Platinum drugs upregulate CXCR4 and PD‐L1 expression via ROS‐dependent pathways, with implications for novel combined treatment in gastric cancer by Xiaoyu Kang, Lin Zhang, Shushang Liu, Fei Wang, Haiming Liu, Fenli Zhou, Fei Wu, Haohao Zhang, Daiming Fan, Yongzhan Nie, Zhangqian Chen

“…Immunohistochemistry, western blot, and RT‐qPCR were performed to determine the expression pattern of CXCR4 and PD‐L1 in GC. Clinical samples, patient‐derived xenografts, and cell‐derived xenografts were utilized to investigate the effects of platinum drugs on the expression levels of CXCR4 and PD‐L1. …”
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Comprehensive analysis of CYP78A family genes reveals the involvement of CYP78A5 and CYP78A10 in fruit development in eggplant by Mengya Zhou, Liying Zhang, Shuangxia Luo, Lijun Song, Shuxing Shen, Jianjun Zhao, Qiang Li, Xueping Chen

“…Comparative syntenic analysis provided further insight into the phylogenetic relationships of CYP78A genes from the four plants. qRT-PCR analysis revealed that the expression of the six SmCYP78As was detected in at least one of the eight tissues, showing a tissue-specific pattern. …”
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Intraspecific and Intracolonial Variation in the Profile of Venom Alkaloids and Cuticular Hydrocarbons of the Fire Ant Solenopsis saevissima Smith (Hymenoptera: Formicidae) by Eduardo Gonçalves Paterson Fox, Adriana Pianaro, Daniel Russ Solis, Jacques Hubert Charles Delabie, Bruno Cunha Vairo, Ednildo de Alcântara Machado, Odair Correa Bueno

“…Many researchers attempted to sort between invasive and native species by using chemical characters, including patterns of venom alkaloids. The present study is the first to report intraspecific variation in some chemical characters, namely, cuticular hydrocarbons and venom alkaloids, within the Brazilian fire ant species Solenopsis saevissima and also reports on within-nest variations among members of different castes. …”
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Genome-Wide Identification of DNA Methyltransferase and Demethylase in <i>Populus</i> sect. Turanga and Their Potential Roles in Heteromorphic Leaf Development in <i>Populus euphra... by Chen Qiu, Jianhao Sun, Mingyu Jia, Xiaoli Han, Jia Song, Zhongshuai Gai, Zhijun Li

“…Transcriptome profiling showed that several <i>PeDMTs</i> and <i>PeDMLs</i> exhibited leaf shape- and developmental stage-specific expression patterns, with <i>PeDML1</i> highly expressed during early stages and in broad-ovate leaves. …”
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Temporal trend in non-melanoma skin cancer mortality in China, 1992–2021: an analysis for the global burden of disease study 2021 by Deng Li, Ge Yan, Shasha Song, Siqi Fan, Haochen Zhao, Gang Hu, Xuewen Xu, Qingfeng Li, Qingfeng Li

“…The aim is to assess the MR data of NMSC patients worldwide from 1992 to 2021, analyze its temporal trends, and provide valuable epidemiological information for future prevention and management strategies of NMSC.MethodsUsing data from the Global Burden of Disease Study 2021 (GBD 2021), we analyzed crude mortality rate (CMR), age-standardized mortality rate (ASMR), and sex- and age-specific mortality trends, with temporal patterns assessed through longitudinal comparisons.ResultsThe MR for NMSC has shown an upward trend globally. …”
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Clinicoradiological profile of children presenting with global developmental delay and microcephaly by ShreyasT.S. Phayde, Suneel C. Mundkur, Rochelle A. Pereira, Leslie E. Lewis, Shrikiran A. Hebbar, Ramesh Bhat Y, Pushpa Kini, Karen J. Moras

“…Data was collected using a pre-designed proforma, documenting presenting complaints, birth and developmental history, growth patterns, physical and neurological examination results, associated co-morbidities with neuroimaging findings. …”
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Pharmacokinetics and brain tissue distribution of Gastrodia elata extract in normal and cerebral ischemic rats: a comparative study by Ji Shao, Qi Xu, Yunyun Luo, Ting Dong, Xue Han, Bilian Chen, Huazhong Ying, Cuifen Fang, Qiaojuan Shi

“…Xenobiotic metabolite analysis identified nine biotransformation products, four of which exhibited quantifiable exposure levels in brain tissues across all experimental groups.ConclusionThis study systematically revealed the bioactive components of Gastrodia elata and their cerebral distribution patterns. The pharmacokinetic characteristics of gastrodin and related bioactive compounds were also elucidated. …”
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Genetic characteristics of rotavirus a in Shenzhen and Zhuhai, China, 2020–2023 by Mingda Hu, Yixiong Lin, Rui Zhang, Xin Wang, Yaqing He, Huitao Huang, Boqian Wang, Wanqiu Liu, Kexin Li, Jingjing Fu, Xinru Zhao, Buaijier Aimaiti, Wensheng Yang, Hongbin Song, Hongguang Ren, Xiaofeng Hu

“…Phylogenetic analysis focusing on the VP7 and VP4 genes revealed distinct evolutionary patterns among different genotypes across temporal and geographical dimensions. …”
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Evaluating Mathematical Concordance Between Taxonomic and Functional Diversity Metrics in Benthic Macroinvertebrate Communities by Gonzalo Sotomayor, Henrietta Hampel, Raúl F. Vázquez, Christine Van der heyden, Marie Anne Eurie Forio, Peter L. M. Goethals

“…Understanding the structural concordance between taxonomic and functional diversity (FD) metrics is essential for improving the ecological interpretation of community patterns in biomonitoring programs. This study evaluated the concordance between taxonomic and FD metrics of benthic macroinvertebrates along a fluvial habitat quality gradient in the Paute River Basin, Ecuador. …”
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The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring by Yan Zhang, Rui Guo, Min Yin, Mei Shi, Ting Zhong, Shanshan Liu, Xia Li

“…Two age-related gene expression patterns were identified in monocytes. Analysis of offspring monocytes from mothers with GDM suggested that exposure to a GDM environment in the womb may lead to increased expression of aging-related genes, a hindered cell cycle, and increased immune age. …”
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Two-Segment Gain-Coupled Distributed Feedback Laser by Feng Gao, Li Qin, Yong-Yi Chen, Peng Jia, Chao Chen, Hong Chen, Lei Liang, Yu-Gang Zeng, Xing Zhang, Yong-Qiang Ning, Ye-Jin Zhang, Li-Jun Wang

“…Periodic surface grooves and 4-<italic>&#x03BC;</italic>m-width ridge were patterned merely by one-step i-line lithography. It provides a novel method for low-cost practical gain-coupled DFB laser fabrication, which can be used in either/both wavelength-tunable applications such as sensing and detection, or/and wavelength stabilization fields such as pumping fiber lasers.…”
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Tissue-specific expression and correlation with promoter DNA methylation of the LBP gene in pigs by Yue CAO, Zhong-cheng GAO, Zheng-chang WU, Hai-fei WANG, Wen-bin BAO

“…This study demonstrated the distinct patterns of LBP expression and promoter methylation in the tissues of Meishan pigs and indicated the potential roles of DNA methylation in regulating LBP expression, which may contribute to further investigations on pig LBP gene expression and function.…”
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A New Disease of Cherry Plum Tree with Yellow Leaf Symptoms Associated with a Novel Phytoplasma in the Aster Yellows Group by Zheng-nan LI, Lei ZHANG, Ye TAO, Ming CHI, Yu XIANG, Yun-feng WU

“…A novel phytoplasma was detected in a cherry plum (Prunus cerasifera Ehrh) tree that mainly showed yellow leaf symptom. …”
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Elevated Methylation Contributes to Suppressed Expression of Special AT‐Rich Sequence‐Binding Protein 2 in Colorectal Cancer: A Gene‐Disease Association Study by Weitong Cui, Cong Lu, Huaru Xue, Lei Wei, Shuai Li, Lianzheng Su, Dianfang Wei, Xiaoyu Feng, Kai Wang, Chao Song

“…Next, we explored the methylation status of the SATB2 promoter and SATB2 expression patterns in the collected CRC tumor and adjacent normal tissues, as well as different cell lines, via methylation‐specific PCR and quantitative PCR. …”
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Evaluation of the relatedness between the biofilm-associated genes and antimicrobial resistance among Acinetobacter baumannii isolates in the southwest Iran by Nafiseh Hosseinzadeh Shakib, Zahra Hashemizadeh, Abolfazl Rafati Zomorodi, Reza Khashei, Yeganeh Sadeghi, Abdollah Bazargani

“…This study aims to explore the relationship between biofilm production, the presence of biofilm-associated genes, and antibiotic resistance patterns in A. baumannii isolates obtained from ICU patients. …”
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Efficacy and safety of a biosimilar laronidase versus the reference laronidase in patients with mucopolysaccharidosis type I by Ali Rabbani, Mohammadreza Alaei, Samaneh Norouzi Asl, Aria Setoodeh, Marjan Shakiba, Shadab Salehpour, Peyman Eshraghi, Omid Salehpour, Araz Sabzvari, Hamidreza Kafi, Ali Jarollahi

“…Post-infusion enzyme activity levels showed similar patterns between Aldurazyme and Laronidase (CinnaGen), with no detectable activity before the infusion. …”
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Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 by Xing-An Jiang, Xing-An Jiang, Hong-Li Zhang, Bin-Tao Ye, Shao-Qi Fang, Jia-Jin Zhang, Hao-Lin Yu, Jun-Bo Liang, Jun-Bo Liang

“…These observations highlight the critical role of evaluating adipose distribution patterns when devising preventive measures against OP and support employing RFM as an potential indicator for initiating early clinical interventions aimed at mitigating bone density deterioration.…”
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Atypical causes of respiratory virus infections in Sub-Saharan Africa from 2013– 2023: a systematic review and meta-analysis by George Agyei, Philip El-Duah, Jonathan Mawutor Gmanyami, Oscar Lambert, Brice Armel Nembot Fogang, Sherihane Aryeetey, Augustina Sylverken, Rexford Mawunyo Dumevi, Yaw Adu-Sarkodie, Richard Odame Phillips, Christian Drosten, Michael Owusu

“…Abstract Background Atypical respiratory viruses (ARVs) are a diverse group of pathogens that cause respiratory infections through less common mechanisms or in unique epidemiological patterns, unlike the typical viruses like respiratory syncytial virus, influenza and human rhinoviruses. …”
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Identification and profiling of microRNAs during sheep’s testicular development by Binpeng Xi, Xuejiao An, Xuejiao An, Yaojing Yue, Yaojing Yue, Haimiao Shen, Gaohui Han, Yanan Yang, Shengguo Zhao

“…In this study, we utilized deep sequencing data to analyze the expression patterns of small RNAs in testicular tissues of Southern × Hu sheep F1 hybrids at 0, 3, 6 months, and 1 year of age, thereby exploring the functions of miRNAs in testicular development and spermatogenesis. …”
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A suite of wildlife crossing structures facilitates mammal movement across tropical forest fragments in a city by Li Si Tay, Ruisheng Choo, Max D. Y. Khoo, Eunice Kong, Yi Xiang Chan, Wivian H. Y. Neo, Sebastian Ow, Yuet Hsin Toh, Han Ling, Malcolm C. K. Soh, Benjamin P. Y.‐H. Lee, Adrian H. B. Loo, Kenneth B. H. Er

“…This allowed us to evaluate the preferences of mammals, assess usage patterns and investigate factors influencing the use of different crossing types. …”
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