Remote work – the new normal needs more research by Annina Ropponen

“…Remote office work: changing work patterns in space and time. Commun ACM. 1983;26(3):182-7. https://doi.org/10.1145/358061.358068 8. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…The third stage involved making judgements as to whether findings presented in different sources were adequate to form patterns in developing context–mechanism–outcome configurations (CMOCs) and programme theory. …”
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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial by Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison

“…Younger adults have a greater tendency to eat sporadically or snack throughout the day, whereas older people tend to have more regular meal patterns and settled routines. Previous studies using stable isotopes indicate that IPE releases propionate 3–4 hours post ingestion. …”
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A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient by Emily K. Ho, Rebecca P. Kim-Yip, Alison G. Simpkins, Payam E. Farahani, Harrison R. Oatman, Eszter Posfai, Stanislav Y. Shvartsman, Jared E. Toettcher

“…Summary: A lack of tools for detecting receptor activity in vivo has limited our ability to fully explore receptor-level control of developmental patterning. …”
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Novel electrical characteristic measurement system of semiconductor films for estimating device characteristics by Kook Chul Moon, Hwarim Im, Gyohyeok Yun, Hyoungsik Kim, JungUn Na, Changhwan Kim, Yong-Sang Kim

“…We carefully designed the array structure and material of the probe pin to effectively detect extremely low-level currents without patterned electrodes on the semiconductor film. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…The feasibility of a further trial requires consideration considering changing patterns of routine stroke care. Trial registration This trial is registered as ClinicalTrials.gov identifier NCT02360670. …”
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Polarization-Selective Holographic Metasurface For Creating Cylindrical Vector Beams by Jiannong Chen, Qinfeng Xu, Jing Han

“…Here, we report a holographic metasurface patterned on a gold film layer for generating a GCVB. …”
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Alcohol-related brain damage in humans. by Amaia M Erdozain, Benito Morentin, Lynn Bedford, Emma King, David Tooth, Charlotte Brewer, Declan Wayne, Laura Johnson, Henry K Gerdes, Peter Wigmore, Luis F Callado, Luis F Callado, Wayne G Carter

“…H & E staining and light microscopy of prefrontal cortex tissue revealed a reduction in the levels of cytoskeleton surrounding the nuclei of cortical and subcortical neurons, and a disruption of subcortical neuron patterning in alcoholic subjects. BA 9 tissue homogenisation and one dimensional polyacrylamide gel electrophoresis (PAGE) proteomics of cytosolic proteins identified dramatic reductions in the protein levels of spectrin β II, and α- and β-tubulins in alcoholics, and these were validated and quantitated by Western blotting. …”
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GPR56 homozygous nonsense mutation p.R271* associated with phenotypic variability in bilateral frontoparietal polymicrogyria by Tülay Öncü-Öner, Semra Hız-Kurul, Bayram Yüksel, Bekir Ergüner, Aydan Saraç, Handan Güleryüz, Sinem Ağılkaya, İlknur Porsuk-Doru, Aycan Ünalp, Sultan Cingöz

“…Therefore, additional functional studies are needed to detect the phenotypic spectrum of the p.R271* mutation in GPR56, and provide insight into the mechanism of normal cortical development and regional patterning of the cerebral cortex. …”
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Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response. by Christoph Schell, Oliver Kretz, Andreas Bregenzer, Manuel Rogg, Martin Helmstädter, Ulrike Lisewski, Michael Gotthardt, Pierre-Louis Tharaux, Tobias B Huber, Florian Grahammer

“…Previous studies in the zebrafish pronephros postulated a potential role of CXADR for the terminal differentiation of glomerular podocytes and correct patterning of the elaborated foot process architecture. …”
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Using the Space Syntax Analysis to Examine the Spatial Configuration of Houses Layouts and Its Transformation over Time in Biskra City by Rihane Barkat, Yassine Bada, Yasemin İnce Güney, Hafnaoui Hamzaoui

“…In the context of discovering the differentiation and the similarities between the samples that consist of 16 houses: four houses from each period; an analysis has been carried out by applying the “Gammaanalysis” using the A-graph program in detecting the genotypical consistencies in their patterning.  …”
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Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination. by Daniel T Grimes, Jennifer L Keynton, Maria T Buenavista, Xingjian Jin, Saloni H Patel, Shinohara Kyosuke, Jennifer Vibert, Debbie J Williams, Hiroshi Hamada, Rohanah Hussain, Surya M Nauli, Dominic P Norris

“…Whilst the PKD2-interacting protein PKD1L1 has also been implicated in L-R patterning, the underlying mechanism by which flow is detected and the genetic relationship between Polycystin function and asymmetric gene expression remains unknown. …”
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Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite by Yanjing Gao, Jielin Chen, Jiangbo Liu, Mingqiang Li, Yichun Wang

“…In addition, DNA tetrahedron origami is employed as a rigid, precise, and programmable three‐dimensional framework for controlled patterning of gold nanoparticles on HOPG surface, demonstrating the potential for constructing plasmonic devices and arranging other functional species on sp2 carbon‐based substrates for specific applications. …”
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Long-term activity-dependent plasticity of action potential propagation delay and amplitude in cortical networks. by Douglas J Bakkum, Zenas C Chao, Steve M Potter

“…We used a multi-electrode array to induce, detect, and track changes in propagation in multiple neurons while they adapted to different patterned stimuli in controlled neocortical networks in vitro. …”
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Impact of c-JUN deficiency on thalamus development in mice and human neural models by Jiantao Shi, Qing Chen, Jianheng Lai, Jieying Zhu, Ran Zhang, Md. Abdul Mazid, Dongwei Li, Huanxing Su, Dajiang Qin

“…Notably, in guided ThOs, c-JUN KO led to inadequate thalamus patterning with sparse internal nerve fibers. Chromatin accessibility analysis confirmed a less accessible chromatin state in genes related to the thalamus. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Comparing agreement in the data, we found sources agreed on ‘non-use’, but suitable informant over- and under-reporting of ‘use’ compared with hospital records did not follow a consistent pattern. Comparing SIR ‘hospital use’ over the 3-month periods pre-baseline and pre-6-month follow-up were identical at both assessments. …”
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Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis. by Michalis Barkoulas, Amhed M Vargas Velazquez, Alexandre E Peluffo, Marie-Anne Félix

“…Patterning of C. elegans vulval cell fates relies on inductive signaling. …”
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A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila. by Aidan J Peterson, Stephen J Murphy, Melinda G Mundt, MaryJane Shimell, Edward B Leof, Michael B O'Connor

“…We explored whether such regulation occurs in the Drosophila wing disc, an epithelial tissue featuring the TGF-β family member Decapentaplegic (Dpp) as a morphogen controlling growth and patterning. Dpp protein has been observed in an extracellular gradient within the columnar cell layer of the disc, but also uniformly in the disc lumen, leading to the question of how graded signaling is achieved in the face of 2 distinctly localized ligand pools. …”
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Chemokine induces phase transition from non-directional to directional migration during angiogenesis by Ning Gui, Keisuke Sako, Moe Fukumoto, Naoki Mochizuki, Hiroyuki Nakajima

“…In cxcr4a mutants, sprouting tip cells lose their directionality and tend to connect to nearby sprouting ECs, resulting in altered capillary network patterning. Furthermore, in wild-type (WT) larvae, local Ca2+ oscillations were detected in protrusions of tip cells, specifically in the non-directional phase, but almost disappeared in the directional phase as a result of the Cxcr4-dependent phase transition. …”
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Trends of maternal waterpipe, cigarettes, and dual tobacco smoking in Jordan. A decade of lost opportunities. by Khalid A Kheirallah, Nuha Shugaa Addin, Maan M Alolimat

“…We estimated the prevalence of current maternal tobacco use by tobacco product (cigarette, waterpipe, and dual use) over a period of ten years (2007 to 2017), and examined the socio-demographic patterning of maternal tobacco use.<h4>Methods</h4>A secondary analysis of Jordan DHS four data waves was conducted for women who reported to be pregnant at the time of the survey. …”
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