Association of Blood Donor-derived Cell-free DNA Levels With Banff Scores and Histopathological Lesions in Kidney Allograft Biopsies: Results From an Observational Study by Aylin Akifova, MD, Klemens Budde, MD, Mira Choi, MD, Kerstin Amann, MD, Maike Buettner-Herold, MD, Michael Oellerich, MD, Julia Beck, PhD, Kirsten Bornemann-Kolatzki, PhD, Ekkehard Schütz, PhD, Friederike Bachmann, MD, Fabian Halleck, MD, Eva V. Schrezenmeier, MD, Evelyn Seelow, MD, Bianca Zukunft, MD, Charlotte Hammett, MD, Nathan A. Pohl, Benedetta Mordà, MD, Jan Kowald, MD, Nils Lachmann, Diana Stauch, Bilgin Osmanodja, MD

“…To evaluate the association between dd-cfDNA and different histological patterns, we correlated absolute and relative dd-cfDNA (thresholds of 50 copies/mL and 0.5%, respectively) with the Banff 2022 lesion scores and the assigned diagnoses. …”
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Linking biogenic high-temperature ice nucleating particles in Arctic soils and streams to their microbial producers by L. Z. Jensen, L. Z. Jensen, L. Z. Jensen, J. K. Simonsen, J. K. Simonsen, A. Pastor, A. Pastor, C. Pearce, C. Pearce, C. Pearce, P. Nørnberg, P. Nørnberg, L. C. Lund-Hansen, L. C. Lund-Hansen, K. Finster, K. Finster, K. Finster, K. Finster, T. Šantl-Temkiv, T. Šantl-Temkiv, T. Šantl-Temkiv, T. Šantl-Temkiv

“…The potential release and aerosolization of these bioINPs into the atmosphere – whether directly from the soil, from streams into which they are washed, or from the oceans where they might be transported – could impact cloud formation and precipitation patterns in the Arctic. This research contributes valuable knowledge to the understanding of microbial communities and the potential microbial producers of highly active bioINPs in Arctic soils and their connectivity with Arctic streams.…”
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EGFR and MUC1 as dual-TAA drug targets for lung cancer and colorectal cancer by Huilin Cui, Qianqian Yu, Qumiao Xu, Chen Lin, Long Zhang, Wei Ye, Yifei Yang, Sijia Tian, Yilu Zhou, Runzhe Sun, Yongsheng Meng, Ningning Yao, Haizhen Wang, Feilin Cao, Meilin Liu, Jinfeng Ma, Cheng Liao, Ruifang Sun

“…Besides, high expression of EGFR and MUC1 was significantly associated with poor prognosis of LUAD and CRC patients.ConclusionsSingle-cell RNA, bulk RNA and IHC data demonstrated the high expression levels and co-expression patterns of EGFR and MUC1 in tumors but not normal tissues. …”
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Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. by Izabela Maurício de Rezende, Lívia Sacchetto, Érica Munhoz de Mello, Pedro Augusto Alves, Felipe Campos de Melo Iani, Talita Émile Ribeiro Adelino, Myrian Morato Duarte, Ana Luísa Furtado Cury, André Felipe Leal Bernardes, Tayrine Araújo Santos, Leonardo Soares Pereira, Maria Rita Teixeira Dutra, Dario Brock Ramalho, Benoit de Thoisy, Erna Geessien Kroon, Giliane de Souza Trindade, Betânia Paiva Drumond

“…The topology of lineage BR-YFV_2016/18 was congruent with epidemiological and temporal patterns of the ongoing epidemic. YFV isolates detected in 2016, in São Paulo state were located in the most basal position of the lineage, followed by the isolates from Minas Gerais and Espírito Santo obtained in 2017 and 2018. …”
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Glycogen depletion in astrocytes induces sex-dimorphic remodeling of astrocytic and synaptic structures with concomitant anxiety-like behaviors and maternal care deficits by Xiaotong Shi, Yuanyuan Zhu, Zhaoyichun Zhang, Ningcan Ma, Danyi He, You Wu, Ziyi Dai, Xinyan Qin, Yingyi Chen, Youyi Zhao, Haopeng Zhang, Jing Huang, Hui Zhang, Ze Fan

“…Results Pygb-KI mice exhibited glycogen deficiency in astrocytes in both sexes, causing disrupted energy metabolic patterns, particularly in glycolysis. Subsequently, we observed in female-specific decreases in area, branching, and length of astrocytes and loss of mature dendritic spines in neurons. …”
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The Relation between AGN and Host-galaxy Properties in the JWST Era. I. Seyferts at Cosmic Noon are Obscured and Disturbed by Nina Bonaventura, Jianwei Lyu, George H. Rieke, Stacey Alberts, Christopher N. A. Willmer, Pablo G. Pérez-González, Andrew J. Bunker, Meredith Stone, Francesco D’Eugenio, Christina C. Williams, Michael V. Maseda, Chris J. Willott, Zhiyuan Ji, William M. Baker, Stefano Carniani, Stephane Charlot, Jacopo Chevallard, Emma Curtis-Lake, Daniel J. Eisenstein, Kevin Hainline, Ryan Hausen, Erica J. Nelson, Marcia J. Rieke, Brant Robertson, Irene Shivaei

“…Placing the observed pattern of disturbances in the context of the other average host-galaxy properties, we conclude that mergers are common among obscured AGN. …”
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The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells by Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen

“…Importantly, we identified GAAGAA as the binding motif of Bcas2 to RNAs and revealed its essential role in the regulation of Bcas2‐dependent AS and CSR. In addition, we detected a mutation of at the 3’UTR of Bcas2 gene in children with HIGM1 and observed similar patterns of AS events and CSR in the patient that were discovered in the Bcas2‐cKO B cells. …”
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High-resolution analyses of the secretomes from murine C2C12 cells and primary human skeletal muscle cells reveal distinct differences in contraction-regulated myokine secretion by Pia Marlene Förster, Pia Marlene Förster, Julian Hogenkamp, Julian Hogenkamp, Moira Fee Pottgießer, Christian Binsch, Christian Binsch, Awovi Didi Humpert, Awovi Didi Humpert, Carolin Laura Brügge, Michelle Isabel Deatc, Regina Ensenauer, Alexandra Chadt, Alexandra Chadt, G. Hege Thoresen, G. Hege Thoresen, D. Margriet Ouwens, D. Margriet Ouwens, D. Margriet Ouwens, Sonja Hartwig, Sonja Hartwig, Stefan Lehr, Stefan Lehr, Hadi Al-Hasani, Hadi Al-Hasani

“…Previous studies with cultured rodent and human myotubes have revealed highly complex patterns of myokine secretion. However, the commonalities and differences in the secretory response of the different cell models have not been explored, limiting the interpretation of these results. …”
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Epidemiology and Genetic Evolutionary Analysis of Influenza Virus Among Children in Hainan Island, China, 2021–2023 by Meng Chang, Shengjie Shi, Yan Jin, Gaoyu Wang, Ruoyan Peng, Jing An, Yi Huang, Xiaoyuan Hu, Chuanning Tang, Yi Niu, Xiuying Tian, Wanxin Deng, Cheng Tang, Xiuji Cui, Jasper Fuk-Woo Chan, Yibo Jia, Feifei Yin

“…These findings highlight the need for adaptive influenza vaccination and containment strategies, particularly in tropical regions like Hainan, where climate and public health policies significantly impact viral transmission patterns. The insights gained from this study could inform more effective public health strategies in similar regions to mitigate the impact of influenza outbreaks in the future.…”
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Frequency of the different mutations causing spinocerebellar ataxia (SCA1, SCA2, MJD/SCA3 and DRPLA) in a large group of Brazilian patients Freqüência das mutações que causam ataxi... by Iscia Lopes-Cendesi, Hélio G.A. Teive, Maria E Calcagnotto, Jaderson C. da Costa, Francisco Cardoso, Erika Viana, Jaime A. Maciel, João Radvany, Walter O. Arruda, Paulo C. Trevisol-Bittencourt, Pedro Rosa Neto, Isabel Silveira, Carlos E. Steiner, Walter Pinto-Júnior, André S. Santos, Ylmar Correa Neto, Lineu C. Werneck, Abelardo Q.C. Araújo, Gerson Carakushansky, Luiz R. Mello, Laura B. Jardim, Guy A. Rouleau

“…We investigated the frequency of the SCA1, SCA2, MJD/SCA3 and DRPLA mutations in 328 Brazilian patients with SCA, belonging to 90 unrelated families with various patterns of inheritance and originating in different geographic regions of Brazil. …”
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CEDAR-GPP: spatiotemporally upscaled estimates of gross primary productivity incorporating CO₂ fertilization by Y. Kang, Y. Kang, Y. Kang, M. Bassiouni, M. Bassiouni, M. Gaber, M. Gaber, X. Lu, X. Lu, T. F. Keenan, T. F. Keenan

“…After incorporating the direct CO<span class="inline-formula">₂</span> effects, the predicted long-term GPP trend across global flux towers substantially increases from 3.1 to 4.5–5.4 gC m<span class="inline-formula">⁻²</span> yr<span class="inline-formula">⁻¹</span>, which aligns more closely with the 7.7 gC m<span class="inline-formula">⁻²</span> yr<span class="inline-formula">⁻¹</span> trend detected from eddy covariance data. While the global patterns of annual mean GPP, seasonality, and interannual variability generally align with existing satellite-based products, CEDAR-GPP demonstrates higher long-term trends globally after incorporating CO<span class="inline-formula">₂</span> fertilization and reflected a strong temperature control on direct CO<span class="inline-formula">₂</span> effects. …”
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Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis. by Soo-Yon Rhee, Jose Luis Blanco, Michael R Jordan, Jonathan Taylor, Philippe Lemey, Vici Varghese, Raph L Hamers, Silvia Bertagnolio, Tobias F Rinke de Wit, Avelin F Aghokeng, Jan Albert, Radko Avi, Santiago Avila-Rios, Pascal O Bessong, James I Brooks, Charles A B Boucher, Zabrina L Brumme, Michael P Busch, Hermann Bussmann, Marie-Laure Chaix, Bum Sik Chin, Toni T D'Aquin, Cillian F De Gascun, Anne Derache, Diane Descamps, Alaka K Deshpande, Cyrille F Djoko, Susan H Eshleman, Herve Fleury, Pierre Frange, Seiichiro Fujisaki, P Richard Harrigan, Junko Hattori, Africa Holguin, Gillian M Hunt, Hiroshi Ichimura, Pontiano Kaleebu, David Katzenstein, Sasisopin Kiertiburanakul, Jerome H Kim, Sung Soon Kim, Yanpeng Li, Irja Lutsar, Lynn Morris, Nicaise Ndembi, Kee Peng Ng, Ramesh S Paranjape, Martine Peeters, Mario Poljak, Matt A Price, Manon L Ragonnet-Cronin, Gustavo Reyes-Terán, Morgane Rolland, Sunee Sirivichayakul, Davey M Smith, Marcelo A Soares, Vincent V Soriano, Deogratius Ssemwanga, Maja Stanojevic, Mariane A Stefani, Wataru Sugiura, Somnuek Sungkanuparph, Amilcar Tanuri, Kok Keng Tee, Hong-Ha M Truong, David A M C van de Vijver, Nicole Vidal, Chunfu Yang, Rongge Yang, Gonzalo Yebra, John P A Ioannidis, Anne-Mieke Vandamme, Robert W Shafer

“…<h4>Background</h4>Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is not affordable. …”
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Sodium arsenite influences proliferation and apoptosis in normal thyroid cells via modulation of ER-PI3K/AKT signaling pathway by Zhihong JIANG, Hongyun LI, Xiaowei MA, Yuanyan LAI, Jun WU

“…The mRNA expression patterns of ERα, ERβ, c-MYC, Bcl-2, and Bax were consistent with the WB results. …”
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Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T by Kexin Wang, Licheng Ju, Guanda Qiao, Yajie Liang, Yihan Wu, Chengyan Chu, Joshua Rogers, Yuguo Li, Suyi Cao, Valina L. Dawson, Ted M Dawson, Piotr Walczak, Jiadi Xu

“…Both pMCAO and tMCAO models were utilized to examine the B1-dependence patterns and pH sensitivity of the different CEST contrasts in ischemic lesions compared to contralateral region. …”
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Multi-temporal remote sensing of inland surface waters: A fusion of sentinel-1&2 data applied to small seasonal ponds in semiarid environments by Francesco Valerio, Sérgio Godinho, Gonçalo Ferraz, Ricardo Pita, João Gameiro, Bruno Silva, Ana Teresa Marques, João Paulo Silva

“…The SLSW model demonstrated satisfactory results in detecting surface water occurrence (μ ≈ 72 %), and provided far greater completeness and reconstructed seasonality patterns than the LGSW model. …”
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Effects of 1-MCP on the genes related to wax anabolism in pear peel based on transcriptomics by YU Wanting, ZHANG Xinnan, SUN Xiaonan, WANG Wenhui, JIA Xiaohui

“…The results of RT-qPCR showed that 1-MCP treatment significantly inhibited the up-regulated expression of PyLACS9, PyKCS20 and PyCER1 genes during the whole shelf life, and inhibited the up-regulated expression of PyPLDALPHA4 and PyFAD2 genes in the first 7 days of shelf life, which verified the regulation of 1-MCP on the expression pattern of wax anabolism genes in the peel of Yuluxiang pear. …”
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First assessment of biofouling assemblages in the northern Red Sea, an important region for marine non-indigenous species transfer by Juan Sempere-Valverde, Juan Sempere-Valverde, Eva Aylagas, Vitaly Syomin, Vitaly Syomin, Marcos A. L. Teixeira, Glafira D. Kolbasova, Glafira D. Kolbasova, Sofía Ruiz-Velasco, Sahar Chebaane, Arthur Anker, João Curdia, Ronald Cadiz, Dylan M. Cottrell, Andrea Desiderato, Luiz F. Andrade, Chakkiath Paul Antony, Carolina Bocanegra-Castano, Matilde Marzucchi, Angelo Poliseno, Doaa Baker, Basmah Alabdulaziz, Flor Torres, Ameer A. Eweida, Ameer A. Eweida, Susana Carvalho, Susana Carvalho

“…The environmental characteristics of each site were obtained by deploying temperature data loggers and through an environmental risk assessment.ResultsCommunity patterns observed from the PhQd and bulk DNA datasets revealed a clear separation of two sites within Sharma lagoon from the remaining sites. …”
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Population Structure of the Invasive Asian Tiger Mosquito, Aedes albopictus, in Europe by Margaret K. Corley, Luciano Veiga Cosme, Peter A. Armbruster, Nigel Beebe, Anna Bega, Sebastien Boyer, Beniamino Caputo, Chun‐Hong Chen, Jacob E. Crawford, Alessandra dellaTorre, Roger Eritja, Michael C. Fontaine, Richard J. Gill, Trang Huynh, Perparim Kadriaj, Kevin Maringer, Ademir Jesus Martins, Andrew Maynard, Shomen Mukherjee, Leonard E. Munstermann, Verena Pichler, Maria Sharakhova, Sinnathamby Noble Surendran, Sandra Urbanelli, Enkelejda Velo, Isra Wahid, Muhammet Mustafa Akiner, Georgios Balatsos, Gilles Besnard, Maria Louise Borg, Daniel Bravo‐Barriga, Rubén Bueno Marí, Francisco Collantes, Cintia Horvath, Mihaela Kavran, Raquel Medialdea‐Carrera, Tanya Melillo, Antonios Michaelakis, Ognyan Mikov, Arianna Puggioli, Elton Rogozi, Francis Schaffner, Kayleigh Hackett, Thomas Johnson, Tina Wu, João Pinto, Vera Valadas, Adalgisa Caccone

“…The SNP and microsatellite datasets found similar patterns of genetic differentiation in Europe, but the microsatellite dataset could not detect the more subtle genetic structure revealed using SNPs. …”
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Increased Risk of Myositis-Specific and Myositis-Associated Autoantibodies After COVID-19 Pandemic and Vaccination: A Spanish Multicenter Collaborative Study by Laura García-Bravo, Alvaro Prada, María Gutiérrez Larrañaga, Eduardo Espinosa Ros, Delia Almeida González, Dolores Martín Martínez, Telesforo Rodríguez Sánchez, Carlos Gustavo Mingorance Gámez, Aurora Jurado Roger, Rocío Aguado Álvarez, María De Las Mercedes Díaz Luna, Carmen Rodríguez Hernández, Raquel de la Varga-Martínez, María López-Cueto, Maria Rosa Julià Benique, Miriam San José-Cascón, Bibiana Quirant-Sánchez, Alba Martínez-Chamorro, Goitzane Marcaida-Benito, Pilar Teresa Timoneda Timoneda, Marta Fandos Sánchez, Beatriz Sacristán Enciso, Kauzar Mohamed Mohamed, Teresa Guerra-Galán, Ángela Villegas, Andrés Roncancio-Clavijo, Margarita Rodríguez-Mahou, Silvia Sánchez-Ramón, Miguel Fernández-Arquero, Gloria Candelas-Rodríguez, Juliana Ochoa-Grullón, on behalf of the GEAI-SEI Group

“…<b>Results</b>: The study identified distinct patterns in aminoacyl-tRNA synthetase (ARS) antibody frequencies compared to pre-pandemic periods. …”
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Investigation of methicillin, beta lactam, carbapenem, and multidrug resistant bacteria from blood cultures of septicemia suspected patients in Northwest Ethiopia by Abebe Birhanu, Getachew Gebre, Eden Getaneh, Hana Yohannes, Netsanet Baye, Gizeaddis Belay Mersha, Mitkie Tigabie, Mulat Dagnew, Getachew Ferede, Teshiwal Deress, Wondwossen Abebe

“…Aimed to characterize pathogens isolated from positive blood cultures, including bacterial profiles and antibiotic susceptibility patterns, and to identify predictors of blood culture positivity in septicemia-suspected patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. …”
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