La educación física como fortalecimiento de valores ciudadanos para la convivencia (Physical education as a strengthening of citizen values for coexistence) by Felix Giovanni Cañon Salinas, Mario Alberto Villarreal Angeles

“…Employed a qualitative-quantitative methodology with a cybernetic approach, Through a self-observation plan, it was possible to detect behaviors in the formation of values of students from sixth to ninth grade, compared to the patterns of citizenship formation expressed when receiving physical education classes. …”
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Conventional in vitro fertilization enhances preimplantation genetic testing for aneuploidy outcomes in couples with non-male factor infertility by Xiaolan Li, Qian Li, Yajie Chang, Shujing He, Yanfang Wang, Xiaoyan Liang, Zhiqiang Zhang

“…However, after controlling the potential confounders, c-IVF demonstrated significantly higher euploid embryo rate compared to ICSI (adjusted RR = 1.611, 95% CI 1.228–2.114, P = 0.001). Patterns of chromosomal aberrations were similar between groups, with chromosomes 15, 16, 21, and 22 showing the highest frequencies of abnormalities. …”
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Metabolomic Profiling Reveals Serum Tryptophan as a Potential Therapeutic Target for Systemic Lupus Erythematosus by Wang K, Zhu R, Xu M, Zhu K, Li J, Li C, Meng D, Chen H, Sun L

“…Two key metabolites, tryptophan and beta-alanine, showed significantly decreased levels in SLE patients compared to healthy controls (both p< 0.05), while exhibiting opposite patterns in other autoimmune diseases. In the mouse model, tryptophan supplementation improved renal histology, reduced proteinuria, increased naïve T cells and central memory T cells, and decreased effector T cell frequencies in both peripheral blood and spleen.Conclusion: This study demonstrates the successful application of machine learning algorithms to metabolomics data for SLE classification and identifies tryptophan and beta-alanine as potential SLE-specific biomarkers. …”
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The global impact of non-alcoholic fatty liver disease (including cirrhosis) in the elderly from 1990 to 2021 and future projections of disease burden. by Siying Huang, Weitao Hu, Taiyong Fang

“…This study systematically examines the global incidence patterns and epidemiological characteristics of NAFLD in older adults(>60 years), while establishing predictive models for its future disease burden.…”
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Integrating advanced analytical methods to assess epigenetic marks affecting response to hypomethylating agents in higher risk myelodysplastic syndrome by Theodoros Nikolopoulos, Eleftherios Bochalis, Theodora Chatzilygeroudi, Vasiliki Chondrou, Irene Dereki, Katerina Athanasopoulou, John Zafeiropoulos, Kyriakos Bourikas, George P. Patrinos, Argiris Symeonidis, Argyro Sgourou

“…Abstract Background Patients with higher-risk (HR) myelodysplastic syndrome (MDS), ineligible for allogeneic hematopoietic stem cell transplantation (alloHSCT), require prompt therapeutic interventions, such as treatment with hypomethylating agents (HMAs) to restore normal DNA methylation patterns, mainly of oncosuppressor genes, and consequently to delay disease progression and increase overall survival (OS). …”
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New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics by Xue Fan, Ying Li, Yuehao Xu, Jianqing Lin, Xin Guo, Jinwen Liao, Mingguo Xu

“…Finally, MRM-MS confirmed the expression patterns of 12 DEPs (IFIT3, UB2L6, HP, A1AT, HSP90AA1, HNRPC, HSP90AB1, SAA1, MX1, B2M, FKBP4, and TRAP1), thereby demonstrating high consistency with the DIA results and further validating the DEPs’ potential as biomarkers for KD.ConclusionOur findings suggest that 12 proteins in GCF could serve as potential biomarkers for the early diagnosis of KD. …”
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Population immunity to SARS-CoV-2 virus in residents of the Irkutsk Region in the dynamics of the epidemic by S. V. Balakhonov, V. I. Dubrovina, M. V. Chesnokova, D. D. Bryukhova, N. O. Kiseleva, A. B. Pyatidesyatnikova, K. M. Korytov, V. V. Voitkova, A. N. Perezhogin, T. A. Gavrilova, A. A. Seledtsov

“…In this regard, the study of the manifestations of the epidemic process of the new coronavirus infection COVID-19 and the patterns of its development are an urgent area of research. …”
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Distribution of sasX, mupA, and qacA/B genes and determination of genetic relatedness of epidemic methicillin-resistant Staphylococcus aureus strains associated with bloodstream in... by Rui Zhao, Bingyu Du, Lingling Hu, Chenxi Li, Fen Xue, Xing Wang, Changhong Jiang, Jinghua Wang, Yanfeng Zhao

“…The gene distribution patterns revealed that sasX+ qacA/B+ mupA+ strains were closely associated with epidemic clones ST6290 and ST88, whereas sasX+ qacA/B+ mupA- strains were linked to ST59, ST239, and ST764. …”
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Emergence and clinical challenges of ST11-K64 carbapenem-resistant Klebsiella pneumoniae: molecular insights and implications for antimicrobial resistance and virulence in Southwes... by Linlin LI, Jiahui Liang, Huan Zhang, Jing Guo, Shan LI, Meng Li

“…Objectives This study aimed to comprehensively investigate the clinical characteristics, antimicrobial resistance patterns, resistance and virulence-associated genes, and molecular epidemiology of ST11-K64 CRKP in Southwest China. …”
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Rifampicin-resistant tuberculosis in Fujian Province, Southeast China: a retrospective analysis of drug resistance screening and treatment outcomes, 2019–2024 by Yinfa Zhou, Zhisong Dai, Zhisong Dai, Shufang Lin, Shufang Lin, Daiquan Chen, Jian Lin, Kun Chen, Yongming Lin, Yanqin Deng, Yanqin Deng

“…This study aimed to analyze RR-TB characteristics, resistance patterns, and treatment outcomes to inform evidence-based control strategies.MethodsAn observational study was conducted utilizing data from China’s National Tuberculosis Information Management System, focusing on bacteriologically confirmed tuberculosis cases reported in Fujian Province during 2019–2024. …”
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Associations among IL-6 Signaling Molecules in Treg Populations in Patients with Relapsing-Remitting Multiple Sclerosis by Magdalena Kierasińska, Maja Machcińska, Marta Maruszewska-Cheruiyot, Ludmiła Szewczak, Anna Karlińska, Rafał Rola, Michael Stear, Katarzyna Donskow-Łysoniewska

“…RRMS may interfere with normal immune aging patterns, possibly by promoting a sustained inflammatory state that overrides the senescence of Tregs.…”
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Proteomic analysis of plasma unravels dynamic pathways and potential biomarkers indicating disease stages following Mtb infection by Zonglei Zhou, Jie Tian, Yuying He, Haiyan Xiong, Weibing Wang

“…Protein-protein interaction network suggested similar functional enrichment patterns as aforementioned for core DEPs. Weighted gene co-expression network analyses identified six modules, among which the brown module significantly correlated with TB stages. …”
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Antibiotic Resistance Trends in Carbapenem-Resistant Gram-Negative Pathogens and Eight-Year Surveillance of XDR Bloodstream Infections in a Western Greece Tertiary Hospital by Maria Lagadinou, Marina Amerali, Christos Michailides, Anna Chondroleou, Katerina Skintzi, Anastasia Spiliopoulou, Fevronia Kolonitsiou, Leonidia Leonidou, Stelios F. Assimakopoulos, Markos Marangos

“…The prevalence and distribution of these pathogens across different hospital wards and their susceptibility patterns to key antibiotics (aminoglycosides, trimethoprim-sulfamethoxazole, tigecycline, colistin, ampicillin-sulbactam, ceftolozane-tazobactam and ceftazidime-avibactam) were recorded. …”
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Maternal air temperature exposure and risk of small vulnerable newborn: Identifying critical windows by Mingzhao Huang, Jian Fang, Yaqi Zhang, Luli Xu, Xiya Qin, Kai Chen, Zhiguo Xia, Jun Li, Lianting Hu, Xiaofeng Mu, Xiaoxuan Fan, Youjie Wang, Aifen Zhou, Chao Xiong

“…Conclusions: While the overall exposure-response relationship exhibits a U-shaped pattern throughout gestation, our findings reveal substantial heterogeneity in temperature sensitivity across developmental windows. …”
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Molecular investigation on measles cases rise and variants co-circulation in the Lazio region, Italy by Cesare Ernesto Maria Gruber, Silvia Gioacchini, Lavinia Fabeni, Martina Rueca, Licia Bordi, Eleonora Lalle, Melissa Baggieri, Paola Bucci, Raoul Fioravanti, Roberto Giuseppetti, Eliana Specchiarello, Pietro Giorgio Spezia, Giulia Berno, Fabrizio Carletti, Gabriella De Carli, Maria Concetta Fusco, Alessandra Barca, Paola Scognamiglio, Antonella Marchi, Emilio D’Ugo, Enrico Girardi, Francesco Vairo, Fabio Magurano, Fabrizio Maggi

“…Phylogenetic analysis identified four distinct clusters: three associating 50% of sporadic cases, and one confirming the epidemiological investigation. Several mutational patterns were identified, one of which had three nucleotide mutations potentially affecting the diagnostic test. …”
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Identifying nontuberculous mycobacteria from a mycobacteria growth indicator tube with nuclear magnetic resonance spectroscopy: A laboratory metabolomics analysis case report by Dr Christoffel Opperman, Dr Marwaan Rylands, Dr Sarishna Singh, Ms Aysha Amien, Mr Yonas Ghebrekristos, Prof Rob Warren, Dr Wynand Goosen

“…Common techniques such as DNA-DNA reverse hybridization (line probe assays) also struggle to discriminate between NTM mixture patterns and have a limited spectrum of NTM that can be identified. …”
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Genomic insights into the population structure, antimicrobial resistance, and virulence of Brachyspira hyodysenteriae from diverse geographical regions by Maria Hakimi, Fangshu Ye, Anugrah Saxena, Xiao Hu, Huigang Shen, Paarthiphan Elankumaran, Chloe C. Stinman, Nubia Macedo, Orhan Sahin, Eric R. Burrough, Ganwu Li

“…Association between specific lineages, STs, and geographical regions was evident, highlighting evolutionary and regional patterns. The pan-genome analysis identified 5,231 genes, categorized into core (1,648), accessory (2,619), and unique (964) components. …”
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Incidence of underlying CAD in chest pain patients with intermediate risk for ACS: a retrospective analysis by Abigail Coutinho, Faith Oluwaseun Williams, Ibukunoluwa Ogunbowale, Mohamed Azmi Kasmi Elmetwali, Abdul Basit Malik, Ramabala Vuyyuru, Sayak Roy, Taiwo Ikuesan, Pradeep Singh, Francis Castaneda, Marifel Rojo

“…Of the remaining 117 patients, 61 with baseline troponin levels and standard ECG patterns were accepted for further investigations.We used online software5 to estimate the mean with 95% confidence intervals (CIs) for baseline continuous variables, and we represented the categorical variables as percentages out of the total available dataset. …”
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Characterization of a blaKPC-3-carrying plasmid in a clinical isolate of Klebsiella pneumoniae belonging to the emerging successful clone ST147 by Esther Recacha, Mercedes Delgado-Valverde, Marina R. Pulido, Elena Pérez-Nadales, Patricia Pérez-Palacios, Inés Portillo-Calderón, Juan Manuel Sánchez-Calvo, Irene Gracia-Ahufinger, Álvaro Pascual

“…The first ST147 isolate detected was compared with two previous isolates of K. pneumoniae ST512/KPC-3 and KPC-3-encoding plasmid pKpQIL as reference plasmid. …”
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Differential Expression Characteristics of Two Isoforms <i>nr5a2f</i> and <i>nr5a2m</i> in Gonadal Differentiation of Chinese Giant Salamanders, <i>Andrias davidianus</i> by Dan Hu, Guanglve Li, Guohua Zou, Jiaqing Xu, Wenyin Luo, Qiaomu Hu

“…These results suggested that <i>Nr5a2</i>f and <i>Nr5a2m</i> exhibited different expression patterns in the process of sex differentiation, which provided a foundation for further functional characterizations.…”
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