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17081
Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration
Published 2025-02-01“…Analysis of protein-protein interaction (PPI) networks and machine learning algorithms were used to identify hub genes. Single-gene Gene Set Enrichment Analysis (GSEA) identified biological functions, while nomograms and ROC curves assessed diagnostic potential. …”
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17082
Constructing a Glioblastoma Prognostic Model Related to Fatty Acid Metabolism Using Machine Learning and Identifying F13A1 as a Potential Target
Published 2025-01-01“…On the basis of 10 kinds of machine learning methods, we used 101 combinations of algorithms to construct prognostic models and obtain the best model. …”
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17083
Teens and opioids postsurgery (TOPS): protocol for a prospective observational study describing associations between sleep deficiency and opioid use following outpatient surgery in...
Published 2025-04-01“…We will apply modern machine learning algorithms to develop and validate models predicting adolescent prescription opioid misuse at 24 months from surgery.Ethics and dissemination This study was approved by Advarra’s Center for Institutional Review Board Intelligence (CIRBI) (Protocol 00072049), which serves as the single IRB of record for this multisite study.…”
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17084
Fc-Binding Cyclopeptide Induces Allostery from Fc to Fab: Revealed Through in Silico Structural Analysis to Anti-Phenobarbital Antibody
Published 2025-04-01“…The combination of molecular docking and multiple allosteric site prediction algorithms in these methods identified that the cyclopeptide binds to the interface of heavy chain region-1 (CH<sub>1</sub>) in antibody Fab and heavy chain region-2 (CH<sub>2</sub>) in antibody Fc. …”
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17085
Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer
Published 2025-07-01“…A 7-gene mCAF-associated risk model was constructed using advanced machine learning algorithms, and the biological significance of PHLDA1 was validated through co-culture experiments and pan-cancer analyses.ResultsOur multiomics analysis revealed that the novel 7-gene model (comprising USP36, KLF5, MT2A, KDM6B, PHLDA1, REL, and DDIT4) accurately predicts patient survival, immunotherapy response, and TME status. …”
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17086
The effect of canine lingual attachments during maxillary arch distalization with clear aligner: a 4D finite element analysis and in vitro simulator study
Published 2025-05-01“…Method A dual-methodological approach was employed: 1) A four-dimensional finite element model (4D FEM) incorporating automated staging simulation was developed, utilizing iterative computations for long-term tooth movement prediction and thermal expansion algorithms for CA morphology adaptation; 2) An electromechanical orthodontic simulator (OSIM) was implemented for in vitro validation. …”
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17087
The Association of Aortic Stenosis Severity and Symptom Status With Morbidity and Mortality
Published 2025-08-01“…Methods: In this retrospective cohort study from a large, integrated health care system serving >4.5 M individuals, we applied validated natural language processing algorithms to echocardiogram reports to identify physician-assessed AS severity and potential AS-related symptoms (eg, chest pain, syncope, dyspnea, worsening heart failure) via diagnosis codes and natural language processing-applied physician notes. …”
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17088
Application of artificial intelligence in the materials science, with a special focus on fuel cells and electrolyzers
Published 2024-12-01“…This review begins by explaining the fundamental concepts of artificial intelligence and introducing commonly used artificial intelligence-based algorithms in a simplified and clearly comprehensible way, establishing a foundational knowledge base for further discussion. …”
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17089
Kun–Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile
Published 2025-08-01“…We aim to develop multimodal risk prediction models by integrating genomics and artificial intelligence algorithms. …”
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17090
Artificial Intelligence in Pediatric Orthopedics: A Comprehensive Review
Published 2025-05-01“…In spinal deformities, models such as support vector machines and convolutional neural networks achieved over 90% accuracy in classification and curve prediction. For developmental dysplasia of the hip, deep learning algorithms demonstrated high diagnostic performance in radiographic interpretation. …”
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17091
Neuromorphic, physics-informed spiking neural network for molecular dynamics
Published 2025-01-01“…The results indicate that NP-SNN provides a robust Sci-ML framework that can make accurate predictions across diverse scientific molecular applications. …”
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17092
In-Silico discovery of novel cephalosporin antibiotic conformers via ligand-based pharmacophore modelling and de novo molecular design
Published 2025-09-01“…This research aims to predict new compounds using ligand-based pharmacophore models while optimizing existing drugs. …”
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17093
Nondestructive estimation of leaf chlorophyll content in banana based on unmanned aerial vehicle hyperspectral images using image feature combination methods
Published 2025-02-01“…We concluded that the nonlinear Gaussian process regression model with the VIs and TFs-PC1 combination selected by maximal information coefficient as input achieved the highest accuracy in LCC prediction for banana, with the highest R2 of 0.776 and lowest RMSE of 2.04. …”
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17094
Application and prospect of artificial intelligence in empowering the operation and managment of oil and gas pipelines
Published 2024-06-01“…AI methodologies have found extensive application across various research domains, largely focusing on leak detection, corrosion analysis, risk evaluation, identification, prediction, and optimization. The evolution of AI-driven research has transitioned from conventional approaches like neural networks, expert systems, fuzzy logic, and wavelet analysis towards new-generation algorithms, including deep learning, transfer learning, and reinforcement learning. …”
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17095
A comprehensive investigation of the relationship between dietary fatty acid intake and preserved ratio impaired spirometry: multimethodology based on NHANES
Published 2025-08-01“…Subsequently, innovative implementation of the principal component analysis (PCA), Weighted Quantile Sum (WQS) regression, and Bayesian Kernel Machine Regression (BKMR) approaches were employed to assess the joint impact of the various intake of FAs, as well as total saturated, monounsaturated, and polyunsaturated FAs on PRISm. To facilitate the prediction of PRISm, six distinct machine learning algorithms were constructed, followed by the application of SHAP analysis to elucidate the contribution of individual predictors. …”
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17096
Multiplicity dependence of charged-particle intra-jet properties in pp collisions at $$\sqrt{{{\varvec{s}}}}$$ s = 13 TeV
Published 2024-10-01“…The results are compared with predictions of QCD-inspired event generators, PYTHIA 8 with Monash 2013 tune and EPOS LHC. …”
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17097
Estimation of the water content of needles under stress by Erannis jacobsoni Djak. via Sentinel-2 satellite remote sensing
Published 2025-04-01“…Needle leaf water content exhibits a clear response to these changes and is highly sensitive in reflecting the degree of tree damage.MethodsIn this work, we combine vegetation indices with machine learning algorithms to estimate the water content of needles at a large scale. …”
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17098
Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: results from EMBR...
Published 2025-05-01“…Conclusion Information on the distribution of cancer risk factors in PV carriers is needed for incorporating these factors into multifactorial cancer risk prediction algorithms. Contrary to previous reports, we found no evidence that BRCA1 or BRCA2 PV are associated with hormonal or anthropometric factors, except for a weak association with height. …”
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17099
The research on enhancing LA estimation accuracy across domains for small sample data based on data augmentation and data transfer integration optimization system
Published 2025-12-01“…Objective: In this research, our goal is to develop a novel framework to mitigate prediction biases in LA caused by sample limitations and data heterogeneity. …”
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17100
DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure
Published 2025-01-01“…In addition, we further explored potential mechanism and function of hub genes in HF of patients with MHD through GSEA, immune cell infiltration analysis, drug analysis and establishment of molecular regulatory network.ResultsTotally 23 candidate genes were screened out by overlapping 673 differentially expressed genes (DEGs) and 147 key module genes, of which four hub genes (DEPDC1B, CDCA2, APOBEC3B and TYMS) were obtained by two machine learning algorithms. Through GSEA analysis, it was found that the four genes were closely related to ribosome, cell cycle, ubiquitin-mediated proteolysis. …”
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