucci, Julian García–Feijoo

“…Outstanding clinical trials and animal-model study designs, innovative technology, and analytical approaches in bioinformatics are essential tools to successfully uncover novel glaucoma biomarkers with a high potential for translation into clinical practice.MethodsTo better understand the clinical and biochemical-molecular-genetic glaucoma pathogenesis, we conducted an analytical, observational, and case-comparative/control study in 358 primary open-angle glaucoma (POAG) patients and 226 comparative-control individuals (CG) to collect tears, aqueous humor, and blood samples to be processed for identifying POAG biomarkers by exploring several biological pathways, such as inflammation, neurotransmitter/neurotrophin alteration, oxidative stress, gene expression, miRNAs fingerprint and its biological targets, and vascular endothelial dysfunction, Statistics were done by using the IBM SPSS 25.0 program. …”
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Investigating the long-term public health and co-benefit impacts of an urban greenway intervention in the UK: a natural experiment evaluation – study protocol by Frank Kee, Ruoyu Wang, Ruth F Hunter, Mike Clarke, Sophie Jones, John Barry, Ciaran O’Neill, Leandro Garcia, Christopher R Cardwell, Hüseyin Küçükali, Claire Cleland, Aideen Maguire, Niamh O’Kane, Selin Akaraci, Christopher Tate, Shay Mullineaux, Geraint Ellis, Brendan Murtagh, Anna Jurek-Loughrey, Dominic Bryan, Jeremy Hilton, Mehdi Hafezi, Natalie Clewley

“…Findings from the household survey and administrative data analysis will be further explored in focus groups with a subsample of those who complete the household survey and the local community to explore possible mechanistic pathways and other impacts beyond those measured. Process evaluation methods include intercept surveys and direct observation of the number and type of greenway visitors using the Systems for Observing Play and Recreation in Communities tool. …”
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Deep learning for predicting invasive recurrence of ductal carcinoma in situ: leveraging histopathology images and clinical featuresResearch in context by Shannon Doyle, Esther H. Lips, Eric Marcus, Lennart Mulder, Yat-Hee Liu, Francesco Dal Canton, Timo Kootstra, Maartje M. van Seijen, Ihssane Bouybayoune, Elinor J. Sawyer, Alastair M. Thompson, Sarah E. Pinder, Clara I. Sánchez, Jonas Teuwen, Jelle Wesseling, Jelle Wesseling, Jos Jonkers, Jacco van Rheenen, Esther H. Lips, Marjanka Schmidt, Lodewyk F.A. Wessels, Proteeti Bhattacharjee, Alastair Thompson, Serena Nik-Zainal, Helen Davies, Elinor J. Sawyer, Andrew Futreal, Nicholas Navin, E. Shelley Hwang, Fariba Behbod, Daniel Rea, Hilary Stobart, Deborah Collyar, Donna Pinto, Ellen Verschuur, Marja van Oirsouw

“…Interpretation: Deep learning models using routinely processed WSIs hold promise for DCIS risk stratification, while the benefits of integrating clinical data merit further investigation. …”
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Mapping the world's inland surface waters: an upgrade to the Global Lakes and Wetlands Database (GLWD v2) by B. Lehner, M. Anand, E. Fluet-Chouinard, F. Tan, F. Tan, F. Aires, G. H. Allen, P. Bousquet, J. G. Canadell, N. Davidson, N. Davidson, M. Ding, C. M. Finlayson, C. M. Finlayson, T. Gumbricht, L. Hilarides, G. Hugelius, R. B. Jackson, M. C. Korver, L. Liu, P. B. McIntyre, S. Nagy, D. Olefeldt, T. M. Pavelsky, J.-F. Pekel, B. Poulter, C. Prigent, J. Wang, J. Wang, T. A. Worthington, D. Yamazaki, X. Zhang, M. Thieme

“…The Global Lakes and Wetlands Database (GLWD), published in 2004, with its globally seamless depiction of 12 major vegetated and non-vegetated wetland classes at 1 km grid cell resolution, has emerged over the last few decades as a foundational reference map that has advanced research and conservation planning addressing freshwater biodiversity, ecosystem services, greenhouse gas emissions, land surface processes, hydrology, and human health. Here, we present a new iteration of this map, termed GLWD version 2, generated by harmonizing the latest ground- and satellite-based data products into one single database. …”
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miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthmaResearch in context by Rinku Sharma, Kevin Mendez, Sofina Begum, Su Chu, Nicole Prince, Julian Hecker, Rachel S. Kelly, Qingwen Chen, Craig E. Wheelock, Juan C. Celedón, Clary Clish, Robert Gertszen, Kelan G. Tantisira, Scott T. Weiss, Jessica Lasky-Su, Michael McGeachie

“…Summary: Background: There are important inter-relationships between miRNAs and metabolites: alterations in miRNA expression can be induced by various metabolic stimuli, and miRNAs play a regulatory role in numerous cellular processes, impacting metabolism. While both specific miRNAs and metabolites have been identified for their role in childhood asthma, there has been no global assessment of the combined effect of miRNAs and the metabolome in childhood asthma. …”
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Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement by Xinyu Wang, Qianye Chen, Jiping Sun, Zihan Huang, Zijian Zhang, Tingwei Lu, Xiangru Huang, Siyuan Sun, Yuanqi Liu, Houwen Pan, Li Mei, Paul R. Cooper, Qinggang Dai, Lei Shen, Lingyong Jiang

“…The findings demonstrate that jawbone MSCs not only exhibit robust multilineage differentiation potential but also secrete CXCL12 and activate key B cell transcription factors (such as PAX5). This process significantly promotes HSC differentiation into B cells, improves survival rates in infected mice, and attenuates systemic inflammation. …”
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