Untargeted metabolomics reveals the metabolic characteristics and biomarkers of obstetric antiphospholipid syndrome and undifferentiated connective tissue disease by Siyin Li, Juan Shi, Xiaofang Shu, Xuemin Jian, Jinmei Zou, Jing Yang

“…This study employs metabolomics to investigate metabolic reprogramming patterns in OAPS and UCTD, aiming to identify potential biomarkers for early diagnosis.MethodsUsing LC-MS-based metabolomics, we analyzed serum profiles from 40 OAPS patients (B1), 30 OAPS + UCTD patients (B2), 27 UCTD patients (B3), and 30 healthy controls (A1). …”
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Smart diabetes management: remote monitoring and predictive health insights by K.S. Smelyakov, I.A. Lurin, K.V. Misiura, A.S. Chupryna, T.V. Tyzhnenko, O.D. Dolhanenko, V.M. Repikhov

“…Newer CGM technologies like Dexcom and Freestyle Libre enable continuous, non-invasive monitoring of glucose levels, producing time series data essential for detecting patterns and predicting dangerous fluctuations (hypo- or hyperglycemia). …”
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Transcriptome-wide identification and systematic analysis of the Retrotransposon genes and their roles in ginsenoside biosynthesis in Panax ginseng by Chaofan Wang, Ruicen Liu, Dinghui Wang, Li Li, Yue Jiang, Yanfang Wang, Kangyu Wang, Mingzhu Zhao, Yi Wang, Meiping Zhang

“…Results 1,301 Retrotransposon genes were identified in ginseng transcriptome using bioinformatics methods, and a systematic analysis was conducted on their gene structures, phylogenetic relationships, and expression patterns. Phylogenetic analysis revealed phenomenon of horizontal transfer of retrotransposons in ginseng. …”
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Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing <i>Enterobacterales</i> Isolates from Imported Healthy Reptiles by Franziska Unger, Tobias Eisenberg, Ellen Prenger-Berninghoff, Ursula Leidner, Torsten Semmler, Christa Ewers

“…We investigated antimicrobial resistance (AMR) patterns, the diversity of extended-spectrum-/AmpC-β-lactamases (ESBL/AmpC) genes and the genomic organization of the ESBL/AmpC producers. …”
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POLR3A rare variants in a patient with intellectual disability, ataxic gait and cortical malformations: a case-report by Caterina Angela Florio, Federica Mirabella, Adriana Prato, Andrea Longhitano, Rita Barone, Renata Rizzo

“…On the second day of life, tremors in the lower and upper limbs were detected and lasted until the second month of life. …”
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Hormonal balance, anovulatory cycles and luteal phase deficiency: exploring relationships between hematological variables, sex hormones and V̇O2max in athletes by Paula Recacha-Ponce, Pilar Suárez-Alcázar, Carlos Hernando, Pablo Salas-Medina, Maria Muriach, Pablo Baliño, Isabel Guisado-Cuadrado, Eladio Collado-Boira

“…Women with anovulatory menstrual cycles exhibit linear patterns of sex hormones throughout the menstrual cycle, which could lead to the maintenance of physical fitness throughout the cycle. …”
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Disulfidptosis-related gene in acute myocardial infarction and its diagnostic value and functions based on bioinformatics analysis and machine learning by Liwen Chen, Jinru Wei, Jinru Wei, Guoxiong Deng, Guoxiong Deng, Guien Xu

“…The research delved into the expression patterns and molecular mechanisms of differentially expressed disulfidptosis related genes in AMI, offering a foundation for precise AMI diagnosis and the identification of novel therapeutic targets.…”
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The effect of 1,25(OH)2D3 on Dickkopf-1 methylation in colorectal cancer by Hongyan Sun, Liehao Yang, Nan Li, Yue Hu, Qianying Hu, Zilong Zhou, Xianling Cong

“…Overexpression of DKK1 reduced the proliferative and migratory capabilities of colorectal cancer cells. The methylation patterns of DKK1 (− 195 to + 231), including 31 CpG sites, were assayed via BSAS in CRC cells and tissues. …”
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Post-marketing safety surveillance of pneumococcal vaccines: a real-world pharmacovigilance study using the U.S. vaccine adverse event reporting system (VAERS) database by Xinkuo Zheng, Meishen Liu, Aili Ding, Shihong Zhang, Ling Wu, Fanli Kong, Weijia Sun, Yuchen Peng, Yalin Xi

“…These observations reinforce the established safety profile of pneumococcal vaccines while emphasizing temporal risk patterns to guide post-vaccination monitoring protocols and risk-benefit evaluations.…”
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AI-HOPE-TGFbeta: A Conversational AI Agent for Integrative Clinical and Genomic Analysis of TGF-β Pathway Alterations in Colorectal Cancer to Advance Precision Medicine by Ei-Wen Yang, Brigette Waldrup, Enrique Velazquez-Villarreal

“…These findings underscore the platform’s capacity to detect both known and emerging clinical–genomic patterns in CRC. …”
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Restoring South African subtropical succulent thicket using Portulacaria afra: rooting variation across three soil types by Alastair J. Potts, Duncan Liddell, Catherine E. Clarke, Nicholas C. Galuszynski

“…However, in degraded ecosystems, these vegetation patterns may not be apparent due to the homogenization of local plant communities. …”
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Variabilidade espacial de atributos físicos do solo associados ao uso e ocupação da paisagem Spatial variability of physical attributes of soil associated with use and occupation o... by Natalino M. Gomes, Manoel A. de Faria, Antônio M. da Silva, Carlos R. de Mello, Marcelo R. Viola

“…Organic matter values ranges from 1.5 to 4.5 dag kg-1, detecting higher concentrations in lands under eucalyptus, cerrado and wetlands. …”
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Tinea capitis in Hainan: a prospective study by Wenai Zheng, Feng Qiao, Xianxu Yang, Xiaozheng Tang, Changyan Lin, Qin Chen, Zhaobing Pan, Rongqiang Chen

“…Hainan, a tropical island province in China, exhibits distinctive climatic conditions and demographic contact patterns that ​could shape​ its pathogen spectrum. …”
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Ophthalmologic adverse events in childhood head and neck rhabdomyosarcoma survivors treated according to four different local treatment strategies by Michele Morfouace, Marinka L.F. Hol, Natalia Arruti, Richard Bowman, Frederic Kolb, Veronique Minard, Bradley Pieters, Mark Gaze, Henry Mandeville, Eric Sandler, Ludwig E. Smeele, Julie Bradley, Daniel J. Indelicato, Olga Slater, Johannes H.M. Merks, Reineke A. Schoot, Peerooz Saeed

“…In 27 % of survivors additional (surgical) treatment of OAEs was required during follow-up. The patterns observed suggest a possible relationship between OAE type and treatment strategy. …”
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Exploring the Global and Regional Factors Influencing the Density of <i>Trachurus japonicus</i> in the South China Sea by Mingshuai Sun, Yaquan Li, Zuozhi Chen, Youwei Xu, Yutao Yang, Yan Zhang, Yalan Peng, Haoda Zhou

“…This elucidation of the distinct biological and physical pathways linking these diverse factors leading to <i>T. japonicus</i> density provides a significantly improved foundation for predicting distribution patterns globally and offers concrete scientific insights for sustainable fishery management strategies.…”
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Prenatal wildfire smoke PM2.5 exposure has carryover effects on the postnatal calf by Alexandra Pace, Patricia Villamediana, Maristela Rovai, Gabriella Ponce, Natalie Ellis, Angela Stegeman, Mallery Larson, Denise E. Konetchy, Pedram Rezamand, Pedram Rezamand, Amy L. Skibiel

“…Calves were monitored from birth through 6 months of life to evaluate growth patterns, health, and basal metabolic and inflammatory markers.ResultsAlthough there was no difference detected between groups in gestation length or calf frame size at birth, WFS calves had lower birth weights compared with that of CON (36.87 ± 0.87 kg vs. 40.82 ± 0.80 kg). …”
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A very early clinical response to treatment with the Janus kinase inhibitor tofacitinib in patients with active rheumatoid arthritis: the dynamics of pain and central sensitization... by A. E. Karateev, E. S. Filatova, E. Yu. Pogozheva, V. N. Amirdzhanova, E. L. Nasonov, A. M. Lila, V. I. Mazurov, A. Yu. De, A. A. Baranov, N. A. Lapkina, G. V. Lukina, N. A. Kiryukhina, S. Yu. Davidyan, T. S. Salnikova, R. R. Samigullina, D. S. Chakieva, I. M. Marusenko, O. V. Semagina, M. Yu. Semchenkova, A. F. Davydova, E. V. Kalinina

“…The limitation of this investigation was its open observer design pattern.Conclusion. The use of the JK inhibitor TOFA can achieve a rapid analgesic effect, inter alia due to its effect on CS and NPC.…”
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Chaperone-mediated autophagy in fish: A key function amid a changing environment by Simon Schnebert, Emilio J Vélez, Maxime Goguet, Karine Dias, Vincent Véron, Isabel García-Pérez, Lisa M Radler, Emilie Cardona, Stéphanie Fontagné-Dicharry, Pierre Van Delft, Franziska Dittrich-Domergue, Amélie Bernard, Florian Beaumatin, Amaury Herpin, Beth Cleveland, Iban Seiliez

“…Here, we shed light on the existence of 2 genes encoding the CMA-limiting factor Lamp2A (lysosomal associated membrane protein 2A) in rainbow trout (RT, Oncorhynchus mykiss), revealing distinct expression patterns across various tissues. Notably, RT lacking the most expressed Lamp2A exhibit profound hepatic proteome disturbances during acute nutritional stress, underscoring its pivotal role as a guardian of hepatic proteostasis. …”
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Insights into the Driving Factors of Methane Emission from Double-Season Rice Field Under Different Fertilization Practices in South China by Jin Zheng, Yusheng Lu, Peizhi Xu, Kaizhi Xie, Changmin Zhou, Yaying Li, Haoyang Geng, Qianyuan Wang, Wenjie Gu

“…The results showed that CH₄ emission fluxes exhibited seasonal variations, with consistent patterns of change observed across all treatments for both early- and late-season rice. …”
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Impulsivity among healthy adults is associated with diet and fecal microbiota composition by Prokopis Konstanti, Kira F. Ahrens, Rebecca J. Neumann, Michael M. Plichta, Carmen Schiweck, Alea Ruf, Christian J. Fiebach, Raffael Kalisch, Ulrike Basten, Michèle Wessa, Oliver Tuescher, Bianca Kollmann, Klaus Lieb, Alejandro Arias-Vasquez, Hauke Smidt, Andreas Reif, Silke Matura, Clara Belzer

“…Notably, the genera Butyricicoccus and Lachnospiraceae UCG-001 that were negatively associated with urgency were also associated with healthier dietary patterns such as higher fiber, fruits and vegetables consumption and with lower consumption of sugary drinks. …”
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