Effect of Mesenchymal Stem Cell–Derived Extracellular Vesicles Induced by Advanced Glycation End Products on Energy Metabolism in Vascular Endothelial Cells by Jiabin Liang, Sihang Cheng, Qide Song, Yukuan Tang, Qian Wang, Hanwei Chen, Jie Feng, Lin Yang, Shunli Li, Zhiwei Wang, Jinghui Fan, Chen Huang

“…MSC-EVs treated with AGEs decreased HUVEC viability (P < 0.05), pH (P < 0.05), adenosine triphosphate (ATP) metabolism (P < 0.05), glucose metabolism (P < 0.05), while enhancing glycolysis processes, including glycolytic activity, capacity, and reserve (P < 0.05). …”
Get full text

Exhaled volatile organic compounds as novel biomarkers for early detection of COPD, asthma, and PRISm: a cross-sectional study by Jiaxin Tian, Qiurui Zhang, Minhua Peng, Leixin Guo, Qianqian Zhao, Wei Lin, Sitong Chen, Xuefei Liu, Simin Xie, Wenxin Wu, Yijie Li, Junqi Wang, Jin Cao, Ping Wang, Min Zhou

“…Volatile organic compounds (VOCs) in breath can reflect the pathophysiological processes of disease, thereby having the potential to serve as a promising approach for diagnosing respiratory diseases. …”
Get full text

Assessment of Biodegradation Mechanisms of Ceftiofur Sodium by <i>Escherichia</i> sp. CS-1 and Insights from Transcriptomic Analysis by Meng-Yang Yan, Cai-Hong Zhao, Jie Wu, Adil Mohammad, Yi-Tao Li, Liang-Bo Liu, Yi-Bo Cao, Xing-Mei Deng, Jia Guo, Hui Zhang, Hong-Su He, Zhi-Hua Sun

“…Transcriptome sequencing revealed that 758 genes essential for degradation were upregulated in response to the hydrolysis and redox processes associated with CFS. Furthermore, the differentially expressed genes (DEGs) of <i>E. coli</i> CS-1 were functionally annotated using a combination of genomics and bioinformatics approaches. …”
Get full text

Quality Control and Analysis of Treatment for Hospitalized Cancer Patients: Interview and Medical Records Study from Nine Hospitals in Beijing by LU Liting, ZHOU Yanping, WANG Xiang, LI Xiaoyuan, HOU Xiaorong, ZHU Lidong, XU Xiaohong, SUN Guibin, WANG Ziyuan, ZHANG Jieshi, ZHAO Lin, BA Yi

“…It is recommended to standardize tumor staging assessment processes, strengthen entry assessments for non-oncology departments, promote the implementation of multidisciplinary treatment models, and establish a multi-department collaborative management model.Continuous monitoring of cancer diagnosis and treatment quality indicators is essential to promote ongoing improvements in cancer treatment quality.…”
Get full text

Independent validation and outlier analysis of EuroPOND Alzheimer’s disease staging model using ADNI and real-world clinical data by Mandy M. J. Wittens, Diana M. Sima, Arne Brys, Hanne Struyfs, Ellis Niemantsverdriet, Ellen De Roeck, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul de Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaëtane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Maura Bellio, Neil P. Oxtoby, Daniel C. Alexander, Annemie Ribbens, Sebastiaan Engelborghs

“…Abstract Background Event-based modeling (EBM) traces sequential progression of events in complex processes like neurodegenerative diseases, adept at handling uncertainties. …”
Get full text

Syn-to post-orogenic mineralization in the Shuangkoushan Au–Ag–Pb deposit, North Qaidam: insights from H–O–S isotopes and U–Pb geochronology by Junzhen Yu, Junzhen Yu, Dexian Li, Dexian Li, Youye Zheng, Youye Zheng, Bo Ma, Bo Ma, Jian Wang, Jian Wang, Guomei Shi, Guomei Shi, Rongke Xu, Junaid Khan, Asma Tahir

“…The Shuangkoushan Au–Ag–Pb deposits, hosted within meta-basaltic rocks of the Tanjianshan Group in the North Qaidam Orogenic Belt, northwest China, present significant insights into syn-to post-orogenic mineralization processes. Preliminary fluid inclusion studies suggest distinct fluid origins for Ag–Pb and Au mineralization at Shuangkoushan; however, due to the lack of geochronological and isotopic data, as well as comprehensive textural analysis, this hypothesis remains unverified. …”
Get full text

Outpatient Virtual Care Among People Living With and Beyond Cancer From Culturally and Linguistically Diverse Backgrounds in Australia: A Protocol for a Realist Evaluation by Prince Peprah, Sagda Osman, Rebecca Mitchell, Ashfaq Chauhan, Ramya Walsan, Maryam Sina, Bronwyn Newman, Nadine El‐Kabbout, Jan Mumford, Emilie Francis‐Auton, Elizabeth Manias, Virginia Mumford, Kate Churruca, Michelle Moscova, Natalie Taylor, Craig Nelson, Alexander Cardenas, Robyn Clay‐Williams, Jeffrey Braithwaite, Reema Harrison

“…Patients and the public are also represented as Project Steering Group members who will inform the data collection processes, development, and refinement of our program theory.…”
Get full text

Correlation of excess salt intake identified by the survey with urine sodium level and blood pressure: data of ESSE-RF study by Yu. A. Balanova, V. A. Kutsenko, S. A. Shalnova, A. E. Imaev, A. V. Kapustina, G. A. Muromtseva, S. E. Evstifeeva, N. S. Karamnova, S. A. Maksimov, E. B. Yarovaya, O. M. Drapkina, A. N. Redko, S. N. Alekseenko, S. V. Gubarev, I. A. Viktorova, M. A. Livzan, I. A. Grishechkina, M. Yu. Rozhkova, N. N. Prishchepa, N. N. Vezikova, I. S. Skopets, S. S. Yakushin, E. V. Filippov, N. V. Dobrynina, N. N. Nikulina, K. G. Pereverzeva, K. A. Moseichuk

“…In the pattern of ESI components, processed meat and sausage products take first place in terms of association strength with urine sodium. …”
Get full text

miR-34-5p mediates 20E-induced autophagy in the fat body of Bombyx mori by targeting Atg1 by Huili Qiao, Ziqian Tong, Yuanzhuo Wang, Juanjuan Yang, Yanyan Sun, Huixuan Shi, Zhuo Liu, Jianping Duan, Dandan Li, Yunchao Kan

“…The fat body undergoes remarkable transformation during insect metamorphosis and is primarily regulated by 20E. microRNAs (miRNAs) have been identified in different insects and have multiple functions in various physiological processes. However, the interaction of 20E and miRNAs in fat body regulation remains unclear. …”
Get full text

Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany by Anne-Kathrin Ruß, Stefan Schreiber, Wolfgang Lieb, J. Janne Vehreschild, Peter U. Heuschmann, Thomas Illig, Katharina S. Appel, Maria J. G. T. Vehreschild, Dagmar Krefting, Lennart Reinke, Alin Viebke, Susanne Poick, Stefan Störk, Jens-Peter Reese, Thomas Zoller, Lilian Krist, David Ellinghaus, Bärbel U. Foesel, Christian Gieger, Bettina Lorenz-Depiereux, Martin Witzenrath, Gabriele Anton, Michael Krawczak, Jan Heyckendorf, Thomas Bahmer

“…All other gene regions highlighted by our GWAS did not relate to pathophysiological processes currently discussed for PCS. Therefore, and because the genotype-phenotype associations observed in our GWAS were generally not very strong, the complexity of the genetic background of PCS appears to be as high as that of most other multifactorial traits in humans.…”
Get full text

Spatiotemporal variability in the feeding habits of anchovy and sardine: a comparison of upwelling and river-runoff driven ecosystems by Paola Rumolo, Marco Barra, Angelo Bonanno, Simona Altieri, Rosalia Ferreri, Antonella Gargano, Gualtiero Basilone, Serena Gherardi, Simona Genovese, Maria Rosa Di Cicco, Carmine Lubritto

“…These data contribute to a better understanding of food web dynamics and may be used to improve ecosystem models, which requires an understanding of the ecological processes that control the interaction between species.…”
Get full text

Comparative Analysis of Primary Sarcopenia and End‐Stage Renal Disease–Related Muscle Wasting Using Multi‐Omics Approaches by Daiki Setoyama, Dohyun Han, Jingwen Tian, Ho Yeop Lee, Hyun Suk Shin, Ha Thi Nga, Thi Linh Nguyen, Ji Sun Moon, Hyo Ju Jang, Evonne Kim, Seong‐Kyu Choe, Sang Hyeon Ju, Dae Eun Choi, Obin Kwon, Hyon‐Seung Yi

“…Understanding these molecular nuances is imperative for targeted interventions, and the integration of proteomic and metabolomic data elucidate these intricate processes. Methods We generated detailed clinical data and multi‐omics data (plasma proteomics and metabolomics) for 78 participants to characterise sarcopenia (n = 28; mean age, 72.6 ± 7.0 years) or ESRD (n = 22; 61.6 ± 5.5 years) compared with controls (n = 28; 69.3 ± 5.7 years). …”
Get full text

Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults by Hayley S. Ripperger, Rebecca G. Reed, Chaeryon Kang, Alina Lesnovskaya, Alina Lesnovskaya, Sarah L. Aghjayan, Sarah L. Aghjayan, Haiqing Huang, Lu Wan, Bradley P. Sutton, Bradley P. Sutton, Lauren Oberlin, Lauren Oberlin, Audrey M. Collins, Jeffrey M. Burns, Eric D. Vidoni, Arthur F. Kramer, Arthur F. Kramer, Arthur F. Kramer, Edward McAuley, Edward McAuley, Charles H. Hillman, Charles H. Hillman, Charles H. Hillman, George A. Grove, John M. Jakicic, Kirk I. Erickson, Kirk I. Erickson

“…To address these gaps, the current study evaluates the associations among baseline CRF, hippocampal subfield volumes, and episodic memory performance in cognitively unimpaired older adults from the Investigating Gains in Neurocognition Trial of Exercise (IGNITE) (NCT02875301).MethodsParticipants (N = 601, ages 65–80, 72% female) completed assessments including a graded exercise test measuring peak oxygen comsumption (VO2peak) to assess CRF, cognitive testing, and high-resolution magnetic resonance imaging of the hippocampus processed with Automated Segmentation of Hippocampal Subfields (ASHS). …”
Get full text

Effects of ambient temperature, energy density, and energy source on energy partition and plasma metabolomics profile of finishing pigs by Dan Jiang, Kai Zhou, Dongsheng Che, Hailong Jiang, Rui Han, Guixin Qin

“…Ambient temperature is an important factor affecting metabolic processes in animals, and its effect on energy metabolism is becoming more evident. …”
Get full text

Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study by Daniel E. Guzman, Lisa Ruvuna, Claire J. Guo, Yifei Sun, Katherine A. Pratte, Ani W. Manichaikul, John S. Kim, Wendy S. Post, Alain G. Bertoni, Norrina B. Allen, Karol E. Watson, James S. Pankow, Eric A. Hoffman, Ruth F. Dubin, Rajat Deo, Igor Z. Barjaktarevic, Eugene R. Bleecker, Christopher B. Cooper, Victor E. Ortega, Annette T. Hastie, Robert Paine, James Michael Wells, Jeffrey L. Curtis, Edwin K. Silverman, Prescott G. Woodruff, Christine Kim Garcia, Jerome I. Rotter, Russell P. Bowler, Peter Ganz, R. Graham Barr

“…Enrichment analyses identified 40 GO biological processes, including chemokine production and regulation and cell–cell adhesion and regulation, and two Reactome pathways, including RAGE signaling. …”
Get full text

Brain white matter development in 8-year-old children is associated with maternal mental health during pregnancy by Yali Huang, Timothy R. Koscik, Timothy R. Koscik, Aline Andres, Aline Andres, Jayne Bellando, Jayne Bellando, Charles M. Glasier, Charles M. Glasier, Adhitya Ram, Xiawei Ou, Xiawei Ou, Xiawei Ou, Xiawei Ou

“…Key diffusion metrics (FA: fractional anisotropy; MD: mean diffusivity; AD: axial diffusivity; RD: radial diffusivity; MK: mean kurtosis; AK: axial kurtosis; RK: radial kurtosis; NDI: neurite density index; ODI: orientation dispersion index; FWF: free water fraction) were extracted from the limbic system white matter structures including cingulum, fornix, and uncinate fasciculus, which are closely associated with emotional and motivational processes.ResultsHigher maternal depression symptom scores were associated with lower FA (R = –0.3126, p = 0.0305, in CGH.R; R = –0.3025, p = 0.0366, in FXC.R) and MK (R = –0.3284, p = 0.0227, in CGG.R) and higher MD (R = 0.2879, p = 0.0472, in CGH.R) and RD (R = 0.3451, p = 0.0163, in CGH.R; R = 0.3456, p = 0.0161, in FXC.R) in predominately right-hemisphere limbic tracts. …”
Get full text

Dolomites in a carbonate-evaporite system: the fifth member of the Middle Ordovician Majiagou Formation, Eastern Ordos Basin, China by Siyi Fu, Siyi Fu, Siyi Fu, Siyi Fu, Chenggong Zhang, Chenggong Zhang, Chenggong Zhang, Hao Liu, Hao Liu, Hao Liu, Liubin Wei, Hongping Bao, Xingchao Ye, Zhongtang Su, Zhongtang Su, Zhongtang Su, Hongde Chen, Hongde Chen, Hongde Chen, Liangbiao Lin, Liangbiao Lin, Liangbiao Lin

“…The second stage, during deep burial, resulted in Dol-5, which can be further categorized into Dol-5-1, formed by continued dolomitization from pore fluids, and Dol-5-2, formed through hydrothermal processes. The intensity of dolomitization is closely linked to the distribution of evaporites. …”
Get full text

LRRK2G2019S Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease by Yiying Hu, Huijia Yang, Chunli Song, Lulu Tian, Panpan Wang, Tianbai Li, Cheng Cheng, Murad AlNusaif, Song Li, Zhanhua Liang, Weidong Le

“…All of the above pathogenic processes are aggravated by aging. The 14mo‐TG mice EMG examinations show a reduced duration (by 31%, p < 0.01) and increased polyphasic waves of motor unit action potentials (by 28%, p < 0.05). …”
Get full text

Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer by Xin Peng, Yingying Wang, Zixiang Yu, Shengfan Huang, Shaolu Zhang, Zhenxing Zhong, Yongzhe Wang, Shanshan Liu, Kailin Wang, Christophe Nicot, Francois X. Claret, Dexin Kong

“…Methods RNA-Seq analysis revealed that shRNA-mediated Jab1 knockdown profoundly affected HRR and DNA replication processes in TNBC cells. Using Nuclear Run-On Assay, RNA Immunoprecipitation, RNA Pull-Down Assay, and RIP-Seq, we identified Jab1 as a potential RNA-binding protein (RBP) that stabilizes HRR-related mRNAs by competing with the exosome complex. …”
Get full text

Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study by Bernard A Fox, Chichung Wang, Kristin Roman, Carla Coltharp, Carmen Ballesteros-Merino, Shawn M Jensen, Janis M Taube, David L Rimm, Cliff Hoyt, Mei Jiang, Edwin R Parra, Ignacio Wistuba, Elizabeth L Engle, John McGuire, Bethany Remeniuk, Darren Locke

“…Standardization and validation of an end-to-end workflow that supports multisite trials and clinical laboratory processes are vital. Six institutions collaborated to: (1) optimize an automated six-plex assay focused on the PD-1/PD-L1 axis, (2) assess intersite and intrasite reproducibility of staining using a locked down image analysis algorithm to measure tumor cell and immune cell (IC) subset densities, %PD-L1 expression on tumor cells (TCs) and ICs, and PD-1/PD-L1 proximity assessments.Methods A six-plex mIF panel (PD-L1, PD-1, CD8, CD68, FOXP3, and CK) was rigorously optimized as determined by quantitative equivalence to immunohistochemistry (IHC) chromogenic assays. …”
Get full text