Influence of Hedgehog signaling pathway activation on calvarial defect healing in type I diabetic mice by WU Yingzhang, LIU Linan, LIU Shibo, HU Pei, LUO En

“…The impact of T1DM on osteogenic differentiation and the Hh signaling pathway during cranial defect healing was explored by MicroCT scanning and immunohistochemical (IHC) analysis of osteocalcin (Ocn), Indian Hedgehog (Ihh), Patched1 (Ptch1), and zinc finger protein GLI1 (Gli1). …”
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Fruit Sorting Based on Maturity Reduces Internal Disorders in Vapor Heat-Treated ‘B74’ Mango by Amit Khanal, Muhammad Asad Ullah, Priya Joyce, Neil White, Andrew Macnish, Eleanor Hoffman, Donald Irving, Richard Webb, Daryl Joyce

“…Flesh cavity with white patches (FCWP) was the only disorder observed exclusively in VHT fruit. …”
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Risk prediction model for precancerous gastric lesions based on magnifying endoscopy combined with narrow-band imaging features by Jingna Tao, Zhongmian Zhang, Linghan Meng, Liju Zhang, Jiaqi Wang, Zhihong Li

“…Risk factors for high-risk OLGA included lesion location (subcardial and lower body greater curvature), intestinal metaplasia patches, lesion size, demarcation line (DL), and margin regularity of micro-capillary demarcation line (MCDL). …”
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Application of deep learning in cloud cover prediction using geostationary satellite images by Yeonjin Lee, Seyun Min, Jihyun Yoon, Jongsung Ha, Seungtaek Jeong, Seonghyun Ryu, Myoung-Hwan Ahn

“…For improved computational efficiency, each image is divided into four patches during training. Notably, this research incorporates a dynamic learning model, continuously updating with the most recent data, in contrast with static models which do not update their parameters with new data once trained. …”
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Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. by Charlie W Lees, William J Zacharias, Mark Tremelling, Colin L Noble, Elaine R Nimmo, Albert Tenesa, Jennine Cornelius, Leif Torkvist, John Kao, Susan Farrington, Hazel E Drummond, Gwo-Tzer Ho, Ian D R Arnott, Henry D Appelman, Lauri Diehl, Harry Campbell, Malcolm G Dunlop, Miles Parkes, Sarah E M Howie, Deborah L Gumucio, Jack Satsangi

“…In complementary expression studies, we noted the colonic HH response, including GLI1, patched (PTCH), and hedgehog-interacting protein (HHIP), to be down-regulated in patients with UC. …”
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Analysis of Spatial and Temporal Changes and Driving Forces of Ecological Environment Quality in Tuojiang River Basin Based on RSEI Improved Modeling by ZHAO Xiaoyan, TAN Shucheng, ZHANG Su, LI Yongping, WU Han, WANG Chao

“…The urbanized areas with high population density and high level of socio-economic development are dominated by higher fluctuations in ecological environment quality, accounting for 18.15%. (3) The global autocorrelation Moran index of Tuojiang River Basin during 20 years ranged from 0.769 to 0.870, which was mainly distributed in the first and third quadrants, and the ranges of local autocorrelation high-high agglomerations and low-low agglomerations showed significant changes over time, with obvious fragmentation of the landscape patches. (4) The OPGD results show that land use type, slope, elevation, and nighttime lighting are the main drivers of ecological quality change in the watershed, population density, temperature, and GDP are secondary drivers, and precipitation and slope orientation factors are less influential. …”
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Combination Therapy with Baricitinib and Narrowband Ultraviolet B for Active Non-Segmental Vitiligo: A Retrospective Controlled Study by Zhou B, Gui J, Wang T, Li Z, Hu W, Zhang Y, Li Q

“…Bin Zhou,1,2 Jiachen Gui,2,3 Tao Wang,2,4 Zhimin Li,2 Wenzhi Hu,5 Yue Zhang,2 Qiang Li2 1Graduate School, Hebei North University, Zhangjiakou, People’s Republic of China; 2Department of Dermatology, Air Force Medical Center, PLA, Beijing, People’s Republic of China; 3Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China; 4Department of Dermatology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 5Department of Burn and Plastic Surgery, the Air Force Medical Center of Air, Force Military Medical University of Chinese PLA, Beijing, People’s Republic of ChinaCorrespondence: Qiang Li, Department of Dermatology, Air Force Medical Center, PLA, Beijing, 100142, People’s Republic of China, Email 16585260@qq.comBackground: Vitiligo is a chronic autoimmune disease manifested by depigmented patches of skin devoid of melanocytes. Baricitinib, a JAK inhibitor selectively targeting JAK1/2, has shown preliminary efficacy for vitiligo. …”
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METASOMATIC AND MAGMATIC PROCESSES IN THE MANTLE LITHOSPHERE OF THE BIREKTE TERRAIN OF THE SIBERIAN CRATON AND THEIR EFFECT ON THE LITHOSPHERE EVOLUTION by Lidia V. Solov’eva, Tatiana V. Kalashnikova, Sergei I. Kostrovitsky, Alexei V. Ivanov, Stanislav S. Matsuk, Ludmila F. Suvorova

“…The mantle metasomatic phlogopite and amphibole are revealed in all petrographic types of the rocks in this series and compose transverse veins and irregular patchs at grain boundaries of primary minerals. At contacts of xenolith and its host kimberlite, grains of phlogopite and amphibole are often cut off, which gives an evidence of the development of metasomatic phlogopite-amphibole mineralization in the rocks before its’ entraiment into the kimberlite. …”
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Comparative chemical characters of Ziziphi Spinosae Semen from geographical origins of China by Pengwang Wang, Miao Sha, Weimei Zhang, Hongyue Tian, Xu Liang, Wei Tian, Bo Xu, Guanglu Chang, Xia Li, Wenyuan Gao

“…As revealed by the results of protein-protein interaction network analysis, Gene Ontology analysis, and Kyoto Encyclopedia of Genes and Genomes pathway analysis, 14 core components, 10 core targets, and 25 pathways were identified. Thirty-four batches of ZSS fingerprints were established through the HPLC method, which identified 12 characteristic peaks, with 6 being qualitatively identified. …”
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The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a... by Xiaoting Gu, Xiaohe Li, Weixue Tian, Chaoyue Zheng, Chaoyue Zheng, Yutian Cai, Yutian Cai, Xiang Xu, Xiang Xu, Conglu Zhao, Conglu Zhao, Hongting Liu, Hongting Liu, Yao Sun, Yao Sun, Zhilin Luo, Zhilin Luo, Shuwen Zhu, Shuwen Zhu, Honggang Zhou, Honggang Zhou, Xiaoyu Ai, Cheng Yang, Cheng Yang

“…Deg-AZM showed moderate inhibition with CYP2B6 and CYP2D6. Data in three batches of human primary hepatocytes disclosed induction potential of Deg-AZM on CYP2B6 and CYP3A4.ConclusionThe in vivo metabolic pathway of Deg-AZM and in vitro possibility of drug interaction for Deg-AZM with CYP enzymes and drug transporter were fully investigated. …”
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The mechanism of Guanxin Qiwei dropping pills target Dubosiella to improve atherosclerosis by Yuanhong Liao, Yuanhong Liao, Jun Li, Jun Li, Yuxin Li, Jing Liu, Jing Liu, Tingting Chen, Jingkun Lu, Hongxia Li, Qian Zhang, Qian Zhang, Yuewu Wang, Yuewu Wang

“…ObjectiveTo investigate the therapeutic effects of Guanxin Qiwei dropping pills (GXQW) on atherosclerosis (AS) and to delineate the mechanisms underlying these effects.MethodsFirst, the chemical constituents of GXQW were identified using liquid chromatography-mass spectrometry (LC-MS). In addition, 15 batches of GXQW were used for fingerprint determination. …”
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Pharmaceutical evaluation of plantain peel pectin as a disintegrant in conventional tablets by Desmond A.B. Otu, Frederick W.A. Owusu, Mariam E. Boakye-Gyasi, Raphael Johnson, Marcel T. Bayor, Prince G. Acquah Jnr, Yayra Edzor-Agbo, Mary-Ann Archer

“…As a result, all tablet batches met the dissolution test requirement (Diss, Q > 75%), except for those that failed the disintegration test. …”
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…This study aims to develop fully characterized, reproducible, clinical-grade batches of sEV derived from umbilical cord (UC)-MSC for the treatment of OA while assessing its efficacy and safety. …”
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Functional Trait Responses of <i>Brasenia schreberi</i> to Water and Soil Conditions Reveal Its Endangered Status by Jingyu Yao, Zhenya Liu, Junbao Yu, Yun Zhang, Rui Xu, Jiahua Li, Yang Xu, Mei Sun

“…Compared with sporadic distribution, <i>B. schreberi</i> in continuous patches have significantly higher stomatal conductance, intercellular CO₂ concentration, transpiration rate, and vein density, while these plants have significantly smaller leaf area and perimeter. (2) Good water quality directly promotes photosynthetic, morphological, and structural traits. …”
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An experimental chimeric hepatitis E virus vaccine elicits both local and systemic immune responses by Melisa Florencia Müller, Jacinto Sacur, Julia Matias Brancher, María Daniela Vera, Lorena Arce, María Fernanda Raya-Tonetti, Haruki Kitazawa, Haruki Kitazawa, Julio Villena, María Guadalupe Vizoso-Pinto, María Guadalupe Vizoso-Pinto

“…Sera and small intestine fluid were analyzed for humoral response, while Peyer’s patches and spleen immune cells were used for ex vivo stimulation with capsid protein to assess cellular response.ResultsThe oral scheme failed to elicit an IgG response, but this was overcome by a subcutaneous priming dose followed by oral boosters, which led to increasing IgG titers in the combined scheme. …”
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A GIS Approach to Modeling the Ecological Niche of an Ecotype of <i>Bouteloua curtipendula</i> (Michx.) Torr. in Mexican Grasslands by Alma Delia Baez-Gonzalez, Jose Miguel Prieto-Rivero, Alan Alvarez-Holguin, Alicia Melgoza-Castillo, Mario Humberto Royo-Marquez, Jesus Manuel Ochoa-Rivero

“…The predicted population distribution areas in Chihuahua (18,158 ha) in the form of discontinuous patches cohered with those in previous reports on the distribution form of <i>B. curtipendula</i>. …”
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Advancing forest inventory: a comparative study of low-cost MLS lidar device with professional laser scanners by M. Balestra, C. Cabo, A. Murtiyoso, A. Murtiyoso, A. Vitali, F. Alvarez-Taboada, A. Cantero-Amiano, R. Bolaños, D. Laino, R. Pierdicca

“…The cost associated with TLS is also significant; although feasible for small forest patches, scaling these methods to larger areas would demand substantial resources. …”
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Radiation accidents associated with violation of rules of gathering and recycling of ferrous and non-ferrous metal scrap in the Russian Federation in 2010-2023 by A. V. Gromov, A. M. Biblin, K. A. Sednev, R. R. Akhmatdinov

“…In most (64%) of the registered radiation accidents, the batches of scrap metal were accompanied by radiation control certificates from accredited laboratories, confirming compliance with sanitary standards and regulations. …”
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Handheld X-ray Fluorescence Spectrometers: A Forensic Application in Cigarette Ashes by Beatriz P. Senra, Helena Ribeiro, Alexandra Guedes

“…These elements are considered micronutrients in the plants, in this case, the tobacco plant [1,2], and therefore can result in greater variability among the various batches produced. However, it is possible to state that there are four brands whose five cigarettes are grouped. …”
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Las Cabras volcano, Michoacán-Guanajuato Volcanic Field, México: Topographic, climatic, and shallow magmatic controls on scoria cone eruptions by Marie-Noëlle Guilbaud, Athziri Hernández-Jiménez, Claus Siebe, Sergio Salinas

“…Whole-rock chemical variations and crystal disequilibrium textures point toward a complex magma feeding system, involving mixing and mingling between different magma batches. This study shows that the formation of scoria cones on a terrain with a marked slope (>10°) has profound impacts on the eruption dynamics and related hazards due to its effect on cone stability and ash erosion. …”
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