Metabolomic Profiling Reveals Serum Tryptophan as a Potential Therapeutic Target for Systemic Lupus Erythematosus by Wang K, Zhu R, Xu M, Zhu K, Li J, Li C, Meng D, Chen H, Sun L

“…Two key metabolites, tryptophan and beta-alanine, showed significantly decreased levels in SLE patients compared to healthy controls (both p< 0.05), while exhibiting opposite patterns in other autoimmune diseases. In the mouse model, tryptophan supplementation improved renal histology, reduced proteinuria, increased naïve T cells and central memory T cells, and decreased effector T cell frequencies in both peripheral blood and spleen.Conclusion: This study demonstrates the successful application of machine learning algorithms to metabolomics data for SLE classification and identifies tryptophan and beta-alanine as potential SLE-specific biomarkers. …”
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Aerosols in the Mixed Layer and Mid-Troposphere from Long-Term Data of the Italian Automated Lidar-Ceilometer Network (ALICENET) and Comparison with the ERA5 and CAMS Models by Annachiara Bellini, Henri Diémoz, Gian Paolo Gobbi, Luca Di Liberto, Alessandro Bracci, Francesca Barnaba

“…We also integrated ALC observations with relevant, state-of-the-art model reanalysis datasets (ERA5 and CAMS) to support our understanding of the aerosol patterns, related sources, and transport dynamics. …”
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