Roles of the lipopolysaccharide biosynthesis-related gene HP0858 in the fitness of Helicobacter pylori and its virulence in Galleria mellonella by Tram Thi Hong Nguyen, Pei-Chun Chen, Po-Chuan Wang, Wen-Han Wang, Chung-Yu Lan, Steffen Backert, Mou-Chieh Kao

“…Recent studies have indicated that ADP-heptose, an intermediate in the heptose biosynthetic pathway involved in the LPS synthesis cascade, is a novel pathogen-associated molecular pattern for H. pylori. This study focuses on the HP0858 gene, which is predicted to encode RfaE/HldE, an enzyme with kinase and ADP-transferase activities essential for heptose production. …”
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Non-targeted screening of organic micropollutants in drinking water: Evidence of contamination from purification systems and plastic materials by Kailin Shen, Daeho Kang, Heewon Jang, Junho Jeon

“…A total of 41 MPs were tentatively identified through MS/MS spectral pattern diagnosis, including plasticizers, plastic derivatives, organophosphorus flame retardants (OPFRs), pesticides, and pharmaceuticals. …”
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Central line-associated bloodstream infection trend in Brazilian adult intensive care units: an ecological study by Alexsandra Gomes Resende de Souza da Silva, Sergiane Bisinoto Alves, Elisângela Eurípedes Resende Guimarães, Jessyca Rodrigues Braga, Heliny Carneiro Cunha Neves, Silvana de Lima Vieira dos Santos, Maria Auxiliadora Carmo Moreira

“…The aim of this study was to analyze the historical trend of central line-associated bloodstream infections in patients in intensive care units, the rate of infection, central venous catheter utilization ratio, type of pathogen and their antimicrobial resistance pattern. Methodology: This ecological study was performed at 42 intensive care units from a state capital of the Midwest region of Brazil. …”
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Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy by Sjoerd H van der Burg, Ilina Ehsan, Mariette I E van Poelgeest, Dana A M Mustafa, Helena C van Doorn, Kim E Kortekaas, Saskia J Santegoets, Liselotte Tas, Pornpimol Charoentong

“…Here, an in-depth interrogation of T cell infiltration, local immune contexture, signaling pathways and checkpoint molecule expression was performed in early-stage and late-stage VSCC.Methods The type, location, and infiltration pattern of T cells were studied in 109 patients with primary VSCC FIGO stage I–III. …”
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Silent but significant: Functional elucidation of a synonymous ATP7B mutation in Wilson’s disease pedigrees by Qi Zhang, Qi Zhang, Xiaoming Xie, Hairong Li, Yulei Li, Hongyao Huang, Hongyao Huang

“…Tyr715=) synonymous mutation, resulting in reduced abundance of normal transcripts.ConclusionThe compound heterozygous variants (c.2145C>T and c.2304dupC) in ATP7B likely synergistically contribute to the proband’s abnormal clinical phenotype, aligning with the recessive inheritance pattern of Wilson’s disease.…”
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Invasive solid papillary carcinoma with neuroendocrine differentiation of the breast: a case report and literature review by Xue Lin, Yoshiaki Matsumoto, Tomomi Nakakimura, Kazuo Ono, Shigeaki Umeoka, Masae Torii, Hiroshi Yoshibayashi, Masakazu Toi

“…A core needle biopsy (CNB) was performed, and the pathological findings showed a solid papillary pattern and atypical cells suggestive of noninvasive SPC. …”
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Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling by Shuo Qiu, Yachao Jia, Yunchu Sun, Pei Han, Jia Xu, Gen Wen, Yimin Chai

“…The VH298-treated wound had a better healing pattern, activation of HIF-1 signalling, and vascularization. …”
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Preterm infants at low risk for early-onset sepsis differ in early fecal microbiome assembly by Sagori Mukhopadhyay, Jung-Jin Lee, Erica Hartman, Emily Woodford, Miren B. Dhudasia, Lisa M. Mattei, Scott G. Daniel, Kelly C. Wade, Mark A. Underwood, Kyle Bittinger

“…In conclusion, LRE infants present a distinct pattern of microbiome development that is aligned with their low risk for EOS. …”
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Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology by Monique Marylin Alves de Almeida, Yves De Repentigny, Sabrina Gagnon, Emma R Sutton, Rashmi Kothary

“…These changes were transient, as mice at P60 exhibited recovery of liver and pancreatic function. While the mosaic pattern of the Cre-mediated excision precludes definitive conclusions regarding the contribution of liver-specific SMN depletion to overall tissue pathology, our findings highlight an intricate connection between liver function and pancreatic abnormalities in SMA.…”
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Irrigation uniformity assessment with high-resolution aerial sensors by Moshe Meron, Moti Peres, Valerie Levin-Orlov, Gil Shoshani, Uri Marchaim, Assaf Chen

“…For linear move systems, RTK-GNSS monitoring revealed irregularities in tower movement creating a zigzag irrigation pattern, leading to areas of over- and under-irrigation. …”
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Respiratory pathogens in infants and young children with acute respiratory illness: a prospective cohort study, China, 2023–2024 by Yuqing Li, Mingwei Wei, Mingwei Wei, Lunbiao Cui, Xiang Huo, Lisha Ma, Ran Tao, Tao Wu, Suyang Qi, Baolong Wang, Xiuyun Shi, Yuanbao Liu, Wenqing Liu, Yiyue Ge, Li Chen, Xiujuan Zhao, Jingjing Wu, Runjie Qi, Fengcai Zhu, Fengcai Zhu, Fengcai Zhu, Jingxin Li, Jingxin Li, Jingxin Li

“…Among the pathogens, human adenovirus (HAdV) and human respiratory syncytial virus (RSV) (18, 36.0%) were the most common pathogens detected among 50 hospitalized cases of ARIs.ConclusionOur data provide a better understanding of epidemiological patterns of respiratory pathogens in infants and young children from 2023 to 2024. …”
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Multidecadal changes in hydrological droughts across Sub-Saharan Africa by Dhais Peña-Angulo, Yves Tramblay, Sergio M. Vicente-Serrano, Job Ekolu, Bastien Dieppois, Ahmed El Kenawy

“…Using the African Database of Hydrometric Indices (ADHI), we analyze streamflow data from 1466 gauging stations spanning 1951–2018 to detect trends in drought characteristics. New Hydrological Insight: A major shift in hydrological drought patterns occurred in the 1980s, with increased drought duration and severity during 1951–1980, followed by a general decrease from 1981 onward. …”
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Applied anatomy and morphology of minor salivary glands in commonly used experimental animals by Zhi-zheng Li, Hui Zhu, Yan-ping Zou, Yi Ding, Jia-zeng Su, Guang-yan Yu

“…The sialomucin nature was examined and the expression patterns of aquaporin (AQP) family were assessed. MSGs were widely distributed beneath the oral mucosa in all four species, mainly as mucous glands, with mixed seromucinous glands in dogs and miniature pigs. …”
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Inferring past demography and genetic adaptation in Spain using the GCAT cohort by Jorge Garcia-Calleja, Simone A. Biagini, Rafael de Cid, Francesc Calafell, Elena Bosch

“…This geographical position may have conditioned distinct selective pressures compared to the rest of Europe and influenced differential patterns of gene flow. In this work, we analyse 704 whole-genome sequences from the GCAT reference panel to quantify gene flow into Spain from various historical sources and identify the top signatures of positive (adaptive) selection. …”
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Impact of easing COVID-19 restrictions on antibiotic usage in Eastern China using wastewater-based epidemiology by Jinxin Zang, Lufang Jiang, Yingying Wang, Yue Chen, Chaowei Fu, Barbara Kasprzyk-Hordern, Na Wang, Qingwu Jiang, Helen Lambert

“…Our study aimed to compare antibiotic consumption and patterns before and after this policy adjustment. We utilised wastewater-based epidemiology (WBE) to analyse antibiotic levels in samples collected from five wastewater treatment plants in Eastern China during January and February of 2021 and 2023. 27 antibiotics were quantified using ultra-high performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UPLC-MS/MS) and analysed via WBE, with the resulting estimates compared with catchment-specific prescription data. 23 antibiotics were detected in wastewater samples, with a substantial increase in usage in 2023 (ranging from 531% to 3734%), consistent with prescription data. …”
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Identification of Simultaneous Occurrence of Amphibian Chytrid Fungi and Ranavirus in South Korea by Ji-Eun Lee, Young Jin Park, Mun-Gyeong Kwon, Yun-Kyeong Oh, Min Sun Kim, Yuno Do

“…Results indicated distinct prevalence patterns driven by ecological traits. <i>Bd</i> was predominantly detected in mountainous and coastal habitats, whereas RV was more common in flat inland areas. …”
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Groundwater Quality Analysis: Assessing the Impact of a Closed Landfill—A Case Study on Physico-Chemical and Microplastic Contaminants by Grzegorz Przydatek, Józef Ciuła, Narcis Barsan, Diana Mirila, Emilian Mosnegutu

“…Additionally, PET microplastics were detected in correlation with increased precipitation and leachate generation. …”
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The Applicability Evaluation of Multisource Precipitation Data for Runoff Simulation in a Typical Basin on the Tianshan Mountains by WANG Wenyu, LIU Gang, WANG Xiaoyan, PANG Liling, FENG Tongfei, GU Huanghe

“…[Results] The spatial pattern for all the precipitation products was characterized by a first increase and then a decrease from the north to south, whereas only AIMERG and CMFD were able to display higher precipitation in the glacier area. …”
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Molecular Characterization of PDGFR-α/PDGF-A and c-KIT/SCF in Gliosarcomas by Rui M. Reis, Albino Martins, Susana A. Ribeiro, Diana Basto, Adhemar Longatto-Filho, Fernando C. Schmitt, José M. Lopes

“…Gliosarcomas are rare and poorly characterized malignant brain tumors that exhibit a biphasic tissue pattern with areas of gliomatous and sarcomatous differentiation. …”
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Unmasking the Hidden Morbidity of Ocular Diseases in Primary Care Through a Collaboration with Specialists in Remote Areas: A Cross-Sectional Study from Rural Crete, Greece by Konstantinos Chliveros, Manolis Linardakis, Ioanna Tsiligianni, Miltiadis Tsilimbaris, Ioannis Pallikaris, Christos Lionis

“…The aim of the study was to assess the prevalence and pattern of eye diseases in a remote rural population of Crete and to explore whether they represent a hidden morbidity. …”
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