Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury by Jason-Alexander Hörauf, Cora Rebecca Schindler, Inna Schaible, Minhong Wang, Birte Weber, André El Saman, Christiane Pallas, Marek Widera, Ingo Marzi, Dirk Henrich, Liudmila Leppik

“…However, the existing evidence regarding their function as biomarkers and their role in the pathobiology of traumatic spinal cord injuries (tSCI), particularly in humans, is scarce.ObjectiveThe primary goal of this study was to investigate whether a distinct pattern of EV surface epitopes detected in the plasma of individuals suffering from spinal cord injury is indicative of tSCI.MethodsThe study includes patients with isolated tSCI (n=8), polytrauma patients without tSCI (PT; ISS ≥16, n=8), and healthy volunteers (HV; n=8). …”
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Selection for Growth Performance in <i>Oreochromis niloticus</i> Across Different Aquatic Environments Using Growth Hormone Gene Polymorphisms by Fawzia S. Ali, Simone T. Awad, Mohamed Ismail, Shabaan A. Hemeda, Abeer F. El Nahas, Eman M. Abbas, Ahmed Mamoon, Hani Nazmi, Ehab El-Haroun

“…Furthermore, their progenies documented the most promising gene expression patterns of all tested genes. The current research highlights the importance of molecular selection and the potential use of population-specific SNPs in tilapia breeding programs.…”
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Tumor budding and poorly differentiated clusters as a biological continuum in colorectal cancer invasion and prognosis by Tariq Sami Haddad, John-Melle Bokhorst, Luuk van den Dobbelsteen, Sonay K. Öztürk, Elias Baumann, Shannon van Vliet, Kiek Verrijp, Nigel B Jamieson, Colin Wood, Martin D. Berger, Richard Kirsch, Marco Aben, Natasja Rutgers, Hideki Ueno, Francesco Ciompi, Femke Simmer, Jeroen van der Laak, Alessandro Lugli, Inti Zlobec, Iris Nagtegaal

“…Abstract Tumor budding (TB) and poorly differentiated clusters (PDCs) are features of infiltrative growth patterns and powerful independent prognostic factors in colorectal cancer (CRC), yet the underlying biological mechanisms behind their role in CRC invasion is less understood. …”
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Pleistocene chronology and history of hominins and fauna at Denisova Cave by Zenobia Jacobs, Elena I. Zavala, Bo Li, Kieran O’Gorman, Michael V. Shunkov, Maxim B. Kozlikin, Anatoly P. Derevianko, Vladimir A. Uliyanov, Paul Goldberg, Alexander K. Agadjanian, Sergei K. Vasiliev, Frank Brink, Stéphane Peyrégne, Viviane Slon, Svante Pääbo, Janet Kelso, Matthias Meyer, Richard G. Roberts

“…The timing of hominin occupation and major turnovers in the mtDNA of Denisovans and large mammals largely accords with the patterns detected in Main and East Chambers. Time gaps in those sequences are partly filled by the South Chamber data and the sediment DNA record of Denisovans after 80,000 years ago is more than doubled in size. …”
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A global view of protein expression in human cells, tissues, and organs by Fredrik Pontén, Marcus Gry, Linn Fagerberg, Emma Lundberg, Anna Asplund, Lisa Berglund, Per Oksvold, Erik Björling, Sophia Hober, Caroline Kampf, Sanjay Navani, Peter Nilsson, Jenny Ottosson, Anja Persson, Henrik Wernérus, Kenneth Wester, Mathias Uhlén

“…Despite this ubiquitous expression, hierarchical clustering analysis, based on global protein expression patterns, shows that the analyzed cells can be still subdivided into groups according to the current concepts of histology and cellular differentiation. …”
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Seasonal and Interannual Variations in M₂ Tidal Current in Offshore Guangdong by Caijing Huang, Tingting Zu, Lili Zeng, Rui Shi, Qiang Wang, Ping Wang, Yingwei Tian, Rongwei Zhai, Xinjun Xu

“…However, an abrupt change occurred in the coastal area of Shantou in 2021, primarily caused by the distortion of the antenna patterns.…”
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Diversity and Composition of the Airborne Fungal Community in Mexico City with a Metagenomic Approach by Carolina Brunner-Mendoza, María del Carmen Calderón-Ezquerro, César Guerrero-Guerra, Alejandro Sanchez-Flores, Ilse Salinas-Peralta, Conchita Toriello

“…Regarding the areas, the north and center sites showed similar meteorological conditions and fungal community composition patterns. According to the Shannon and Simpson indices, the south area showed a greater species diversity during the dry season. …”
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Thyroid Peroxidase Gene Mutation in Patients with Congenital Hypothyroidism in Isfahan, Iran by Mahin Hashemipour, Fahimeh Soheilipour, Sakineh Karimizare, Hossein Khanahmad, Morteza Karimipour, Sepideh Aminzadeh, Leila Kokabee, Massoud Amini, Silva Hovsepian, Rezvaneh Hadian

“…DNA sequencing was performed for those with different migration patterns in SSCP by chain termination method. Exon 8 was sequenced directly in all patients. …”
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Comparative Study of Free Amino Acid Profiles in Underground Organs of Several Species of the Genus Rumex During Different Phases of the Vegetation Cycle by A. M. Poluyanov, U. A. Matvienko, A. Yu. Sokolova, A. E. Savelyeva, N. A. Durnova, N. V. Bobkova

“…However, R. crispus L. showed an unusual pattern, with the highest quantitative content of AA detected in the regrowth phase.…”
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Interferon Regulatory Factor 3 Exacerbates the Severity of COVID-19 in Mice by Wendy E. Walker, PhD, Luiz F. Garcia, MS, Pedro M. Palermo, PhD, Nawar Hakim, MD, Dinesh G. Goswami, PhD, Alok K. Dwivedi, PhD, Douglas M. Watts, PhD

“…Interferon regulatory factor 3 (IRF3) is a transcription factor that is activated when pattern recognition receptors detect viruses. Upon activation, IRF3 induces the expression of interferon beta (IFN-β) and interferon-stimulated genes, which protect the host from viral infection. …”
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Lactylation-related gene signature accurately predicts prognosis and immunotherapy response in gastric cancer by Xuezeng Sun, Haifeng Dong, Rishun Su, Jingyao Chen, Wenchao Li, Songcheng Yin, Changhua Zhang

“…A genetic pattern linked to lactylation was created using Univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression. …”
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Geospatial analysis of limited access to drinking water services in East African countries: insights from recent demographic and health surveys by Gelila Yitageasu, Kassaw Chekole Adane, Amensisa Hailu Tesfaye, Amensisa Hailu Tesfaye, Zemichael Gizaw, Tigist Kifle, Lidetu Demoze

“…Global spatial autocorrelation was performed to analyze whether the pattern of limited access to drinking water service is clustered, dispersed, or random across the study areas. …”
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On the tracks of an uninvited guest, the Asian tiger mosquito, Aedes albopictus in Cyprus by Riccardo Piccinno, Giulia Fiorenza, Marlen Ines Vasquez, Jeremy Bouyer, Gregoris Notarides, Ludvik Marcus Gomulski, Soteris Meletiou, Mustafa Akiner, Antonios Michaelakis, Federico Forneris, Giovanni Maga, Giuliano Gasperi, Anna Rodolfa Malacrida

“…Methods We applied highly polymorphic simple sequence repeat (SSR) markers to the Ae. albopictus mosquitoes collected in Cyprus and to specimens from Italy, France, Switzerland, the Balkans, Greece and Turkey to construct an SSR individual genotype dataset that would enable the invasion pattern of Ae. albopictus in Cyprus to be traced. …”
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Generation and characterization of a tamoxifen-inducible lineage tracing tool Cd2-P2A-CreERT2 knock-in mice by Yang Guo, Mengyan Zhu, Zhilan Yu, Qing Li, Yanjuan Chen, Lei Ci, Ruilin Sun, Ruling Shen

“…By mating the Cd2-CreERT2 strain with a Rosa26-LSL-tdTomato reporter mouse strain which contains a tdTomato expression fragment blocked with a loxP-flanked STOP cassette (LSL) driven by a CAG promoter, a Cd2-CreERT2;Rosa26-LSL-tdTomato reporter strain was obtained to evaluate the expression pattern of CD2 in different cell types.ResultsAfter treatment with tamoxifen, the Cd2-CreERT2 knock-in mice were induced to perform efficient recombination at the loxP site following CreERT2 activation and cause the expression of tdTomato fluorescence. …”
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A case of resected hepatocellular carcinoma with gallbladder metastasis by Takaaki Hanazawa, Yasuyuki Fukami, Takaaki Osawa, Shintaro Kurahashi, Tatsuki Matsumura, Takuya Saito, Shunichiro Komatsu, Kenitiro Kaneko, Toyonori Tsuzuki, Tsuyoshi Sano

“…Contrast-enhanced magnetic resonance imaging (MRI) demonstrated that the liver tumor showed a pattern of early enhancement and washout. The gallbladder tumor was also detected as an enhanced mass. …”
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First-in-human clinical outcomes with NG-350A, an anti-CD40 expressing tumor-selective vector designed to remodel immunosuppressive tumor microenvironments by Aung Naing, Danny Khalil, Matthew Thomas, Tom Lillie, Oliver Rosen, Lee Rosen, D Ross Camidge, Rui-Ru Ji, Andrea Stacey

“…Delivery of NG-350A to tumors was demonstrated in biopsy samples following both routes of administration; a dose-dependent pattern was seen with intravenous infusion, with four patients remaining positive for vector DNA in biopsies at Day 57. …”
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Amino acid 138 in the HA of a H3N2 subtype influenza A virus increases affinity for the lower respiratory tract and alveolar macrophages in pigs. by Matias Cardenas, Brittany Seibert, Brianna Cowan, Ana Luiza S Fraiha, Silvia Carnaccini, L Claire Gay, Flavio Cargnin Faccin, C Joaquin Caceres, Tavis K Anderson, Amy L Vincent Baker, Daniel R Perez, Daniela S Rajao

“…The hVIC/11A138S infected the upper respiratory tract, right caudal, and both cranial lobes while hVIC/11 was only detected in nose and trachea samples. Viruses induced a distinct expression pattern of various pro-inflammatory cytokines such as IL-8, TNF-α, and IFN-β. …”
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Lung function trajectories in children with early diagnosis of non-cystic fibrosis bronchiectasis: a retrospective observational study by Rossella Lamberti, Simona Ferraro, Andrea Farolfi, Michele Ghezzi, Salvatore Zirpoli, Alice Marianna Munari, Sai Spandana Adivishnu, Giuseppe Marano, Elia Biganzoli, Gian Vincenzo Zuccotti, Enza D’Auria

“…The aims of this study were to characterize the pattern of the trajectories of lung function parameters and to consider the relationship between the lung function and radiological severity according to the modified Reiff score. …”
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Acute Hepatitis A-Induced Autoimmune Hepatitis: A Case Report by Brenda N. Loza-Hernández, Héctor M. Herrera-Martínez, Erika G. Salgado-Parra, Arturo-Rodríguez Guajardo, Violeta López-Gutierrez, Mauricio Old-Morales

“…She presented with acute hepatitis due to virus A in February 2024 (symptomatic clinical pattern with jaundice), corroborated by serology (IgM + antibodies) remission with supportive treatment in April. …”
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Effects of dihydroquercetin (DHQ “P” drops) in patients with previous transitory ischemic attacks associated with visual disorders by Wang Zi Way, O.V. Pohorielov, S.V. Bobokalo, O.M. Baranenko, Chun Liu

“…Such positive effects in the conducted study were characterized as tendency pattern (OR 2.87; p=0.08 for perivascular edema and OR 2.77; p=0.08 for microhemorrhages). …”
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