Exploring AMR and virulence in Klebsiella pneumoniae isolated from humans and pet animals: A complement of phenotype by WGS-derived profiles in a One Health study in Egypt by Enas A. Soliman, Alaa Saad, Ashraf A. Abd El Tawab, Fatma I. Elhofy, Amira M. Rizk, Manar Elkhayat, Tamara Kozytska, Majdil Ilyas, Marwa Bassiouny, Hanka Brangsch, Mathias W. Pletz, Heinrich Neubauer, Lisa D. Sprague, Gamal Wareth

“…Isolates from humans exhibited more pronounced resistance patterns compared to the animal isolates. High levels of resistance were observed for piperacillin, trimethoprim/sulfamethoxazole, and cephalosporins, and resistance to carbapenem compounds was only found in isolates of human origin. …”
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Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies by Xingyao Chen, Xingyao Chen, Xingyao Chen, Nuo Chen, Nuo Chen, Nuo Chen, Peng Lai, Peng Lai, Yiqi Sun, Jie Yu, Ming Xin, Deliang Zhu, Fanrong Liang, Fanrong Liang, Fanrong Liang, Qian Song, Shirui Cheng, Shirui Cheng, Shirui Cheng, Zhengjie Li, Zhengjie Li, Zhengjie Li, Zhengjie Li

“…In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.MethodsA systematic search of neuroimaging studies investigating the brain activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024. …”
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Whole-genome resequencing to investigate the genetic diversity and the molecular basis underlying key economic traits in indigenous sheep breeds adapted to hypoxic environments by Dehong Tian, Dehong Tian, Dehong Tian, Buying Han, Buying Han, Buying Han, Xue Li, Xue Li, Xue Li, Quanbang Pei, Baicheng Zhou, Kai Zhao, Kai Zhao

“…Population analyses, including NJ and maximum likelihood trees, revealed clear genetic differentiation and migration patterns. Selective sweep analyses (Fst and θπ) identified hypoxia-related genes (DOCK8, IGF1R, JAK1, SLC47, TMTC2, and VPS13A) and wool color genes (TCF25, MITF, and MC1R). …”
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Nasopharyngeal carriage of Staphylococcus aureus in a rural population, Sierra Leone by Lisa Maria Kleine, Emmanuel Marx Kanu, Tobias Grebe, Desmond Mohamed Sesay, Henning Loismann, Maxwell Sesay, Tom Theiler, Viktoria Rudolf, Alexander Mellmann, Laura C. Kalkman, Martin P. Grobusch, Frieder Schaumburg

“…The aim of this study was to assess colonization rates, resistance patterns and selected virulence factors of S. aureus from rural Sierra Leone. …”
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The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors by Jiajun Zhou, Jiajun Zhou, Wenhao An, Lei Guan, Lei Guan, Jinyu Shi, Qiaozhen Qin, Shuai Zhong, Zheng Huang, Rui Liu, Chenxing Wu, Zhong Ma, Xueling Qi, Xiaoxia Jiang, Yan Wang, Shouwei Li

“…Immunohistochemistry and immunofluorescence staining were used to assess the infiltration patterns of T cell subsets (CD3+, CD4+, CD8+, Foxp3+) and the expression levels of immune checkpoints (CTLA-4, PD-1, PD-L1). …”
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CD169+ Macrophages Mediate the Immune Response of Allergic Rhinitis Through the Keap1/Nrf2/HO‐1 Axis by Wenwen Qi, Chengcheng Liu, Lei Shi, Hui Li, Xiaozhi Hou, Hongjie Du, Luqiu Chen, Xiaochen Gao, Xue Cao, Na Guo, Yuhan Dong, Chengzhilin Li, Fanyu Yuan, Zhenxiao Teng, Houyang Hu, Fangyuan Zhu, Xuanchen Zhou, Lulu Guo, Miaoqing Zhao, Ming Xia

“…To investigate the characteristics of CD169+ macrophages in AR, this work first detects their expression patterns in the nasal mucosa of clinical patients. …”
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STRAS: a new high-time-resolution aerosol sampler for particle-induced X-ray emission (PIXE) analysis by S. Nava, S. Nava, R. Vecchi, R. Vecchi, P. Prati, P. Prati, V. Bernardoni, V. Bernardoni, L. Cadeo, G. Calzolai, L. Carraresi, L. Carraresi, C. Cialdai, M. Chiari, F. Crova, F. Crova, A. Forello, A. Forello, C. Fratticioli, C. Fratticioli, F. Giardi, M. Manetti, D. Massabò, D. Massabò, F. Mazzei, F. Mazzei, L. Repetto, G. Valli, G. Valli, V. Vernocchi, F. Lucarelli, F. Lucarelli

“…<p>The joint use of hourly resolution sampling and analyses with accelerated ion beams such as with the particle-induced X-ray emission (PIXE) technique has allowed the measurement of hourly temporal patterns of particulate matter (PM) composition at many sites in different parts of the world. …”
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Comparative Transcriptome Analysis of Mature Leaves of <i>Dimocarpus longan</i> cv. ‘Sijimi’ Provides Insight into Its Continuous-Flowering Trait by Shilian Huang, Xinmin Lv, Junbin Wei, Dongmei Han, Jianguang Li, Dongliang Guo

“…Different gene-expression patterns were detected between CF and OF longan in bisque4 and darkorange2 modules, especially the high levels of transcription factor (TF) expression and the large number of gibberellic acid (GA)-signaling-pathway-specific genes expressed at high levels in CF longan (SJ). …”
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Endocrine disrupting chemicals in maternal and umbilical cord plasma and their associations with birthweight in the GUSTO cohort by Sharon Ng, Ling-Wei Chen, Ze-Ying Chen, Mei-Huei Chen, Anne H. Y. Chu, Keith M. Godfrey, Kok Hian Tan, Peter D. Gluckman, Johan G. Eriksson, Fabian Yap, Pau-Chung Chen, Yap Seng Chong, Chia-Yang Chen, Shiao-Yng Chan

“…Abstract Background With daily exposure to multiple endocrine disrupting chemicals (EDCs), understanding individualized co-exposure patterns could better identify chemicals that threaten health. …”
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Prevalence and spatial distributions of trachomatous inflammation-follicular among children aged 1–9 years in rural areas of Yilmana Densa and Gonji Kolela districts, Northwestern... by Misganaw Alelign, Asmamaw Malede, Eshetu Shifaw, Tesfahun Taddege, Yideg Abinew, Metadel Adane

“…It was clustered at the village levels and showed strong spatial patterns. It was affected by different locations based on sociodemographic, environmental, and behavioral factors. …”
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Comparative Genome Sequencing of Canine Distemper Virus Across Different Continents and Lineages, using Nanopore Technology by Dr Zsófia Lanszki, Dr. József Lanszki, Dr. Tamás Cserkész, Dr. Vito Martella, Dr. Georgia Diakoudi, Dr. Gianvito Lanave, Mr. Md. Nurul Islam, Mrs. Sazeda Akter, Dr. Gábor Kemenesi

“…The widely used Hemagglutinin gene-based grouping alone is insufficient for uncovering genomic-level evolutionary patterns, specific mutations, or recombination events. …”
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Diabetic Retinopathy Screening in Patients with Diabetes Using a Handheld Fundus Camera: The Experience from the South-Eastern Region in Hungary by Dóra Júlia Eszes, Dóra Júlia Szabó, Greg Russell, Csaba Lengyel, Tamás Várkonyi, Edit Paulik, László Nagymajtényi, Andrea Facskó, Goran Petrovski, Beáta Éva Petrovski

“…Furthermore, we aimed to detect the risk factors for developing DR and the diabetology/ophthalmology screening patterns and frequencies, as well as the effect of socioeconomic status- (SES-) related factors on the health and behavior of DM patients. …”
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Virulence genes and antibiotic resistance profiling of staphylococcus species isolated from mastitic dairy cows in and around Bahir dar, Ethiopia by Dessie Debeb Getahun, Habtamu Tassew Tarekegn, Bizuneh Tsehayneh Azene, Laikemariam Teshome Abebe, Mequanint Addisu Belete, Tesfaye Sisay Tessema

“…Therefore, the present study aimed to investigate the virulence gene profiles and antimicrobial resistance (AMR) patterns of Staphylococcus species isolated from mastitic dairy cows in and around Bahir Dar, Ethiopia. …”
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Intra-familial transmission of Hepatitis B virus in a peri-urban community from the Democratic Republic of the Congo by Florence Cindibu Kalonji, Yu Nakagama, Evariste Tshibangu-Kabamba, Nadine Kayiba Kalenda, Shun Nakagama, Sachie Nakagama, Pathy Kamanga Nkolongo, Nestor Kalala-Tshituka, Alphonse Lufuluabu Mpemba, Faustin Ndjibu Mpoji, André Kabongu Kalala, Benjamin Muamba Mpoyi, Dieudonné Mumba Ngoyi, Natsuko Kaku, Yusuke Shimakawa, Ghislain Tumba Disashi, Yasutoshi Kido

“…Genotyping and phylogenetic analysis of preS/S sequences were performed to explore regional HBV diversity and transmission patterns. Results A total of 751 participants from 677 households were included. …”
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Spatiotemporal perturbations of the plasminogen activation system in a rat model of acute organophosphate intoxication by Thomas J. Blackmon, Jeremy A. MacMahon, Pedro N. Bernardino, Ryan E. Hogans, Mei-Yun Cheng, Joan Vu, Ruth Diana Lee, Naomi H. Saito, Ana Cristina Grodzki, Donald A. Bruun, Heike Wulff, Kevin D. Woolard, Amy Brooks-Kayal, Danielle J. Harvey, Fredric A. Gorin, Pamela J. Lein

“…To address this data gap, we characterized the spatiotemporal expression patterns of multiple components of the PAS in a rat model of acute intoxication with the OP, diisopropylfluorophosphate (DFP). …”
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Regional Differences in the Frequency of BRCA1 and BRCA2 Variants in Northeastern Japan: A Cohort Study by Hidekazu Shirota, Akimitsu Miyake, Maako Kawamura, Shuhei Suzuki, Kensuke Saito, Jun Yasuda, Hiroyuki Shibata, Motonobu Saito, Takeshi Iwaya, Hiroshi Tada, Muneaki Shimada, Naoki Kawamorita, Masayuki Kanamori, Eisaku Miyauchi, Hidetaka Niizuma, Tomoyuki Iwasaki, Yuki Kasahara, Hiroo Imai, Ken Saijo, Keigo Komine, Masanobu Takahashi, Tetsuya Niihori, Yoko Aoki, Toru Furukawa, Gen Tamiya, Chikashi Ishioka

“…The regional distribution of BRCA1 and BRCA2 variants showed distinct patterns: pathogenic variants of BRCA1 exhibited regional differences and were less prevalent compared to VUS, whereas BRCA2 variants, including both pathogenic variants and VUS, did not exhibit such clear regional localization. …”
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Epidemic features and megagenomic analysis of childhood Mycoplasma pneumoniae post COVID-19 pandemic: a 6-year study in southern China by Yi Xu, Chen Yang, Panpan Sun, Fansen Zeng, Qian Wang, Jianlong Wu, Chunxiao Fang, Che Zhang, Jinping Wang, Yiling Gu, Xiaohuan Wu, Xiaoxian Zhang, Bin Yang, Juhua Yang, Hongwei Zhang, Jiacee Lian, Jinqiu Zhang, Li Huang, Qizhou Lian

“…This multicentre, retrospective study was designed to analyse the epidemic patterns of MPI before and after the COVID-19 pandemic, as well as genotypes and the macrolide-resistance-associated mutations in MP sampled from paediatric patients in Southern China. …”
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miRNA Expression Response of <i>Aedes aegypti</i> (Linnaeus 1762) (Diptera: Culicidae) to Imidacloprid Exposure by Gerardo Trujillo-Rodríguez, Mariana Lizbeth Jiménez-Martínez, Elda Flores-Contreras, Everardo González Gonzalez, María de Lourdes Ramírez Ahuja, Idalia Garza Veloz, Adriana E. Flores Suarez, Fabian Correa Morales, Felipe Dzul Manzanilla, Iram P. Rodriguez Sanchez, Margarita L. Martínez Fierro

“…Distinct miRNA expression patterns were observed between the field and susceptible strains, with specific miRNAs showing condition-dependent expression. …”
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Combination of suspect and nontarget screening with exposure assessment for per- and polyfluoroalkyl substance prioritization in Chinese municipal wastewater by Hongxin Mu, Ling Chen, Rong Zhou, Luyao Gu, Yue Yu, Jin Tang, Houhu Zhang, Hongqiang Ren, Bing Wu, Yuanqing Bu

“…As the PFAS risk removal efficiency by conventional biological treatment processes was only 0.7 %, the PFAS risk priority patterns in influent and effluent were similar (r = 0.86, p < 0.01). …”
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AI-Driven Dental Caries Management Strategies: From Clinical Practice to Professional Education and Public Self Care by Yutong Liang, Dongling Li, Dongmei Deng, Chun Hung Chu, May Lei Mei, Yunpeng Li, Na Yu, Jinzhi He, Lei Cheng

“…Additionally, AI tracks brushing patterns and provides feedback to improve oral hygiene practices of the patients and the general population, thereby improving their understanding and compliance. …”
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